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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular ketone body metabolic process
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Accession:GO:0046950 term browser browse the term
Definition:The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.
Synonyms:exact_synonym: cellular ketone body metabolism


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cellular ketone body metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G OXCT1 3-oxoacid CoA-transferase 1 JBrowse link 5 73,571,227 73,710,316 RGD:9068941
ketone body biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AACS acetoacetyl-CoA synthetase JBrowse link 12 126,942,340 127,019,374 RGD:9068941
G ACAT1 acetyl-CoA acetyltransferase 1 JBrowse link 11 106,483,563 106,509,793 RGD:9068941
G ACSS3 acyl-CoA synthetase short chain family member 3 JBrowse link 12 81,698,782 81,878,325 RGD:9068941
G BDH1 3-hydroxybutyrate dehydrogenase 1 JBrowse link 3 204,797,765 204,862,387 RGD:9068941
G BDH2 3-hydroxybutyrate dehydrogenase 2 JBrowse link 4 106,157,222 106,179,402 RGD:9068941
G HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase JBrowse link 1 23,977,723 24,016,262 RGD:9068941
G HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 JBrowse link 6 56,614,757 56,759,659 RGD:9068941
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 JBrowse link 1 117,776,165 117,796,679 RGD:9068941
G SLC27A5 solute carrier family 27 member 5 JBrowse link 19 64,329,567 64,342,630 RGD:9068941
ketone body catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACAT1 acetyl-CoA acetyltransferase 1 JBrowse link 11 106,483,563 106,509,793 RGD:9068941
G BDH1 3-hydroxybutyrate dehydrogenase 1 JBrowse link 3 204,797,765 204,862,387 RGD:9068941
G OXCT1 3-oxoacid CoA-transferase 1 JBrowse link 5 73,571,227 73,710,316 RGD:9068941

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  biological_process 15758
    metabolic process 10722
      cellular metabolic process 9943
        cellular ketone body metabolic process 10
          ketone body biosynthetic process + 9
          ketone body catabolic process + 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.