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ONTOLOGY REPORT - ANNOTATIONS


Term:platelet-derived growth factor receptor signaling pathway
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Accession:GO:0048008 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
Synonyms:exact_synonym: PDGF receptor signaling pathway;   PDGF receptor signalling pathway;   PDGFR signaling pathway


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platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO (MGI:MGI:4462113|PMID:20417104)
(MGI:MGI:3814963|PMID:18827006)
MGI PMID:18827006, PMID:20417104 MGI:MGI:3814963, MGI:MGI:4462113 NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941
JBrowse link
G ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase ISO (MGI:MGI:3814963|PMID:18827006) MGI PMID:18827006 MGI:MGI:3814963 NCBI chr 1:154,586,423...154,711,621
Ensembl chr 1:158,280,994...158,313,915
JBrowse link
G ARID5B AT-rich interaction domain 5B ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chr10:58,426,519...58,621,986
Ensembl chr10:60,756,484...60,952,174
JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member ISO (MGI:MGI:3687409|PMID:9083073) UniProtKB PMID:9083073 MGI:MGI:3687409 NCBI chr16:55,798,578...55,838,448
Ensembl chr16:75,150,122...75,188,775
JBrowse link
G BCR BCR activator of RhoGEF and GTPase ISO RGD PMID:11560856 RGD:1600511
G CSPG4 chondroitin sulfate proteoglycan 4 ISO (MGI:MGI:5699914|PMID:26437238) MGI PMID:26437238 MGI:MGI:5699914 NCBI chr15:54,583,010...54,621,240
Ensembl chr15:74,177,909...74,200,498
JBrowse link
G CSRNP1 cysteine and serine rich nuclear protein 1 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chr 3:39,038,039...39,050,754
Ensembl chr 3:39,318,438...39,331,228
JBrowse link
G FER FER tyrosine kinase ISO (MGI:MGI:5319623|PMID:7623846) UniProtKB PMID:7623846 MGI:MGI:5319623 NCBI chr 5:104,099,620...104,548,077
Ensembl chr 5:109,964,823...110,350,576
JBrowse link
G GAB1 GRB2 associated binding protein 1 ISO (MGI:MGI:1355592|PMID:10779359) MGI PMID:10779359 MGI:MGI:1355592 NCBI chr 4:135,697,939...135,834,755
Ensembl chr 4:146,996,936...147,133,672
JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 ISO (MGI:MGI:5430891|PMID:17563371) BHF-UCL PMID:17563371 MGI:MGI:5430891 NCBI chr15:69,076,025...69,190,082
Ensembl chr15:88,276,851...88,388,594
JBrowse link
G ITGB3 integrin subunit beta 3 ISO (MGI:MGI:5462513|PMID:22984613) MGI PMID:22984613 MGI:MGI:5462513 NCBI chr17:10,134,450...10,194,596 JBrowse link
G JAK2 Janus kinase 2 ISO PDGF-induced pancreatic stellate cell proliferation RGD PMID:15948243 RGD:1600095 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626
JBrowse link
G LOC100971374 thioredoxin-interacting protein ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chr 1:90,007,878...90,012,055 JBrowse link
G MYO1E myosin IE ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chr15:38,106,599...38,343,040
Ensembl chr15:56,413,570...56,649,722
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 ISO (PMID:23554459) BHF-UCL PMID:23554459 NCBI chr 9:70,907,056...70,950,221 JBrowse link
G NRP1 neuropilin 1 ISO (PMID:21245381) BHF-UCL PMID:21245381 NCBI chr10:33,298,918...33,456,466
Ensembl chr10:33,883,173...34,039,648
JBrowse link
G PDGFA platelet derived growth factor subunit A ISO (PMID:2439522), (PMID:2536956), (PMID:2836953) BHF-UCL PMID:2439522, PMID:2536956, PMID:2836953 NCBI chr 7:648,722...672,023 JBrowse link
G PDGFB platelet derived growth factor subunit B ISO (PMID:19088079), (PMID:21245381), (PMID:23554459), (PMID:2439522), (PMID:2536956), (PMID:2836953) BHF-UCL
RGD
PMID:2439522, PMID:2536956, PMID:2836953, PMID:17449016, PMID:19088079, PMID:21245381, PMID:23554459 RGD:2292197 NCBI chr22:20,127,223...20,148,407
Ensembl chr22:37,944,018...37,964,883
JBrowse link
G PDGFC platelet derived growth factor C ISO (PMID:10806482)
(MGI:MGI:3056973|PMID:15372073)
BHF-UCL
MGI
PMID:10806482, PMID:15372073 MGI:MGI:3056973 NCBI chr 4:149,105,330...149,317,254
Ensembl chr 4:160,922,827...161,131,960
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO (PMID:10806482), (PMID:2536956)
(MGI:MGI:3696608|PMID:17143286)
BHF-UCL
MGI
PMID:2536956, PMID:10806482, PMID:17143286 MGI:MGI:3696608 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097
JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO (MGI:MGI:5699914|PMID:26437238)
(MGI:MGI:3696608|PMID:17143286)
(PMID:1314164), (PMID:2536956)
MGI
UniProtKB
PMID:1314164, PMID:2536956, PMID:17143286, PMID:26437238 MGI:MGI:3696608, MGI:MGI:5699914 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530
JBrowse link
G PLAT plasminogen activator, tissue type ISO (MGI:MGI:3056973|PMID:15372073) MGI PMID:15372073 MGI:MGI:3056973 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chr10:118,942,896...119,001,185
Ensembl chr10:122,354,765...122,412,588
JBrowse link
G PTEN phosphatase and tensin homolog ISO RGD PMID:14718524 RGD:1358422 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605
JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO (MGI:MGI:3814963|PMID:18827006) MGI PMID:18827006 MGI:MGI:3814963 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762
JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J ISO (PMID:21091576) UniProtKB PMID:21091576 NCBI chr11:47,941,134...48,130,538
Ensembl chr11:48,613,761...48,670,494
JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 ISO (MGI:MGI:2445332|PMID:12466202) MGI PMID:12466202 MGI:MGI:2445332 NCBI chr 9:102,698,970...102,861,482
Ensembl chr 9:131,337,001...131,495,664
JBrowse link
G RGS14 regulator of G protein signaling 14 ISO PMID:19878719 UniProt PMID:19878719 RGD:8553779 NCBI chr 5:172,659,323...172,674,084
Ensembl chr 5:179,721,876...179,739,453
JBrowse link
G SCHIP1 schwannomin interacting protein 1 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chr 3:156,307,829...156,919,728 JBrowse link
G SGPL1 sphingosine-1-phosphate lyase 1 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chr10:67,286,349...67,351,574
Ensembl chr10:69,812,092...69,876,438
JBrowse link
G SMPD3 sphingomyelin phosphodiesterase 3 ISO (MGI:MGI:5518963|PMID:23651497) MGI PMID:23651497 MGI:MGI:5518963 NCBI chr16:48,734,664...48,825,241
Ensembl chr16:68,131,905...68,142,871
JBrowse link
G STON1 stonin 1 ISO (MGI:MGI:5699914|PMID:26437238) MGI PMID:26437238 MGI:MGI:5699914 NCBI chr2A:48,656,425...48,722,288
Ensembl chr2A:49,577,562...49,721,845
JBrowse link
G TIPARP TCDD inducible poly(ADP-ribose) polymerase ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chr 3:153,730,307...153,762,442
Ensembl chr 3:161,783,999...161,816,525
JBrowse link
G ZFAND5 zinc finger AN1-type containing 5 ISO (MGI:MGI:3696608|PMID:17143286) MGI PMID:17143286 MGI:MGI:3696608 NCBI chr 9:52,446,788...52,457,527
Ensembl chr 9:71,144,900...71,154,869
JBrowse link
negative regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO (MGI:MGI:4943654|PMID:19460854)
(PMID:12070119)
UniProtKB PMID:12070119, PMID:19460854 MGI:MGI:4943654 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G APOD apolipoprotein D ISO (PMID:14551159) UniProtKB PMID:14551159 NCBI chr 3:192,852,887...192,868,233
Ensembl chr 3:203,152,476...203,168,060
JBrowse link
G HGS hepatocyte growth factor-regulated tyrosine kinase substrate ISO (PMID:18977327) BHF-UCL PMID:18977327 NCBI chr17:76,143,212...76,161,469
Ensembl chr17:81,844,379...81,862,335
JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chr11:67,302,066...67,317,785
Ensembl chr11:70,527,017...70,540,846
JBrowse link
G NDRG4 NDRG family member 4 ISO (PMID:12755708) BHF-UCL PMID:12755708 NCBI chr16:38,729,616...38,780,173
Ensembl chr16:57,857,414...57,907,557
JBrowse link
G PTGIR prostaglandin I2 receptor ISO (MGI:MGI:5437428|PMID:20622039) BHF-UCL PMID:20622039 MGI:MGI:5437428 NCBI chr19:43,613,065...43,617,700
Ensembl chr19:52,141,822...52,146,473
JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J ISO (MGI:MGI:4942250|PMID:12833140)
(PMID:14709717)
UniProtKB PMID:12833140, PMID:14709717 MGI:MGI:4942250 NCBI chr11:47,941,134...48,130,538
Ensembl chr11:48,613,761...48,670,494
JBrowse link
G SLC9A3R1 SLC9A3 regulator 1 ISO (MGI:MGI:4943390|PMID:18190691) UniProtKB PMID:18190691 MGI:MGI:4943390 NCBI chr17:68,694,468...68,715,157
Ensembl chr17:74,250,406...74,271,234
JBrowse link
G SNCA synuclein alpha ISO (PMID:12239163) UniProtKB PMID:12239163 NCBI chr 4:82,018,585...82,132,938
Ensembl chr 4:92,737,608...92,850,600
JBrowse link
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO (MGI:MGI:4943654|PMID:19460854) UniProtKB PMID:19460854 MGI:MGI:4943654 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885
JBrowse link
G PHF14 PHD finger protein 14 ISO (MGI:MGI:5426441|PMID:22730381) MGI PMID:22730381 MGI:MGI:5426441 NCBI chr 7:11,608,934...11,822,039
Ensembl chr 7:10,972,503...11,169,377
JBrowse link
negative regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLRX glutaredoxin ISO RGD PMID:16893901 RGD:9686048 NCBI chr 5:19,526,210...19,535,237
Ensembl chr 5:19,671,965...19,680,685
JBrowse link
G LRP1 LDL receptor related protein 1 ISO (MGI:MGI:4365879|PMID:19742316) BHF-UCL PMID:19742316 MGI:MGI:4365879 NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979
JBrowse link
G MYOCD myocardin ISO (MGI:MGI:5644147|PMID:23825366) BHF-UCL PMID:23825366 MGI:MGI:5644147 NCBI chr17:38,880,120...38,983,246
Ensembl chr17:43,584,259...43,681,659
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 ISO (MGI:MGI:3029644|PMID:14966296) UniProtKB PMID:14966296 MGI:MGI:3029644 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570
JBrowse link
platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFRA platelet derived growth factor receptor alpha ISO (PMID:2554309)
(MGI:MGI:5294530|PMID:20110689)
UniProtKB PMID:2554309, PMID:20110689 MGI:MGI:5294530 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097
JBrowse link
platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO (PMID:24520051) UniProtKB PMID:24520051 NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941
JBrowse link
G CLASP2 cytoplasmic linker associated protein 2 ISO (PMID:24520051) UniProtKB PMID:24520051 NCBI chr 3:33,418,300...33,640,185 JBrowse link
G LOX lysyl oxidase ISO PMID:18586678
(MGI:MGI:3813418|PMID:18586678)
MGI PMID:18586678 MGI:MGI:3813418, RGD:14390060 NCBI chr 5:117,450,833...117,464,957
Ensembl chr 5:123,234,662...123,248,717
JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO (PMID:2554309), (PMID:26599395) UniProtKB PMID:2554309, PMID:26599395 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 ISO (MGI:MGI:3029644|PMID:14966296)
(PMID:14966296)
UniProtKB PMID:14966296 MGI:MGI:3029644 NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421
JBrowse link
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFRA platelet derived growth factor receptor alpha ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097
JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530
JBrowse link
G VEGFA vascular endothelial growth factor A ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFA platelet derived growth factor subunit A ISO (PMID:19019919) UniProtKB PMID:19019919 NCBI chr 7:648,722...672,023 JBrowse link
G PDGFB platelet derived growth factor subunit B ISO (PMID:19019919) UniProtKB PMID:19019919 NCBI chr22:20,127,223...20,148,407
Ensembl chr22:37,944,018...37,964,883
JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO (MGI:MGI:5284758|PMID:19019919) UniProtKB PMID:19019919 MGI:MGI:5284758 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530
JBrowse link
positive regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor ISO (PMID:17991872) BHF-UCL PMID:17991872 NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050
JBrowse link
G F7 coagulation factor VII ISO (PMID:17991872) BHF-UCL PMID:17991872 NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO PMID:16530387 UniProt PMID:16530387 RGD:8553998 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634
JBrowse link
positive regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIP1 huntingtin interacting protein 1 ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chr 7:68,281,899...68,464,233 JBrowse link
G HIP1R huntingtin interacting protein 1 related ISO (PMID:14732715) ParkinsonsUK-UCL PMID:14732715 NCBI chr12:120,438,841...120,467,489
Ensembl chr12:124,685,091...124,700,726
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO (MGI:MGI:5518963|PMID:23651497) MGI PMID:23651497 MGI:MGI:5518963 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634
JBrowse link
regulation of platelet-derived growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FSHR follicle stimulating hormone receptor ISO (MGI:MGI:3768889|PMID:16344272) MGI PMID:16344272 MGI:MGI:3768889 NCBI chr2A:49,088,450...49,287,688
Ensembl chr2A:50,008,328...50,207,258
JBrowse link
regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBL Cbl proto-oncogene ISO (MGI:MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:MGI:6108066 NCBI chr11:114,044,996...114,149,204
Ensembl chr11:117,973,187...118,074,671
JBrowse link
G CBLB Cbl proto-oncogene B ISO (MGI:MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:MGI:6108066 NCBI chr 3:102,752,406...102,966,414
Ensembl chr 3:109,690,120...109,905,191
JBrowse link
G IFT20 intraflagellar transport 20 ISO (MGI:MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:MGI:6108066 NCBI chr17:28,438,960...28,446,113
Ensembl chr17:28,941,303...28,948,129
JBrowse link
regulation of platelet-derived growth factor receptor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOX lysyl oxidase ISO (MGI:MGI:5293278|PMID:21665949) MGI PMID:21665949 MGI:MGI:5293278 NCBI chr 5:117,450,833...117,464,957
Ensembl chr 5:123,234,662...123,248,717
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12529
    signaling 4286
      signal transduction 3809
        cell surface receptor signaling pathway 2090
          enzyme linked receptor protein signaling pathway 812
            transmembrane receptor protein tyrosine kinase signaling pathway 506
              platelet-derived growth factor receptor signaling pathway 60
                VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                negative regulation of platelet-derived growth factor receptor signaling pathway + 14
                platelet-derived growth factor receptor-alpha signaling pathway + 6
                platelet-derived growth factor receptor-beta signaling pathway + 14
                positive regulation of platelet-derived growth factor receptor signaling pathway + 5
                regulation of platelet-derived growth factor receptor signaling pathway + 24
Path 2
Term Annotations click to browse term
  biological_process 12529
    biological regulation 9138
      regulation of biological process 8652
        regulation of cellular process 8181
          signal transduction 3809
            cell surface receptor signaling pathway 2090
              enzyme linked receptor protein signaling pathway 812
                transmembrane receptor protein tyrosine kinase signaling pathway 506
                  platelet-derived growth factor receptor signaling pathway 60
                    VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                    negative regulation of platelet-derived growth factor receptor signaling pathway + 14
                    platelet-derived growth factor receptor-alpha signaling pathway + 6
                    platelet-derived growth factor receptor-beta signaling pathway + 14
                    positive regulation of platelet-derived growth factor receptor signaling pathway + 5
                    regulation of platelet-derived growth factor receptor signaling pathway + 24
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.