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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular transition metal ion homeostasis
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Accession:GO:0046916 term browser browse the term
Definition:Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.


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cellular cadmium ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a1 solute carrier family 11 member 1 involved_in ISO
IEA
IBA
UniProtKB:P38356 (PMID:17932044)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:17932044, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
JBrowse link
G Slc39a8 solute carrier family 39 member 8 involved_in ISS
ISO
GO_REF:0000024
(PMID:27466201)
UniProt
RGD
PMID:27466201 GO_REF:0000024 NCBI chr 2:241,028,851...241,092,584
Ensembl chr 2:241,029,693...241,092,582
JBrowse link
cellular copper ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 involved_in IDA PMID:18160489 UniProt PMID:18160489 RGD:42722002 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Aplp2 amyloid beta precursor like protein 2 acts_upstream_of_or_within ISO MGI:2137246 (MGI:1346371|PMID:10526140) RGD PMID:10526140 MGI:1346371 NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839
JBrowse link
G App amyloid beta precursor protein involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:2136847|MGI:88047 (MGI:1346371|PMID:10526140), (MGI:3056718|PMID:15447675)
UniProt
RGD
PMID:10526140 PMID:15447675 GO_REF:0000024 MGI:1346371 MGI:3056718 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arf1 ADP-ribosylation factor 1 involved_in ISO (PMID:21034850) RGD PMID:21034850 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Atox1 antioxidant 1 copper chaperone involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2158341 (MGI:2157818|PMID:11391006)
RGD PMID:11391006, PMID:21873635 MGI:2157818, RGD:13792537 NCBI chr10:40,790,850...40,805,886
Ensembl chr10:40,790,845...40,805,941
JBrowse link
G Atp7a ATPase copper transporting alpha involved_in
acts_upstream_of_or_within
ISS
ISO
IBA
GO_REF:0000024
MGI:1856097|MGI:1856098|MGI:1856099|MGI:1856101|MGI:1856322|MGI:1856323|MGI:1856324|MGI:1856325|MGI:1856466|MGI:1858103|MGI:3588774|MGI:97171|MGI:97172 (MGI:1097375|PMID:9321757), (MGI:1277426|PMID:9686356), (MGI:1337919|PMID:10332039), (MGI:2654381|PMID:7197928), (MGI:3616522|PMID:16338116), (MGI:3760368|PMID:11311799), (MGI:49153|PMID:1779648), (MGI:53940|PMID:4858102), (MGI:54224|PMID:187892), (MGI:54433|PMID:564942), (MGI:54490|PMID:27591), (MGI:54627|PMID:571898), (MGI:54681|PMID:573617), (MGI:54683|PMID:573619), (MGI:63555|PMID:7688531), (MGI:67983|PMID:8025644), (MGI:70984|PMID:7873696), (MGI:80756|PMID:8640230), (MGI:83733|PMID:6685755), (MGI:83736|PMID:3674914), (MGI:83737|PMID:8096378)
(MGI:5637881|PMID:25639447)
PMID:21873635
(PMID:16397091), (PMID:28389643)
UniProt
RGD
PMID:27591 PMID:187892 PMID:564942 PMID:571898 PMID:573617 PMID:573619 PMID:1779648 PMID:3674914 PMID:4858102 PMID:6685755 PMID:7197928 PMID:7688531 PMID:7873696 PMID:8025644 PMID:8096378 PMID:8640230 PMID:9321757 PMID:9686356 PMID:10332039 PMID:11311799 PMID:16338116 PMID:16397091 PMID:25639447 PMID:28389643, PMID:21873635 GO_REF:0000024 MGI:1097375 MGI:1277426 MGI:1337919 MGI:2654381 MGI:3616522 MGI:3760368 MGI:49153 MGI:53940 MGI:54224 MGI:54433 MGI:54490 MGI:54627 MGI:54681 MGI:54683 MGI:5637881 MGI:60964 MGI:61151 MGI:63555 MGI:63873 MGI:67983 MGI:70984 MGI:80756 MGI:83733 MGI:83736 MGI:83737, RGD:13792537 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
MGI:1856220|MGI:2158253 (MGI:1100407|PMID:9392450), (MGI:1196719|PMID:9484715), (MGI:1345026|PMID:10441329), (MGI:1929057|PMID:11085952), (MGI:49578|PMID:1588441), (MGI:55573|PMID:6863890), (MGI:64054|PMID:8257436), (MGI:66663|PMID:8040371), (MGI:87446|PMID:2845190)
GO_REF:0000107
RGD
Ensembl
PMID:1588441 PMID:2845190 PMID:6863890 PMID:8040371 PMID:8257436 PMID:9392450 PMID:9484715 PMID:10441329 PMID:11085952, PMID:21873635 GO_REF:0000107 MGI:1100407 MGI:1196719 MGI:1345026 MGI:1929057 MGI:49578 MGI:55573 MGI:64054 MGI:66663 MGI:87446, RGD:13792537 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Ccdc22 coiled-coil domain containing 22 involved_in ISO (PMID:25355947) RGD PMID:25355947 NCBI chr  X:15,742,978...15,754,925
Ensembl chr  X:15,742,978...15,754,925
JBrowse link
G Cox19 cytochrome c oxidase assembly factor COX19 involved_in ISO (PMID:23345593) RGD PMID:23345593 NCBI chr12:17,395,624...17,405,103
Ensembl chr12:17,395,624...17,405,103
JBrowse link
G Prnd prion like protein doppel involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2652948|PMID:12482851)
RGD PMID:12482851, PMID:21873635 MGI:2652948, RGD:13792537 NCBI chr 3:124,543,227...124,548,548
Ensembl chr 3:124,545,364...124,545,900
JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO MGI:2176228|MGI:2182095|MGI:2386742|MGI:5758867 (MGI:5643882|PMID:25683716), (MGI:6093414|PMID:28973536), (MGI:6103245|PMID:28647369) RGD PMID:25683716 PMID:28647369 PMID:28973536 MGI:5643882 MGI:6093414 MGI:6103245 NCBI chr10:53,595,854...53,608,437
Ensembl chr10:53,595,854...53,608,435
JBrowse link
G Slc31a1 solute carrier family 31 member 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1333844 (MGI:5523354|PMID:24167251)
RGD PMID:24167251, PMID:21873635 MGI:5523354, RGD:13792537 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Slc31a2 solute carrier family 31 member 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1333843 (MGI:5523354|PMID:24167251)
RGD PMID:24167251, PMID:21873635 MGI:5523354, RGD:13792537 NCBI chr 5:78,120,606...78,131,111
Ensembl chr 5:78,120,607...78,131,114
JBrowse link
cellular iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:3628654 (MGI:3617043|PMID:16424901)
PMID:21873635
Ensembl
RGD
PMID:16424901, PMID:21873635 GO_REF:0000107 MGI:3617043, RGD:13792537 NCBI chr  X:75,150,511...75,291,950
Ensembl chr  X:75,150,608...75,291,938
JBrowse link
G Aco1 aconitase 1 acts_upstream_of_or_within
involved_in
IDA
ISO
IEA
MGI:1928268|MGI:3029223 (MGI:3028434|PMID:14726953)
GO_REF:0000107
RGD
Ensembl
PMID:14726953, PMID:15086359 GO_REF:0000107 MGI:3028434, RGD:1642737 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180151 (MGI:1347738|PMID:10562540)
Ensembl
RGD
PMID:10562540 GO_REF:0000107 MGI:1347738 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:26818499) RGD PMID:26818499 NCBI chr 5:159,512,208...159,531,631
Ensembl chr 5:159,512,285...159,531,637
JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 involved_in ISO
ISS
IEA
(PMID:28296633)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:28296633 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:156,407,973...156,415,053
Ensembl chr  X:156,407,937...156,415,145
JBrowse link
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr12:37,368,321...37,398,233
Ensembl chr12:37,363,906...37,425,596
JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr19:37,481,782...37,525,762
Ensembl chr19:37,481,782...37,525,762
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr11:61,531,386...61,584,634
Ensembl chr11:61,531,416...61,584,634
JBrowse link
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr 5:79,367,663...79,373,843
Ensembl chr 5:79,367,663...79,373,843
JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in
acts_upstream_of_or_within
ISO (MGI:4352622|PMID:19252488)
MGI:2136985 (MGI:5050766|PMID:21703414)
RGD PMID:19252488 PMID:21703414 MGI:4352622 MGI:5050766 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Bola2 bolA family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:198,120,104...198,121,158
Ensembl chr 1:198,120,099...198,121,158
JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr 9:37,774,876...37,778,839
Ensembl chr 9:37,775,311...37,779,967
JBrowse link
G Cp ceruloplasmin TAS RGD PMID:12099680 RGD:727703 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cyb561 cytochrome b-561 involved_in IEA
ISO
GO_REF:0000107
(MGI:3688365|PMID:14499595)
Ensembl
RGD
PMID:14499595 GO_REF:0000107 MGI:3688365 NCBI chr10:94,136,993...94,147,567
Ensembl chr10:94,136,993...94,147,621
JBrowse link
G Cyb561a3 cytochrome b561 family, member A3 involved_in ISS
ISO
GO_REF:0000024
(MGI:6508497|PMID:16911521)
UniProt
RGD
PMID:16911521 GO_REF:0000024 MGI:6508497 NCBI chr 1:226,620,933...226,642,246
Ensembl chr 1:226,634,009...226,642,243
JBrowse link
G Cybrd1 cytochrome b reductase 1 involved_in ISO
IEA
(PMID:14499595)
GO_REF:0000107
RGD
Ensembl
PMID:14499595 GO_REF:0000107 NCBI chr 3:57,718,496...57,745,749
Ensembl chr 3:57,718,364...57,746,097
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 involved_in ISO (MGI:5752072|PMID:26818499) RGD PMID:26818499 MGI:5752072 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Erfe erythroferrone involved_in ISS
ISO
GO_REF:0000024
(MGI:5574517|PMID:24880340)
UniProt
RGD
PMID:24880340 GO_REF:0000024 MGI:5574517 NCBI chr 9:98,505,136...98,513,005
Ensembl chr 9:98,505,259...98,511,160
JBrowse link
G Frrs1 ferric-chelate reductase 1 involved_in ISO (MGI:3688365|PMID:14499595) RGD PMID:14499595 MGI:3688365 NCBI chr 2:220,415,568...220,469,559
Ensembl chr 2:220,432,037...220,468,859
JBrowse link
G Ftl1 ferritin light chain 1 TAS RGD PMID:3584116 RGD:61589 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Ftmt ferritin mitochondrial involved_in ISO (PMID:18160053) RGD PMID:18160053 NCBI chr18:47,294,292...47,295,541
Ensembl chr18:47,294,292...47,295,541
JBrowse link
G Fxn frataxin acts_upstream_of_or_within
involved_in
NAS
ISO
IEA
IBA
MGI:2177175|MGI:2177176 (MGI:2158372|PMID:9405681)
GO_REF:0000107
(PMID:18160053)
PMID:21873635
RGD
Ensembl
PMID:9405681 PMID:18160053, PMID:15247478, PMID:21873635 GO_REF:0000107 MGI:2158372, RGD:1304347, RGD:13792537 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Glrx3 glutaredoxin 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:209,768,696...209,799,912
Ensembl chr 1:209,768,696...209,799,903
JBrowse link
G Hamp hepcidin antimicrobial peptide involved_in IDA
ISO
IBA
(MGI:2137426|PMID:11447267)
(PMID:15514116)
PMID:21873635
RGD PMID:11447267 PMID:15514116, PMID:14592944, PMID:21873635 MGI:2137426, RGD:1304454, RGD:13792537 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Heph hephaestin involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:65,377,313...65,658,479
Ensembl chr  X:65,563,122...65,658,516
JBrowse link
G Hephl1 hephaestin-like 1 involved_in ISO (PMID:31125343) RGD PMID:31125343 NCBI chr 8:13,614,800...13,680,870
Ensembl chr 8:13,614,800...13,680,870
JBrowse link
G Hfe homeostatic iron regulator involved_in TAS
ISO
(PMID:10085150) RGD PMID:10085150, PMID:12927914 RGD:1304426 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857719 (MGI:3695187|PMID:16787915)
Ensembl
RGD
PMID:16787915 GO_REF:0000107 MGI:3695187 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hjv hemojuvelin BMP co-receptor involved_in IEA
ISO
GO_REF:0000107
(MGI:5644209|PMID:25860887)
Ensembl
RGD
PMID:25860887 GO_REF:0000107 MGI:5644209 NCBI chr 2:198,655,437...198,659,318
Ensembl chr 2:198,655,437...198,659,317
JBrowse link
G Hmox1 heme oxygenase 1 involved_in ISO (PMID:22989377) RGD PMID:22989377 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpx hemopexin involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Ireb2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181660|MGI:87879 (MGI:1930376|PMID:11175792), (MGI:3028434|PMID:14726953), (MGI:3695992|PMID:15831703)
Ensembl
RGD
PMID:11175792 PMID:14726953 PMID:15831703 GO_REF:0000107 MGI:1930376 MGI:3028434 MGI:3695992 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:48,621,454...48,627,297
Ensembl chr12:48,621,454...48,627,297
JBrowse link
G Meltf melanotransferrin NOT|acts_upstream_of_or_within ISO MGI:3691276 (MGI:3691200|PMID:16291590) RGD PMID:16291590 MGI:3691200 NCBI chr11:72,135,311...72,158,106
Ensembl chr11:72,135,668...72,157,522
JBrowse link
G Mon1a MON1 homolog A, secretory trafficking associated acts_upstream_of_or_within ISO (MGI:3718750|PMID:17632513) RGD PMID:17632513 MGI:3718750 NCBI chr 8:116,657,345...116,682,172
Ensembl chr 8:116,657,371...116,682,178
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO
ISS
(PMID:9924025)
GO_REF:0000024
RGD
UniProt
PMID:9924025 GO_REF:0000024 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 acts_upstream_of_or_within ISO (MGI:5615337|PMID:25327288) RGD PMID:25327288 MGI:5615337 NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in ISO (PMID:18776082) RGD PMID:18776082 NCBI chr18:31,574,759...31,625,286
Ensembl chr18:31,574,821...31,625,274
JBrowse link
G Nubp1 nucleotide binding protein 1 involved_in ISO (PMID:18573874) RGD PMID:18573874 NCBI chr10:5,333,378...5,343,949
Ensembl chr10:5,333,378...5,344,121
JBrowse link
G Scara5 scavenger receptor class A, member 5 involved_in ISO (MGI:3833042|PMID:19154717) RGD PMID:19154717 MGI:3833042 NCBI chr15:49,069,142...49,177,159
Ensembl chr15:49,069,145...49,177,166
JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:2446573 (MGI:2178064|PMID:11903051), (MGI:3807860|PMID:18456389), (MGI:3841492|PMID:19321419)
(PMID:16510578)
PMID:21873635
Ensembl
RGD
PMID:11903051 PMID:16510578 PMID:18456389 PMID:19321419, PMID:21873635 GO_REF:0000107 MGI:2178064 MGI:3807860 MGI:3841492, RGD:13792537 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
JBrowse link
G Slc40a1 solute carrier family 40 member 1 involved_in ISO (PMID:12091367) RGD PMID:12091367 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:3769957|PMID:16330325)
Ensembl
RGD
PMID:16330325 GO_REF:0000107 MGI:3769957 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Sod1 superoxide dismutase 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:1857872 (MGI:3640408|PMID:16377630)
UniProt
RGD
PMID:16377630 GO_REF:0000024 MGI:3640408 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tf transferrin TAS RGD PMID:12608731 RGD:737676 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfrc transferrin receptor acts_upstream_of_or_within ISO MGI:1859944 (MGI:1334105|PMID:10192390) RGD PMID:10192390 MGI:1334105 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISO
ISS
(PMID:28296633)
GO_REF:0000024
RGD
UniProt
PMID:28296633 GO_REF:0000024 NCBI chr10:65,775,721...65,780,293
Ensembl chr10:65,775,715...65,780,349
JBrowse link
G Tmprss6 transmembrane serine protease 6 involved_in ISO (MGI:5644209|PMID:25860887) RGD PMID:25860887 MGI:5644209 NCBI chr 7:119,659,323...119,689,953
Ensembl chr 7:119,659,324...119,689,938
JBrowse link
G Ttc7a tetratricopeptide repeat domain 7A acts_upstream_of_or_within ISO MGI:1856879 (MGI:3054313|PMID:15155459) RGD PMID:15155459 MGI:3054313 NCBI chr 6:10,912,383...11,014,279
Ensembl chr 6:10,912,383...11,014,278
JBrowse link
cellular manganese ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:12707275)
UniProt
RGD
PMID:12707275 GO_REF:0000024 NCBI chr 8:113,953,959...114,039,965
Ensembl chr 8:113,955,647...114,013,623
JBrowse link
G Slc39a8 solute carrier family 39 member 8 involved_in ISS
ISO
GO_REF:0000024
(MGI:5912781|PMID:28481222)
UniProt
RGD
PMID:28481222 GO_REF:0000024 MGI:5912781 NCBI chr 2:241,028,851...241,092,584
Ensembl chr 2:241,029,693...241,092,582
JBrowse link
cellular response to iron ion starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator IEP RGD PMID:16208485 RGD:1582698 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
cellular zinc ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC128848.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr19:11,302,125...11,302,938 JBrowse link
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (MGI:6415001|PMID:30786955) RGD PMID:30786955 MGI:6415001 NCBI chr 2:24,022,815...24,227,522
Ensembl chr 2:24,024,791...24,226,224
JBrowse link
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:24603074) RGD PMID:24603074 NCBI chr 5:159,512,208...159,531,631
Ensembl chr 5:159,512,285...159,531,637
JBrowse link
G Atp7b ATPase copper transporting beta involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856220 (MGI:1100407|PMID:9392450), (MGI:1196719|PMID:9484715), (MGI:64054|PMID:8257436), (MGI:66663|PMID:8040371)
Ensembl
RGD
PMID:8040371 PMID:8257436 PMID:9392450 PMID:9484715 GO_REF:0000107 MGI:1100407 MGI:1196719 MGI:64054 MGI:66663 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 acts_upstream_of_or_within ISO (MGI:6415001|PMID:30786955) RGD PMID:30786955 MGI:6415001 NCBI chr 1:261,989,178...262,015,282
Ensembl chr 1:261,989,178...262,015,153
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase involved_in IEA
ISO
GO_REF:0000107
(PMID:11739864)
Ensembl
RGD
PMID:11739864 GO_REF:0000107 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Mt1 metallothionein 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2668454 (MGI:2177111|PMID:11792622)
RGD PMID:11792622, PMID:21873635 MGI:2177111, RGD:13792537 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt1m metallothionein 1M involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,677,460...3,677,838
Ensembl chr20:3,677,474...3,677,847
JBrowse link
G Mt2A metallothionein 2A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2668455 (MGI:2177111|PMID:11792622)
RGD PMID:11792622, PMID:21873635 MGI:2177111, RGD:13792537 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mt3 metallothionein 3 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:4881636|PMID:20544854), (MGI:5299282|PMID:21726645), (MGI:5315330|PMID:21359432)
GO_REF:0000024
RGD
UniProt
PMID:20544854 PMID:21359432 PMID:21726645, PMID:21873635 GO_REF:0000024 MGI:4881636 MGI:5299282 MGI:5315330, RGD:13792537 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Mt4 metallothionein 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:11,339,767...11,341,863
Ensembl chr19:11,339,767...11,341,863
JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in
acts_upstream_of_or_within
ISO MGI:2655190 (MGI:4845788|PMID:21084597)
(MGI:6478087|PMID:22575539)
RGD PMID:21084597 PMID:22575539 MGI:4845788 MGI:6478087 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc30a1 solute carrier family 30 member 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3056498 (MGI:3056220|PMID:15452870)
(MGI:4456947|PMID:15451416)
RGD PMID:15451416 PMID:15452870, PMID:21873635 MGI:3056220 MGI:4456947, RGD:13792537 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc30a10 solute carrier family 30, member 10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363
JBrowse link
G Slc30a5 solute carrier family 30 member 5 involved_in ISO (PMID:11937503) RGD PMID:11937503 NCBI chr 2:30,815,683...30,845,796
Ensembl chr 2:30,815,703...30,846,149
JBrowse link
G Slc30a8 solute carrier family 30 member 8 involved_in IMP
ISO
IEA
PMID:19479076
(MGI:4359332|PMID:19450229)
GO_REF:0000002
RGD
InterPro
PMID:19450229, PMID:19479076 GO_REF:0000002 MGI:4359332, RGD:2315022 NCBI chr 7:91,832,988...91,869,329
Ensembl chr 7:91,832,988...91,867,300
JBrowse link
G Slc30a9 solute carrier family 30 member 9 involved_in ISO (PMID:28334855) RGD PMID:28334855 NCBI chr14:42,464,814...42,519,760
Ensembl chr14:42,465,807...42,520,020
JBrowse link
G Slc39a10 solute carrier family 39 member 10 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5642301 (MGI:5586917|PMID:25074913)
RGD PMID:25074913, PMID:21873635 MGI:5586917, RGD:13792537 NCBI chr 9:59,947,562...60,070,549
Ensembl chr 9:60,021,534...60,070,552
JBrowse link
G Slc39a12 solute carrier family 39 member 12 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:81,455,731...81,541,742
Ensembl chr17:81,455,955...81,541,759
JBrowse link
G Slc39a13 solute carrier family 39 member 13 involved_in IBA
ISO
PMID:21873635
(MGI:3829328|PMID:18985159)
(PMID:21917916)
RGD PMID:18985159 PMID:21917916, PMID:21873635 MGI:3829328, RGD:13792537 NCBI chr 3:79,884,524...79,892,664
Ensembl chr 3:79,884,524...79,892,429
JBrowse link
G Slc39a14 solute carrier family 39 member 14 involved_in IBA
ISO
PMID:21873635
(MGI:4950776|PMID:21445361), (MGI:5812606|PMID:27703010)
(PMID:15642354), (PMID:21917916)
RGD PMID:15642354 PMID:21445361 PMID:21917916 PMID:27703010, PMID:21873635 MGI:4950776 MGI:5812606, RGD:13792537 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
JBrowse link
G Slc39a4 solute carrier family 39 member 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3028750|PMID:14612438)
RGD PMID:14612438, PMID:21873635 MGI:3028750, RGD:13792537 NCBI chr 7:117,675,718...117,682,586
Ensembl chr 7:117,675,720...117,680,004
JBrowse link
G Slc39a5 solute carrier family 39 member 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:2,813,875...2,819,917
Ensembl chr 7:2,813,875...2,819,299
JBrowse link
G Slc39a6 solute carrier family 39 member 6 involved_in IBA
ISO
PMID:21873635
(PMID:15642354)
RGD PMID:15642354, PMID:21873635 RGD:13792537 NCBI chr18:16,523,450...16,543,992
Ensembl chr18:16,522,982...16,543,992
JBrowse link
G Slc39a7 solute carrier family 39 member 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,819,416...3,822,788
Ensembl chr20:3,819,414...3,822,778
JBrowse link
G Slc39a8 solute carrier family 39 member 8 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:5577232|PMID:24529376)
GO_REF:0000024
(PMID:19401385)
RGD
UniProt
PMID:19401385 PMID:24529376, PMID:21873635 GO_REF:0000024 MGI:5577232, RGD:13792537 NCBI chr 2:241,028,851...241,092,584
Ensembl chr 2:241,029,693...241,092,582
JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tfr2 transferrin receptor 2 involved_in IBA
ISO
PMID:21873635
UniProtKB:P02787|UniProtKB:Q07891 (PMID:18353247)
RGD PMID:18353247, PMID:21873635 RGD:13792537 NCBI chr12:22,177,382...22,194,330
Ensembl chr12:22,177,382...22,194,299
JBrowse link
intracellular sequestering of iron ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07004746.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:154,131,926...154,132,330 JBrowse link
G AABR07005031.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:176,078,574...176,079,125 JBrowse link
G AABR07008293.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 2:52,170,929...52,171,620 JBrowse link
G AABR07037161.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr  X:14,733,145...14,733,696 JBrowse link
G AABR07041778.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr  X:139,475,655...139,476,206 JBrowse link
G AC115277.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 7:15,385,868...15,386,419 JBrowse link
G Fth1 ferritin heavy chain 1 involved_in IBA
ISO
IEA
PMID:21873635
(PMID:9924025)
GO_REF:0000107
RGD
Ensembl
PMID:9924025, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Fthl17c ferritin, heavy polypeptide-like 17, member C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr  X:14,782,958...14,783,792 JBrowse link
G Fthl17e ferritin, heavy polypeptide-like 17, member E involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:53,628,946...53,629,936
Ensembl chr  X:53,629,255...53,629,803
JBrowse link
G Ftl1 ferritin light chain 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Ftl1l1 ferritin light chain 1-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:139,475,498...139,476,412 JBrowse link
G Ftmt ferritin mitochondrial involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:47,294,292...47,295,541
Ensembl chr18:47,294,292...47,295,541
JBrowse link
G LOC100359668 ferritin light chain 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:76,652,033...76,652,975
Ensembl chr 6:76,652,206...76,652,757
JBrowse link
G LOC100360087 ferritin light chain 1-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:152,325,852...152,326,798
Ensembl chr 5:152,325,871...152,326,778
JBrowse link
G LOC100362384 ferritin light chain 1-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:89,253,404...89,254,341
Ensembl chr13:89,253,617...89,254,171
JBrowse link
G LOC102549852 ferritin light chain 1-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:154,131,725...154,132,449 JBrowse link
G LOC108352322 ferritin heavy chain-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:44,089,613...44,101,137
Ensembl chr11:44,089,797...44,092,877
JBrowse link
G LOC680520 similar to CG4349-PA involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:44,071,086...44,079,483
Ensembl chr11:44,072,043...44,075,501
JBrowse link
G LOC691895 similar to ferritin, heavy polypeptide-like 17 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:14,782,958...14,783,792
Ensembl chr  X:14,782,958...14,783,792
JBrowse link
G RGD1560203 similar to ferritin heavy polypeptide-like 17 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:34,161,671...34,165,304
Ensembl chr  X:34,162,297...34,162,827
JBrowse link
G RGD1560687 similar to Ferritin light chain (Ferritin L subunit) involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:15,362,899...15,386,478 JBrowse link
G RGD1561106 similar to ferritin heavy chain - chicken involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:14,732,998...14,733,850 JBrowse link
G RGD1561661 similar to Ferritin light chain (Ferritin L subunit) involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:13,441,558...13,443,470
Ensembl chr  X:13,441,558...13,443,470
JBrowse link
G RGD1563378 similar to ferritin heavy polypeptide-like 17 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:45,635,751...45,640,012
Ensembl chr  X:45,637,415...45,637,945
JBrowse link
G RGD1566189 similar to ferritin light chain involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:176,078,420...176,079,344 JBrowse link
iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:1856400 (MGI:3691553|PMID:11739192)
(MGI:3037617|PMID:15024413)
PMID:21873635
(PMID:17109629)
Ensembl
RGD
PMID:11739192 PMID:15024413 PMID:17109629, PMID:21873635 GO_REF:0000107 MGI:3037617 MGI:3691553, RGD:13792537 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc39a14 solute carrier family 39 member 14 involved_in ISO (PMID:20682781)
(MGI:6392986|PMID:20682781)
RGD PMID:20682781 MGI:6392986 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (MGI:3807452|PMID:16609065) RGD PMID:16609065 MGI:3807452 NCBI chr13:36,257,220...36,274,144
Ensembl chr13:36,257,112...36,290,531
JBrowse link
G Steap4 STEAP4 metalloreductase acts_upstream_of_or_within ISO (MGI:3807452|PMID:16609065) RGD PMID:16609065 MGI:3807452 NCBI chr 4:23,112,682...23,135,354
Ensembl chr 4:23,090,029...23,135,354
JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Slc39a8 solute carrier family 39 member 8 involved_in ISO
IDA
(PMID:22898811)
(MGI:6383325|PMID:30015240)
RGD PMID:22898811 PMID:30015240, PMID:22898811 MGI:6383325, RGD:15090842 NCBI chr 2:241,028,851...241,092,584
Ensembl chr 2:241,029,693...241,092,582
JBrowse link
G Steap2 STEAP2 metalloreductase acts_upstream_of_or_within ISO (MGI:3807452|PMID:16609065) RGD PMID:16609065 MGI:3807452 NCBI chr 4:25,506,604...25,527,088
Ensembl chr 4:25,507,463...25,527,087
JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO (PMID:20436681) RGD PMID:20436681 NCBI chr12:48,621,454...48,627,297
Ensembl chr12:48,621,454...48,627,297
JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (MGI:6304699|PMID:29061364) RGD PMID:29061364 MGI:6304699 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Slc6a9 solute carrier family 6 member 9 acts_upstream_of ISO (MGI:6450351|PMID:28495915) RGD PMID:28495915 MGI:6450351 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
positive regulation of sequestering of zinc ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc30a2 solute carrier family 30 member 2 involved_in ISO
IEA
(PMID:17349999)
GO_REF:0000107
RGD
Ensembl
PMID:17349999 GO_REF:0000107 NCBI chr 5:152,559,577...152,571,800
Ensembl chr 5:152,559,577...152,571,799
JBrowse link
regulation of sequestering of zinc ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3d1 adaptor related protein complex 3 subunit delta 1 involved_in ISO (PMID:17349999) RGD PMID:17349999 NCBI chr 7:11,838,639...11,873,992
Ensembl chr 7:11,838,639...11,873,984
JBrowse link
G Slc30a2 solute carrier family 30 member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:152,559,577...152,571,800
Ensembl chr 5:152,559,577...152,571,799
JBrowse link
G Slc30a3 solute carrier family 30 member 3 involved_in ISO
IBA
(PMID:17349999)
PMID:21873635
RGD PMID:17349999, PMID:21873635 RGD:13792537 NCBI chr 6:26,629,752...26,650,106
Ensembl chr 6:26,642,783...26,650,105
JBrowse link
G Slc30a4 solute carrier family 30 member 4 involved_in ISO
IEA
IBA
(PMID:17349999)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:17349999, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:114,805,919...114,828,154
Ensembl chr 3:114,805,922...114,828,154
JBrowse link
G Slc30a8 solute carrier family 30 member 8 involved_in IMP
IBA
PMID:19479076
PMID:21873635
BHF-UCL
GO_Central
PMID:19479076, PMID:21873635 RGD:2315022, RGD:13792537 NCBI chr 7:91,832,988...91,869,329
Ensembl chr 7:91,832,988...91,867,300
JBrowse link
sequestering of iron ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcn2 lipocalin 2 involved_in ISO
ISS
(PMID:27780864)
GO_REF:0000024
RGD
UniProt
PMID:27780864 GO_REF:0000024 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
sequestering of zinc ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc30a7 solute carrier family 30 member 7 acts_upstream_of_or_within ISO (PMID:17720550) RGD PMID:17720550 NCBI chr 2:218,888,431...218,951,030
Ensembl chr 2:218,888,431...218,951,030
JBrowse link
G Slc30a8 solute carrier family 30 member 8 involved_in ISO (PMID:15331542) RGD PMID:15331542 NCBI chr 7:91,832,988...91,869,329
Ensembl chr 7:91,832,988...91,867,300
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19633
    cellular process 18481
      cellular homeostasis 1049
        cellular chemical homeostasis 961
          cellular ion homeostasis 736
            cellular cation homeostasis 722
              cellular metal ion homeostasis 655
                cellular transition metal ion homeostasis 123
                  cellular cadmium ion homeostasis 2
                  cellular cobalt ion homeostasis 0
                  cellular copper ion homeostasis + 13
                  cellular iron ion homeostasis + 82
                  cellular manganese ion homeostasis + 2
                  cellular nickel ion homeostasis 0
                  cellular zinc ion homeostasis + 31
Path 2
Term Annotations click to browse term
  biological_process 19633
    biological regulation 13611
      regulation of biological quality 4333
        homeostatic process 2085
          chemical homeostasis 1342
            ion homeostasis 865
              cellular ion homeostasis 736
                cellular cation homeostasis 722
                  cellular metal ion homeostasis 655
                    cellular transition metal ion homeostasis 123
                      cellular cadmium ion homeostasis 2
                      cellular cobalt ion homeostasis 0
                      cellular copper ion homeostasis + 13
                      cellular iron ion homeostasis + 82
                      cellular manganese ion homeostasis + 2
                      cellular nickel ion homeostasis 0
                      cellular zinc ion homeostasis + 31
paths to the root