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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of bone remodeling
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Accession:GO:0046850 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.
Synonyms:exact_synonym: regulation of bone remodelling
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa;   NCBITaxon:7742 ! Vertebrata



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regulation of bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARTPT CART prepropeptide involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15724149) Ensembl
MGI
PMID:15724149 GO_REF:0000107 NCBI chr16:48,043,558...48,045,592
Ensembl chr16:48,043,492...48,045,592
JBrowse link
G FGFR3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (PMID:20053668) MGI PMID:20053668 NCBI chr 8:879,151...894,968
Ensembl chr 8:879,159...894,964
JBrowse link
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21346198) Ensembl
MGI
PMID:21346198 GO_REF:0000107 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156
JBrowse link
G INPP4B inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO (PMID:21982707) MGI PMID:21982707 NCBI chr 8:84,812,041...85,555,200
Ensembl chr 8:85,084,133...85,514,516
JBrowse link
G LEP leptin involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323
JBrowse link
G LEPR leptin receptor involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,801,954...146,895,995
JBrowse link
G MDK midkine involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,788...16,133,510
JBrowse link
G MEPE matrix extracellular phosphoglycoprotein ISO RGD PMID:10967096 RGD:70633 NCBI chr 8:131,186,563...131,198,418
Ensembl chr 8:131,186,888...131,200,330
JBrowse link
G SUCO SUN domain containing ossification factor involved_in IEA
IBA
Ensembl
GO_Central
GO_REF:0000033 GO_REF:0000107 NCBI chr 9:114,916,957...115,007,979
Ensembl chr 9:114,916,855...115,007,972
JBrowse link
G SYT7 synaptotagmin 7 involved_in ISO (MGI:3798323|PMID:18539119) UniProt PMID:18539119 MGI:3798323 NCBI chr 2:9,947,962...10,012,713
Ensembl chr 2:9,947,925...10,012,496
JBrowse link
negative regulation of bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GREM1 gremlin 1, DAN family BMP antagonist involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:136,617,041...136,629,293
Ensembl chr 1:136,617,105...136,629,292
JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748
JBrowse link
negative regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCB calcitonin-related polypeptide beta involved_in ISO (PMID:10822112), (PMID:17241109) UniProt PMID:10822112 PMID:17241109 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G CARTPT CART prepropeptide involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:48,043,558...48,045,592
Ensembl chr16:48,043,492...48,045,592
JBrowse link
G CD38 CD38 molecule ISO RGD PMID:10477767 RGD:2307268 NCBI chr 8:11,083,682...11,130,783
Ensembl chr 8:11,083,682...11,130,756
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (PMID:25490771) MGI PMID:25490771 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22437732) Ensembl
MGI
PMID:22437732 GO_REF:0000107 NCBI chr13:78,794,573...78,823,761
Ensembl chr13:78,794,580...78,822,796
JBrowse link
G CSK C-terminal Src kinase ISO RGD PMID:10411542 RGD:5134371 NCBI chr 7:58,736,473...58,755,034
Ensembl chr 7:58,736,531...58,755,260
JBrowse link
G CYP19A2 cytochrome P450 19A2 ISO RGD PMID:8694895 RGD:7257714 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G FSHR follicle stimulating hormone receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11089565), (PMID:17332067) Ensembl
MGI
PMID:11089565 PMID:17332067 GO_REF:0000107 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G GPR137 G protein-coupled receptor 137 involved_in IBA
IEA
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr 2:7,826,454...7,831,010
Ensembl chr 2:7,826,456...7,830,969
JBrowse link
G GPR137B G protein-coupled receptor 137B involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:55,125,405...55,181,688
Ensembl chr14:55,125,409...55,181,670
JBrowse link
G HAMP hepcidin antimicrobial peptide acts_upstream_of_or_within ISO (PMID:24561287) MGI PMID:24561287 NCBI chr 6:44,785,863...44,787,303
Ensembl chr 6:44,784,160...44,787,305
JBrowse link
G IAPP islet amyloid polypeptide acts_upstream_of_or_within ISO (PMID:14970190) MGI PMID:14970190 NCBI chr 5:52,046,570...52,051,475
Ensembl chr 5:52,046,573...52,050,446
JBrowse link
G IL6 interleukin 6 involved_in ISO (MGI:5795829|PMID:11159963) BHF-UCL PMID:11159963 MGI:5795829 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:12161749) Ensembl
MGI
GO_Central
PMID:12161749 GO_REF:0000033 GO_REF:0000107 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,644
JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12677010) Ensembl
MGI
PMID:12677010 GO_REF:0000107 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472
JBrowse link
G TMEM119 transmembrane protein 119 involved_in ISO (MGI:5543589|PMID:22416756) ARUK-UCL PMID:22416756 MGI:5543589 NCBI chr14:42,190,958...42,197,384 JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO RGD PMID:11839361 PMID:16912914 RGD:1624170 RGD:730196 NCBI chr 4:19,850,212...19,879,132
Ensembl chr 4:19,850,350...19,879,125
JBrowse link
G UBASH3B ubiquitin associated and SH3 domain containing B involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:23149425) Ensembl
TreeGrafter
MGI
GO_Central
PMID:23149425 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:49,630,678...49,772,348
Ensembl chr 9:49,630,793...49,770,897
JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:15312247 RGD:1580559 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366
JBrowse link
positive regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM8 ADAM metallopeptidase domain 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:141,221,177...141,233,728
Ensembl chr14:141,221,198...141,232,306
JBrowse link
G AHSG alpha 2-HS glycoprotein ISO RGD PMID:10500999 RGD:1625797 NCBI chr13:124,426,313...124,438,848
Ensembl chr13:124,426,308...124,438,840
JBrowse link
G CA2 carbonic anhydrase 2 ISO RGD PMID:8674544 RGD:1600722 NCBI chr 4:51,194,686...51,211,436
Ensembl chr 4:51,193,756...51,211,259
JBrowse link
G DCSTAMP dendrocyte expressed seven transmembrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:32,912,320...32,928,323
Ensembl chr 4:32,913,152...32,928,235
JBrowse link
G DEF8 differentially expressed in FDCP 8 homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:140,854...160,936
Ensembl chr 6:140,908...160,692
JBrowse link
G DLK1 delta like non-canonical Notch ligand 1 acts_upstream_of_or_within ISO (PMID:21308776) MGI PMID:21308776 NCBI chr 7:121,565,844...121,577,493
Ensembl chr 7:121,565,854...121,576,654
JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:2981075 RGD:10395245 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589
JBrowse link
G FCGR3A Fc fragment of IgG receptor IIIa involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:88,948,357...88,956,513 JBrowse link
G FSHB follicle stimulating hormone subunit beta acts_upstream_of_or_within ISO (PMID:16630814) MGI PMID:16630814 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G IDUA alpha-L-iduronidase acts_upstream_of_or_within ISO (PMID:19834056) MGI PMID:19834056 NCBI chr 8:334,604...351,970
Ensembl chr 8:334,617...351,969
JBrowse link
G ITGB3 integrin subunit beta 3 ISO RGD PMID:8603604 RGD:5024929 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292
JBrowse link
G LRP6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:18505367) MGI PMID:18505367 NCBI chr 5:60,149,041...60,318,719
Ensembl chr 5:60,149,028...60,314,662
JBrowse link
G LTBP3 latent transforming growth factor beta binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15878314) Ensembl
MGI
PMID:15878314 GO_REF:0000107 NCBI chr 2:6,701,455...6,720,191
Ensembl chr 2:6,701,510...6,720,153
JBrowse link
G MC4R melanocortin 4 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:160,772,013...160,774,124
Ensembl chr 1:160,772,013...160,774,124
JBrowse link
G OSCAR osteoclast associated Ig-like receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11805147) Ensembl
MGI
PMID:11805147 GO_REF:0000107 NCBI chr 6:56,021,434...56,029,398
Ensembl chr 6:56,022,256...56,030,646
JBrowse link
G PLEKHM1 pleckstrin homology and RUN domain containing M1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:17,984,169...18,035,377
Ensembl chr12:17,993,036...18,035,375
JBrowse link
G PPARGC1B PPARG coactivator 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:150,823,338...150,924,871
Ensembl chr 2:150,823,373...150,919,376
JBrowse link
G PRKCA protein kinase C alpha involved_in ISO (MGI:5284791|PMID:16014375) BHF-UCL PMID:16014375 MGI:5284791 NCBI chr12:12,882,287...13,268,647
Ensembl chr12:12,882,064...13,263,554
JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:11792579 RGD:729815 NCBI chr16:25,670,832...25,686,556
Ensembl chr16:25,670,862...25,686,552
JBrowse link
G SPP1 secreted phosphoprotein 1 involved_in ISO
IBA
RGD
GO_Central
PMID:11792563 GO_REF:0000033 RGD:1581129 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:8514886 RGD:150524326 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860
JBrowse link
G SYK spleen associated tyrosine kinase involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171
JBrowse link
G TF transferrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:74,930,655...74,970,599
Ensembl chr13:74,930,655...74,972,763
JBrowse link
G TFRC transferrin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:133,976,765...133,997,554
Ensembl chr13:133,970,985...134,000,276
JBrowse link
G TMEM64 transmembrane protein 64 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23395171) Ensembl
MGI
PMID:23395171 GO_REF:0000107 NCBI chr 4:46,340,409...46,365,808
Ensembl chr 4:46,340,449...46,365,963
JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:11805147) Ensembl
MGI
GO_Central
PMID:11805147 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:159,128,039...159,187,476
Ensembl chr 1:159,128,038...159,187,481
JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in ISO
IEA
RGD
Ensembl
PMID:11092398 GO_REF:0000107 RGD:730134 NCBI chr11:24,468,011...24,505,421
Ensembl chr11:24,468,110...24,505,477
JBrowse link
regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCR calcitonin receptor NOT|acts_upstream_of_or_within ISO (PMID:14970190) MGI PMID:14970190 NCBI chr 9:73,279,874...73,403,516
Ensembl chr 9:73,279,879...73,403,436
JBrowse link
G CSF1R colony stimulating factor 1 receptor involved_in ISO PMID:17121910 UniProt PMID:17121910 RGD:2293713 NCBI chr 2:151,102,138...151,130,311
Ensembl chr 2:151,102,147...151,147,633
JBrowse link
G IL20RA interleukin 20 receptor subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21844205) Ensembl
MGI
PMID:21844205 GO_REF:0000107 NCBI chr 1:27,137,545...27,172,341
Ensembl chr 1:27,137,558...27,172,720
JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within ISO (PMID:17053831) MGI PMID:17053831 NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,813...43,753,969
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:75,246,956...75,260,134
Ensembl chr 9:75,246,002...75,260,134
JBrowse link
G S1PR1 sphingosine-1-phosphate receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:117,064,632...117,069,724
Ensembl chr 4:117,064,755...117,069,650
JBrowse link
G SIGLEC15 sialic acid binding Ig like lectin 15 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:22451653) Ensembl
MGI
GO_Central
PMID:22451653 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:95,475,108...95,492,675
Ensembl chr 1:95,475,438...95,492,709
JBrowse link
G SLC4A2 solute carrier family 4 member 2 involved_in ISO (MGI:5469753|PMID:23341620) UniProt PMID:23341620 MGI:5469753 NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,459...6,165,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17639
    multicellular organismal process 8646
      tissue remodeling 221
        regulation of tissue remodeling 88
          regulation of bone remodeling 65
            negative regulation of bone remodeling + 21
            positive regulation of bone remodeling 0
            regulation of bone resorption + 54
Path 2
Term Annotations click to browse term
  biological_process 17639
    biological regulation 12783
      regulation of biological process 12430
        regulation of multicellular organismal process 3219
          regulation of tissue remodeling 88
            regulation of bone remodeling 65
              negative regulation of bone remodeling + 21
              positive regulation of bone remodeling 0
              regulation of bone resorption + 54
paths to the root