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ONTOLOGY REPORT - ANNOTATIONS

Term:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
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Accession:GO:0047238 term browser browse the term
Definition:Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP.
Synonyms:exact_synonym: N-acetylgalactosaminyltransferase II activity;   glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;   glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity
 related_synonym: UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity;   UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;   chondroitin synthase activity;   uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity
 xref: EC:2.4.1.175;   MetaCyc:RXN-16325;   Reactome:R-HSA-1971487 "CHPF,CHSY3 transfer GalNAc to chondroitin";   Reactome:R-HSA-3595176 "Defective CHSY1 does not transfer GalNAc to chondroitin";   Reactome:R-HSA-9632033 "CHSY1 transfers GalNAc to chondroitin";   reactome:R-HSA-1971482 "The addition of GalNAc to the terminal glucuronate residue forms chondroitin"


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glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07047835.1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 5:48,925,362...48,927,475 JBrowse link
G B4galnt3 beta-1,4-N-acetyl-galactosaminyl transferase 3 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 4:153,409,019...153,509,019
Ensembl chr 4:153,409,004...153,509,321 		JBrowse link
G B4galnt4 beta-1,4-N-acetyl-galactosaminyl transferase 4 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 1:196,171,394...196,182,294
Ensembl chr 1:196,171,394...196,182,294 		JBrowse link
G Chpf chondroitin polymerizing factor enables ISO
IBA		 (PMID:12761225)
GO_REF:0000033
MGI:1926173|MGI:2681120 (PMID:17253960), (PMID:22952769)		 RGD
GO_Central		 PMID:12761225 PMID:17253960 PMID:22952769 GO_REF:0000033 NCBI chr 9:76,963,178...76,967,878
Ensembl chr 9:76,963,184...76,967,878 		JBrowse link
G Chpf2 chondroitin polymerizing factor 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:10,578,470...10,585,940
Ensembl chr 4:10,580,462...10,585,916 		JBrowse link
G Chsy1 chondroitin sulfate synthase 1 enables ISO
IBA		 (PMID:11514575)
GO_REF:0000033
MGI:106576 (PMID:22952769)		 RGD
GO_Central		 PMID:11514575 PMID:22952769 GO_REF:0000033 NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601 		JBrowse link
G Chsy3 chondroitin sulfate synthase 3 enables IBA
ISO		 GO_REF:0000033
MGI:106576 (PMID:17253960)		 GO_Central
RGD		 PMID:17253960 GO_REF:0000033 NCBI chr18:52,644,356...52,901,257
Ensembl chr18:52,644,461...52,898,098 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 enables ISO
IBA		 (PMID:12163485)
GO_REF:0000033
MGI:1926002|MGI:4868209 (PMID:17145758), (PMID:25568321), (PMID:29287114)		 RGD
GO_Central		 PMID:12163485 PMID:17145758 PMID:25568321 PMID:29287114 GO_REF:0000033 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319 		JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 enables IBA
ISO		 GO_REF:0000033
MGI:2442354 (PMID:25568321), (PMID:29287114)		 GO_Central
RGD		 PMID:25568321 PMID:29287114 GO_REF:0000033 NCBI chr 4:151,271,774...151,308,856
Ensembl chr 4:151,277,645...151,308,839 		JBrowse link
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  molecular_function 21086
    catalytic activity 6121
      transferase activity 2441
        glycosyltransferase activity 287
          hexosyltransferase activity 210
            acetylgalactosaminyltransferase activity 36
              glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity 9
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