ONTOLOGY REPORT - ANNOTATIONS
Term: antigen processing and presentation of peptide antigen
Accession: GO:0048002
browse the term
Definition: The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
Synonyms: exact_synonym: antigen presentation, peptide antigen; peptide antigen processing and presentation
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CTSL3
cathepsin L family member 3
involved_in
ISO
(MGI:2655909|PMID:9545226), (MGI:3655445|PMID:12021314)
UniProt
PMID:9545226 PMID:12021314
MGI:2655909 MGI:3655445
NCBI chr 1:72,215,774...72,219,093
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CTSS
cathepsin S
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:59,893,840...59,910,878
Ensembl chr17:59,893,840...59,910,849
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CTSV
cathepsin V
involved_in
ISS
UniProt
GO_REF:0000024
NCBI chr 1:69,937,550...69,943,316
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DLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:2,221,181...2,227,600
Ensembl chr12:2,221,137...2,227,600
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DLA-DQB1
major histocompatibility complex, class II, DQ beta 1
acts_upstream_of_or_within
ISO
(MGI:1913231|PMID:11069069)
MGI
PMID:11069069
MGI:1913231
NCBI chr12:2,305,307...2,307,711
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SLC11A1
solute carrier family 11 member 1
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:3758128|PMID:17620357)
MGI Ensembl
PMID:17620357
GO_REF:0000107 MGI:3758128
NCBI chr37:25,039,203...25,047,461
Ensembl chr37:25,038,360...25,047,282
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B2M
beta-2-microglobulin
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997
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B2M
beta-2-microglobulin
involved_in
IEA
Ensembl
GO_REF:0000107
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DLA-DOB
major histocompatibility complex, class II, DO beta
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr12:2,376,957...2,384,179
Ensembl chr12:2,378,126...2,432,303
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IDE
insulin degrading enzyme
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr28:6,844,480...6,967,713
Ensembl chr28:6,844,055...6,967,713
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PSMB8
proteasome 20S subunit beta 8
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr12:2,419,456...2,422,832
Ensembl chr12:2,378,126...2,432,303
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TAP1
transporter 1, ATP binding cassette subfamily B member
involved_in
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr12:2,424,049...2,432,165
Ensembl chr12:2,378,126...2,432,303
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TAP2
transporter 2, ATP binding cassette subfamily B member
acts_upstream_of_or_within involved_in
ISO IEA
PMID:1758495
MGI Ensembl InterPro
PMID:1758495
GO_REF:0000002 GO_REF:0000107 RGD:1299069
NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303
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TAPBP
TAP binding protein
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr12:2,740,276...2,751,808
Ensembl chr12:2,740,276...2,751,808
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TAP2
transporter 2, ATP binding cassette subfamily B member
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:50291|PMID:1538753)
MGI Ensembl
PMID:1538753
GO_REF:0000107 MGI:50291
NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303
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DLA88
MHC class I DLA-88
involved_in
IBA
(PMID:21873635)
GO_Central
PMID:21873635
NCBI chr12:892,442...895,691
Ensembl chr12:892,388...1,021,690
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DLA-12
MHC class I DLA-12
involved_in
ISO
(PMID:9754572)
UniProt
PMID:9754572
NCBI chr12:933,321...936,671
Ensembl chr12:932,613...987,561
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DLA-79
MHC class Ib
involved_in
ISO
(PMID:28636952)
UniProt
PMID:28636952
NCBI chr18:41,142,312...41,170,018
Ensembl chr18:41,142,307...41,170,100
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DLA88
MHC class I DLA-88
involved_in
IBA
(PMID:21873635)
GO_Central
PMID:21873635
NCBI chr12:892,442...895,691
Ensembl chr12:892,388...1,021,690
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TAP2
transporter 2, ATP binding cassette subfamily B member
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:50291|PMID:1538753)
MGI Ensembl
PMID:1538753
GO_REF:0000107 MGI:50291
NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303
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DLA-DRA
MHC class II DR alpha chain
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:2,133,026...2,137,825
Ensembl chr12:2,132,499...2,168,975
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HLA-DRB1
MHC class II DLA DRB1 beta chain
involved_in
ISO
(PMID:15322540)
UniProt
PMID:15322540
NCBI chr12:2,151,409...2,164,564
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MPEG1
macrophage expressed 1
involved_in
ISO
(MGI:7539255|PMID:35471730)
UniProt
PMID:35471730
MGI:7539255
NCBI chr18:37,530,895...37,535,334
Ensembl chr18:37,531,032...37,533,179
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CLEC4A
C-type lectin domain family 4, member A
involved_in
ISO
(PMID:20530286)
UniProt
PMID:20530286
NCBI chr27:37,493,740...37,510,276
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FCER1G
Fc epsilon receptor Ig
acts_upstream_of_or_within
ISO
(MGI:2664488|PMID:11911824)
MGI
PMID:11911824
MGI:2664488
NCBI chr38:21,267,841...21,271,036
Ensembl chr38:21,268,001...21,270,940
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FCGR1A
Fc fragment of IgG receptor Ia
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:2664488|PMID:11911824)
MGI Ensembl
PMID:11911824
GO_REF:0000107 MGI:2664488
NCBI chr17:59,073,139...59,102,023
Ensembl chr17:59,092,933...59,102,015
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IFI30
IFI30 lysosomal thiol reductase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:44,819,862...44,823,261
Ensembl chr20:44,819,893...44,823,342
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MFSD6
major facilitator superfamily domain containing 6
acts_upstream_of_or_within
ISO
(MGI:3692789|PMID:17010536)
MGI
PMID:17010536
MGI:3692789
NCBI chr37:1,012,202...1,078,759
Ensembl chr37:1,013,234...1,077,112
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MPEG1
macrophage expressed 1
involved_in
ISO
(MGI:7493537|PMID:37347855)
UniProt
PMID:37347855
MGI:7493537
NCBI chr18:37,530,895...37,535,334
Ensembl chr18:37,531,032...37,533,179
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TAPBP
TAP binding protein
acts_upstream_of_or_within involved_in
ISO
(MGI:1289739|PMID:9716645)
MGI UniProt
PMID:9716645
MGI:1289739
NCBI chr12:2,740,276...2,751,808
Ensembl chr12:2,740,276...2,751,808
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DLA-12
MHC class I DLA-12
involved_in
ISO
(PMID:20195504), (PMID:30087334)
UniProt
PMID:20195504 PMID:30087334
NCBI chr12:933,321...936,671
Ensembl chr12:932,613...987,561
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DLA-79
MHC class Ib
involved_in
ISO
(PMID:23851683)
UniProt
PMID:23851683
NCBI chr18:41,142,312...41,170,018
Ensembl chr18:41,142,307...41,170,100
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CD74
CD74 molecule
acts_upstream_of_or_within
ISO
(MGI:52620|PMID:7679955), (MGI:79110|PMID:8598040)
MGI
PMID:7679955 PMID:8598040
MGI:52620 MGI:79110
NCBI chr 4:58,689,745...58,698,421
Ensembl chr 4:58,689,752...58,698,151
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CTSE
cathepsin E
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr38:2,368,711...2,380,554
Ensembl chr38:2,369,265...2,380,459
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CTSS
cathepsin S
involved_in
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr17:59,893,840...59,910,878
Ensembl chr17:59,893,840...59,910,849
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DLA-DMA
major histocompatibility complex, class II, DM alpha
acts_upstream_of_or_within involved_in
ISO IBA
(MGI:3033882|PMID:11027433) (PMID:21873635) (MGI:2153656|PMID:11714799) (MGI:79111|PMID:8598041) (MGI:79110|PMID:8598040)
MGI GO_Central
PMID:8598040 PMID:8598041 PMID:11027433 PMID:11714799 PMID:21873635
MGI:2153656 MGI:3033882 MGI:79110 MGI:79111
NCBI chr12:2,516,974...2,534,085
Ensembl chr12:2,503,325...2,533,990
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DLA-DMB
major histocompatibility complex, class II, DM beta
involved_in
IEA IBA
(PMID:21873635)
Ensembl GO_Central
PMID:21873635
GO_REF:0000107
NCBI chr12:2,503,325...2,508,380
Ensembl chr12:2,503,325...2,533,990
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DLA-DOA
HLA class II histocompatibility antigen, DO alpha chain-like
acts_upstream_of_or_within involved_in
ISO IBA IEA
(MGI:2671681|PMID:9492004) (PMID:21873635)
MGI GO_Central Ensembl
PMID:9492004 PMID:21873635
GO_REF:0000107 MGI:2671681
NCBI chr12:2,563,673...2,568,328
Ensembl chr12:2,563,673...2,568,328
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DLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:2,221,181...2,227,600
Ensembl chr12:2,221,137...2,227,600
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DLA-DQB1
major histocompatibility complex, class II, DQ beta 1
acts_upstream_of_or_within involved_in
ISO
(MGI:1913231|PMID:11069069), (MGI:2153656|PMID:11714799), (MGI:2671681|PMID:9492004), (MGI:3033881|PMID:9432982), (MGI:3033882|PMID:11027433), (MGI:52620|PMID:7679955), (MGI:79110|PMID:8598040), (MGI:79111|PMID:8598041) (PMID:32341563)
MGI UniProt
PMID:7679955 PMID:8598040 PMID:8598041 PMID:9432982 PMID:9492004 PMID:11027433 PMID:11069069 PMID:11714799 PMID:32341563 More...
MGI:1913231 MGI:2153656 MGI:2671681 MGI:3033881 MGI:3033882 MGI:52620 MGI:79110 MGI:79111
NCBI chr12:2,305,307...2,307,711
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DLA-DRA
MHC class II DR alpha chain
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:2153656|PMID:11714799), (MGI:3033882|PMID:11027433)
MGI Ensembl
PMID:11027433 PMID:11714799
GO_REF:0000107 MGI:2153656 MGI:3033882
NCBI chr12:2,133,026...2,137,825
Ensembl chr12:2,132,499...2,168,975
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FCER1G
Fc epsilon receptor Ig
acts_upstream_of_or_within
ISO
(MGI:2687086|PMID:14643301)
MGI
PMID:14643301
MGI:2687086
NCBI chr38:21,267,841...21,271,036
Ensembl chr38:21,268,001...21,270,940
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FCGR2B
Fc fragment of IgG receptor IIb
acts_upstream_of_or_within
ISO
(MGI:2687086|PMID:14643301)
MGI
PMID:14643301
MGI:2687086
NCBI chr38:20,980,777...20,994,403
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HLA-DRB1
MHC class II DLA DRB1 beta chain
acts_upstream_of_or_within involved_in
ISO IBA
(MGI:2153656|PMID:11714799), (MGI:3033882|PMID:11027433) (PMID:21873635)
MGI GO_Central
PMID:11027433 PMID:11714799 PMID:21873635
MGI:2153656 MGI:3033882
NCBI chr12:2,151,409...2,164,564
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IFI30
IFI30 lysosomal thiol reductase
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:2153425|PMID:11701933)
MGI Ensembl
PMID:11701933
GO_REF:0000107 MGI:2153425
NCBI chr20:44,819,862...44,823,261
Ensembl chr20:44,819,893...44,823,342
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IL10
interleukin 10
involved_in
NAS
(PMID:8746793)
UniProt
PMID:8746793
NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
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LGMN
legumain
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:1,810,263...1,843,116
Ensembl chr 8:1,728,273...1,843,050
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PIKFYVE
phosphoinositide kinase, FYVE-type zinc finger containing
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr37:16,537,095...16,620,427
Ensembl chr37:16,541,562...16,619,554
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TRAF6
TNF receptor associated factor 6
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:2677080|PMID:14499111)
MGI Ensembl
PMID:14499111
GO_REF:0000107 MGI:2677080
NCBI chr18:31,674,242...31,689,160
Ensembl chr18:31,675,391...31,688,641
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UNC93B1
unc-93 homolog B1, TLR signaling regulator
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:3615690|PMID:16415873)
MGI Ensembl
PMID:16415873
GO_REF:0000107 MGI:3615690
NCBI chr18:49,826,044...49,835,417
Ensembl chr18:49,826,026...49,882,461
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B2M
beta-2-microglobulin
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:3611636|PMID:16299293)
MGI Ensembl
PMID:16299293
GO_REF:0000107 MGI:3611636
NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997
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B2M
beta-2-microglobulin
involved_in
IEA
Ensembl
GO_REF:0000107
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TAP2
transporter 2, ATP binding cassette subfamily B member
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:3611636|PMID:16299293)
MGI Ensembl
PMID:16299293
GO_REF:0000107 MGI:3611636
NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303
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ABCB9
ATP binding cassette subfamily B member 9
NOT|involved_in
ISO
(PMID:17977821)
UniProt
PMID:17977821
NCBI chr26:6,538,705...6,569,074
Ensembl chr26:6,544,796...6,576,237
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B2M
beta-2-microglobulin
involved_in
IEA
UniProt
GO_REF:0000043
NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997
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B2M
beta-2-microglobulin
involved_in
IEA
UniProt
GO_REF:0000043
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DLA88
MHC class I DLA-88
involved_in
IEA
UniProt
GO_REF:0000043
NCBI chr12:892,442...895,691
Ensembl chr12:892,388...1,021,690
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MARCHF1
membrane associated ring-CH-type finger 1
involved_in
ISO
(PMID:18389477) (MGI:3703462|PMID:17255932), (MGI:4430994|PMID:19917682)
UniProt
PMID:17255932 PMID:18389477 PMID:19917682
MGI:3703462 MGI:4430994
NCBI chr15:59,753,597...60,279,692
Ensembl chr15:59,753,216...60,036,060
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MARCHF8
membrane associated ring-CH-type finger 8
involved_in
ISO
(MGI:3785681|PMID:16785530)
UniProt
PMID:16785530
MGI:3785681
NCBI chr28:2,006,923...2,165,491
Ensembl chr28:2,072,181...2,161,981
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HFE
homeostatic iron regulator
involved_in
ISO
(PMID:24643698)
BHF-UCL
PMID:24643698
NCBI chr35:24,031,479...24,038,922
Ensembl chr35:24,031,387...24,042,413
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TAPBPL
TAP binding protein like
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr27:38,526,968...38,534,585
Ensembl chr27:38,526,528...38,535,937
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DLA-DOA
HLA class II histocompatibility antigen, DO alpha chain-like
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:2,563,673...2,568,328
Ensembl chr12:2,563,673...2,568,328
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DLA-DOB
major histocompatibility complex, class II, DO beta
involved_in
ISO
(PMID:22733780)
UniProt
PMID:22733780
NCBI chr12:2,376,957...2,384,179
Ensembl chr12:2,378,126...2,432,303
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CALR
calreticulin
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:49,251,390...49,255,291
Ensembl chr20:49,251,777...49,255,245
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PDIA3
protein disulfide isomerase family A member 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr30:10,487,926...10,513,437
Ensembl chr30:10,487,921...10,513,397
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TAPBP
TAP binding protein
involved_in
IEA IBA
(PMID:21873635)
Ensembl GO_Central
PMID:21873635
GO_REF:0000107
NCBI chr12:2,740,276...2,751,808
Ensembl chr12:2,740,276...2,751,808
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TAPBPL
TAP binding protein like
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr27:38,526,968...38,534,585
Ensembl chr27:38,526,528...38,535,937
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DLA-DMA
major histocompatibility complex, class II, DM alpha
involved_in
IEA IBA
(PMID:21873635)
Ensembl GO_Central
PMID:21873635
GO_REF:0000107
NCBI chr12:2,516,974...2,534,085
Ensembl chr12:2,503,325...2,533,990
G
DLA-DMB
major histocompatibility complex, class II, DM beta
involved_in
IEA IBA
(PMID:21873635)
Ensembl GO_Central
PMID:21873635
GO_REF:0000107
NCBI chr12:2,503,325...2,508,380
Ensembl chr12:2,503,325...2,533,990
G
DLA-DOA
HLA class II histocompatibility antigen, DO alpha chain-like
involved_in
IBA
(PMID:21873635)
GO_Central
PMID:21873635
NCBI chr12:2,563,673...2,568,328
Ensembl chr12:2,563,673...2,568,328
G
DLA-DRA
MHC class II DR alpha chain
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:2,133,026...2,137,825
Ensembl chr12:2,132,499...2,168,975
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HLA-DRB1
MHC class II DLA DRB1 beta chain
involved_in
IBA
(PMID:21873635)
GO_Central
PMID:21873635
NCBI chr12:2,151,409...2,164,564
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TAPBP
TAP binding protein
involved_in
ISO
(MGI:3687922|PMID:12594855)
UniProt
PMID:12594855
MGI:3687922
NCBI chr12:2,740,276...2,751,808
Ensembl chr12:2,740,276...2,751,808
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TAP2
transporter 2, ATP binding cassette subfamily B member
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303
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TAP2
transporter 2, ATP binding cassette subfamily B member
ISO
RGD
PMID:1758495
RGD:1299069
NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303
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PYCARD
PYD and CARD domain containing
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240
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TREM2
triggering receptor expressed on myeloid cells 2
involved_in
ISO
(PMID:11602640)
BHF-UCL
PMID:11602640
NCBI chr12:9,915,692...9,928,322
Ensembl chr12:9,915,677...9,928,174
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