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Term:phospholipid-hydroperoxide glutathione peroxidase activity
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Accession:GO:0047066 term browser browse the term
Definition:Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione.
Synonyms:exact_synonym: glutathione:lipid-hydroperoxide oxidoreductase activity;   hydroperoxide glutathione peroxidase activity;   peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)
 related_synonym: PHGPX;   peroxidation-inhibiting protein activity
 xref: EC:;   MetaCyc:;   reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE";   reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE";   reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA";   reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA"

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phospholipid-hydroperoxide glutathione peroxidase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GPX4 glutathione peroxidase 4 JBrowse link 19 1,082,917 1,085,538 RGD:9068941

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  molecular_function 15784
    catalytic activity 5429
      oxidoreductase activity 692
        oxidoreductase activity, acting on peroxide as acceptor 47
          phospholipid-hydroperoxide glutathione peroxidase activity 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.