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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of insulin secretion
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Accession:GO:0046676 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
Synonyms:exact_synonym: down regulation of insulin secretion;   downregulation of insulin secretion
 narrow_synonym: inhibition of insulin secretion


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negative regulation of insulin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP-binding cassette, sub-family C member 8 involved_in ISO
IDA
IMP		 (PMID:25771886)
(PMID:16924481)		 RGD
MGI		 PMID:15163199 PMID:16924481 PMID:25771886 GO_REF:0000096 MGI:4417868 RGD:1598646 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Acvr1c activin A receptor, type IC acts_upstream_of_or_within IMP (PMID:18480258) MGI PMID:18480258 NCBI chr 2:58,157,465...58,247,909
Ensembl chr 2:58,157,465...58,247,907 		JBrowse link
G Adra2a adrenergic receptor, alpha 2a involved_in ISO
IMP
IDA		 (PMID:17992256), (PMID:1898674)
(PMID:1898674)		 MGI PMID:1898674 PMID:17992256 GO_REF:0000119 MGI:4834177 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413 		JBrowse link
G Bmp8a bone morphogenetic protein 8a involved_in ISO (PMID:22579288) UniProt PMID:22579288 NCBI chr 4:123,206,438...123,237,045
Ensembl chr 4:123,206,438...123,237,045 		JBrowse link
G Ccn3 cellular communication network factor 3 involved_in IDA (MGI:5517610|PMID:23705021) UniProt PMID:23705021 MGI:5517610 NCBI chr15:54,609,306...54,617,158
Ensembl chr15:54,609,098...54,617,435 		JBrowse link
G Chga chromogranin A involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:102,521,200...102,531,286
Ensembl chr12:102,521,228...102,531,287 		JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO RGD
MGI		 PMID:18216393 GO_REF:0000096 MGI:4417868 RGD:2311570 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in IMP (PMID:17992256) MGI PMID:17992256 NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735 		JBrowse link
G Fam3d FAM3 metabolism regulating signaling molecule D involved_in ISS
ISO		 (MGI:2384458|PMID:12160727) UniProt
MGI		 PMID:12160727 GO_REF:0000119 MGI:2384458 MGI:4834177 NCBI chr14:14,091,010...14,120,836
Ensembl chr14:14,091,019...14,120,836 		JBrowse link
G Fbn1 fibrillin 1 involved_in IDA (MGI:6442875|PMID:30997682) UniProt PMID:30997682 MGI:6442875 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913 		JBrowse link
G Ffar2 free fatty acid receptor 2 involved_in IGI
IMP		 (PMID:25581519)
(PMID:26075576)		 MGI PMID:25581519 PMID:26075576 NCBI chr 7:30,517,778...30,523,200
Ensembl chr 7:30,517,773...30,523,200 		JBrowse link
G Ffar3 free fatty acid receptor 3 involved_in IMP
IGI		 (PMID:26091414), (PMID:32073900)
(PMID:25581519)		 MGI PMID:25581519 PMID:26091414 PMID:32073900 NCBI chr 7:30,553,755...30,555,603
Ensembl chr 7:30,553,755...30,555,603 		JBrowse link
G Foxo1 forkhead box O1 involved_in IDA (MGI:2388494|PMID:12219087), (MGI:6101624|PMID:27457971) UniProt PMID:12219087 PMID:27457971 MGI:2388494 MGI:6101624 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Ghrl ghrelin acts_upstream_of_or_within ISO
IMP		 (PMID:17130496) MGI PMID:17130496 NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841 		JBrowse link
G Ghsr growth hormone secretagogue receptor acts_upstream_of_or_within ISO (PMID:17130496) MGI PMID:17130496 NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159 		JBrowse link
G Gnao1 guanine nucleotide binding protein, alpha O involved_in IMP (PMID:20622165) MGI PMID:20622165 NCBI chr 8:94,537,213...94,696,016
Ensembl chr 8:94,536,594...94,696,016 		JBrowse link
G Gnaz guanine nucleotide binding protein, alpha z subunit involved_in IMP (PMID:18096703) MGI PMID:18096703 NCBI chr10:74,803,009...74,852,739
Ensembl chr10:74,803,009...74,852,739 		JBrowse link
G Hadh hydroxyacyl-Coenzyme A dehydrogenase involved_in ISO RGD
MGI		 PMID:17491019 GO_REF:0000096 MGI:4417868 RGD:2302227 NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750 		JBrowse link
G Hdac1 histone deacetylase 1 ISO RGD PMID:22772764 RGD:9590127 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Inhbb inhibin beta-B acts_upstream_of_or_within IMP (PMID:18480258) MGI PMID:18480258 NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978 		JBrowse link
G Irs1 insulin receptor substrate 1 involved_in ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 involved_in IMP (MGI:3770494|PMID:17767909) UniProt PMID:17767909 MGI:3770494 NCBI chr 2:166,937,889...167,032,088
Ensembl chr 2:166,937,889...167,032,075 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 involved_in ISO
IMP		 (PMID:33196462)
(PMID:16924481)		 MGI PMID:16924481 PMID:33196462 GO_REF:0000119 MGI:4834177 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 involved_in TAS (PMID:34636409) MGI PMID:34636409 NCBI chr16:94,545,839...94,798,719
Ensembl chr16:94,549,495...94,798,560 		JBrowse link
G Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 involved_in ISO RGD
MGI		 PMID:16133261 GO_REF:0000096 MGI:4417868 RGD:1581603 NCBI chr 7:142,660,614...142,980,787
Ensembl chr 7:142,660,099...142,980,779 		JBrowse link
G Midn midnolin acts_upstream_of_or_within ISO (PMID:24187134) MGI PMID:24187134 NCBI chr10:79,984,106...79,994,202
Ensembl chr10:79,984,106...79,994,202 		JBrowse link
G Mtnr1a melatonin receptor 1A involved_in ISO RGD
MGI		 PMID:22288848 GO_REF:0000096 MGI:4417868 RGD:9686057 NCBI chr 8:45,522,144...45,542,270
Ensembl chr 8:45,522,174...45,541,543 		JBrowse link
G Mtnr1b melatonin receptor 1B involved_in ISO RGD
MGI		 PMID:18363673 GO_REF:0000096 MGI:4417868 RGD:9588673 NCBI chr 9:15,773,910...15,785,852
Ensembl chr 9:15,735,824...15,785,852 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal involved_in ISO RGD
MGI		 PMID:17130471 GO_REF:0000096 MGI:4417868 RGD:1642149 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor involved_in ISO RGD
MGI		 PMID:1704109 GO_REF:0000096 MGI:4417868 RGD:2316580 NCBI chr15:102,432,274...102,433,056
Ensembl chr15:102,432,274...102,433,377 		JBrowse link
G Pde8b phosphodiesterase 8B involved_in ISO RGD
MGI		 PMID:17991719 GO_REF:0000096 MGI:4417868 RGD:2312519 NCBI chr13:95,160,962...95,386,904
Ensembl chr13:95,160,962...95,386,844 		JBrowse link
G Pfkl phosphofructokinase, liver, B-type acts_upstream_of_or_within IDA (PMID:9287040) MGI PMID:9287040 NCBI chr10:77,822,781...77,845,641
Ensembl chr10:77,822,781...77,845,917 		JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Psmd9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 involved_in ISS
ISO		 (MGI:3611092|PMID:16099819) BHF-UCL
MGI		 PMID:16099819 GO_REF:0000096 MGI:3611092 MGI:4417868 NCBI chr 5:123,366,253...123,388,189
Ensembl chr 5:123,307,476...123,388,194 		JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
MGI		 PMID:10531320 GO_REF:0000096 MGI:4417868 RGD:10043332 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within IMP (PMID:15520383) MGI PMID:15520383 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460 		JBrowse link
G Ptprv protein tyrosine phosphatase receptor type V acts_upstream_of_or_within IMP (PMID:17693256) MGI PMID:17693256 NCBI chr 1:135,036,236...135,060,313
Ensembl chr 1:135,036,235...135,060,332 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:77,413,273...77,434,279
Ensembl chr 5:77,413,338...77,434,279 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 involved_in IMP (MGI:5619445|PMID:23092880) CACAO PMID:23092880 MGI:5619445 NCBI chr11:119,493,731...119,790,417
Ensembl chr11:119,493,731...119,790,402 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:23,901,401...23,939,648
Ensembl chr 8:23,901,518...23,939,648 		JBrowse link
G Sirt4 sirtuin 4 involved_in
acts_upstream_of_or_within		 ISO
IMP
IGI		 (PMID:16959573) MGI PMID:16959573 GO_REF:0000119 MGI:4834177 NCBI chr 5:115,616,065...115,628,322
Ensembl chr 5:115,616,069...115,622,784 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within IMP (PMID:16890542) MGI PMID:16890542 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Stxbp5l syntaxin binding protein 5-like acts_upstream_of_or_within IDA (PMID:21998599) MGI PMID:21998599 NCBI chr16:36,927,437...37,205,377
Ensembl chr16:36,935,304...37,205,324 		JBrowse link
G Sytl4 synaptotagmin-like 4 acts_upstream_of_or_within IMP (PMID:16890542) MGI PMID:16890542 NCBI chr  X:132,837,134...132,882,569
Ensembl chr  X:132,837,134...132,882,561 		JBrowse link
G Uts2 urotensin 2 involved_in ISO RGD
MGI		 PMID:17931748 GO_REF:0000096 MGI:4417868 RGD:2306798 NCBI chr 4:151,081,554...151,086,267
Ensembl chr 4:151,081,554...151,086,267 		JBrowse link
G Vsnl1 visinin-like 1 acts_upstream_of_or_within IMP (PMID:16731532) MGI PMID:16731532 NCBI chr12:11,375,258...11,486,579
Ensembl chr12:11,375,243...11,486,614 		JBrowse link
negative regulation of insulin secretion involved in cellular response to glucose stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenergic receptor, alpha 2a involved_in ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 involved_in ISO RGD
MGI		 PMID:17360501 GO_REF:0000096 MGI:4417868 RGD:2306172 NCBI chr 6:55,067,033...55,110,001
Ensembl chr 6:55,067,034...55,110,001 		JBrowse link
G Eny2 ENY2 transcription and export complex 2 subunit involved_in ISO RGD
MGI		 PMID:22649445 GO_REF:0000096 MGI:4417868 RGD:9590329 NCBI chr15:44,291,488...44,301,652
Ensembl chr15:44,291,438...44,301,652 		JBrowse link
G Fkbp1b FK506 binding protein 1b acts_upstream_of_or_within IMP (PMID:19805579) MGI PMID:19805579 NCBI chr12:4,883,174...4,891,736
Ensembl chr12:4,883,174...4,891,591 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase involved_in ISO RGD
MGI		 PMID:20610886 GO_REF:0000096 MGI:4417868 RGD:5508687 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Jagn1 jagunal homolog 1 involved_in ISO RGD
MGI		 PMID:26882284 GO_REF:0000096 MGI:4417868 RGD:11520872 NCBI chr 6:113,419,478...113,425,190
Ensembl chr 6:113,419,530...113,425,190 		JBrowse link
G Klf7 Kruppel-like transcription factor 7 (ubiquitous) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:64,068,607...64,161,504
Ensembl chr 1:64,068,606...64,161,441 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 involved_in ISO RGD
MGI		 PMID:19690174 GO_REF:0000096 MGI:4417868 RGD:7495848 NCBI chr 1:39,939,806...40,065,470
Ensembl chr 1:39,940,073...40,065,470 		JBrowse link
G Mup1 major urinary protein 1 involved_in IDA (MGI:3850893|PMID:19336396) UniProt PMID:19336396 MGI:3850893 NCBI chr 4:60,454,011...60,457,959
Ensembl chr 4:60,454,011...60,457,959 		JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 acts_upstream_of_or_within IMP (PMID:22587331) MGI PMID:22587331 NCBI chr13:108,189,123...108,295,189
Ensembl chr13:108,139,249...108,295,157 		JBrowse link
G Pde1c phosphodiesterase 1C involved_in ISO RGD
MGI		 PMID:18706893 GO_REF:0000096 MGI:4417868 RGD:2302857 NCBI chr 6:56,046,783...56,629,590
Ensembl chr 6:56,046,789...56,629,472 		JBrowse link
G Pde3b phosphodiesterase 3B, cGMP-inhibited involved_in ISO RGD
MGI		 PMID:18706893 GO_REF:0000096 MGI:4417868 RGD:2302857 NCBI chr 7:114,014,388...114,137,173
Ensembl chr 7:114,014,516...114,138,486 		JBrowse link
G Pde4c phosphodiesterase 4C, cAMP specific involved_in ISO RGD
MGI		 PMID:18706893 GO_REF:0000096 MGI:4417868 RGD:2302857 NCBI chr 8:71,176,485...71,203,835
Ensembl chr 8:71,176,369...71,203,835 		JBrowse link
G Pde8b phosphodiesterase 8B involved_in ISO RGD
MGI		 PMID:18706893 GO_REF:0000096 MGI:4417868 RGD:2302857 NCBI chr13:95,160,962...95,386,904
Ensembl chr13:95,160,962...95,386,844 		JBrowse link
G Pim3 proviral integration site 3 involved_in IMP (MGI:5294526|PMID:21099329) UniProt PMID:21099329 MGI:5294526 NCBI chr15:88,746,397...88,749,929
Ensembl chr15:88,746,389...88,749,929 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 involved_in ISO RGD
MGI		 PMID:20167843 GO_REF:0000096 MGI:4417868 RGD:12904047 NCBI chr 2:90,741,057...90,748,395
Ensembl chr 2:90,739,060...90,748,389 		JBrowse link
G Tbc1d1 TBC1 domain family, member 1 involved_in ISO RGD
MGI		 PMID:28177704 GO_REF:0000096 MGI:4417868 RGD:150521607 NCBI chr 5:64,313,648...64,508,829
Ensembl chr 5:64,313,648...64,508,829 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) involved_in ISO RGD
MGI		 PMID:21172424 GO_REF:0000096 MGI:4417868 RGD:7204422 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    negative regulation of biological process 5939
      negative regulation of transport 552
        negative regulation of protein transport 158
          negative regulation of protein secretion 106
            negative regulation of insulin secretion 63
              negative regulation of insulin secretion involved in cellular response to glucose stimulus 18
Path 2
Term Annotations click to browse term
  biological_process 28573
    localization 5534
      establishment of localization 4833
        transport 4515
          nitrogen compound transport 2024
            amide transport 409
              peptide transport 356
                peptide secretion 348
                  peptide hormone secretion 340
                    insulin secretion 274
                      regulation of insulin secretion 231
                        negative regulation of insulin secretion 63
                          negative regulation of insulin secretion involved in cellular response to glucose stimulus 18
paths to the root