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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of insulin secretion
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Accession:GO:0046676 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
Synonyms:exact_synonym: down regulation of insulin secretion;   downregulation of insulin secretion
 narrow_synonym: inhibition of insulin secretion



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negative regulation of insulin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 IDA RGD PMID:15163199 RGD:1598646 NCBI chr 1:96,598,663...96,679,495
Ensembl chr 1:96,598,647...96,679,510
JBrowse link
G Acvr1c activin A receptor type 1C involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3512292 (MGI:3796011|PMID:18480258)
Ensembl
RGD
PMID:18480258 GO_REF:0000107 MGI:3796011 NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327
JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in ISO (PMID:10952463) RGD PMID:10952463 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Bmp8a bone morphogenetic protein 8a involved_in ISO (PMID:22579288) RGD PMID:22579288 NCBI chr 5:135,589,839...135,617,785
Ensembl chr 5:135,591,716...135,617,785
JBrowse link
G Ccn3 cellular communication network factor 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5517610|PMID:23705021)
UniProt
RGD
PMID:23705021 GO_REF:0000024 MGI:5517610 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
JBrowse link
G Chga chromogranin A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G Drd2 dopamine receptor D2 IMP RGD PMID:18216393 RGD:2311570 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Fam3d FAM3 metabolism regulating signaling molecule D involved_in ISS
ISO
GO_REF:0000024
(PMID:12160727)
UniProt
RGD
PMID:12160727 GO_REF:0000024 NCBI chr15:16,538,881...16,574,468
Ensembl chr15:16,539,489...16,573,034
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide acts_upstream_of_or_within ISO
IDA
MGI:3709886 (MGI:3709118|PMID:17130496) RGD PMID:17130496 PMID:17130496 MGI:3709118, RGD:8553721 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Ghsr growth hormone secretagogue receptor acts_upstream_of_or_within IDA PMID:17130496 MGI PMID:17130496 RGD:8553721 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase IMP RGD PMID:17491019 RGD:2302227 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Hdac1 histone deacetylase 1 IMP RGD PMID:22772764 RGD:9590127 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Inhbb inhibin subunit beta B involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
GO_REF:0000107
MGI:1857203 (MGI:3796011|PMID:18480258)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18480258 GO_REF:0000024 GO_REF:0000107 MGI:3796011 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
JBrowse link
G Irs1 insulin receptor substrate 1 involved_in IMP
IEA
ISO
PMID:12435589
GO_REF:0000107
(PMID:15572028)
Ensembl
RGD
PMID:15572028 PMID:12435589 GO_REF:0000107, RGD:729325 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3770494|PMID:17767909)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17767909 GO_REF:0000024 GO_REF:0000107 MGI:3770494 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 involved_in ISO (PMID:8923010) RGD PMID:8923010 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 IDA RGD PMID:16133261 RGD:1581603 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
JBrowse link
G Midn midnolin acts_upstream_of_or_within IDA PMID:24187134 MGI PMID:24187134 RGD:8655525 NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752
JBrowse link
G Mtnr1a melatonin receptor 1A IMP RGD PMID:22288848 RGD:9686057 NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
JBrowse link
G Mtnr1b melatonin receptor 1B IMP RGD PMID:18363673 RGD:9588673 NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
JBrowse link
G Nos1 nitric oxide synthase 1 IMP RGD PMID:17130471 RGD:1642149 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Npff neuropeptide FF-amide peptide precursor IDA RGD PMID:1704109 RGD:2316580 NCBI chr 7:133,654,530...133,655,319 JBrowse link
G Pde8b phosphodiesterase 8B IMP RGD PMID:17991719 RGD:2312519 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
JBrowse link
G Pfkl phosphofructokinase, liver type acts_upstream_of_or_within ISO (MGI:1096000|PMID:9287040) RGD PMID:9287040 MGI:1096000 NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in IMP PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:24187134)
ParkinsonsUK-UCL
RGD
PMID:24187134 GO_REF:0000024 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Psmd9 proteasome 26S subunit, non-ATPase 9 involved_in IMP PMID:16099819 BHF-UCL PMID:16099819 RGD:8554418 NCBI chr12:33,337,182...33,357,468 JBrowse link
G Ptger3 prostaglandin E receptor 3 IDA RGD PMID:10531320 RGD:10043332 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within ISO MGI:3522021 (MGI:3513751|PMID:15520383) RGD PMID:15520383 MGI:3513751 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Rest RE1-silencing transcription factor involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:20942606)
UniProt
Ensembl
RGD
PMID:20942606 GO_REF:0000024 GO_REF:0000107 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 involved_in ISO (MGI:5619445|PMID:23092880) RGD PMID:23092880 MGI:5619445 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:17994217)
Ensembl
RGD
PMID:17994217 GO_REF:0000107 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Sirt4 sirtuin 4 involved_in
acts_upstream_of_or_within
ISO (PMID:17715127)
MGI:3769237|MGI:95753 (MGI:3769241|PMID:16959573)
RGD PMID:16959573 PMID:17715127 MGI:3769241 NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within ISO MGI:2177773 (MGI:3770077|PMID:16890542) RGD PMID:16890542 MGI:3770077 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stxbp5l syntaxin binding protein 5L acts_upstream_of_or_within ISO (MGI:5296997|PMID:21998599) RGD PMID:21998599 MGI:5296997 NCBI chr11:63,334,667...63,654,270
Ensembl chr11:63,334,667...63,657,014
JBrowse link
G Sytl4 synaptotagmin-like 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3770077|PMID:16890542)
Ensembl
RGD
PMID:16890542 GO_REF:0000107 MGI:3770077 NCBI chr  X:97,135,500...97,185,867
Ensembl chr  X:97,135,500...97,185,854
JBrowse link
G Uts2 urotensin 2 IMP RGD PMID:17931748 RGD:2306798 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237
JBrowse link
G Vsnl1 visinin-like 1 acts_upstream_of_or_within ISO (MGI:3694336|PMID:16731532) RGD PMID:16731532 MGI:3694336 NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
JBrowse link
negative regulation of insulin secretion involved in cellular response to glucose stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07067882.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Adra2a adrenoceptor alpha 2A involved_in ISO
IMP
(PMID:19965390) RGD PMID:19965390 PMID:19965390 RGD:2316628 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:17360501 RGD:2306172 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
JBrowse link
G Eny2 ENY2, transcription and export complex 2 subunit IMP RGD PMID:22649445 RGD:9590329 NCBI chr 7:75,581,215...75,605,903
Ensembl chr 7:75,581,240...75,605,897
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B acts_upstream_of_or_within ISO MGI:2182644 (MGI:4421103|PMID:19805579) RGD PMID:19805579 MGI:4421103 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase IMP RGD PMID:20610886 RGD:5508687 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Jagn1 jagunal homolog 1 IMP RGD PMID:26882284 RGD:11520872 NCBI chr 4:146,591,577...146,596,287
Ensembl chr 4:146,591,510...146,596,288
JBrowse link
G Klf7 Kruppel like factor 7 involved_in ISO (PMID:16339272) RGD PMID:16339272 NCBI chr 9:65,437,535...65,484,720
Ensembl chr 9:65,437,167...65,526,261
JBrowse link
G LOC259246 alpha-2u globulin PGCL1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 IMP RGD PMID:19690174 RGD:7495848 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698
JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 acts_upstream_of_or_within ISO (MGI:5467193|PMID:22587331) RGD PMID:22587331 MGI:5467193 NCBI chr 2:39,535,680...39,647,378
Ensembl chr 2:39,535,689...39,647,316
JBrowse link
G Pde1c phosphodiesterase 1C IMP RGD PMID:18706893 RGD:2302857 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219
JBrowse link
G Pde3b phosphodiesterase 3B IMP RGD PMID:18706893 RGD:2302857 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334
JBrowse link
G Pde4c phosphodiesterase 4C IMP RGD PMID:18706893 RGD:2302857 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640
JBrowse link
G Pde8b phosphodiesterase 8B IMP RGD PMID:18706893 RGD:2302857 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
JBrowse link
G Pim3 Pim-3 proto-oncogene, serine/threonine kinase involved_in ISS
ISO
GO_REF:0000024
(MGI:5294526|PMID:21099329)
UniProt
RGD
PMID:21099329 GO_REF:0000024 MGI:5294526 NCBI chr 7:119,953,377...119,956,587
Ensembl chr 7:119,953,175...119,956,587
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 IMP RGD PMID:20167843 RGD:12904047 NCBI chr 3:76,889,922...76,899,427
Ensembl chr 3:76,889,922...76,899,427
JBrowse link
G Ucp2 uncoupling protein 2 IMP RGD PMID:21172424 RGD:7204422 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19504
    negative regulation of biological process 5622
      negative regulation of transport 531
        negative regulation of protein transport 147
          negative regulation of protein secretion 85
            negative regulation of insulin secretion 54
              negative regulation of insulin secretion involved in cellular response to glucose stimulus 18
Path 2
Term Annotations click to browse term
  biological_process 19504
    localization 6451
      establishment of localization 4866
        transport 4702
          secretion 1159
            secretion by cell 963
              signal release 623
                hormone secretion 395
                  regulation of hormone secretion 334
                    regulation of peptide hormone secretion 258
                      regulation of insulin secretion 207
                        negative regulation of insulin secretion 54
                          negative regulation of insulin secretion involved in cellular response to glucose stimulus 18
paths to the root