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ONTOLOGY REPORT - ANNOTATIONS


Term:viral entry into host cell
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Accession:GO:0046718 term browser browse the term
Definition:The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
Comment:Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
Synonyms:exact_synonym: entry of virus into host cell;   phage translocation;   viral penetration;   virion penetration;   virion penetration into host cell;   virus entry into host cell
 alt_id: GO:0019063
 xref: VZ:936


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viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 involved_in ISO (PMID:16051304), (PMID:32221306), (PMID:33000221), (PMID:33082294), (PMID:33713620) UniProt PMID:16051304 PMID:32221306 PMID:33000221 PMID:33082294 PMID:33713620 NCBI chr  X:8,189,267...8,229,415
Ensembl chr  X:15,470,896...15,510,891
JBrowse link
G AGTR1 angiotensin II receptor type 1 involved_in ISO (PMID:33713620) UniProt PMID:33713620 NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380
JBrowse link
G AVP arginine vasopressin involved_in ISO (PMID:33713620) UniProt PMID:33713620 NCBI chr20:3,169,094...3,172,900 JBrowse link
G AVPR1B arginine vasopressin receptor 1B involved_in ISO (PMID:33713620) UniProt PMID:33713620 NCBI chr 1:181,713,548...181,723,645
Ensembl chr 1:185,999,627...186,007,043
JBrowse link
G AXL AXL receptor tyrosine kinase involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chr19:38,211,555...38,254,464
Ensembl chr19:46,719,615...46,761,747
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:49235|PMID:1719235) MGI PMID:1719235 MGI:49235 NCBI chr19:39,395,550...39,417,063 JBrowse link
G CLEC4G C-type lectin domain family 4 member G involved_in ISO (PMID:16051304), (PMID:24623090) FlyBase PMID:16051304 PMID:24623090 NCBI chr19:7,015,848...7,019,396
Ensembl chr19:7,870,730...7,873,631
JBrowse link
G CTSB cathepsin B involved_in ISO (MGI:5640952|PMID:15831716) CACAO PMID:15831716 MGI:5640952 NCBI chr 8:7,333,498...7,359,264 JBrowse link
G CTSL cathepsin L involved_in ISO (PMID:16339146), (PMID:18562523), (PMID:26953343), (PMID:32855215) UniProt PMID:16339146 PMID:18562523 PMID:26953343 PMID:32855215 NCBI chr 9:58,851,899...58,857,170
Ensembl chr 9:86,903,006...86,908,303
JBrowse link
G EPS15 epidermal growth factor receptor pathway substrate 15 involved_in ISO (PMID:20202662) CACAO PMID:20202662 NCBI chr 1:50,598,692...50,763,585
Ensembl chr 1:52,097,387...52,223,533
JBrowse link
G GPR15 G protein-coupled receptor 15 involved_in ISO (PMID:15650194) UniProt PMID:15650194 NCBI chr 3:95,627,750...95,630,518
Ensembl chr 3:102,311,203...102,312,285
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 involved_in ISO (PMID:23029581) CACAO PMID:23029581 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G HYAL2 hyaluronidase 2 ISO facilitates RGD PMID:12584308 RGD:633153 NCBI chr 3:50,243,926...50,248,972
Ensembl chr 3:51,479,020...51,482,551
JBrowse link
G ITGAV integrin subunit alpha V involved_in ISO (PMID:25063885) UniProt PMID:25063885 NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028
JBrowse link
G ITGB3 integrin subunit beta 3 involved_in ISO (PMID:25063885) UniProt PMID:25063885 NCBI chr17:10,134,450...10,194,596 JBrowse link
G LAMP3 lysosomal associated membrane protein 3 NOT|involved_in ISO (PMID:21810281) ParkinsonsUK-UCL PMID:21810281 NCBI chr 3:180,152,363...180,193,223
Ensembl chr 3:188,324,660...188,363,268
JBrowse link
G LOC100978434 C-type lectin domain family 4 member M involved_in ISO (PMID:24623090) FlyBase PMID:24623090 NCBI chr19:7,062,961...7,069,381 JBrowse link
G NECTIN1 nectin cell adhesion molecule 1 ISO RGD PMID:12584355 RGD:1599797 NCBI chr11:114,497,177...114,565,338
Ensembl chr11:118,401,321...118,493,090
JBrowse link
G NPC1 NPC intracellular cholesterol transporter 1 involved_in ISO (PMID:21866101), (PMID:21866103)
(MGI:5289741|PMID:21866103), (MGI:5619456|PMID:21866101)
CACAO PMID:21866101 PMID:21866103 MGI:5289741 MGI:5619456 NCBI chr18:16,783,096...16,838,301
Ensembl chr18:20,409,040...20,463,623
JBrowse link
G NRP1 neuropilin 1 involved_in ISO (PMID:33000221), (PMID:33082294) UniProt PMID:33000221 PMID:33082294 NCBI chr10:33,298,918...33,456,466
Ensembl chr10:33,883,173...34,039,648
JBrowse link
G PHB prohibitin involved_in ISO (MGI:6436975|PMID:29324904) UniProt PMID:29324904 MGI:6436975 NCBI chr17:8,189,555...8,200,491
Ensembl chr17:8,175,968...8,186,790
JBrowse link
G SIGLEC1 sialic acid binding Ig like lectin 1 involved_in ISO (PMID:12857889) AgBase PMID:12857889 NCBI chr20:3,769,118...3,795,678
Ensembl chr20:3,526,791...3,552,309
JBrowse link
G SLC3A2 solute carrier family 3 member 2 involved_in ISO (PMID:30341327) UniProt PMID:30341327 NCBI chr11:58,212,395...58,241,686
Ensembl chr11:61,565,680...61,594,579
JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 involved_in ISO (PMID:22573858) UniProt PMID:22573858 NCBI chr11:6,521,812...6,526,349 JBrowse link
G UVRAG UV radiation resistance associated acts_upstream_of_or_within ISO (MGI:5552992|PMID:24550300) MGI PMID:24550300 MGI:5552992 NCBI chr11:70,870,341...71,197,559
Ensembl chr11:74,172,919...74,496,046
JBrowse link
G VAMP8 vesicle associated membrane protein 8 acts_upstream_of_or_within ISO (PMID:24550300) MGI PMID:24550300 NCBI chr2A:85,627,678...85,632,205
Ensembl chr2A:87,180,681...87,185,195
JBrowse link
G VPS16 VPS16 core subunit of CORVET and HOPS complexes acts_upstream_of_or_within ISO (MGI:5552992|PMID:24550300) MGI PMID:24550300 MGI:5552992 NCBI chr20:2,931,553...2,956,604
Ensembl chr20:2,695,335...2,720,030
JBrowse link
G VPS18 VPS18 core subunit of CORVET and HOPS complexes acts_upstream_of_or_within ISO (MGI:5552992|PMID:24550300) MGI PMID:24550300 MGI:5552992 NCBI chr15:19,836,707...19,846,231
Ensembl chr15:38,086,518...38,095,835
JBrowse link
G ZNF639 zinc finger protein 639 involved_in ISO (PMID:20484494) UniProt PMID:20484494 NCBI chr 3:176,353,400...176,366,142
Ensembl chr 3:184,533,061...184,539,270
JBrowse link
clathrin-dependent endocytosis of virus by host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIGLEC1 sialic acid binding Ig like lectin 1 involved_in ISO (PMID:12857889) AgBase PMID:12857889 NCBI chr20:3,769,118...3,795,678
Ensembl chr20:3,526,791...3,552,309
JBrowse link
fusion of virus membrane with host endosome membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTSL cathepsin L involved_in ISO (PMID:16081529), (PMID:18562523) UniProt PMID:16081529 PMID:18562523 NCBI chr 9:58,851,899...58,857,170
Ensembl chr 9:86,903,006...86,908,303
JBrowse link
fusion of virus membrane with host plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTSL cathepsin L involved_in ISO (PMID:32855215) UniProt PMID:32855215 NCBI chr 9:58,851,899...58,857,170
Ensembl chr 9:86,903,006...86,908,303
JBrowse link
G HYAL2 hyaluronidase 2 involved_in ISO (PMID:11296287) UniProt PMID:11296287 NCBI chr 3:50,243,926...50,248,972
Ensembl chr 3:51,479,020...51,482,551
JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in ISO (PMID:12915581) BHF-UCL PMID:12915581 NCBI chr19:41,794,037...41,837,047
Ensembl chr19:50,399,668...50,443,024
JBrowse link
negative regulation of viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APCS amyloid P component, serum involved_in ISO (PMID:23544079) BHF-UCL PMID:23544079 NCBI chr 1:134,937,472...134,938,512
Ensembl chr 1:138,734,046...138,735,093
JBrowse link
G CD74 CD74 molecule involved_in ISO (PMID:32855215) UniProt PMID:32855215 NCBI chr 5:145,825,635...145,836,916
Ensembl chr 5:151,830,311...151,841,334
JBrowse link
G CIITA class II major histocompatibility complex transactivator involved_in ISO (PMID:32855215) UniProt PMID:32855215 NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485
JBrowse link
G FCN1 ficolin 1 involved_in ISO (PMID:22851708) UniProt PMID:22851708 NCBI chr 9:106,039,315...106,047,648
Ensembl chr 9:135,040,310...135,049,111
JBrowse link
G FCN3 ficolin 3 involved_in ISO (PMID:22851708) UniProt PMID:22851708 NCBI chr 1:26,620,373...26,636,424
Ensembl chr 1:27,676,866...27,683,861
JBrowse link
G GSN gelsolin involved_in ISO (PMID:23575248) UniProt PMID:23575248 NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831
JBrowse link
G IFITM1 interferon induced transmembrane protein 1 involved_in ISO (PMID:21253575), (PMID:23358889), (PMID:26354436) UniProt PMID:21253575 PMID:23358889 PMID:26354436 NCBI chr11:309,930...311,177 JBrowse link
G IFITM2 interferon induced transmembrane protein 2 involved_in ISO (PMID:21253575), (PMID:23358889), (PMID:26354436), (PMID:33563656) UniProt PMID:21253575 PMID:23358889 PMID:26354436 PMID:33563656 NCBI chr11:304,068...305,273 JBrowse link
G LOC100969436 interferon-induced transmembrane protein 2 involved_in ISO (MGI:5437420|PMID:21253575) UniProt PMID:21253575 MGI:5437420 Ensembl chr11:348,341...349,551 JBrowse link
G LOC100970132 interferon-induced transmembrane protein 1 acts_upstream_of_or_within
involved_in
ISO (MGI:5780029|PMID:25738301)
(MGI:5437420|PMID:21253575)
MGI
UniProt
PMID:21253575 PMID:25738301 MGI:5437420 MGI:5780029 Ensembl chr11:353,236...354,986 JBrowse link
G LOC100972354 interferon alpha-2 involved_in ISO (PMID:22783022) BHF-UCL PMID:22783022 NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736
JBrowse link
G MID2 midline 2 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chr  X:96,917,731...97,026,545
Ensembl chr  X:107,290,776...107,393,162
JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease ISO RGD PMID:22850678 RGD:8693392 NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966
JBrowse link
G NBN nibrin ISO RGD PMID:22850678 RGD:8693392 NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307
JBrowse link
G PTX3 pentraxin 3 involved_in ISO (PMID:23544079) BHF-UCL PMID:23544079 NCBI chr 3:154,485,470...154,492,293
Ensembl chr 3:162,537,577...162,543,652
JBrowse link
G RAD50 RAD50 double strand break repair protein ISO RGD PMID:22850678 RGD:8693392 NCBI chr 5:127,972,630...128,059,911 JBrowse link
G SNX3 sorting nexin 3 involved_in ISO (PMID:18767904) UniProt PMID:18767904 NCBI chr 6:106,010,633...106,063,331
Ensembl chr 6:109,874,105...109,924,185
JBrowse link
G TRIM10 tripartite motif containing 10 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chr 6:29,929,516...29,938,355
Ensembl chr 6:30,601,812...30,608,082
JBrowse link
G TRIM11 tripartite motif containing 11 involved_in ISO (PMID:18248090)
(MGI:5545996|PMID:18248090)
UniProt PMID:18248090 MGI:5545996 NCBI chr 1:203,795,924...203,809,703
Ensembl chr 1:209,006,979...209,019,994
JBrowse link
G TRIM25 tripartite motif containing 25 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chr17:50,965,592...50,991,630
Ensembl chr17:55,826,458...55,852,422
JBrowse link
G TRIM26 tripartite motif containing 26 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chr 6:29,962,838...29,990,710
Ensembl chr 6:30,632,948...30,660,809
JBrowse link
G TRIM31 tripartite motif containing 31 involved_in ISO (PMID:18248090)
(MGI:5545996|PMID:18248090)
UniProt PMID:18248090 MGI:5545996 NCBI chr 6:29,880,668...29,890,905
Ensembl chr 6:30,550,802...30,560,977
JBrowse link
G TRIM5 tripartite motif containing 5 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chr11:5,798,336...5,819,876
Ensembl chr11:5,479,033...5,500,758
JBrowse link
G TRIM56 tripartite motif containing 56 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chr 7:93,225,830...93,231,127
Ensembl chr 7:106,469,474...106,471,741
JBrowse link
G TRIM59 tripartite motif containing 59 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chr 3:157,458,982...157,471,521 JBrowse link
G TRIM8 tripartite motif containing 8 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chr10:99,242,187...99,256,342
Ensembl chr10:102,707,199...102,720,565
JBrowse link
positive regulation of viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD4 CD4 molecule involved_in ISO (PMID:24942581) CAFA PMID:24942581 NCBI chr12:6,920,587...6,951,814
Ensembl chr12:6,834,011...6,864,204
JBrowse link
G CD74 CD74 molecule involved_in ISO (PMID:24942581) CAFA PMID:24942581 NCBI chr 5:145,825,635...145,836,916
Ensembl chr 5:151,830,311...151,841,334
JBrowse link
G LGALS1 galectin 1 involved_in ISO (PMID:21670307) UniProt PMID:21670307 NCBI chr22:18,593,154...18,597,432
Ensembl chr22:36,426,228...36,430,356
JBrowse link
G LGALS9 galectin 9 involved_in ISO (PMID:21670307) UniProt PMID:21670307 NCBI chr17:29,125,460...29,145,028
Ensembl chr17:29,623,398...29,642,959
JBrowse link
G NECTIN1 nectin cell adhesion molecule 1 involved_in ISO (PMID:11277703) AgBase PMID:11277703 NCBI chr11:114,497,177...114,565,338
Ensembl chr11:118,401,321...118,493,090
JBrowse link
G P4HB prolyl 4-hydroxylase subunit beta involved_in ISO (PMID:21670307) UniProt PMID:21670307 NCBI chr17:76,248,252...76,266,152
Ensembl chr17:81,950,422...81,968,109
JBrowse link
G TMPRSS2 transmembrane serine protease 2 involved_in ISO (PMID:21068237), (PMID:24227843), (PMID:32404436) UniProt PMID:21068237 PMID:24227843 PMID:32404436 NCBI chr21:27,800,466...27,843,395
Ensembl chr21:41,131,515...41,161,088
JBrowse link
G TMPRSS4 transmembrane serine protease 4 involved_in ISO (PMID:32404436) UniProt PMID:32404436 NCBI chr11:112,910,223...112,953,677
Ensembl chr11:116,843,287...116,884,767
JBrowse link
G TRIM11 tripartite motif containing 11 involved_in ISO (PMID:18248090)
(MGI:5545996|PMID:18248090)
UniProt PMID:18248090 MGI:5545996 NCBI chr 1:203,795,924...203,809,703
Ensembl chr 1:209,006,979...209,019,994
JBrowse link
G TRIM21 tripartite motif containing 21 involved_in ISO (MGI:5545996|PMID:18248090) UniProt PMID:18248090 MGI:5545996 NCBI chr11:4,588,083...4,596,942
Ensembl chr11:4,254,152...4,262,981
JBrowse link
G TRIM38 tripartite motif containing 38 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chr 6:25,796,278...25,818,610
Ensembl chr 6:26,454,051...26,475,842
JBrowse link
receptor-mediated endocytosis of virus by host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655
JBrowse link
G CAV2 caveolin 2 involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chr 7:108,254,074...108,480,716
Ensembl chr 7:121,168,579...121,177,415
JBrowse link
G CTSL cathepsin L involved_in ISO (PMID:16081529), (PMID:32221306), (PMID:32855215) UniProt PMID:16081529 PMID:32221306 PMID:32855215 NCBI chr 9:58,851,899...58,857,170
Ensembl chr 9:86,903,006...86,908,303
JBrowse link
G EPS15 epidermal growth factor receptor pathway substrate 15 involved_in ISO (PMID:21047970) CACAO PMID:21047970 NCBI chr 1:50,598,692...50,763,585
Ensembl chr 1:52,097,387...52,223,533
JBrowse link
G KIAA0319L KIAA0319 like acts_upstream_of_or_within ISO (MGI:5750797|PMID:26814968) MGI PMID:26814968 MGI:5750797 NCBI chr 1:34,701,571...34,825,628
Ensembl chr 1:35,879,029...36,002,516
JBrowse link
G PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing involved_in ISO (PMID:32221306) UniProt PMID:32221306 NCBI chr2B:95,505,376...95,597,792
Ensembl chr2B:213,628,997...213,721,299
JBrowse link
G TPCN2 two pore segment channel 2 involved_in ISO (PMID:32221306) UniProt PMID:32221306 NCBI chr11:64,139,512...64,227,913 JBrowse link
regulation of viral entry into host cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 involved_in ISO (PMID:12138164) UniProt PMID:12138164 NCBI chr 6:111,846,143...112,132,706
Ensembl chr 6:115,917,004...116,089,942
JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in ISO (PMID:11602758) CACAO PMID:11602758 NCBI chr19:41,794,037...41,837,047
Ensembl chr19:50,399,668...50,443,024
JBrowse link
G TRIM25 tripartite motif containing 25 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chr17:50,965,592...50,991,630
Ensembl chr17:55,826,458...55,852,422
JBrowse link
G TRIM62 tripartite motif containing 62 involved_in ISO (PMID:18248090) UniProt PMID:18248090 NCBI chr 1:32,429,824...32,467,185
Ensembl chr 1:33,614,555...33,650,859
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12613
    viral process 304
      viral life cycle 228
        viral entry into host cell 71
          disruption of host cell envelope during viral entry + 0
          endocytosis involved in viral entry into host cell + 8
          lysis of host organelle involved in viral entry into host cell + 0
          membrane fusion involved in viral entry into host cell + 3
          negative regulation of viral entry into host cell + 26
          pore-mediated entry of viral genome into host cell 0
          positive regulation of viral entry into host cell + 11
          regulation of viral entry into host cell + 38
          viral entry into host cell via pilus retraction + 0
          viral entry via permeabilization of host membrane + 0
          viral genome ejection through host cell envelope + 0
Path 2
Term Annotations click to browse term
  biological_process 12613
    biological process involved in interspecies interaction between organisms 1332
      biological process involved in symbiotic interaction 240
        biological process involved in interaction with host 139
          movement in host environment 100
            entry into host 76
              viral entry into host cell 71
                disruption of host cell envelope during viral entry + 0
                endocytosis involved in viral entry into host cell + 8
                lysis of host organelle involved in viral entry into host cell + 0
                membrane fusion involved in viral entry into host cell + 3
                negative regulation of viral entry into host cell + 26
                pore-mediated entry of viral genome into host cell 0
                positive regulation of viral entry into host cell + 11
                regulation of viral entry into host cell + 38
                viral entry into host cell via pilus retraction + 0
                viral entry via permeabilization of host membrane + 0
                viral genome ejection through host cell envelope + 0
paths to the root