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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of neurotransmitter secretion
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Accession:GO:0046929 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.
Synonyms:exact_synonym: down regulation of neurotransmitter secretion;   downregulation of neurotransmitter secretion
 narrow_synonym: conotoxin activity;   inhibition of neurotransmitter secretion


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negative regulation of neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic1 acid sensing ion channel subunit 1 ISO MGI:MGI:2179834 (MGI:MGI:3841883|PMID:18094106) RGD PMID:18094106 MGI:MGI:3841883 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Nf1 neurofibromin 1 ISO
IEA
MGI:MGI:1857478|MGI:MGI:97321 (MGI:MGI:3612345|PMID:16298082)
GO_REF:0000107
RGD
Ensembl
PMID:16298082 GO_REF:0000107, MGI:MGI:3612345 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing ISO MGI:MGI:2152971|MGI:MGI:2152972 (MGI:MGI:5634213|PMID:25730884)
(PMID:25730884)
RGD PMID:25730884 MGI:MGI:5634213 NCBI chr 9:81,566,074...81,634,531
Ensembl chr 9:81,566,074...81,634,534
JBrowse link
G Slc30a1 solute carrier family 30 member 1 IMP PMID:16741752 BHF-UCL PMID:16741752 RGD:8554228 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Syt4 synaptotagmin 4 IDA PMID:10397765 ParkinsonsUK-UCL PMID:10397765 RGD:11535116 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012
JBrowse link
negative regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr6 5-hydroxytryptamine receptor 6 IMP RGD PMID:16987217 RGD:2317005 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631
JBrowse link
negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A IMP RGD PMID:16899074 RGD:10002752 NCBI chr 4:29,976,485...30,247,371
Ensembl chr 4:29,978,739...30,241,911
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:22314364) RGD PMID:22314364 NCBI chr 1:48,880,015...50,069,998 JBrowse link
negative regulation of synaptic vesicle exocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO (MGI:MGI:5490391|PMID:23616533) RGD PMID:23616533 MGI:MGI:5490391 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Fmr1 FMRP translational regulator 1 IMP PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO
IBA
MGI:MGI:894315 (MGI:MGI:5490391|PMID:23616533)
PMID:21873635
RGD PMID:23616533, PMID:21873635 MGI:MGI:5490391, RGD:13792537 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rap1b RAP1B, member of RAS oncogene family ISO
IBA
MGI:MGI:97852 (MGI:MGI:5490391|PMID:23616533)
PMID:21873635
RGD PMID:23616533, PMID:21873635 MGI:MGI:5490391, RGD:13792537 NCBI chr 7:60,850,406...60,878,226
Ensembl chr 7:60,853,930...60,860,990
JBrowse link
G Syt4 synaptotagmin 4 ISO (MGI:MGI:4457852|PMID:19448629) RGD PMID:19448629 MGI:MGI:4457852 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      negative regulation of signaling 1373
        negative regulation of synaptic transmission 83
          negative regulation of neurotransmitter secretion 12
            negative regulation by symbiont of host neurotransmitter secretion 0
            negative regulation of acetylcholine secretion, neurotransmission 1
            negative regulation of glutamate secretion, neurotransmission 0
            negative regulation of glycine secretion, neurotransmission 0
            negative regulation of spontaneous neurotransmitter secretion 2
            negative regulation of substance P secretion, neurotransmission 0
            negative regulation of synaptic vesicle exocytosis + 5
Path 2
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cell communication 7664
        cell-cell signaling 1738
          synaptic signaling 917
            trans-synaptic signaling 889
              anterograde trans-synaptic signaling 880
                chemical synaptic transmission 880
                  modulation of chemical synaptic transmission 656
                    regulation of neurotransmitter secretion 141
                      negative regulation of neurotransmitter secretion 12
                        negative regulation by symbiont of host neurotransmitter secretion 0
                        negative regulation of acetylcholine secretion, neurotransmission 1
                        negative regulation of glutamate secretion, neurotransmission 0
                        negative regulation of glycine secretion, neurotransmission 0
                        negative regulation of spontaneous neurotransmitter secretion 2
                        negative regulation of substance P secretion, neurotransmission 0
                        negative regulation of synaptic vesicle exocytosis + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.