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ONTOLOGY REPORT - ANNOTATIONS

Term:folic acid metabolic process
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Accession:GO:0046655 term browser browse the term
Definition:The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
Synonyms:exact_synonym: folate metabolic process;   folate metabolism;   folic acid metabolism;   vitamin B9 metabolic process;   vitamin B9 metabolism;   vitamin M metabolic process;   vitamin M metabolism
 xref: Reactome:R-HSA-196757 "Metabolism of folate and pterines"


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folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 involved_in IDA PMID:1848231 UniProt PMID:1848231 RGD:632027 NCBI chr 4:124,617,182...124,663,674
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 involved_in ISO
IEA		 (PMID:33168096)
GO_REF:0000107		 RGD
Ensembl		 PMID:33168096 GO_REF:0000107 NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G Dhfr dihydrofolate reductase involved_in IDA
IBA		 PMID:20424322
GO_REF:0000033		 GO_Central PMID:20424322 GO_REF:0000033, RGD:10054082 NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Folr1 folate receptor alpha acts_upstream_of_or_within ISO
IEA		 MGI:2383986 (PMID:12854656)
GO_REF:0000107		 RGD
Ensembl		 PMID:12854656 GO_REF:0000107 NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (PMID:25633902) RGD PMID:25633902 NCBI chr 6:100,713,510...100,781,013
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISS
ISO		 GO_REF:0000024
(PMID:24074862)
(PMID:11466310)		 UniProt
RGD		 PMID:11466310 PMID:24074862 GO_REF:0000024 NCBI chr 1:36,695,376...36,727,341
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in ISO (PMID:11278996) RGD PMID:11278996 NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:12764149) RGD PMID:12764149 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Pm20d2 peptidase M20 domain containing 2 NOT|involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:47,566,059...47,586,334
Ensembl chr 5:47,566,072...47,586,212 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        amide metabolic process 482
          folic acid metabolic process 9
            folic acid biosynthetic process 0
            folic acid catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        small molecule metabolic process 1928
          organic acid metabolic process 1048
            oxoacid metabolic process 1026
              carboxylic acid metabolic process 1011
                dicarboxylic acid metabolic process 106
                  folic acid metabolic process 9
                    folic acid biosynthetic process 0
                    folic acid catabolic process 2
paths to the root