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ONTOLOGY REPORT - ANNOTATIONS

Term:bone remodeling
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Accession:GO:0046849 term browser browse the term
Definition:The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
Synonyms:exact_synonym: bone remodelling
 xref: Wikipedia:Bone_remodeling


show annotations for term's descendants           Sort by:
bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc154 coiled-coil domain containing 154 acts_upstream_of_or_within ISO (PMID:33614666) RGD PMID:33614666 NCBI chr10:14,681,938...14,691,757
Ensembl chr10:14,681,923...14,691,759 		JBrowse link
G Ctnnb1 catenin beta 1 IEP RGD PMID:29224185 RGD:13792728 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Dock5 dedicator of cytokinesis 5 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:27505886) 		Ensembl
RGD		 PMID:27505886 GO_REF:0000107 NCBI chr15:46,155,124...46,334,127
Ensembl chr15:46,155,125...46,334,042 		JBrowse link
G Efna2 ephrin A2 involved_in IBA
ISO
IEA 		GO_REF:0000033
(PMID:19299512)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:19299512 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:10,167,091...10,177,719
Ensembl chr 7:10,167,091...10,177,719 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 acts_upstream_of_or_within
involved_in 		ISO MGI:1857079 (PMID:10024383)
MGI:1857079 (PMID:9541520) 		RGD PMID:9541520 PMID:10024383 NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044 		JBrowse link
G Epha2 Eph receptor A2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19299512) 		Ensembl
RGD		 PMID:19299512 GO_REF:0000107 NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:158,888,629...158,917,234 		JBrowse link
G Gja1 gap junction protein, alpha 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:25270829) 		UniProt
RGD		 PMID:25270829 GO_REF:0000024 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IDA RGD PMID:29224185 RGD:13792728 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:36635269) 		Ensembl
RGD		 PMID:36635269 GO_REF:0000107 NCBI chr 8:75,796,347...75,965,347
Ensembl chr 8:75,796,357...75,965,347 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000002
MGI:1278315|MGI:98796 (PMID:19041748) 		InterPro
RGD		 PMID:19041748 GO_REF:0000002 NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583 		JBrowse link
G Il6 interleukin 6 IEP RGD PMID:16193234 RGD:1601024 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:19605502)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:19605502 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:116,901,968...117,004,584
Ensembl chr 3:116,901,968...117,004,153 		JBrowse link
G Lrp5 LDL receptor related protein 5 acts_upstream_of_or_within
involved_in 		IEA
ISO 		GO_REF:0000107
MGI:1298218|MGI:2183279|MGI:3530598|MGI:3612485|MGI:96274|MGI:98796 (PMID:11956231), (PMID:12817748), (PMID:15207752), (PMID:15537447), (PMID:16790443), (PMID:17147489), (PMID:17627087), (PMID:19041748)
GO_REF:0000117 		Ensembl
RGD
UniProt		 PMID:11956231 PMID:12817748 PMID:15207752 PMID:15537447 PMID:16790443 More... GO_REF:0000107 GO_REF:0000117 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822 		JBrowse link
G Lrp6 LDL receptor related protein 6 involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000117
MGI:1278315 (PMID:15537447) 		UniProt
RGD		 PMID:15537447 GO_REF:0000117 NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2180017 (PMID:11790802) 		Ensembl
RGD		 PMID:11790802 GO_REF:0000107 NCBI chr 1:212,458,362...212,475,302
Ensembl chr 1:212,459,185...212,475,302 		JBrowse link
G Lypd8l1 LY6/PLAUR domain containing 8 like 1 involved_in IEP PMID:9461570 UniProt PMID:9461570 RGD:1299027 NCBI chr10:43,115,979...43,124,349
Ensembl chr10:43,117,891...43,124,875 		JBrowse link
G Mitf melanocyte inducing transcription factor acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1856095 (PMID:12086670) 		Ensembl
RGD		 PMID:12086670 GO_REF:0000107 NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790 		JBrowse link
G Notch2 notch receptor 2 involved_in ISO
IEA 		(PMID:21378985), (PMID:21378989)
GO_REF:0000107 		RGD
Ensembl		 PMID:21378985 PMID:21378989 GO_REF:0000107 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823 		JBrowse link
G P3h4 prolyl 3-hydroxylase family member 4 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:23959653), (PMID:27119146)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:23959653 PMID:27119146 GO_REF:0000024 GO_REF:0000107 NCBI chr10:85,838,528...85,845,476
Ensembl chr10:85,838,528...85,845,476 		JBrowse link
G Ptprv protein tyrosine phosphatase, receptor type, V IEP RGD PMID:7527035 RGD:632779 NCBI chr13:49,099,922...49,120,247
Ensembl chr13:49,099,925...49,120,121 		JBrowse link
G Rassf2 Ras association domain family member 2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:5314787 (PMID:22227519) 		Ensembl
RGD		 PMID:22227519 GO_REF:0000107 NCBI chr 3:139,697,187...139,733,402
Ensembl chr 3:139,697,187...139,733,368 		JBrowse link
G Slc34a1 solute carrier family 34 member 1 acts_upstream_of_or_within ISO MGI:2386786 (PMID:9560283) RGD PMID:9560283 NCBI chr17:9,224,010...9,238,983
Ensembl chr17:9,224,010...9,238,983 		JBrowse link
G Snx10 sorting nexin 10 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:5690193 (PMID:25811986) 		Ensembl
RGD		 PMID:25811986 GO_REF:0000107 NCBI chr 4:81,943,262...82,007,667
Ensembl chr 4:81,943,287...82,007,651 		JBrowse link
G Spp2 secreted phosphoprotein 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:96,454,636...96,474,453
Ensembl chr 9:96,454,957...96,474,452 		JBrowse link
G Tph1 tryptophan hydroxylase 1 acts_upstream_of_or_within ISO MGI:1278315|MGI:96274 (PMID:19041748) RGD PMID:19041748 NCBI chr 1:106,293,695...106,314,628
Ensembl chr 1:106,085,953...106,312,484 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO (PMID:10421844) RGD PMID:10421844 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
G Wnt16 Wnt family member 16 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:5467557 (PMID:22792071) 		Ensembl
RGD		 PMID:22792071 GO_REF:0000107 NCBI chr 4:51,786,728...51,797,137
Ensembl chr 4:51,786,660...51,816,568 		JBrowse link
bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant involved_in
acts_upstream_of_or_within 		TAS
IEP
IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
GO_REF:0000117
MGI:2180086 (PMID:8898228) 		GO_Central
Ensembl
UniProt
RGD		 PMID:8898228 PMID:1722212 PMID:20069278 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:1298628, RGD:2315871 NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929 		JBrowse link
G Adrb2 adrenoceptor beta 2 acts_upstream_of_or_within ISO MGI:1859675 (PMID:15724149) RGD PMID:15724149 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Bbln bublin coiled coil protein acts_upstream_of_or_within ISO (PMID:32569872) RGD PMID:32569872 NCBI chr 3:36,072,325...36,075,070
Ensembl chr 3:36,072,328...36,075,093 		JBrowse link
G Ccdc154 coiled-coil domain containing 154 acts_upstream_of_or_within ISO MGI:5702426 (PMID:20121924) RGD PMID:20121924 NCBI chr10:14,681,938...14,691,757
Ensembl chr10:14,681,923...14,691,759 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1858008|MGI:2148567|MGI:3041864|MGI:98504 (PMID:15866165) 		Ensembl
RGD		 PMID:15866165 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsk cathepsin K acts_upstream_of_or_within IMP
ISO 		MGI:2182131 (PMID:19834056) RGD PMID:19834056 PMID:10430032 RGD:1601030 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582 		JBrowse link
G Ctss cathepsin S IMP RGD PMID:10470376 RGD:5687153 NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:185,775,296...185,803,440 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:1857079 (PMID:28798354) RGD PMID:28798354 NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:29415886) 		Ensembl
RGD		 PMID:29415886 GO_REF:0000107 NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:86,259,900...86,544,567 		JBrowse link
G Gpr55 G protein-coupled receptor 55 involved_in ISO
IEA 		(PMID:19805329)
GO_REF:0000107 		RGD
Ensembl		 PMID:19805329 GO_REF:0000107 NCBI chr 9:94,037,748...94,081,426
Ensembl chr 9:94,036,162...94,088,707 		JBrowse link
G Gusb glucuronidase, beta acts_upstream_of_or_within ISO (PMID:31974587) RGD PMID:31974587 NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024 		JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:88276 (PMID:15866165) 		Ensembl
RGD		 PMID:15866165 GO_REF:0000107 NCBI chr12:47,299,171...47,333,457
Ensembl chr12:47,306,245...47,332,755 		JBrowse link
G Iapp islet amyloid polypeptide acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:176,968,097...176,975,363 		JBrowse link
G Ihh Indian hedgehog signaling molecule acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:10208865) 		Ensembl
RGD		 PMID:10208865 GO_REF:0000107 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:83,952,986...83,959,203 		JBrowse link
G Il7 interleukin 7 involved_in
acts_upstream_of_or_within 		ISS
ISO 		GO_REF:0000024
(PMID:12490655) 		UniProt
RGD		 PMID:12490655 GO_REF:0000024 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389 		JBrowse link
G Lrrk1 leucine-rich repeat kinase 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:5568128 (PMID:23526378) 		Ensembl
RGD		 PMID:23526378 GO_REF:0000107 NCBI chr 1:129,254,815...129,390,217
Ensembl chr 1:129,254,515...129,389,941 		JBrowse link
G Ncdn neurochondrin acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:10231559) 		Ensembl
RGD		 PMID:10231559 GO_REF:0000107 NCBI chr 5:144,322,287...144,332,117
Ensembl chr 5:144,322,287...144,332,047 		JBrowse link
G Nox4 NADPH oxidase 4 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:11098048) 		Ensembl
RGD		 PMID:11098048 GO_REF:0000107 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Pth parathyroid hormone TAS RGD PMID:11145578 RGD:61525 NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:176,943,102...176,946,034 		JBrowse link
G Pth1r parathyroid hormone 1 receptor acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2154519 (PMID:9832460) 		Ensembl
RGD		 PMID:9832460 GO_REF:0000107 NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:119,575,868...119,598,108 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO 		GO_REF:0000024
(PMID:14739300) 		UniProt
RGD		 PMID:14739300 GO_REF:0000024 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806 		JBrowse link
G Rab3d RAB3D, member RAS oncogene family involved_in ISO
IEA 		(PMID:21262767)
GO_REF:0000107 		RGD
Ensembl		 PMID:21262767 GO_REF:0000107 NCBI chr 8:28,714,706...28,725,379
Ensembl chr 8:28,716,241...28,725,317 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family IMP RGD PMID:11514537 RGD:729760 NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:121,983,938...122,064,185 		JBrowse link
G Rac1 Rac family small GTPase 1 IDA RGD PMID:10350213 RGD:1599401 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Rac2 Rac family small GTPase 2 IDA RGD PMID:10350213 RGD:1599401 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:111,996,742...112,009,267 		JBrowse link
G Snx10 sorting nexin 10 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:5690193 (PMID:25811986) 		Ensembl
RGD		 PMID:25811986 GO_REF:0000107 NCBI chr 4:81,943,262...82,007,667
Ensembl chr 4:81,943,287...82,007,651 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in
acts_upstream_of_or_within 		ISS
ISO 		GO_REF:0000024
MGI:1857247 (PMID:19448635)
(PMID:14739300) 		UniProt
RGD		 PMID:14739300 PMID:19448635 GO_REF:0000024 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1856973|MGI:5496553 (PMID:18768394), (PMID:21305608), (PMID:22087326), (PMID:23166162), (PMID:23908015) 		Ensembl
RGD		 PMID:18768394 PMID:21305608 PMID:22087326 PMID:23166162 PMID:23908015 GO_REF:0000107 NCBI chr 1:210,556,270...210,568,021
Ensembl chr 1:210,556,270...210,568,033 		JBrowse link
G Tnfsf11 TNF superfamily member 11 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:12490655) 		Ensembl
RGD		 PMID:12490655 GO_REF:0000107 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Tns3 tensin 3 acts_upstream_of_or_within ISO (PMID:27505886) RGD PMID:27505886 NCBI chr14:87,387,441...87,619,457
Ensembl chr14:87,387,441...87,619,712 		JBrowse link
G Tpp1 tripeptidyl peptidase 1 involved_in ISS
IEA
ISO 		PMID:14609438
GO_REF:0000107
(PMID:8215436) 		Ensembl
RGD		 PMID:8215436 PMID:14609438 GO_REF:0000107, RGD:8554137 NCBI chr 1:169,509,816...169,515,939
Ensembl chr 1:169,509,815...169,516,024 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO (PMID:10215628) RGD PMID:10215628 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
negative regulation of bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:120,966,623...120,979,089 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19072540) 		Ensembl
RGD		 PMID:19072540 GO_REF:0000107 NCBI chr16:75,278,325...75,316,736
Ensembl chr16:75,278,325...75,316,736 		JBrowse link
negative regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha involved_in ISO
IEA 		(PMID:10822112), (PMID:17241109)
GO_REF:0000107 		RGD
Ensembl		 PMID:10822112 PMID:17241109 GO_REF:0000107 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Cartpt CART prepropeptide involved_in ISO
IEA 		(PMID:16614075)
UniProtKB:P56450 (PMID:16614075)
GO_REF:0000107 		RGD
Ensembl		 PMID:16614075 GO_REF:0000107 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712 		JBrowse link
G Cd38 CD38 molecule IDA RGD PMID:10477767 RGD:2307268 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO MGI:5560663 (PMID:25490771) RGD PMID:25490771 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798 		JBrowse link
G Cldn18 claudin 18 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:22437732)
MGI:5007067 (PMID:22437732) 		Ensembl
RGD		 PMID:22437732 GO_REF:0000107 NCBI chr 8:109,125,819...109,145,110
Ensembl chr 8:109,126,949...109,152,701 		JBrowse link
G Csk C-terminal Src kinase IDA RGD PMID:10411542 RGD:5134371 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:66,925,651...66,930,274 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IMP RGD PMID:8694895 RGD:7257714 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Dusp18 dual specificity phosphatase 18 involved_in ISO (PMID:38346942) RGD PMID:38346942 NCBI chr14:83,013,850...83,035,168
Ensembl chr14:83,011,014...83,056,929 		JBrowse link
G Fshr follicle stimulating hormone receptor acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2384087 (PMID:11089565), (PMID:17332067) 		Ensembl
RGD		 PMID:11089565 PMID:17332067 GO_REF:0000107 NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288 		JBrowse link
G Gpr137b G protein-coupled receptor 137B involved_in IBA
ISO 		GO_REF:0000033
(PMID:31173907) 		GO_Central
RGD		 PMID:31173907 GO_REF:0000033 NCBI chr17:92,987,792...93,026,003
Ensembl chr17:92,942,559...93,025,911 		JBrowse link
G Hamp hepcidin antimicrobial peptide acts_upstream_of_or_within ISO MGI:4351741 (PMID:24561287) RGD PMID:24561287 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297 		JBrowse link
G Iapp islet amyloid polypeptide acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2656235 (PMID:14970190) 		Ensembl
RGD		 PMID:14970190 GO_REF:0000107 NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:176,968,097...176,975,363 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:11159963) RGD PMID:11159963 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within 		IBA
ISO
IEA 		GO_REF:0000033
MGI:2386884 (PMID:12161749)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:12161749 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:95,735,530...95,840,589 		JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor involved_in ISO (PMID:38346942) RGD PMID:38346942 NCBI chr13:47,327,159...47,332,759
Ensembl chr13:47,327,004...47,332,906 		JBrowse link
G Kiss1r KISS1 receptor involved_in ISO (PMID:38346942) RGD PMID:38346942 NCBI chr 7:10,435,766...10,439,424
Ensembl chr 7:10,435,766...10,439,424 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (PMID:12677010) RGD PMID:12677010 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G Tmem119 transmembrane protein 119 involved_in IEA
ISO 		GO_REF:0000107
(PMID:22416756) 		Ensembl
RGD		 PMID:22416756 GO_REF:0000107 NCBI chr12:48,489,157...48,496,214
Ensembl chr12:48,489,137...48,496,261 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B IMP
IDA 		RGD PMID:11839361 PMID:16912914 RGD:730196, RGD:1624170 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075 		JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:23149425) 		Ensembl
RGD		 PMID:23149425 GO_REF:0000107 NCBI chr 8:50,282,510...50,430,034
Ensembl chr 8:50,285,431...50,326,351 		JBrowse link
G Vegfa vascular endothelial growth factor A IMP RGD PMID:15312247 RGD:1580559 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
ossification involved in bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cthrc1 collagen triple helix repeat containing 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3830252 (PMID:18779865) 		Ensembl
RGD		 PMID:18779865 GO_REF:0000107 NCBI chr 7:72,007,372...72,017,654
Ensembl chr 7:72,007,372...72,017,654 		JBrowse link
G Gdf5 growth differentiation factor 5 IEP RGD PMID:10404008 RGD:2289026 NCBI chr 3:164,914,401...164,918,593
Ensembl chr 3:164,914,401...164,918,593 		JBrowse link
G Ptn pleiotrophin involved_in ISS
ISO 		GO_REF:0000024
(PMID:19442624) 		UniProt
RGD		 PMID:19442624 GO_REF:0000024 NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:66,260,764...66,342,482 		JBrowse link
positive regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07002627.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 1:86,040,445...86,042,607 JBrowse link
G Adam8 ADAM metallopeptidase domain 8 involved_in IEA
ISO 		GO_REF:0000107
(PMID:11341326), (PMID:20683884) 		Ensembl
RGD		 PMID:11341326 PMID:20683884 GO_REF:0000107 NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:204,206,199...204,218,485 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein IMP RGD PMID:10500999 RGD:1625797 NCBI chr11:91,625,975...91,632,583
Ensembl chr11:91,625,975...91,634,039 		JBrowse link
G Car2 carbonic anhydrase 2 IMP RGD PMID:8674544 RGD:1600722 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein involved_in ISO (PMID:16061724), (PMID:16937266), (PMID:17164993) RGD PMID:16061724 PMID:16937266 PMID:17164993 NCBI chr 7:72,692,364...72,706,983
Ensembl chr 7:72,671,477...72,707,009 		JBrowse link
G Def8 differentially expressed in FDCP 8 homolog involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:27777970)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:27777970 GO_REF:0000024 GO_REF:0000107 NCBI chr19:68,383,293...68,404,133
Ensembl chr19:68,383,349...68,404,125 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 involved_in
acts_upstream_of_or_within 		ISO (PMID:21308776)
MGI:3526402 (PMID:21308776) 		RGD PMID:21308776 NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:134,192,518...134,200,529 		JBrowse link
G Egfr epidermal growth factor receptor IMP RGD PMID:2981075 RGD:10395245 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Fcgr3a Fc gamma receptor 3A involved_in IEA
ISO 		GO_REF:0000107
(PMID:25824719) 		Ensembl
RGD		 PMID:25824719 GO_REF:0000107 NCBI chr13:85,782,636...85,792,656
Ensembl chr13:85,782,490...85,792,651 		JBrowse link
G Fshb follicle stimulating hormone subunit beta acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1857434 (PMID:16630814) 		Ensembl
RGD		 PMID:16630814 GO_REF:0000107 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072 		JBrowse link
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2176236 (PMID:19834056) RGD PMID:19834056 NCBI chr14:1,175,994...1,203,913
Ensembl chr14:1,176,577...1,204,066 		JBrowse link
G Itgb3 integrin subunit beta 3 involved_in IMP
IEA 		GO_REF:0000117 UniProt
RGD		 PMID:8603604 GO_REF:0000117, RGD:5024929 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2673982 (PMID:18505367) RGD PMID:18505367 NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2180017 (PMID:15878314) 		Ensembl
RGD		 PMID:15878314 GO_REF:0000107 NCBI chr 1:212,458,362...212,475,302
Ensembl chr 1:212,459,185...212,475,302 		JBrowse link
G Mc4r melanocortin 4 receptor involved_in ISO (PMID:16614075) RGD PMID:16614075 NCBI chr18:62,689,798...62,691,685 JBrowse link
G Oscar osteoclast associated Ig-like receptor acts_upstream_of_or_within ISO (PMID:11805147) RGD PMID:11805147 NCBI chr 1:74,521,626...74,529,119
Ensembl chr 1:74,515,001...74,529,119 		JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:27777970)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:27777970 GO_REF:0000024 GO_REF:0000107 NCBI chr10:88,814,699...88,876,570
Ensembl chr10:88,814,699...88,862,544 		JBrowse link
G Prkca protein kinase C, alpha involved_in ISO (PMID:16014375) RGD PMID:16014375 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11792579 RGD:729815 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:56,062,890...56,074,135 		JBrowse link
G Rufy4 RUN and FYVE domain containing 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:38744829) 		Ensembl
RGD		 PMID:38744829 GO_REF:0000107 NCBI chr 9:83,152,139...83,172,683
Ensembl chr 9:83,154,445...83,172,897 		JBrowse link
G Spp1 secreted phosphoprotein 1 involved_in IDA
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:11792563 GO_REF:0000033, RGD:1581129 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IMP RGD PMID:8514886 RGD:150524326 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:17353363)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:17353363 GO_REF:0000024 GO_REF:0000107 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278 		JBrowse link
G Tmem64 transmembrane protein 64 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:3880885 (PMID:23395171) 		GO_Central
RGD		 PMID:23395171 GO_REF:0000033 NCBI chr 5:33,495,992...33,542,390
Ensembl chr 5:33,496,032...33,542,389 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A involved_in
acts_upstream_of_or_within 		IBA
ISO
IEA 		GO_REF:0000033
(PMID:11805147)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:11805147 GO_REF:0000033 GO_REF:0000107 NCBI chr13:22,442,930...22,501,257
Ensembl chr13:22,442,665...22,501,257 		JBrowse link
G Tnfsf11 TNF superfamily member 11 involved_in IMP
IEA
ISO 		GO_REF:0000107
(PMID:17241109) 		Ensembl
RGD		 PMID:17241109 PMID:11092398 GO_REF:0000107, RGD:730134 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
regulation of bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cartpt CART prepropeptide acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3576858 (PMID:15724149) 		Ensembl
RGD		 PMID:15724149 GO_REF:0000107 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 involved_in ISO (PMID:21308776) RGD PMID:21308776 NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:134,192,518...134,200,529 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO MGI:2135670 (PMID:20053668) RGD PMID:20053668 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209 		JBrowse link
G Gja1 gap junction protein, alpha 1 acts_upstream_of_or_within ISO MGI:2445468|MGI:3776013 (PMID:21346198) RGD PMID:21346198 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO MGI:5297505 (PMID:21982707) RGD PMID:21982707 NCBI chr19:42,824,710...43,575,039
Ensembl chr19:42,829,871...43,185,091 		JBrowse link
G Lep leptin involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:10660043)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:10660043 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lepr leptin receptor involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:10660043)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:10660043 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Mdk midkine involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:21185956)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:21185956 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:98,356,789...98,358,743 		JBrowse link
G Mepe matrix extracellular phosphoglycoprotein IEP RGD PMID:10967096 RGD:70633 NCBI chr14:5,725,308...5,736,858
Ensembl chr14:5,725,175...5,736,996 		JBrowse link
G Suco SUN domain containing ossification factor involved_in IEA
ISO
IBA
ISS 		GO_REF:0000107
(PMID:20440000)
GO_REF:0000033
GO_REF:0000024 		Ensembl
RGD
GO_Central
UniProt		 PMID:20440000 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:76,726,095...76,791,174
Ensembl chr13:76,726,859...76,791,174 		JBrowse link
G Syt7 synaptotagmin 7 involved_in ISS
ISO 		GO_REF:0000024
(PMID:18539119) 		UniProt
RGD		 PMID:18539119 GO_REF:0000024 NCBI chr 1:216,456,148...216,518,718
Ensembl chr 1:216,456,259...216,518,718 		JBrowse link
regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:30240610) 		Ensembl
RGD		 PMID:30240610 GO_REF:0000107 NCBI chr 1:165,160,701...165,226,219
Ensembl chr 1:165,160,678...165,226,218 		JBrowse link
G Car2 carbonic anhydrase 2 TAS RGD PMID:9665810 RGD:1342423 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064 		JBrowse link
G Csf1r colony stimulating factor 1 receptor involved_in IMP PMID:17121910 UniProt PMID:17121910 RGD:2293713 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806 		JBrowse link
G Il20ra interleukin 20 receptor subunit alpha acts_upstream_of_or_within ISO MGI:5302406 (PMID:21844205) RGD PMID:21844205 NCBI chr 1:16,243,683...16,313,229
Ensembl chr 1:16,243,801...16,313,221 		JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within 		ISS
ISO
IEA 		GO_REF:0000024
MGI:1857478 (PMID:17053831)
GO_REF:0000107 		HGNC-UCL
RGD
Ensembl		 PMID:17053831 GO_REF:0000024 GO_REF:0000107 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:21803180) 		Ensembl
RGD		 PMID:21803180 GO_REF:0000107 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:19204730)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:19204730 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689 		JBrowse link
G Siglec15 sialic acid binding Ig-like lectin 15 involved_in
acts_upstream_of_or_within 		IBA
ISO
IEA 		GO_REF:0000033
(PMID:22451653)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:22451653 GO_REF:0000033 GO_REF:0000107 NCBI chr18:73,781,536...73,797,014
Ensembl chr18:73,781,536...73,797,014 		JBrowse link
G Slc4a2 solute carrier family 4 member 2 involved_in ISS
ISO 		GO_REF:0000024
(PMID:23341620) 		UniProt
RGD		 PMID:23341620 GO_REF:0000024 NCBI chr 4:11,628,860...11,646,961
Ensembl chr 4:11,628,862...11,645,402 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    multicellular organismal process 9018
      tissue remodeling 244
        bone remodeling 116
          bone resorption + 84
          negative regulation of bone remodeling + 23
          ossification involved in bone remodeling 3
          positive regulation of bone remodeling 0
          regulation of bone remodeling + 66
paths to the root