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ONTOLOGY REPORT - ANNOTATIONS

Term:phospholipid-hydroperoxide glutathione peroxidase activity
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Accession:GO:0047066 term browser browse the term
Definition:Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.
Synonyms:related_synonym: hydroperoxide glutathione peroxidase activity;   peroxidation-inhibiting protein activity
 xref: EC:1.11.1.12;   MetaCyc:1.11.1.12-RXN;   RHEA:19057;   reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE";   reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE";   reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA";   reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA"


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phospholipid-hydroperoxide glutathione peroxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cp ceruloplasmin enables ISS
ISO		 GO_REF:0000024
(PMID:10481051), (PMID:10508415)		 UniProt
RGD		 PMID:10481051 PMID:10508415 GO_REF:0000024 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Gpx1 glutathione peroxidase 1 enables IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:11115402), (PMID:36608588)		 Ensembl
UniProt
RGD		 PMID:11115402 PMID:36608588 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 enables IEA
ISO		 GO_REF:0000107
(PMID:36608588)		 Ensembl
RGD		 PMID:36608588 GO_REF:0000107 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx4 glutathione peroxidase 4 enables IDA
ISO
IBA		 (PMID:2386798), (PMID:8135530)
(MGI:5615528|PMID:25402683), (MGI:6114953|PMID:29290465)
(PMID:11115402), (PMID:36608588)
GO_REF:0000033		 RGD
GO_Central		 PMID:2386798 PMID:8135530 PMID:11115402 PMID:25402683 PMID:29290465 More... GO_REF:0000033 MGI:5615528 MGI:6114953, RGD:68791 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    antioxidant activity 99
      peroxidase activity 70
        phospholipid-hydroperoxide glutathione peroxidase activity 4
Path 2
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      oxidoreductase activity 871
        oxidoreductase activity, acting on peroxide as acceptor 73
          peroxidase activity 70
            phospholipid-hydroperoxide glutathione peroxidase activity 4
paths to the root