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ONTOLOGY REPORT - ANNOTATIONS


Term:ketone body biosynthetic process
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Accession:GO:0046951 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
Synonyms:exact_synonym: ketone body anabolism;   ketone body biosynthesis;   ketone body formation;   ketone body synthesis



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ketone body biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:2573547 PMID:21873635 RGD:1599519 NCBI chr 2:75,688,736...75,703,095
Ensembl chr 2:75,688,827...75,702,965
JBrowse link
G HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 involved_in ISO (PMID:22847177), (PMID:22865860) UniProt PMID:22847177 PMID:22865860 NCBI chr12:22,748,798...22,953,849
Ensembl chr12:22,701,085...22,954,133
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in ISO (PMID:23751782) RGD
UniProt
PMID:12399220 PMID:23751782 RGD:2326121 NCBI chr17:56,679,942...56,698,521
Ensembl chr17:56,680,301...56,698,419
JBrowse link
G SLC27A5 solute carrier family 27 member 5 acts_upstream_of_or_within ISO (MGI:3722951|PMID:16618416) MGI PMID:16618416 MGI:3722951 NCBI chr 1:99,435,140...99,438,388 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13969
    metabolic process 9103
      biosynthetic process 4630
        cellular biosynthetic process 4491
          ketone body biosynthetic process 4
            acetoacetic acid biosynthetic process 0
            acetone biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 13969
    cellular process 13228
      cellular metabolic process 8264
        generation of precursor metabolites and energy 389
          ketone body metabolic process 9
            ketone body biosynthetic process 4
              acetoacetic acid biosynthetic process 0
              acetone biosynthetic process 0
paths to the root