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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of bone remodeling
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Accession:GO:0046850 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.
Synonyms:exact_synonym: regulation of bone remodelling
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa;   NCBITaxon:7742 ! Vertebrata



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regulation of bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARTPT CART prepropeptide involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15724149) Ensembl
MGI
PMID:15724149 GO_REF:0000107 NCBI chr 5:43,591,683...43,593,586
Ensembl chr 5:44,236,114...44,238,229
JBrowse link
G FGFR3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (PMID:20053668) MGI PMID:20053668 NCBI chr 4:1,933,172...1,948,742
Ensembl chr 4:1,843,774...1,861,692
JBrowse link
G GJA1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:21346198) MGI PMID:21346198 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G INPP4B inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO (PMID:21982707) MGI PMID:21982707 NCBI chr 4:134,405,934...135,213,851
Ensembl chr 4:145,706,307...146,141,029
JBrowse link
G LEP leptin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
JBrowse link
G LEPR leptin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768
JBrowse link
G MDK midkine involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254
JBrowse link
G MEPE matrix extracellular phosphoglycoprotein ISO RGD PMID:10967096 RGD:70633 NCBI chr 4:80,125,612...80,139,539
Ensembl chr 4:90,838,938...90,864,332
JBrowse link
G SUCO SUN domain containing ossification factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:148,030,922...148,112,755
Ensembl chr 1:151,739,934...151,821,285
JBrowse link
G SYT7 synaptotagmin 7 involved_in ISO (MGI:3798323|PMID:18539119) UniProt PMID:18539119 MGI:3798323 NCBI chr11:56,814,694...56,880,439
Ensembl chr11:60,175,403...60,242,375
JBrowse link
negative regulation of bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GREM1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) BHF-UCL PMID:15539560 NCBI chr15:11,213,870...11,230,619 JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in ISO (PMID:19072540) UniProt PMID:19072540 NCBI chr 8:40,507,027...40,555,053 JBrowse link
negative regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCA calcitonin related polypeptide alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267
JBrowse link
G CARTPT CART prepropeptide involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:43,591,683...43,593,586
Ensembl chr 5:44,236,114...44,238,229
JBrowse link
G CD38 CD38 molecule ISO RGD PMID:10477767 RGD:2307268 NCBI chr 4:10,228,803...10,295,129
Ensembl chr 4:15,525,835...15,587,677
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (PMID:25490771) MGI PMID:25490771 NCBI chr19:39,395,550...39,417,063
Ensembl chr19:47,989,430...48,008,739
JBrowse link
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22437732) Ensembl
MGI
PMID:22437732 GO_REF:0000107 NCBI chr 3:135,037,555...135,061,105
Ensembl chr 3:142,478,031...142,512,548
JBrowse link
G CSK C-terminal Src kinase ISO RGD PMID:10411542 RGD:5134371 NCBI chr15:53,724,814...53,745,710
Ensembl chr15:73,342,703...73,363,476
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISO RGD PMID:8694895 RGD:7257714 NCBI chr15:30,152,924...30,282,854
Ensembl chr15:48,486,688...48,521,554
JBrowse link
G FSHR follicle stimulating hormone receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11089565), (PMID:17332067) Ensembl
MGI
PMID:11089565 PMID:17332067 GO_REF:0000107 NCBI chr2A:49,088,450...49,287,688
Ensembl chr2A:50,008,328...50,207,258
JBrowse link
G GPR137 G protein-coupled receptor 137 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:59,627,488...59,646,556
Ensembl chr11:62,985,909...62,990,950
JBrowse link
G GPR137B G protein-coupled receptor 137B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:211,709,507...211,775,846
Ensembl chr 1:216,696,105...216,778,370
JBrowse link
G HAMP hepcidin antimicrobial peptide involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24561287) Ensembl
MGI
PMID:24561287 GO_REF:0000107 NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861
JBrowse link
G IAPP islet amyloid polypeptide involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14970190) Ensembl
MGI
PMID:14970190 GO_REF:0000107 NCBI chr12:64,918,000...64,925,191
Ensembl chr12:67,520,986...67,528,103
JBrowse link
G IL6 interleukin 6 involved_in ISO (MGI:5795829|PMID:11159963) BHF-UCL PMID:11159963 MGI:5795829 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12161749) Ensembl
MGI
PMID:12161749 GO_REF:0000107 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190
JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:12677010) MGI PMID:12677010 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068
JBrowse link
G TMEM119 transmembrane protein 119 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:106,166,737...106,173,965
Ensembl chr12:109,563,684...109,564,535
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO RGD PMID:11839361 PMID:16912914 RGD:1624170 RGD:730196 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422
JBrowse link
G UBASH3B ubiquitin associated and SH3 domain containing B involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23149425) Ensembl
TreeGrafter
MGI
PMID:23149425 GO_REF:0000107 GO_REF:0000118 NCBI chr11:117,489,411...117,647,719
Ensembl chr11:121,410,545...121,563,133
JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:15312247 RGD:1580559 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
positive regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM8 ADAM metallopeptidase domain 8 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr10:134,172,724...134,186,227 JBrowse link
G AHSG alpha 2-HS glycoprotein ISO RGD PMID:10500999 RGD:1625797 NCBI chr 3:183,644,223...183,652,620
Ensembl chr 3:192,110,770...192,119,915
JBrowse link
G CA2 carbonic anhydrase 2 ISO RGD PMID:8674544 RGD:1600722 NCBI chr 8:81,991,037...82,009,010
Ensembl chr 8:83,597,440...83,632,580
JBrowse link
G DCSTAMP dendrocyte expressed seven transmembrane protein involved_in ISO (MGI:3588832|PMID:16061724), (MGI:5426134|PMID:17164993), (MGI:5426135|PMID:16937266) UniProt PMID:16061724 PMID:16937266 PMID:17164993 MGI:3588832 MGI:5426134 MGI:5426135 NCBI chr 8:100,967,757...100,985,384
Ensembl chr 8:103,121,332...103,138,223
JBrowse link
G DEF8 differentially expressed in FDCP 8 homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:70,710,131...70,730,332
Ensembl chr16:90,375,667...90,394,225
JBrowse link
G DLK1 delta like non-canonical Notch ligand 1 acts_upstream_of_or_within ISO (PMID:21308776) MGI PMID:21308776 NCBI chr14:81,348,380...81,356,607
Ensembl chr14:100,654,965...100,668,019
JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:2981075 RGD:10395245 NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615
JBrowse link
G FCGR3A Fc gamma receptor IIIa involved_in ISO (MGI:5641770|PMID:25824719) UniProt PMID:25824719 MGI:5641770 NCBI chr 1:137,027,943...137,036,738 JBrowse link
G FSHB follicle stimulating hormone subunit beta involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16630814) Ensembl
MGI
PMID:16630814 GO_REF:0000107 NCBI chr11:30,204,193...30,208,410
Ensembl chr11:30,095,486...30,100,167
JBrowse link
G IDUA alpha-L-iduronidase acts_upstream_of_or_within ISO (PMID:19834056) MGI PMID:19834056 NCBI chr 4:1,102,288...1,120,973
Ensembl chr 4:1,020,582...1,037,877
JBrowse link
G ITGB3 integrin subunit beta 3 ISO RGD PMID:8603604 RGD:5024929 NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382
JBrowse link
G LRP6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:18505367) MGI PMID:18505367 NCBI chr12:12,121,411...12,288,590
Ensembl chr12:12,508,108...12,657,973
JBrowse link
G LTBP3 latent transforming growth factor beta binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15878314) Ensembl
MGI
PMID:15878314 GO_REF:0000107 NCBI chr11:60,897,897...60,917,690
Ensembl chr11:64,233,504...64,252,802
JBrowse link
G MC4R melanocortin 4 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:53,744,172...53,747,282
Ensembl chr18:57,069,259...57,070,257
JBrowse link
G OSCAR osteoclast associated Ig-like receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11805147) Ensembl
MGI
PMID:11805147 GO_REF:0000107 NCBI chr19:51,027,449...51,033,972
Ensembl chr19:59,871,394...59,876,370
JBrowse link
G PLEKHM1 pleckstrin homology and RUN domain containing M1 involved_in ISO (MGI:5806241|PMID:27777970) UniProt PMID:27777970 MGI:5806241 NCBI chr17:11,836,726...11,891,614
Ensembl chr17:12,011,604...12,063,912
JBrowse link
G PPARGC1B PPARG coactivator 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:145,154,517...145,315,567
Ensembl chr 5:151,203,088...151,278,837
JBrowse link
G PRKCA protein kinase C alpha involved_in ISO (MGI:5284791|PMID:16014375) BHF-UCL PMID:16014375 MGI:5284791 NCBI chr17:60,246,485...60,747,158
Ensembl chr17:65,454,907...65,947,903
JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:11792579 RGD:729815 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148
JBrowse link
G SPP1 secreted phosphoprotein 1 involved_in ISO
IEA
RGD
TreeGrafter
PMID:11792563 GO_REF:0000118 RGD:1581129 NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:8514886 RGD:150524326 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634
JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101
JBrowse link
G TF transferrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:130,799,063...130,830,227
Ensembl chr 3:138,274,159...138,305,476
JBrowse link
G TFRC transferrin receptor involved_in ISO (MGI:3838421|PMID:19252502) DFLAT PMID:19252502 MGI:3838421 NCBI chr 3:193,384,817...193,417,532
Ensembl chr 3:203,333,953...203,373,998
JBrowse link
G TMEM64 transmembrane protein 64 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23395171) Ensembl
TreeGrafter
MGI
PMID:23395171 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:87,285,209...87,309,654
Ensembl chr 8:89,234,475...89,317,386
JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11805147) Ensembl
TreeGrafter
MGI
PMID:11805147 GO_REF:0000107 GO_REF:0000118 NCBI chr18:55,695,394...55,761,307
Ensembl chr18:59,034,770...59,075,044
JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in ISO
IEA
RGD
Ensembl
PMID:11092398 GO_REF:0000107 RGD:730134 NCBI chr13:23,750,835...23,784,740 JBrowse link
regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCR calcitonin receptor NOT|acts_upstream_of_or_within ISO (PMID:14970190) MGI PMID:14970190 NCBI chr 7:85,382,167...85,532,562
Ensembl chr 7:98,975,906...99,047,162
JBrowse link
G CSF1R colony stimulating factor 1 receptor involved_in ISO PMID:17121910 UniProt PMID:17121910 RGD:2293713 NCBI chr 5:145,478,725...145,537,858
Ensembl chr 5:151,483,572...151,517,415
JBrowse link
G IL20RA interleukin 20 receptor subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21844205) Ensembl
MGI
PMID:21844205 GO_REF:0000107 NCBI chr 6:134,762,355...134,805,937
Ensembl chr 6:138,848,400...138,866,098
JBrowse link
G NF1 neurofibromin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17053831) Ensembl
MGI
PMID:17053831 GO_REF:0000107 NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:87,540,600...87,553,673
Ensembl chr 7:101,128,060...101,141,157
JBrowse link
G S1PR1 sphingosine-1-phosphate receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:103,893,199...103,898,381
Ensembl chr 1:102,608,839...102,609,987
JBrowse link
G SIGLEC15 sialic acid binding Ig like lectin 15 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:22451653) Ensembl
MGI
PMID:22451653 GO_REF:0000107 NCBI chr18:39,111,697...39,125,631
Ensembl chr18:42,658,534...42,663,773
JBrowse link
G SLC4A2 solute carrier family 4 member 2 involved_in ISO (MGI:5469753|PMID:23341620) UniProt PMID:23341620 MGI:5469753 NCBI chr 7:142,646,413...142,663,376
Ensembl chr 7:154,799,256...154,815,919
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16424
    multicellular organismal process 7217
      tissue remodeling 219
        regulation of tissue remodeling 88
          regulation of bone remodeling 65
            negative regulation of bone remodeling + 21
            positive regulation of bone remodeling 0
            regulation of bone resorption + 54
Path 2
Term Annotations click to browse term
  biological_process 16424
    biological regulation 11388
      regulation of biological process 11038
        regulation of multicellular organismal process 3126
          regulation of tissue remodeling 88
            regulation of bone remodeling 65
              negative regulation of bone remodeling + 21
              positive regulation of bone remodeling 0
              regulation of bone resorption + 54
paths to the root