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ONTOLOGY REPORT - ANNOTATIONS


Term:viral entry into host cell
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Accession:GO:0046718 term browser browse the term
Definition:The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
Comment:Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
Synonyms:exact_synonym: entry of virus into host cell;   phage translocation;   viral penetration;   virion penetration;   virion penetration into host cell;   virus entry into host cell
 alt_id: GO:0019063
 xref: VZ:936


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viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 involved_in ISO (PMID:16051304), (PMID:32221306), (PMID:33000221), (PMID:33082294), (PMID:33713620) UniProt PMID:16051304 PMID:32221306 PMID:33000221 PMID:33082294 PMID:33713620 NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495
JBrowse link
G Agtr1 angiotensin II receptor type 1 involved_in ISO (PMID:33713620) UniProt PMID:33713620 NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255
JBrowse link
G Avpr1b arginine vasopressin receptor 1B involved_in ISO (PMID:33713620) UniProt PMID:33713620 NCBI chrNW_004955406:41,706,088...41,716,173
Ensembl chrNW_004955406:41,705,305...41,716,173
JBrowse link
G Axl AXL receptor tyrosine kinase involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chrNW_004955555:189,445...218,509
Ensembl chrNW_004955555:189,174...218,565
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:49235|PMID:1719235) MGI PMID:1719235 MGI:49235 NCBI chrNW_004955555:426,894...446,235 JBrowse link
G Clec4g C-type lectin domain family 4 member G involved_in ISO (PMID:16051304), (PMID:24623090) FlyBase PMID:16051304 PMID:24623090 NCBI chrNW_004955563:1,571,374...1,574,901
Ensembl chrNW_004955563:1,571,288...1,575,979
JBrowse link
G Ctsb cathepsin B involved_in ISO (MGI:5640952|PMID:15831716) CACAO PMID:15831716 MGI:5640952 NCBI chrNW_004955403:53,086,236...53,100,217
Ensembl chrNW_004955403:53,085,574...53,093,809
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 involved_in ISO (PMID:20202662) CACAO PMID:20202662 NCBI chrNW_004955464:7,569,570...7,688,098
Ensembl chrNW_004955464:7,569,566...7,688,098
JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO (PMID:21501828) UniProt PMID:21501828 NCBI chrNW_004955404:276,397...303,864
Ensembl chrNW_004955404:275,946...304,809
JBrowse link
G Gpr15 G protein-coupled receptor 15 involved_in ISO (PMID:15650194) UniProt PMID:15650194 NCBI chrNW_004955427:115,513...137,557
Ensembl chrNW_004955427:115,513...119,710
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 involved_in ISO (PMID:23029581) CACAO PMID:23029581 NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412
JBrowse link
G Hyal2 hyaluronidase 2 ISO facilitates RGD PMID:12584308 RGD:633153 NCBI chrNW_004955532:2,120,781...2,125,083
Ensembl chrNW_004955532:2,120,781...2,123,726
JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (PMID:25063885) UniProt PMID:25063885 NCBI chrNW_004955403:11,588,536...11,669,809
Ensembl chrNW_004955403:11,592,339...11,659,297
JBrowse link
G Itgb3 integrin subunit beta 3 involved_in ISO (PMID:25063885) UniProt PMID:25063885 NCBI chrNW_004955478:9,788,192...9,830,254 JBrowse link
G Lamp3 lysosomal associated membrane protein 3 NOT|involved_in ISO (PMID:21810281) ParkinsonsUK-UCL PMID:21810281 NCBI chrNW_004955420:24,155,793...24,185,366 JBrowse link
G Nectin1 nectin cell adhesion molecule 1 ISO RGD PMID:12584355 RGD:1599797 NCBI chrNW_004955412:20,683,007...20,745,069
Ensembl chrNW_004955412:20,682,861...20,745,069
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 involved_in ISO (PMID:21866101), (PMID:21866103)
(MGI:5289741|PMID:21866103), (MGI:5619456|PMID:21866101)
CACAO PMID:21866101 PMID:21866103 MGI:5289741 MGI:5619456 NCBI chrNW_004955402:11,699,434...11,742,899
Ensembl chrNW_004955402:11,699,434...11,742,899
JBrowse link
G Nrp1 neuropilin 1 involved_in ISO (PMID:33000221), (PMID:33082294) UniProt PMID:33000221 PMID:33082294 NCBI chrNW_004955462:4,101,997...4,241,012
Ensembl chrNW_004955462:4,101,999...4,241,012
JBrowse link
G Phb prohibitin involved_in ISO (MGI:6436975|PMID:29324904) UniProt PMID:29324904 MGI:6436975 NCBI chrNW_004955451:12,110,290...12,119,870
Ensembl chrNW_004955451:12,110,290...12,120,124
JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 involved_in ISO (PMID:12857889) AgBase PMID:12857889 NCBI chrNW_004955415:14,539,284...14,560,614
Ensembl chrNW_004955415:14,536,266...14,560,632
JBrowse link
G Slc3a2 solute carrier family 3 member 2 involved_in ISO (PMID:30341327) UniProt PMID:30341327 NCBI chrNW_004955599:376,133...391,434
Ensembl chrNW_004955599:376,245...391,311
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 involved_in ISO (PMID:22573858) UniProt PMID:22573858 NCBI chrNW_004955414:22,117,929...22,121,744
Ensembl chrNW_004955414:22,117,930...22,121,744
JBrowse link
G Uvrag UV radiation resistance associated acts_upstream_of_or_within ISO (MGI:5552992|PMID:24550300) MGI PMID:24550300 MGI:5552992 NCBI chrNW_004955414:15,733,116...16,043,555
Ensembl chrNW_004955414:15,731,519...16,043,555
JBrowse link
G Vamp8 vesicle associated membrane protein 8 acts_upstream_of_or_within ISO (PMID:24550300) MGI PMID:24550300 NCBI chrNW_004955424:1,922,830...1,926,844
Ensembl chrNW_004955424:1,923,092...1,926,728
JBrowse link
G Vps16 VPS16 core subunit of CORVET and HOPS complexes acts_upstream_of_or_within ISO (MGI:5552992|PMID:24550300) MGI PMID:24550300 MGI:5552992 NCBI chrNW_004955415:13,791,611...13,813,500
Ensembl chrNW_004955415:13,791,611...13,813,500
JBrowse link
G Vps18 VPS18 core subunit of CORVET and HOPS complexes acts_upstream_of_or_within ISO (MGI:5552992|PMID:24550300) MGI PMID:24550300 MGI:5552992 NCBI chrNW_004955416:7,772,653...7,780,408
Ensembl chrNW_004955416:7,772,653...7,782,542
JBrowse link
G Znf639 zinc finger protein 639 involved_in ISO (PMID:20484494) UniProt PMID:20484494 NCBI chrNW_004955420:8,513,192...8,522,689
Ensembl chrNW_004955420:8,516,973...8,522,629
JBrowse link
clathrin-dependent endocytosis of virus by host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Siglec1 sialic acid binding Ig like lectin 1 involved_in ISO (PMID:12857889) AgBase PMID:12857889 NCBI chrNW_004955415:14,539,284...14,560,614
Ensembl chrNW_004955415:14,536,266...14,560,632
JBrowse link
fusion of virus membrane with host plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gas6 growth arrest specific 6 involved_in ISO (PMID:21501828) UniProt PMID:21501828 NCBI chrNW_004955404:276,397...303,864
Ensembl chrNW_004955404:275,946...304,809
JBrowse link
G Hyal2 hyaluronidase 2 involved_in ISO (PMID:11296287) UniProt PMID:11296287 NCBI chrNW_004955532:2,120,781...2,125,083
Ensembl chrNW_004955532:2,120,781...2,123,726
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO (PMID:12915581) BHF-UCL PMID:12915581 NCBI chrNW_004955555:1,959,702...1,985,679 JBrowse link
negative regulation of viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apcs amyloid P component, serum involved_in ISO (PMID:23544079) BHF-UCL PMID:23544079 NCBI chrNW_004955468:11,388,154...11,389,259
Ensembl chrNW_004955468:11,388,192...11,390,314
JBrowse link
G Cd74 CD74 molecule involved_in ISO (PMID:32855215) UniProt PMID:32855215 NCBI chrNW_004955415:4,129,151...4,138,336
Ensembl chrNW_004955415:4,129,254...4,137,826
JBrowse link
G Ciita class II major histocompatibility complex transactivator involved_in ISO (PMID:32855215) UniProt PMID:32855215 NCBI chrNW_004955442:7,600,903...7,647,619
Ensembl chrNW_004955442:7,603,893...7,647,624
JBrowse link
G Fcn1 ficolin 1 involved_in ISO (PMID:22851708) UniProt PMID:22851708 NCBI chrNW_004955513:3,690,550...3,697,785
Ensembl chrNW_004955513:3,687,232...3,698,673
JBrowse link
G Fcn3 ficolin 3 involved_in ISO (PMID:22851708) UniProt PMID:22851708 NCBI chrNW_004955452:6,630,548...6,635,334
Ensembl chrNW_004955452:6,630,505...6,635,235
JBrowse link
G Gsn gelsolin involved_in ISO (PMID:23575248) UniProt PMID:23575248 NCBI chrNW_004955419:6,682,202...6,733,361
Ensembl chrNW_004955419:6,682,058...6,733,361
JBrowse link
G Mid2 midline 2 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chrNW_004955490:7,977,771...8,168,912
Ensembl chrNW_004955490:7,973,211...8,088,427
JBrowse link
G Nbn nibrin ISO RGD PMID:22850678 RGD:8693392 NCBI chrNW_004955417:6,840,916...6,880,479
Ensembl chrNW_004955417:6,839,312...6,880,133
JBrowse link
G Ptx3 pentraxin 3 involved_in ISO (PMID:23544079) BHF-UCL PMID:23544079 NCBI chrNW_004955448:8,366,795...8,373,010
Ensembl chrNW_004955448:8,366,925...8,372,411
JBrowse link
G Rad50 RAD50 double strand break repair protein ISO RGD PMID:22850678 RGD:8693392 NCBI chrNW_004955408:3,953,801...4,035,494 JBrowse link
G Snx3 sorting nexin 3 involved_in ISO (PMID:18767904) UniProt PMID:18767904 NCBI chrNW_004955411:33,339,974...33,344,563
Ensembl chrNW_004955411:33,340,274...33,345,500
JBrowse link
G Trim10 tripartite motif containing 10 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004955583:268,856...277,079
Ensembl chrNW_004955583:269,266...276,675
JBrowse link
G Trim11 tripartite motif containing 11 involved_in ISO (PMID:18248090)
(MGI:5545996|PMID:18248090)
UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004955581:114,750...123,410
Ensembl chrNW_004955581:114,750...125,143
JBrowse link
G Trim25 tripartite motif containing 25 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004955451:5,918,287...5,934,252
Ensembl chrNW_004955451:5,918,287...5,934,258
JBrowse link
G Trim26 tripartite motif containing 26 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chrNW_004955583:303,081...325,560
Ensembl chrNW_004955583:303,081...325,560
JBrowse link
G Trim56 tripartite motif containing 56 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004955456:16,181,890...16,185,598
Ensembl chrNW_004955456:16,182,453...16,184,669
JBrowse link
G Trim59 tripartite motif containing 59 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004955448:10,962,181...10,971,948
Ensembl chrNW_004955448:10,962,549...10,963,736
JBrowse link
G Trim8 tripartite motif containing 8 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004955485:7,784,625...7,798,131
Ensembl chrNW_004955485:7,782,794...7,797,022
JBrowse link
positive regulation of viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bsg basigin (Ok blood group) involved_in ISO (PMID:11353871), (PMID:15688292)
(PMID:29739904)
UniProt PMID:11353871 PMID:15688292 PMID:29739904 NCBI chrNW_004955495:7,148,806...7,156,296 JBrowse link
G Cd4 CD4 molecule involved_in ISO (PMID:24942581) CAFA PMID:24942581 NCBI chrNW_004955413:4,400,326...4,422,110
Ensembl chrNW_004955413:4,408,390...4,421,535
JBrowse link
G Cd74 CD74 molecule involved_in ISO (PMID:24942581) CAFA PMID:24942581 NCBI chrNW_004955415:4,129,151...4,138,336
Ensembl chrNW_004955415:4,129,254...4,137,826
JBrowse link
G Lgals1 galectin 1 involved_in ISO (PMID:21670307) UniProt PMID:21670307 NCBI chrNW_004955413:24,072,086...24,075,452
Ensembl chrNW_004955413:24,072,086...24,075,452
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:21670307) UniProt PMID:21670307 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
G Nectin1 nectin cell adhesion molecule 1 involved_in ISO (PMID:11277703) AgBase PMID:11277703 NCBI chrNW_004955412:20,683,007...20,745,069
Ensembl chrNW_004955412:20,682,861...20,745,069
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta involved_in ISO (PMID:21670307) UniProt PMID:21670307 NCBI chrNW_004955506:1,307,932...1,322,011
Ensembl chrNW_004955506:1,307,932...1,324,027
JBrowse link
G Tmprss2 transmembrane serine protease 2 involved_in ISO (PMID:21068237), (PMID:24227843), (PMID:32404436) UniProt PMID:21068237 PMID:24227843 PMID:32404436 NCBI chrNW_004955407:40,958,562...40,985,415
Ensembl chrNW_004955407:40,957,122...40,976,644
JBrowse link
G Tmprss4 transmembrane serine protease 4 involved_in ISO (PMID:32404436) UniProt PMID:32404436 NCBI chrNW_004955412:19,258,955...19,292,766
Ensembl chrNW_004955412:19,258,949...19,292,829
JBrowse link
G Trim11 tripartite motif containing 11 involved_in ISO (PMID:18248090)
(MGI:5545996|PMID:18248090)
UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004955581:114,750...123,410
Ensembl chrNW_004955581:114,750...125,143
JBrowse link
G Trim21 tripartite motif containing 21 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chrNW_004955414:20,066,109...20,077,331
Ensembl chrNW_004955414:20,070,359...20,077,595
JBrowse link
receptor-mediated endocytosis of virus by host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chrNW_004955432:22,258,262...22,292,403
Ensembl chrNW_004955432:22,258,250...22,292,403
JBrowse link
G Cav2 caveolin 2 involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chrNW_004955432:22,240,041...22,242,200 JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chrNW_004955464:7,569,570...7,688,098
Ensembl chrNW_004955464:7,569,566...7,688,098
JBrowse link
G Kiaa0319l KIAA0319 like acts_upstream_of_or_within ISO (MGI:5750797|PMID:26814968) MGI PMID:26814968 MGI:5750797 NCBI chrNW_004955452:13,538,524...13,649,823
Ensembl chrNW_004955452:13,507,010...13,646,751
JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing involved_in ISO (PMID:32221306) UniProt PMID:32221306 NCBI chrNW_004955457:6,749,226...6,841,855
Ensembl chrNW_004955457:6,748,534...6,842,489
JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO (PMID:32221306) UniProt PMID:32221306 NCBI chrNW_004955422:16,899,730...16,923,962 JBrowse link
regulation of viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in ISO (PMID:12138164) UniProt PMID:12138164 NCBI chrNW_004955526:2,418,217...2,652,025
Ensembl chrNW_004955526:2,636,579...2,652,405
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO (PMID:11602758) CACAO PMID:11602758 NCBI chrNW_004955555:1,959,702...1,985,679 JBrowse link
G Trim25 tripartite motif containing 25 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chrNW_004955451:5,918,287...5,934,252
Ensembl chrNW_004955451:5,918,287...5,934,258
JBrowse link
G Trim62 tripartite motif containing 62 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chrNW_004955452:11,348,001...11,377,413
Ensembl chrNW_004955452:11,347,741...11,378,040
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11939
    viral process 275
      viral life cycle 202
        viral entry into host cell 61
          disruption of host cell envelope during viral entry + 0
          endocytosis involved in viral entry into host cell + 7
          lysis of host organelle involved in viral entry into host cell + 0
          membrane fusion involved in viral entry into host cell + 3
          negative regulation of viral entry into host cell + 18
          pore-mediated entry of viral genome into host cell 0
          positive regulation of viral entry into host cell + 11
          regulation of viral entry into host cell + 30
          viral entry into host cell via pilus retraction + 0
          viral entry via permeabilization of host membrane + 0
          viral genome ejection through host cell envelope + 0
Path 2
Term Annotations click to browse term
  biological_process 11939
    biological process involved in interspecies interaction between organisms 1176
      biological process involved in symbiotic interaction 203
        biological process involved in interaction with host 124
          movement in host environment 88
            entry into host 66
              viral entry into host cell 61
                disruption of host cell envelope during viral entry + 0
                endocytosis involved in viral entry into host cell + 7
                lysis of host organelle involved in viral entry into host cell + 0
                membrane fusion involved in viral entry into host cell + 3
                negative regulation of viral entry into host cell + 18
                pore-mediated entry of viral genome into host cell 0
                positive regulation of viral entry into host cell + 11
                regulation of viral entry into host cell + 30
                viral entry into host cell via pilus retraction + 0
                viral entry via permeabilization of host membrane + 0
                viral genome ejection through host cell envelope + 0
paths to the root