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ONTOLOGY REPORT - ANNOTATIONS


Term:ketone body biosynthetic process
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Accession:GO:0046951 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
Synonyms:exact_synonym: ketone body anabolism;   ketone body biosynthesis;   ketone body formation;   ketone body synthesis



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ketone body biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase involved_in ISO (PMID:22847177), (PMID:22865860), (PMID:9200711) RGD
UniProt
PMID:2573547 PMID:9200711 PMID:22847177 PMID:22865860 RGD:1599519 NCBI chr 1:22,993,489...23,017,307
Ensembl chr 1:23,977,723...24,001,150
JBrowse link
G HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 involved_in ISO (PMID:22847177), (PMID:22865860) UniProt PMID:22847177 PMID:22865860 NCBI chr 6:54,979,984...55,125,291
Ensembl chr 6:56,614,757...56,759,659
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in ISO (PMID:23751782) RGD
UniProt
PMID:12399220 PMID:23751782 RGD:2326121 NCBI chr 1:82,778,489...82,798,987
Ensembl chr 1:117,775,770...117,796,679
JBrowse link
G SLC27A5 solute carrier family 27 member 5 acts_upstream_of_or_within ISO (MGI:3722951|PMID:16618416) MGI PMID:16618416 MGI:3722951 NCBI chr19:55,507,455...55,520,448
Ensembl chr19:64,329,567...64,342,630
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12786
    metabolic process 8099
      biosynthetic process 4145
        cellular biosynthetic process 4021
          ketone body biosynthetic process 4
            acetoacetic acid biosynthetic process 0
            acetone biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 12786
    cellular process 11938
      cellular metabolic process 7388
        generation of precursor metabolites and energy 342
          ketone body metabolic process 9
            ketone body biosynthetic process 4
              acetoacetic acid biosynthetic process 0
              acetone biosynthetic process 0
paths to the root