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ONTOLOGY REPORT - ANNOTATIONS


Term:platelet-derived growth factor receptor signaling pathway
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Accession:GO:0048008 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
Synonyms:exact_synonym: PDGF receptor signaling pathway;   PDGF receptor signalling pathway;   PDGFR signaling pathway


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platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO (MGI:MGI:3814963|PMID:18827006)
(MGI:MGI:4462113|PMID:20417104)
MGI PMID:18827006, PMID:20417104 MGI:MGI:3814963, MGI:MGI:4462113 NCBI chrNW_004955513:652,048...799,182 JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase ISO (MGI:MGI:3814963|PMID:18827006) MGI PMID:18827006 MGI:MGI:3814963 NCBI chrNW_004955406:18,435,984...18,527,967 JBrowse link
G Arid5b AT-rich interaction domain 5B ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955425:15,253,951...15,433,246 JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member ISO (MGI:MGI:3687409|PMID:9083073) UniProtKB PMID:9083073 MGI:MGI:3687409 NCBI chrNW_004955484:2,223,306...2,258,444 JBrowse link
G Bcr BCR activator of RhoGEF and GTPase ISO RGD PMID:11560856 RGD:1600511 NCBI chrNW_004955455:7,598,794...7,727,386 JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 ISO (MGI:MGI:5699914|PMID:26437238) MGI PMID:26437238 MGI:MGI:5699914 NCBI chrNW_004955450:2,631,310...2,663,118 JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955427:24,825,010...24,830,030 JBrowse link
G Fer FER tyrosine kinase ISO (MGI:MGI:5319623|PMID:7623846) UniProtKB PMID:7623846 MGI:MGI:5319623 NCBI chrNW_004955418:5,612,919...5,981,549 JBrowse link
G Gab1 GRB2 associated binding protein 1 ISO (MGI:MGI:1355592|PMID:10779359) MGI PMID:10779359 MGI:MGI:1355592 NCBI chrNW_004955471:61,580...191,175 JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO (MGI:MGI:5430891|PMID:17563371) BHF-UCL PMID:17563371 MGI:MGI:5430891 NCBI chrNW_004955416:14,558,628...14,652,031 JBrowse link
G Itgb3 integrin subunit beta 3 ISO (MGI:MGI:5462513|PMID:22984613) MGI PMID:22984613 MGI:MGI:5462513 NCBI chrNW_004955478:9,788,192...9,830,254 JBrowse link
G Jak2 Janus kinase 2 ISO PDGF-induced pancreatic stellate cell proliferation RGD PMID:15948243 RGD:1600095 NCBI chrNW_004955434:9,227,897...9,341,208 JBrowse link
G Myo1e myosin IE ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955450:15,421,843...15,551,680 JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 ISO (PMID:23554459) BHF-UCL PMID:23554459 NCBI chrNW_004955419:25,779,368...25,817,445 JBrowse link
G Nrp1 neuropilin 1 ISO (PMID:21245381) BHF-UCL PMID:21245381 NCBI chrNW_004955462:4,101,997...4,241,012 JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO (PMID:2439522), (PMID:2536956), (PMID:2836953) BHF-UCL PMID:2439522, PMID:2536956, PMID:2836953 NCBI chrNW_004955460:8,328,400...8,346,755 JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO (PMID:19088079), (PMID:21245381), (PMID:23554459), (PMID:2439522), (PMID:2536956), (PMID:2836953) RGD
BHF-UCL
PMID:2439522, PMID:2536956, PMID:2836953, PMID:17449016, PMID:19088079, PMID:21245381, PMID:23554459 RGD:2292197 NCBI chrNW_004955413:25,150,702...25,166,987 JBrowse link
G Pdgfc platelet derived growth factor C ISO (PMID:10806482)
(MGI:MGI:3056973|PMID:15372073)
BHF-UCL
MGI
PMID:10806482, PMID:15372073 MGI:MGI:3056973 NCBI chrNW_004955471:10,318,683...10,500,624 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha ISO (PMID:10806482), (PMID:2536956)
(MGI:MGI:3696608|PMID:17143286)
BHF-UCL
MGI
PMID:2536956, PMID:10806482, PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955447:16,570,652...16,613,410 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO (PMID:1314164), (PMID:2536956)
(MGI:MGI:3696608|PMID:17143286)
(MGI:MGI:5699914|PMID:26437238)
UniProtKB
MGI
PMID:1314164, PMID:2536956, PMID:17143286, PMID:26437238 MGI:MGI:3696608, MGI:MGI:5699914 NCBI chrNW_004955415:4,365,848...4,403,317 JBrowse link
G Plat plasminogen activator, tissue type ISO (MGI:MGI:3056973|PMID:15372073) MGI PMID:15372073 MGI:MGI:3056973 NCBI chrNW_004955536:730,962...754,333 JBrowse link
G Plekha1 pleckstrin homology domain containing A1 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955477:659,640...730,394 JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:14718524 RGD:1358422 NCBI chrNW_004955425:5,007,811...5,091,829 JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 ISO (MGI:MGI:3814963|PMID:18827006) MGI PMID:18827006 MGI:MGI:3814963 NCBI chrNW_004955482:8,934,734...9,031,230 JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J ISO (PMID:21091576) UniProtKB PMID:21091576 NCBI chrNW_004955422:396,266...438,792 JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO (MGI:MGI:2445332|PMID:12466202) MGI PMID:12466202 MGI:MGI:2445332 NCBI chrNW_004955513:1,224,418...1,328,176 JBrowse link
G Rgs14 regulator of G protein signaling 14 ISO PMID:19878719 UniProt PMID:19878719 RGD:8553779 NCBI chrNW_004955408:29,602,654...29,616,793 JBrowse link
G Schip1 schwannomin interacting protein 1 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955448:10,364,261...10,502,799 JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955437:20,489,641...20,547,105 JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 ISO (MGI:MGI:5518963|PMID:23651497) MGI PMID:23651497 MGI:MGI:5518963 NCBI chrNW_004955484:8,207,686...8,298,164 JBrowse link
G Ston1 stonin 1 ISO (MGI:MGI:5699914|PMID:26437238) MGI PMID:26437238 MGI:MGI:5699914 NCBI chrNW_004955441:15,071,765...15,126,534 JBrowse link
G Tiparp TCDD inducible poly(ADP-ribose) polymerase ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955448:7,687,668...7,716,481 JBrowse link
G Txnip thioredoxin interacting protein ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955568:103,801...107,791 JBrowse link
G Zfand5 zinc finger AN1-type containing 5 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chrNW_004955434:841,410...847,598 JBrowse link
negative regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO (MGI:MGI:4943654|PMID:19460854)
(PMID:12070119)
UniProtKB PMID:12070119, PMID:19460854 MGI:MGI:4943654 NCBI chrNW_004955420:20,911,181...20,922,992 JBrowse link
G Apod apolipoprotein D ISO (PMID:14551159) UniProtKB PMID:14551159 NCBI chrNW_004955420:13,553,254...13,570,357 JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate ISO (PMID:18977327) BHF-UCL PMID:18977327 NCBI chrNW_004955506:1,405,543...1,418,095 JBrowse link
G Inppl1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chrNW_004955414:19,146,304...19,163,923 JBrowse link
G Ndrg4 NDRG family member 4 ISO (PMID:12755708) BHF-UCL PMID:12755708 NCBI chrNW_004955433:15,914,884...15,933,000 JBrowse link
G Ptgir prostaglandin I2 receptor ISO (MGI:MGI:5437428|PMID:20622039) BHF-UCL PMID:20622039 MGI:MGI:5437428 NCBI chrNW_004955574:686,156...690,126 JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J ISO (MGI:MGI:4942250|PMID:12833140)
(PMID:14709717)
UniProtKB PMID:12833140, PMID:14709717 MGI:MGI:4942250 NCBI chrNW_004955422:396,266...438,792 JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 ISO (MGI:MGI:4943390|PMID:18190691) UniProtKB PMID:18190691 MGI:MGI:4943390 NCBI chrNW_004955553:1,639,267...1,656,850 JBrowse link
G Snca synuclein alpha ISO (PMID:12239163) UniProtKB PMID:12239163 NCBI chrNW_004955405:854,011...962,741 JBrowse link
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO (MGI:MGI:4943654|PMID:19460854) UniProtKB PMID:19460854 MGI:MGI:4943654 NCBI chrNW_004955420:20,911,181...20,922,992 JBrowse link
G Phf14 PHD finger protein 14 ISO (MGI:MGI:5426441|PMID:22730381) MGI PMID:22730381 MGI:MGI:5426441 NCBI chrNW_004955432:17,535,222...17,807,106 JBrowse link
negative regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glrx glutaredoxin ISO RGD PMID:16893901 RGD:9686048 NCBI chrNW_004955418:16,747,709...16,754,718 JBrowse link
G Lrp1 LDL receptor related protein 1 ISO (MGI:MGI:4365879|PMID:19742316) BHF-UCL PMID:19742316 MGI:MGI:4365879 NCBI chrNW_004955458:4,861,431...4,941,939 JBrowse link
G Myocd myocardin ISO (MGI:MGI:5644147|PMID:23825366) BHF-UCL PMID:23825366 MGI:MGI:5644147 NCBI chrNW_004955467:4,653,065...4,743,438 JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 ISO (MGI:MGI:3029644|PMID:14966296) UniProtKB PMID:14966296 MGI:MGI:3029644 NCBI chrNW_004955402:771,410...846,671 JBrowse link
platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfra platelet derived growth factor receptor alpha ISO (PMID:2554309)
(MGI:MGI:5294530|PMID:20110689)
UniProtKB PMID:2554309, PMID:20110689 MGI:MGI:5294530 NCBI chrNW_004955447:16,570,652...16,613,410 JBrowse link
platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO (PMID:24520051) UniProtKB PMID:24520051 NCBI chrNW_004955513:652,048...799,182 JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 ISO (PMID:24520051) UniProtKB PMID:24520051 NCBI chrNW_004955421:767,648...957,160 JBrowse link
G Lox lysyl oxidase ISO PMID:18586678
(MGI:MGI:3813418|PMID:18586678)
MGI PMID:18586678 MGI:MGI:3813418, RGD:14390060 NCBI chrNW_004955521:178,290...193,926 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO (PMID:2554309), (PMID:26599395) UniProtKB PMID:2554309, PMID:26599395 NCBI chrNW_004955415:4,365,848...4,403,317 JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 ISO (MGI:MGI:3029644|PMID:14966296)
(PMID:14966296)
UniProtKB PMID:14966296 MGI:MGI:3029644 NCBI chrNW_004955445:7,754,313...7,819,229 JBrowse link
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfra platelet derived growth factor receptor alpha ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chrNW_004955447:16,570,652...16,613,410 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chrNW_004955415:4,365,848...4,403,317 JBrowse link
G Vegfa vascular endothelial growth factor A ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfa platelet derived growth factor subunit A ISO (PMID:19019919) UniProtKB PMID:19019919 NCBI chrNW_004955460:8,328,400...8,346,755 JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO (PMID:19019919) UniProtKB PMID:19019919 NCBI chrNW_004955413:25,150,702...25,166,987 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO (MGI:MGI:5284758|PMID:19019919) UniProtKB PMID:19019919 MGI:MGI:5284758 NCBI chrNW_004955415:4,365,848...4,403,317 JBrowse link
positive regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor ISO (PMID:17991872) BHF-UCL PMID:17991872 NCBI chrNW_004955423:254,060...264,448 JBrowse link
G F7 coagulation factor VII ISO (PMID:17991872) BHF-UCL PMID:17991872 NCBI chrNW_004955404:685,170...692,797 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PMID:16530387 UniProt PMID:16530387 RGD:8553998 NCBI chrNW_004955445:19,213,210...19,227,670 JBrowse link
positive regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hip1 huntingtin interacting protein 1 ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chrNW_004955456:14,389,282...14,529,317 JBrowse link
G Hip1r huntingtin interacting protein 1 related ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chrNW_004955482:5,885,807...5,896,386 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO (MGI:MGI:5518963|PMID:23651497) MGI PMID:23651497 MGI:MGI:5518963 NCBI chrNW_004955445:19,213,210...19,227,670 JBrowse link
regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fshr follicle stimulating hormone receptor ISO (MGI:MGI:3768889|PMID:16344272) MGI PMID:16344272 MGI:MGI:3768889 NCBI chrNW_004955441:15,422,190...15,585,446 JBrowse link
G Lrig2 leucine rich repeats and immunoglobulin like domains 2 ISO (MGI:MGI:5547441|PMID:24023893) MGI PMID:24023893 MGI:MGI:5547441 NCBI chrNW_004955435:16,468,300...16,522,503 JBrowse link
regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene ISO (MGI:MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:MGI:6108066 NCBI chrNW_004955412:20,307,011...20,388,539 JBrowse link
G Cblb Cbl proto-oncogene B ISO (MGI:MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:MGI:6108066 NCBI chrNW_004955427:6,601,651...6,812,896 JBrowse link
G Ift20 intraflagellar transport 20 ISO (MGI:MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:MGI:6108066 NCBI chrNW_004955481:4,799,548...4,807,751 JBrowse link
regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lox lysyl oxidase ISO (MGI:MGI:5293278|PMID:21665949) MGI PMID:21665949 MGI:MGI:5293278 NCBI chrNW_004955521:178,290...193,926 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11862
    signaling 4138
      signal transduction 3673
        cell surface receptor signaling pathway 2013
          enzyme linked receptor protein signaling pathway 790
            transmembrane receptor protein tyrosine kinase signaling pathway 494
              platelet-derived growth factor receptor signaling pathway 61
                VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                negative regulation of platelet-derived growth factor receptor signaling pathway + 14
                platelet-derived growth factor receptor-alpha signaling pathway + 6
                platelet-derived growth factor receptor-beta signaling pathway + 14
                positive regulation of platelet-derived growth factor receptor signaling pathway + 5
                regulation of platelet-derived growth factor receptor signaling pathway + 25
Path 2
Term Annotations click to browse term
  biological_process 11862
    biological regulation 8697
      regulation of biological process 8250
        regulation of cellular process 7832
          signal transduction 3673
            cell surface receptor signaling pathway 2013
              enzyme linked receptor protein signaling pathway 790
                transmembrane receptor protein tyrosine kinase signaling pathway 494
                  platelet-derived growth factor receptor signaling pathway 61
                    VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                    negative regulation of platelet-derived growth factor receptor signaling pathway + 14
                    platelet-derived growth factor receptor-alpha signaling pathway + 6
                    platelet-derived growth factor receptor-beta signaling pathway + 14
                    positive regulation of platelet-derived growth factor receptor signaling pathway + 5
                    regulation of platelet-derived growth factor receptor signaling pathway + 25
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.