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ONTOLOGY REPORT - ANNOTATIONS


Term:viral entry into host cell
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Accession:GO:0046718 term browser browse the term
Definition:The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
Comment:Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
Synonyms:exact_synonym: entry of virus into host cell;   phage translocation;   viral penetration;   virion penetration;   virion penetration into host cell;   virus entry into host cell
 alt_id: GO:0019063
 xref: VZ:936


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viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 involved_in ISO (PMID:16051304), (PMID:32221306), (PMID:33000221), (PMID:33082294), (PMID:33713620) UniProt PMID:16051304 PMID:32221306 PMID:33000221 PMID:33082294 PMID:33713620 NCBI chrNW_004936470:4,964,526...5,011,808 JBrowse link
G Agtr1 angiotensin II receptor type 1 involved_in ISO (PMID:33713620) UniProt PMID:33713620 NCBI chrNW_004936519:6,831,096...6,873,977 JBrowse link
G Avpr1b arginine vasopressin receptor 1B involved_in ISO (PMID:33713620) UniProt PMID:33713620 NCBI chrNW_004936557:6,415,544...6,423,863 JBrowse link
G Axl AXL receptor tyrosine kinase involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chrNW_004936661:3,658,140...3,687,290 JBrowse link
G Clec4g C-type lectin domain family 4 member G involved_in ISO (PMID:16051304), (PMID:24623090) FlyBase PMID:16051304 PMID:24623090 NCBI chrNW_004936588:4,737,278...4,740,750 JBrowse link
G Ctsl cathepsin L involved_in ISO (PMID:16339146), (PMID:18562523), (PMID:26953343), (PMID:32855215) UniProt PMID:16339146 PMID:18562523 PMID:26953343 PMID:32855215 NCBI chrNW_004936680:3,047,355...3,050,640 JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 involved_in ISO (PMID:20202662) CACAO PMID:20202662 NCBI chrNW_004936522:9,438,929...9,486,781 JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO (PMID:21501828) UniProt PMID:21501828 NCBI chrNW_004936472:27,116...57,158 JBrowse link
G Gpr15 G protein-coupled receptor 15 involved_in ISO (PMID:15650194) UniProt PMID:15650194 NCBI chrNW_004936630:4,459,213...4,462,285 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 involved_in ISO (PMID:23029581) CACAO PMID:23029581 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Hyal2 hyaluronidase 2 ISO facilitates RGD PMID:12584308 RGD:633153 NCBI chrNW_004936529:1,845,445...1,851,106 JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (PMID:25063885) UniProt PMID:25063885 NCBI chrNW_004936506:10,750,116...10,839,018 JBrowse link
G Itgb3 integrin subunit beta 3 involved_in ISO (PMID:25063885) UniProt PMID:25063885 NCBI chrNW_004936541:2,822,789...2,871,069 JBrowse link
G Lamp3 lysosomal associated membrane protein 3 NOT|involved_in ISO (PMID:21810281) ParkinsonsUK-UCL PMID:21810281 NCBI chrNW_004936566:365,326...394,985 JBrowse link
G LOC101954488 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:49235|PMID:1719235) MGI PMID:1719235 MGI:49235 NCBI chrNW_004936706:37,480...53,306 JBrowse link
G Nectin1 nectin cell adhesion molecule 1 ISO RGD PMID:12584355 RGD:1599797 NCBI chrNW_004936542:4,501,081...4,602,338 JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 involved_in ISO (PMID:21866101), (PMID:21866103)
(MGI:5289741|PMID:21866103), (MGI:5619456|PMID:21866101)
CACAO PMID:21866101 PMID:21866103 MGI:5289741 MGI:5619456 NCBI chrNW_004936550:2,983,172...3,032,222 JBrowse link
G Nrp1 neuropilin 1 involved_in ISO (PMID:33000221), (PMID:33082294) UniProt PMID:33000221 PMID:33082294 NCBI chrNW_004936574:1,694,433...1,834,720 JBrowse link
G Phb prohibitin involved_in ISO (MGI:6436975|PMID:29324904) UniProt PMID:29324904 MGI:6436975 NCBI chrNW_004936490:12,127,065...12,138,870 JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 involved_in ISO (PMID:12857889) AgBase PMID:12857889 NCBI chrNW_004936485:14,979,838...14,999,047 JBrowse link
G Slc3a2 solute carrier family 3 member 2 involved_in ISO (PMID:30341327) UniProt PMID:30341327 NCBI chrNW_004936581:424,801...441,592 JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 involved_in ISO (PMID:22573858) UniProt PMID:22573858 NCBI chrNW_004936842:448,315...452,557 JBrowse link
G Uvrag UV radiation resistance associated acts_upstream_of_or_within ISO (MGI:5552992|PMID:24550300) MGI PMID:24550300 MGI:5552992 NCBI chrNW_004936498:4,555,325...4,869,099 JBrowse link
G Vamp8 vesicle associated membrane protein 8 acts_upstream_of_or_within ISO (PMID:24550300) MGI PMID:24550300 NCBI chrNW_004936712:1,688,126...1,689,742 JBrowse link
G Vps16 VPS16 core subunit of CORVET and HOPS complexes acts_upstream_of_or_within ISO (MGI:5552992|PMID:24550300) MGI PMID:24550300 MGI:5552992 NCBI chrNW_004936485:15,879,324...15,900,544 JBrowse link
G Vps18 VPS18 core subunit of CORVET and HOPS complexes acts_upstream_of_or_within ISO (MGI:5552992|PMID:24550300) MGI PMID:24550300 MGI:5552992 NCBI chrNW_004936471:4,289,487...4,297,634 JBrowse link
G Znf639 zinc finger protein 639 involved_in ISO (PMID:20484494) UniProt PMID:20484494 NCBI chrNW_004936566:3,831,234...3,841,972 JBrowse link
clathrin-dependent endocytosis of virus by host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Siglec1 sialic acid binding Ig like lectin 1 involved_in ISO (PMID:12857889) AgBase PMID:12857889 NCBI chrNW_004936485:14,979,838...14,999,047 JBrowse link
fusion of virus membrane with host endosome membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L involved_in ISO (PMID:16081529), (PMID:18562523) UniProt PMID:16081529 PMID:18562523 NCBI chrNW_004936680:3,047,355...3,050,640 JBrowse link
fusion of virus membrane with host plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L involved_in ISO (PMID:32855215) UniProt PMID:32855215 NCBI chrNW_004936680:3,047,355...3,050,640 JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO (PMID:21501828) UniProt PMID:21501828 NCBI chrNW_004936472:27,116...57,158 JBrowse link
G Hyal2 hyaluronidase 2 involved_in ISO (PMID:11296287) UniProt PMID:11296287 NCBI chrNW_004936529:1,845,445...1,851,106 JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO (PMID:12915581) BHF-UCL PMID:12915581 NCBI chrNW_004936706:1,470,910...1,498,986 JBrowse link
negative regulation of viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apcs amyloid P component, serum involved_in ISO (PMID:23544079) BHF-UCL PMID:23544079 NCBI chrNW_004936740:979,007...987,312 JBrowse link
G Cd74 CD74 molecule involved_in ISO (PMID:32855215) UniProt PMID:32855215 NCBI chrNW_004936504:4,522,576...4,532,289 JBrowse link
G Ciita class II major histocompatibility complex transactivator involved_in ISO (PMID:32855215) UniProt PMID:32855215 NCBI chrNW_004936530:9,033,510...9,073,341 JBrowse link
G Fcn3 ficolin 3 involved_in ISO (PMID:22851708) UniProt PMID:22851708 NCBI chrNW_004936474:11,680,166...11,685,214 JBrowse link
G Gsn gelsolin involved_in ISO (PMID:23575248) UniProt PMID:23575248 NCBI chrNW_004936487:9,749,755...9,802,787 JBrowse link
G Ly6e lymphocyte antigen 6 family member E involved_in ISO (PMID:32641482), (PMID:32704094)
(MGI:6448667|PMID:32704094)
UniProt PMID:32641482 PMID:32704094 MGI:6448667 NCBI chrNW_004936470:8,879,217...8,880,777 JBrowse link
G Mid2 midline 2 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chrNW_004936499:6,833,328...6,926,531 JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO RGD PMID:22850678 RGD:8693392 NCBI chrNW_004936674:466,495...528,072 JBrowse link
G Nbn nibrin ISO RGD PMID:22850678 RGD:8693392 NCBI chrNW_004936544:3,773,828...3,812,673 JBrowse link
G Ptx3 pentraxin 3 involved_in ISO (PMID:23544079) BHF-UCL PMID:23544079 NCBI chrNW_004936519:4,303,549...4,309,143 JBrowse link
G Rad50 RAD50 double strand break repair protein ISO RGD PMID:22850678 RGD:8693392 NCBI chrNW_004936647:2,546,100...2,637,524 JBrowse link
G Snx3 sorting nexin 3 involved_in ISO (PMID:18767904) UniProt PMID:18767904 NCBI chrNW_004936564:4,472,171...4,520,732 JBrowse link
G Trim10 tripartite motif containing 10 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004936723:882,960...890,740 JBrowse link
G Trim11 tripartite motif containing 11 involved_in ISO (PMID:18248090)
(MGI:5545996|PMID:18248090)
UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004937135:11,350...21,235 JBrowse link
G Trim25 tripartite motif containing 25 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004936490:5,979,320...5,997,632 JBrowse link
G Trim26 tripartite motif containing 26 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chrNW_004936723:827,847...859,860 JBrowse link
G Trim31 tripartite motif containing 31 involved_in ISO (PMID:18248090)
(MGI:5545996|PMID:18248090)
UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004936723:934,808...945,279 JBrowse link
G Trim56 tripartite motif containing 56 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004936543:1,007,253...1,016,374 JBrowse link
G Trim59 tripartite motif containing 59 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004936708:396,688...410,720 JBrowse link
G Trim8 tripartite motif containing 8 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004936600:3,244,888...3,259,042 JBrowse link
positive regulation of viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bsg basigin (Ok blood group) involved_in ISO (PMID:29739904)
(PMID:11353871), (PMID:15688292)
UniProt PMID:11353871 PMID:15688292 PMID:29739904 NCBI chrNW_004936588:181,688...189,795 JBrowse link
G Cd4 CD4 molecule involved_in ISO (PMID:24942581) CAFA PMID:24942581 NCBI chrNW_004936709:997,776...1,022,791 JBrowse link
G Cd74 CD74 molecule involved_in ISO (PMID:24942581) CAFA PMID:24942581 NCBI chrNW_004936504:4,522,576...4,532,289 JBrowse link
G Lgals1 galectin 1 involved_in ISO (PMID:21670307) UniProt PMID:21670307 NCBI chrNW_004936492:3,407,704...3,411,197 JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:21670307) UniProt PMID:21670307 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G Nectin1 nectin cell adhesion molecule 1 involved_in ISO (PMID:11277703) AgBase PMID:11277703 NCBI chrNW_004936542:4,501,081...4,602,338 JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta involved_in ISO (PMID:21670307) UniProt PMID:21670307 NCBI chrNW_004936594:5,368,199...5,379,215 JBrowse link
G Tmprss2 transmembrane serine protease 2 involved_in ISO (PMID:21068237), (PMID:24227843), (PMID:32404436) UniProt PMID:21068237 PMID:24227843 PMID:32404436 NCBI chrNW_004936500:2,199,877...2,222,174 JBrowse link
G Tmprss4 transmembrane serine protease 4 involved_in ISO (PMID:32404436) UniProt PMID:32404436 NCBI chrNW_004936542:3,180,260...3,216,208 JBrowse link
G Trim11 tripartite motif containing 11 involved_in ISO (PMID:18248090)
(MGI:5545996|PMID:18248090)
UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004937135:11,350...21,235 JBrowse link
G Trim21 tripartite motif containing 21 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004936498:690,481...697,305 JBrowse link
G Trim38 tripartite motif containing 38 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chrNW_004936671:1,841,722...1,853,804 JBrowse link
receptor-mediated endocytosis of virus by host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chrNW_004936589:2,504,235...2,536,778 JBrowse link
G Cav2 caveolin 2 involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chrNW_004936589:2,553,932...2,561,186 JBrowse link
G Ctsl cathepsin L involved_in ISO (PMID:16081529), (PMID:32221306), (PMID:32855215) UniProt PMID:16081529 PMID:32221306 PMID:32855215 NCBI chrNW_004936680:3,047,355...3,050,640 JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chrNW_004936522:9,438,929...9,486,781 JBrowse link
G Kiaa0319l KIAA0319 like acts_upstream_of_or_within ISO (MGI:5750797|PMID:26814968) MGI PMID:26814968 MGI:5750797 NCBI chrNW_004936474:18,002,864...18,110,000 JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing involved_in ISO (PMID:32221306) UniProt PMID:32221306 NCBI chrNW_004936950:242,071...323,204 JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO (PMID:32221306) UniProt PMID:32221306 NCBI chrNW_004936599:1,301,937...1,343,046 JBrowse link
regulation of viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in ISO (PMID:12138164) UniProt PMID:12138164 NCBI chrNW_004936679:2,540,894...2,737,462 JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO (PMID:11602758) CACAO PMID:11602758 NCBI chrNW_004936706:1,470,910...1,498,986 JBrowse link
G Trim25 tripartite motif containing 25 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chrNW_004936490:5,979,320...5,997,632 JBrowse link
G Trim62 tripartite motif containing 62 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chrNW_004936474:15,998,996...16,029,555 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12130
    viral process 284
      viral life cycle 210
        viral entry into host cell 64
          disruption of host cell envelope during viral entry + 0
          endocytosis involved in viral entry into host cell + 8
          lysis of host organelle involved in viral entry into host cell + 0
          membrane fusion involved in viral entry into host cell + 4
          negative regulation of viral entry into host cell + 20
          pore-mediated entry of viral genome into host cell 0
          positive regulation of viral entry into host cell + 12
          regulation of viral entry into host cell + 33
          viral entry into host cell via pilus retraction + 0
          viral entry via permeabilization of host membrane + 0
          viral genome ejection through host cell envelope + 0
Path 2
Term Annotations click to browse term
  biological_process 12130
    biological process involved in interspecies interaction between organisms 1207
      biological process involved in symbiotic interaction 206
        biological process involved in interaction with host 127
          movement in host environment 93
            entry into host 69
              viral entry into host cell 64
                disruption of host cell envelope during viral entry + 0
                endocytosis involved in viral entry into host cell + 8
                lysis of host organelle involved in viral entry into host cell + 0
                membrane fusion involved in viral entry into host cell + 4
                negative regulation of viral entry into host cell + 20
                pore-mediated entry of viral genome into host cell 0
                positive regulation of viral entry into host cell + 12
                regulation of viral entry into host cell + 33
                viral entry into host cell via pilus retraction + 0
                viral entry via permeabilization of host membrane + 0
                viral genome ejection through host cell envelope + 0
paths to the root