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Term:tetrahydrofolylpolyglutamate biosynthetic process
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Accession:GO:0046901 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.
Synonyms:exact_synonym: THF polyglutamylation;   tetrahydrofolate polyglutamylation;   tetrahydrofolyl-[Glu](n) biosynthesis;   tetrahydrofolyl-[Glu](n) biosynthetic process;   tetrahydrofolylpolyglutamate anabolism;   tetrahydrofolylpolyglutamate biosynthesis;   tetrahydrofolylpolyglutamate formation;   tetrahydrofolylpolyglutamate synthesis
 broad_synonym: folic-acid containing compound polyglutamylation

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tetrahydrofolylpolyglutamate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FPGS folylpolyglutamate synthase IEA
(PMID:25164808), (PMID:3619447)
PMID:3619447 PMID:21873635 PMID:25164808 GO_REF:0000041 NCBI chr 9:127,802,858...127,814,520
Ensembl chr 9:127,794,597...127,814,327
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  biological_process 18678
    cellular process 17726
      cellular metabolic process 11177
        cellular modified amino acid metabolic process 224
          folic acid-containing compound metabolic process 32
            tetrahydrofolylpolyglutamate metabolic process 2
              tetrahydrofolylpolyglutamate biosynthetic process 1
Path 2
Term Annotations click to browse term
  biological_process 18678
    metabolic process 12129
      cellular metabolic process 11177
        heterocycle metabolic process 6152
          pteridine-containing compound metabolic process 37
            pteridine-containing compound biosynthetic process 15
              folic acid-containing compound biosynthetic process 10
                tetrahydrofolylpolyglutamate biosynthetic process 1
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