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ONTOLOGY REPORT - ANNOTATIONS


Term:viral entry into host cell
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Accession:GO:0046718 term browser browse the term
Definition:The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
Comment:Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
Synonyms:exact_synonym: entry of virus into host cell;   phage translocation;   viral penetration;   virion penetration;   virion penetration into host cell;   virus entry into host cell
 alt_id: GO:0019063
 xref: VZ:936


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viral entry into host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:1600115
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:1624291
G Cd300lf Cd300 molecule-like family member F JBrowse link 10 103,669,781 103,690,584 RGD:1600115
G Cd55 CD55 molecule (Cromer blood group) JBrowse link 13 47,125,156 47,153,557 RGD:1600115
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
G Cldn1 claudin 1 JBrowse link 11 77,815,216 77,830,373 RGD:1600115
G Cldn6 claudin 6 JBrowse link 10 12,999,256 13,002,860 RGD:1600115
G Cldn9 claudin 9 JBrowse link 10 13,003,010 13,004,441 RGD:1600115
G Clec4m C-type lectin domain family 4 member M JBrowse link 12 2,817,633 2,826,303 RGD:1600115
G Clec5a C-type lectin domain containing 5A JBrowse link 4 68,810,330 68,819,921 RGD:1600115
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:1624291
RGD:1600115
G Dpp4 dipeptidylpeptidase 4 JBrowse link 3 48,291,055 48,372,672 RGD:1600115
G Eps15 epidermal growth factor receptor pathway substrate 15 JBrowse link 5 128,923,809 129,022,268 RGD:1624291
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Gpr15 G protein-coupled receptor 15 JBrowse link 11 43,992,739 44,004,189 RGD:1624291
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:1624291
RGD:1600115
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:1600115
G Hyal1 hyaluronidase 1 JBrowse link 8 116,332,834 116,337,522 RGD:1600115
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:633153
G Hyal3 hyaluronidase 3 JBrowse link 8 116,336,512 116,342,147 RGD:1600115
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:1624291
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:1624291
G Lamp3 lysosomal-associated membrane protein 3 JBrowse link 11 84,930,965 85,000,694 RGD:1624291
G Nectin1 nectin cell adhesion molecule 1 JBrowse link 8 48,094,233 48,198,499 RGD:1599797
G Nectin4 nectin cell adhesion molecule 4 JBrowse link 13 89,755,665 89,774,185 RGD:1600115
G Npc1 NPC intracellular cholesterol transporter 1 JBrowse link 18 3,616,878 3,662,656 RGD:1624291
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1600115
G Serpinb3 serpin family B member 3 JBrowse link 13 27,186,701 27,193,211 RGD:1600115
G Siglec1 sialic acid binding Ig like lectin 1 JBrowse link 3 123,612,067 123,631,718 RGD:1624291
G Siva1 SIVA1, apoptosis-inducing factor JBrowse link 6 137,209,999 137,214,379 RGD:1600115
G Uvrag UV radiation resistance associated JBrowse link 1 163,844,804 164,101,568 RGD:1624291
G Vamp8 vesicle-associated membrane protein 8 JBrowse link 4 100,250,301 100,252,756 RGD:1624291
RGD:1600115
G Vps16 VPS16 core subunit of CORVET and HOPS complexes JBrowse link 3 122,947,887 122,969,543 RGD:1624291
G Vps18 VPS18 core subunit of CORVET and HOPS complexes JBrowse link 3 111,097,352 111,108,206 RGD:1624291
G Xpr1 xenotropic and polytropic retrovirus receptor 1 JBrowse link 13 72,918,552 73,056,785 RGD:1600115
G Zfp639 zinc finger protein 639 JBrowse link 2 118,906,479 118,917,491 RGD:1624291
RGD:1600115
clathrin-dependent endocytosis of virus by host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Siglec1 sialic acid binding Ig like lectin 1 JBrowse link 3 123,612,067 123,631,718 RGD:1624291
fusion of virus membrane with host plasma membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:1600115
RGD:1624291
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
negative regulation of viral entry into host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07015596.1 RGD:13792537
G Apcs amyloid P component, serum JBrowse link 13 91,426,621 91,427,417 RGD:1624291
RGD:1600115
G Fcna ficolin A JBrowse link 3 2,850,006 2,853,230 RGD:1624291
G Fcnb ficolin B JBrowse link 3 6,617,816 6,626,193 RGD:1624291
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:1624291
G Ifitm1 interferon induced transmembrane protein 1 JBrowse link 1 213,765,825 213,767,841 RGD:1624291
RGD:13792537
G Ifitm2 interferon induced transmembrane protein 2 JBrowse link 1 213,750,219 213,751,399 RGD:1624291
RGD:13792537
G Ifitm3 interferon induced transmembrane protein 3 JBrowse link 1 213,810,712 213,811,821 RGD:1624291
RGD:13792537
G Ifitm6 interferon induced transmembrane protein 6 JBrowse link 1 213,816,966 213,856,570 RGD:13792537
G Mid2 midline 2 JBrowse link X 112,019,897 112,121,980 RGD:1624291
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:8693392
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:8693392
G Ptx3 pentraxin 3 JBrowse link 2 158,097,843 158,103,653 RGD:1624291
G Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:8693392
G Snx3 sorting nexin 3 JBrowse link 20 47,225,382 47,263,390 RGD:1624291
G Trim10 tripartite motif-containing 10 JBrowse link 20 2,182,945 2,191,640 RGD:1624291
G Trim11 tripartite motif-containing 11 JBrowse link 10 45,322,199 45,335,030 RGD:1624291
G Trim25 tripartite motif-containing 25 JBrowse link 10 76,343,847 76,362,159 RGD:1624291
G Trim26 tripartite motif-containing 26 JBrowse link 20 2,201,685 2,224,481 RGD:1600115
RGD:1624291
G Trim31 tripartite motif-containing 31 JBrowse link 20 2,146,245 2,159,875 RGD:1624291
G Trim5 tripartite motif-containing 5 JBrowse link 1 169,446,774 169,463,760 RGD:1624291
G Trim59 tripartite motif-containing 59 JBrowse link 2 165,629,903 165,641,751 RGD:1624291
G Trim8 tripartite motif-containing 8 JBrowse link 1 266,255,797 266,270,694 RGD:1624291
positive regulation of viral entry into host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd4 Cd4 molecule JBrowse link 4 157,381,862 157,408,357 RGD:1624291
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Lgals1 galectin 1 JBrowse link 7 120,153,184 120,156,290 RGD:1624291
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Nectin1 nectin cell adhesion molecule 1 JBrowse link 8 48,094,233 48,198,499 RGD:1624291
G P4hb prolyl 4-hydroxylase subunit beta JBrowse link 10 109,736,459 109,748,070 RGD:1624291
G Tmprss2 transmembrane serine protease 2 JBrowse link 11 38,063,914 38,103,406 RGD:1624291
G Trim11 tripartite motif-containing 11 JBrowse link 10 45,322,199 45,335,030 RGD:1624291
G Trim21 tripartite motif-containing 21 JBrowse link 1 167,686,148 167,708,735 RGD:1624291
G Trim38 tripartite motif containing 38 JBrowse link 17 43,600,006 43,607,879 RGD:1624291
receptor-mediated endocytosis of virus by host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Cav2 caveolin 2 JBrowse link 4 44,573,264 44,580,640 RGD:1624291
RGD:1600115
G Eps15 epidermal growth factor receptor pathway substrate 15 JBrowse link 5 128,923,809 129,022,268 RGD:1624291
G LOC100294508 dyslexia susceptibility 2-like JBrowse link 5 144,779,306 144,872,271 RGD:1624291
regulation of viral entry into host cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 JBrowse link 20 40,236,437 40,545,502 RGD:1624291
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
G Trim25 tripartite motif-containing 25 JBrowse link 10 76,343,847 76,362,159 RGD:1624291
G Trim62 tripartite motif-containing 62 JBrowse link 5 147,068,725 147,099,024 RGD:1624291

Term paths to the root
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Term Annotations click to browse term
  biological_process 19336
    interspecies interaction between organisms 1764
      symbiotic process 376
        interaction with host 138
          entry into host 77
            viral entry into host cell 74
              disruption of host cell envelope during viral entry + 0
              endocytosis involved in viral entry into host cell + 5
              lysis of host organelle involved in viral entry into host cell + 0
              membrane fusion involved in viral entry into host cell + 3
              negative regulation of viral entry into host cell + 23
              pore-mediated entry of viral genome into host cell 0
              positive regulation of viral entry into host cell + 10
              regulation of viral entry into host cell + 35
              viral entry into host cell via pilus retraction + 0
              viral entry via permeabilization of host membrane + 0
              viral genome ejection through host cell envelope + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.