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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular ketone body metabolic process
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Accession:GO:0046950 term browser browse the term
Definition:The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.
Synonyms:exact_synonym: cellular ketone body metabolism


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cellular ketone body metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Oxct1 3-oxoacid CoA transferase 1 JBrowse link 2 53,859,738 54,007,733 RGD:2326212
RGD:1624291
G Oxct2a 3-oxoacid CoA transferase 2A JBrowse link 5 141,016,542 141,018,832 RGD:1624291
ketone body biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase JBrowse link 5 154,294,841 154,308,582 RGD:1599519
RGD:13792537
RGD:1624291
G Hmgcll1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 JBrowse link 8 83,069,837 83,204,778 RGD:1600115
RGD:13792537
RGD:1624291
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 JBrowse link 2 200,452,623 200,480,785 RGD:728598
RGD:1624291
RGD:2326121
G Slc27a5 solute carrier family 27 member 5 JBrowse link 1 65,576,599 65,587,192 RGD:1624291
RGD:13792537
ketone body catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acat1 acetyl-CoA acetyltransferase 1 JBrowse link 8 58,166,990 58,195,884 RGD:1624291
G Acat2 acetyl-CoA acetyltransferase 2 JBrowse link 1 47,972,399 47,992,654 RGD:2326095
G Oxct1 3-oxoacid CoA transferase 1 JBrowse link 2 53,859,738 54,007,733 RGD:1624291
G Oxct2b 3-oxoacid CoA transferase 2B JBrowse link 5 140,813,957 140,815,711 RGD:1600115

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  biological_process 19576
    metabolic process 11899
      cellular metabolic process 10737
        cellular ketone body metabolic process 9
          ketone body biosynthetic process + 4
          ketone body catabolic process + 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.