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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular ketone body metabolic process
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Accession:GO:0046950 term browser browse the term
Definition:The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.
Synonyms:exact_synonym: cellular ketone body metabolism



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cellular ketone body metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oxct1 3-oxoacid CoA transferase 1 acts_upstream_of_or_within
involved_in
IEP
ISO
IBA
(MGI:2664113|PMID:12534938)
PMID:21873635
(PMID:9671268)
RGD PMID:9671268 PMID:12534938 PMID:3860190 PMID:21873635 MGI:2664113, RGD:2326212, RGD:13792537 NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714
JBrowse link
G Oxct2a 3-oxoacid CoA transferase 2A acts_upstream_of_or_within ISO (MGI:2664113|PMID:12534938) RGD PMID:12534938 MGI:2664113 NCBI chr 5:135,600,812...135,603,045 JBrowse link
G Oxct2b 3-oxoacid CoA transferase 2B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:135,396,632...135,398,386 JBrowse link
ketone body biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase involved_in IDA
IBA
ISO
PMID:21873635
(PMID:22847177), (PMID:22865860), (PMID:9200711)
RGD PMID:9200711 PMID:22847177 PMID:22865860 PMID:2573547 PMID:21873635 RGD:1599519, RGD:13792537 NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068
JBrowse link
G Hmgcll1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:22847177), (PMID:22865860)
UniProt
RGD
PMID:22847177 PMID:22865860 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:76,757,301...76,887,300
Ensembl chr 8:76,757,497...76,886,816
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in TAS
ISO
IEP
(PMID:23751782) RGD PMID:23751782 PMID:8097464 PMID:12399220 RGD:728598, RGD:2326121 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Slc27a5 solute carrier family 27 member 5 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3757682 (MGI:3722951|PMID:16618416)
RGD PMID:16618416 PMID:21873635 MGI:3722951, RGD:13792537 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link
ketone body catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:1979337) RGD PMID:1979337 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 IEP RGD PMID:5116556 RGD:2326095 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 acts_upstream_of_or_within ISO MGI:4364940 (MGI:4946851|PMID:21209089) RGD PMID:21209089 MGI:4946851 NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714
JBrowse link
G Oxct2b 3-oxoacid CoA transferase 2B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:135,396,632...135,398,386 JBrowse link

Term paths to the root
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  biological_process 19497
    metabolic process 11824
      cellular metabolic process 10719
        cellular ketone body metabolic process 9
          ketone body biosynthetic process + 4
          ketone body catabolic process + 4
paths to the root