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ONTOLOGY REPORT - ANNOTATIONS


Term:ketone body biosynthetic process
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Accession:GO:0046951 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
Synonyms:exact_synonym: ketone body anabolism;   ketone body biosynthesis;   ketone body formation;   ketone body synthesis



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ketone body biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AACS acetoacetyl-CoA synthetase involved_in TAS Reactome Reactome:R-HSA-77111 NCBI chr12:125,065,435...125,143,327
Ensembl chr12:125,065,434...125,143,333
JBrowse link
G ACSS3 acyl-CoA synthetase short chain family member 3 involved_in TAS Reactome Reactome:R-HSA-77111 NCBI chr12:81,078,037...81,261,210
Ensembl chr12:80,936,414...81,261,210
JBrowse link
G HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase involved_in IDA
ISO
IBA
(PMID:22847177), (PMID:22865860), (PMID:9200711)
(PMID:21873635)
UniProt
RGD
GO_Central
PMID:2573547 PMID:9200711 PMID:21873635 PMID:22847177 PMID:22865860 RGD:1599519 NCBI chr 1:23,801,885...23,825,429
Ensembl chr 1:23,801,885...23,838,620
JBrowse link
G HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 involved_in IDA
IEA
IBA
(PMID:22847177), (PMID:22865860)
(PMID:21873635)
UniProt
InterPro
GO_Central
PMID:21873635 PMID:22847177 PMID:22865860 GO_REF:0000002 NCBI chr 6:55,434,373...55,607,573
Ensembl chr 6:55,434,373...55,579,197
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in IMP
ISO
TAS
(PMID:23751782) UniProt
RGD
Reactome
PMID:12399220 PMID:23751782 RGD:2326121 Reactome:R-HSA-77111 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905
JBrowse link
G SLC27A5 solute carrier family 27 member 5 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3722951|PMID:16618416)
GO_Central
MGI
PMID:16618416 PMID:21873635 MGI:3722951 NCBI chr19:58,498,333...58,512,028
Ensembl chr19:58,479,512...58,512,413
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18539
    metabolic process 11871
      biosynthetic process 6187
        cellular biosynthetic process 6017
          ketone body biosynthetic process 6
            acetoacetic acid biosynthetic process 0
            acetone biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 18539
    cellular process 17461
      cellular metabolic process 10813
        generation of precursor metabolites and energy 534
          ketone body metabolic process 12
            ketone body biosynthetic process 6
              acetoacetic acid biosynthetic process 0
              acetone biosynthetic process 0
paths to the root