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ONTOLOGY REPORT - ANNOTATIONS


Term:viral entry into host cell
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Accession:GO:0046718 term browser browse the term
Definition:The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
Comment:Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
Synonyms:exact_synonym: entry of virus into host cell;   phage translocation;   viral penetration;   virion penetration;   virion penetration into host cell;   virus entry into host cell
 alt_id: GO:0019063
 xref: VZ:936


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viral entry into host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace2 angiotensin I converting enzyme 2 JBrowse link NW_004955519 2,591,229 2,643,705 RGD:9068941
G Anpep alanyl aminopeptidase, membrane JBrowse link NW_004955416 15,415,981 15,442,032 RGD:9068941
G Axl AXL receptor tyrosine kinase JBrowse link NW_004955555 189,445 218,509 RGD:9068941
G Cd46 CD46 molecule JBrowse link NW_004955406 43,002,817 43,034,555 RGD:9068941
G Cd55 CD55 molecule (Cromer blood group) JBrowse link NW_004955406 42,773,368 42,796,205 RGD:9068941
G Cd80 CD80 molecule JBrowse link NW_004955427 19,237,251 19,274,001 RGD:9068941
G Cd81 CD81 molecule JBrowse link NW_004955422 14,155,682 14,175,181 RGD:9068941
G Cd86 CD86 molecule JBrowse link NW_004955427 21,375,820 21,436,767 RGD:9068941
G Cdhr3 cadherin related family member 3 JBrowse link NW_004955410 10,457,078 10,520,429 RGD:9068941
G Cdk1 cyclin dependent kinase 1 JBrowse link NW_004955425 14,210,681 14,226,474 RGD:9068941
G Cldn1 claudin 1 JBrowse link NW_004955420 17,798,974 17,815,049 RGD:9068941
G Cldn6 claudin 6 JBrowse link NW_004955442 14,323,193 14,326,311 RGD:9068941
G Cldn9 claudin 9 JBrowse link NW_004955442 14,326,705 14,328,150 RGD:9068941
G Clec4g C-type lectin domain family 4 member G JBrowse link NW_004955563 1,571,374 1,574,901 RGD:9068941
G Clec5a C-type lectin domain containing 5A JBrowse link NW_004955494 1,683,926 1,694,914 RGD:9068941
G Cr2 complement C3d receptor 2 JBrowse link NW_004955406 42,877,041 42,910,970 RGD:9068941
G Ctsb cathepsin B JBrowse link NW_004955403 53,086,236 53,100,217 RGD:9068941
G Cxadr CXADR Ig-like cell adhesion molecule JBrowse link NW_004955407 18,894,853 18,927,129 RGD:9068941
G Dag1 dystroglycan 1 JBrowse link NW_004955532 1,446,553 1,465,310 RGD:9068941
G Dpp4 dipeptidyl peptidase 4 JBrowse link NW_004955449 11,795,994 11,873,408 RGD:9068941
G Dynlt1 dynein light chain Tctex-type 1 JBrowse link NW_004955439 3,833,525 3,842,393 RGD:9068941
G Efnb2 ephrin B2 JBrowse link NW_004955404 5,000,906 5,030,068 RGD:9068941
G Efnb3 ephrin B3 JBrowse link NW_004955467 9,217,796 9,225,223 RGD:9068941
G Egfr epidermal growth factor receptor JBrowse link NW_004955456 321,222 456,431 RGD:9068941
G Epha2 EPH receptor A2 JBrowse link NW_004955527 2,120,447 2,151,932 RGD:9068941
G Eps15 epidermal growth factor receptor pathway substrate 15 JBrowse link NW_004955464 7,569,570 7,688,098 RGD:9068941
G F11r F11 receptor JBrowse link NW_004955468 12,764,968 12,785,956 RGD:9068941
G Gas6 growth arrest specific 6 JBrowse link NW_004955404 276,397 303,864 RGD:9068941
G Gpr15 G protein-coupled receptor 15 JBrowse link NW_004955427 115,513 137,557 RGD:9068941
G Grk2 G protein-coupled receptor kinase 2 JBrowse link NW_004955422 18,173,438 18,192,357 RGD:9068941
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link NW_004955408 11,047,679 11,070,492 RGD:9068941
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link NW_004955431 583,165 646,991 RGD:9068941
G Hyal1 hyaluronidase 1 JBrowse link NW_004955532 2,113,016 2,116,093 RGD:9068941
G Hyal2 hyaluronidase 2 JBrowse link NW_004955532 2,120,781 2,125,083 RGD:9068941
G Hyal3 hyaluronidase 3 JBrowse link NW_004955532 2,107,019 2,112,356 RGD:9068941
G Icam1 intercellular adhesion molecule 1 JBrowse link NW_004955495 1,561,464 1,573,282 RGD:9068941
G Ide insulin degrading enzyme JBrowse link NW_004955425 819,461 926,440 RGD:9068941
G Itch itchy E3 ubiquitin protein ligase JBrowse link NW_004955422 26,810,829 26,918,517 RGD:9068941
G Itga2 integrin subunit alpha 2 JBrowse link NW_004955446 14,309,516 14,421,991 RGD:9068941
G Itga5 integrin subunit alpha 5 JBrowse link NW_004955458 1,635,554 1,657,609 RGD:9068941
G Itgav integrin subunit alpha V JBrowse link NW_004955403 11,588,536 11,669,809 RGD:9068941
G Itgb1 integrin subunit beta 1 JBrowse link NW_004955462 4,454,809 4,483,227 RGD:9068941
G Itgb3 integrin subunit beta 3 JBrowse link NW_004955478 9,788,192 9,830,254 RGD:9068941
G Itgb5 integrin subunit beta 5 JBrowse link NW_004955427 23,851,475 23,952,211 RGD:9068941
G Itgb6 integrin subunit beta 6 JBrowse link NW_004955449 13,387,013 13,520,879 RGD:9068941
G Itgb7 integrin subunit beta 7 JBrowse link NW_004955458 460,619 478,361 RGD:9068941
G Kpna3 karyopherin subunit alpha 3 JBrowse link NW_004955431 3,147,679 3,176,577 RGD:9068941
G Lamp1 lysosomal associated membrane protein 1 JBrowse link NW_004955404 557,090 573,532 RGD:9068941
G Lamp3 lysosomal associated membrane protein 3 JBrowse link NW_004955420 24,155,793 24,185,366 RGD:9068941
G Ldlr low density lipoprotein receptor JBrowse link NW_004955495 2,114,702 2,135,584 RGD:9068941
G Mog myelin oligodendrocyte glycoprotein JBrowse link NW_004955583 136,077 150,597 RGD:9068941
G Mrc1 mannose receptor C-type 1 JBrowse link NW_004955429 10,139,398 10,232,541 RGD:9068941
G Ncam1 neural cell adhesion molecule 1 JBrowse link NW_004955412 14,630,109 14,923,847 RGD:9068941
G Nectin1 nectin cell adhesion molecule 1 JBrowse link NW_004955412 20,683,007 20,745,069 RGD:9068941
G Nectin4 nectin cell adhesion molecule 4 JBrowse link NW_004955468 12,841,369 12,858,331 RGD:9068941
G Npc1 NPC intracellular cholesterol transporter 1 JBrowse link NW_004955402 11,699,434 11,742,899 RGD:9068941
G Nup153 nucleoporin 153 JBrowse link NW_004955483 8,377,253 8,457,018 RGD:9068941
G Rpsa ribosomal protein SA JBrowse link NW_004955420 29,978,160 29,983,544 RGD:9068941
G Scarb1 scavenger receptor class B member 1 JBrowse link NW_004955482 4,813,502 4,836,479 RGD:9068941
G Scarb2 scavenger receptor class B member 2 JBrowse link NW_004955433 884,740 962,932 RGD:9068941
G Selplg selectin P ligand JBrowse link NW_004955455 9,883,271 9,892,572 RGD:9068941
G Siva1 SIVA1 apoptosis inducing factor JBrowse link NW_004955538 3,197,983 3,202,782 RGD:9068941
G Slamf1 signaling lymphocytic activation molecule family member 1 JBrowse link NW_004955468 12,336,744 12,383,917 RGD:9068941
G Slc10a1 solute carrier family 10 member 1 JBrowse link NW_004955466 597,081 609,254 RGD:9068941
G Slc1a5 solute carrier family 1 member 5 JBrowse link NW_004955574 798,004 806,631 RGD:9068941
G Slc20a2 solute carrier family 20 member 2 JBrowse link NW_004955536 392,341 496,616 RGD:9068941
G Slc52a2 solute carrier family 52 member 2 JBrowse link NW_004955454 2,944,169 2,982,203 RGD:9068941
G Tfrc transferrin receptor JBrowse link NW_004955420 12,348,392 12,372,714 RGD:9068941
G Tnfrsf14 TNF receptor superfamily member 14 JBrowse link NW_004955486 8,670,182 8,684,677 RGD:9068941
G Tnfrsf4 TNF receptor superfamily member 4 JBrowse link NW_004955486 9,565,424 9,569,836 RGD:9068941
G Tyro3 TYRO3 protein tyrosine kinase JBrowse link NW_004955416 8,361,722 8,377,629 RGD:9068941
G Uvrag UV radiation resistance associated JBrowse link NW_004955414 15,733,116 16,043,555 RGD:9068941
G Vamp8 vesicle associated membrane protein 8 JBrowse link NW_004955424 1,922,830 1,926,844 RGD:9068941
G Vps18 VPS18 core subunit of CORVET and HOPS complexes JBrowse link NW_004955416 7,772,653 7,780,408 RGD:9068941
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 JBrowse link NW_004955417 4,011,302 4,064,584 RGD:9068941
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link NW_004955484 6,853,820 6,967,261 RGD:9068941
G Xpr1 xenotropic and polytropic retrovirus receptor 1 JBrowse link NW_004955406 19,831,398 19,980,994 RGD:9068941
G Znf639 zinc finger protein 639 JBrowse link NW_004955420 8,513,192 8,522,689 RGD:9068941
fusion of virus membrane with host plasma membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd4 CD4 molecule JBrowse link NW_004955413 4,400,326 4,422,110 RGD:9068941
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link NW_004955440 3,456,165 3,460,024 RGD:9068941
G Gas6 growth arrest specific 6 JBrowse link NW_004955404 276,397 303,864 RGD:9068941
G Hyal2 hyaluronidase 2 JBrowse link NW_004955532 2,120,781 2,125,083 RGD:9068941
G Nectin2 nectin cell adhesion molecule 2 JBrowse link NW_004955555 1,959,702 1,985,679 RGD:9068941
G Ppia peptidylprolyl isomerase A JBrowse link NW_004955456 7,381,923 7,383,203 RGD:9068941
negative regulation of viral entry into host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apcs amyloid P component, serum JBrowse link NW_004955468 11,388,154 11,389,259 RGD:9068941
G Fcn1 ficolin 1 JBrowse link NW_004955513 3,690,550 3,697,785 RGD:9068941
G Fcn3 ficolin 3 JBrowse link NW_004955452 6,630,548 6,635,334 RGD:9068941
G Gsn gelsolin JBrowse link NW_004955419 6,682,202 6,733,361 RGD:9068941
G Mid2 midline 2 JBrowse link NW_004955490 7,977,771 8,168,912 RGD:9068941
G Ptx3 pentraxin 3 JBrowse link NW_004955448 8,366,795 8,373,010 RGD:9068941
G Snx3 sorting nexin 3 JBrowse link NW_004955411 33,339,974 33,344,563 RGD:9068941
G Trim10 tripartite motif containing 10 JBrowse link NW_004955583 268,856 277,079 RGD:9068941
G Trim11 tripartite motif containing 11 JBrowse link NW_004955581 114,750 123,410 RGD:9068941
G Trim25 tripartite motif containing 25 JBrowse link NW_004955451 5,918,287 5,934,252 RGD:9068941
G Trim26 tripartite motif containing 26 JBrowse link NW_004955583 303,081 325,560 RGD:9068941
G Trim8 tripartite motif containing 8 JBrowse link NW_004955485 7,784,625 7,798,131 RGD:9068941
positive regulation of viral entry into host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd4 CD4 molecule JBrowse link NW_004955413 4,400,326 4,422,110 RGD:9068941
G Cd74 CD74 molecule JBrowse link NW_004955415 4,129,151 4,138,336 RGD:9068941
G Lgals1 galectin 1 JBrowse link NW_004955413 24,072,086 24,075,452 RGD:9068941
G Lgals9 galectin 9 JBrowse link NW_004955481 5,234,125 5,249,564 RGD:9068941
G P4hb prolyl 4-hydroxylase subunit beta JBrowse link NW_004955506 1,307,932 1,322,011 RGD:9068941
G Tmprss2 transmembrane serine protease 2 JBrowse link NW_004955407 40,958,562 40,985,415 RGD:9068941
G Trim11 tripartite motif containing 11 JBrowse link NW_004955581 114,750 123,410 RGD:9068941
G Trim21 tripartite motif containing 21 JBrowse link NW_004955414 20,066,109 20,077,331 RGD:9068941
receptor-mediated endocytosis of virus by host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link NW_004955432 22,258,262 22,292,403 RGD:9068941
G Cav2 caveolin 2 JBrowse link NW_004955432 22,240,041 22,242,200 RGD:9068941
G Eps15 epidermal growth factor receptor pathway substrate 15 JBrowse link NW_004955464 7,569,570 7,688,098 RGD:9068941
regulation of viral entry into host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 JBrowse link NW_004955526 2,418,217 2,652,025 RGD:9068941
G Nectin2 nectin cell adhesion molecule 2 JBrowse link NW_004955555 1,959,702 1,985,679 RGD:9068941
G Trim25 tripartite motif containing 25 JBrowse link NW_004955451 5,918,287 5,934,252 RGD:9068941
G Trim62 tripartite motif containing 62 JBrowse link NW_004955452 11,348,001 11,377,413 RGD:9068941

Term paths to the root
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Term Annotations click to browse term
  biological_process 14546
    interspecies interaction between organisms 1762
      symbiotic process 883
        interaction with host 182
          entry into host 117
            viral entry into host cell 104
              disruption of host cell envelope during viral entry + 0
              endocytosis involved in viral entry into host cell + 3
              lysis of host organelle involved in viral entry into host cell + 0
              membrane fusion involved in viral entry into host cell + 6
              negative regulation of viral entry into host cell + 12
              pore-mediated entry of viral genome into host cell 0
              positive regulation of viral entry into host cell + 8
              regulation of viral entry into host cell + 22
              viral entry into host cell via pilus retraction + 0
              viral entry via permeabilization of host membrane + 0
              viral genome ejection through host cell envelope + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.