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Term:lipopolysaccharide receptor complex
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Accession:GO:0046696 term browser browse the term
Definition:A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens.
Comment:Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of.
Synonyms:exact_synonym: LPS receptor complex

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lipopolysaccharide receptor complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:727423
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:1624291
G Ly96 lymphocyte antigen 96 JBrowse link 5 1,972,212 1,989,448 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1600115
G Tril TLR4 interactor with leucine-rich repeats JBrowse link 4 83,967,695 83,972,540 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20300
    protein-containing complex 6094
      receptor complex 407
        lipopolysaccharide receptor complex 5
Path 2
Term Annotations click to browse term
  cellular_component 20300
    cellular anatomical entity 19956
      membrane 10079
        intrinsic component of membrane 6907
          integral component of membrane 6769
            lipopolysaccharide receptor complex 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.