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ONTOLOGY REPORT - ANNOTATIONS

Term:heparosan-N-sulfate-glucuronate 5-epimerase activity
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Accession:GO:0047464 term browser browse the term
Definition:Catalysis of the reaction: (heparosan-N-sulfate)(n) = (heparan-N-sulfate)(n). Converts D-glucosyluronate residues to L-iduronate residues.
Synonyms:exact_synonym: heparosan-N-sulphate-glucuronate 5-epimerase activity
 related_synonym: C-5 uronosyl epimerase activity;   D-glucuronyl C-5 epimerase activity;   heparosan epimerase activity;   heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity;   poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity;   polyglucuronate epimerase activity
 xref: EC:5.1.3.17;   MetaCyc:5.1.3.17-RXN;   RHEA:20197;   Reactome:R-HSA-2024100 "GLCE epimerises GlcA to IdoA";   Reactome:R-HSA-2076371 "GLCE epimerises more GlcA to IdoA as sulfate content rises"


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heparosan-N-sulfate-glucuronate 5-epimerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLCE glucuronic acid epimerase enables IEA
IDA
IMP
IBA		 (PMID:15853773), (PMID:30872481)
(PMID:20118238)		 UniProt
InterPro
RHEA
Ensembl
GO_Central		 PMID:15853773 PMID:20118238 PMID:30872481 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr15:69,160,635...69,272,207
Ensembl chr15:69,160,584...69,272,217 		JBrowse link
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  molecular_function 19683
    catalytic activity 6023
      isomerase activity 203
        racemase and epimerase activity 19
          racemase and epimerase activity, acting on carbohydrates and derivatives 11
            heparosan-N-sulfate-glucuronate 5-epimerase activity 1
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