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ONTOLOGY REPORT - ANNOTATIONS

Term:tetrahydrofolate metabolic process
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Accession:GO:0046653 term browser browse the term
Definition:The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Synonyms:exact_synonym: tetrahydrofolate metabolism


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tetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHFR dihydrofolate reductase involved_in IDA (PMID:12096917), (PMID:21876184) UniProt PMID:12096917 PMID:21876184 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983 		JBrowse link
G DHFR2 dihydrofolate reductase 2 involved_in IDA (PMID:21876184) UniProt PMID:21876184 NCBI chr 3:94,057,922...94,063,320
Ensembl chr 3:94,047,836...94,063,389 		JBrowse link
G DHFRP1 dihydrofolate reductase pseudogene 1 involved_in IDA (PMID:12096917), (PMID:21876184) UniProt PMID:12096917 PMID:21876184 NCBI chr18:26,167,862...26,171,357
Ensembl chr18:26,170,726...26,171,284 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in IDA (PMID:8218174) UniProt PMID:8218174 NCBI chr 2:74,198,615...74,217,565
Ensembl chr 2:74,186,172...74,217,565 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in ISO
IEA		 RGD
Ensembl		 PMID:11730351 GO_REF:0000107 RGD:1601423 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G MTHFS methenyltetrahydrofolate synthetase involved_in IDA (PMID:19738041), (PMID:7766710) UniProt PMID:7766710 PMID:19738041 NCBI chr15:79,843,547...79,897,285
Ensembl chr15:79,833,585...79,897,379 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in ISO
IEA
IBA		 RGD
TreeGrafter
GO_Central		 PMID:11730351 PMID:21121936 GO_REF:0000033 GO_REF:0000118 RGD:1601423 RGD:7207080 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 involved_in IDA
IBA		 (PMID:24698160) UniProt
GO_Central		 PMID:24698160 GO_REF:0000033 NCBI chr17:18,327,873...18,363,550
Ensembl chr17:18,327,873...18,363,550 		JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 involved_in IDA
IEA
IBA		 (PMID:24075985), (PMID:25619277) UniProt
TreeGrafter
GO_Central		 PMID:24075985 PMID:25619277 GO_REF:0000033 GO_REF:0000118 NCBI chr12:57,229,711...57,234,935
Ensembl chr12:57,229,573...57,234,935 		JBrowse link
G TYMS thymidylate synthetase involved_in ISO
IEA		 5-formyltetrahydrofolate RGD
Ensembl		 PMID:7503782 GO_REF:0000107 RGD:5133451 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578 		JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISS
IEA
IDA		 (PMID:1881876) BHF-UCL
Ensembl		 PMID:1881876 GO_REF:0000024 GO_REF:0000107 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like involved_in IDA (PMID:12937168) BHF-UCL PMID:12937168 NCBI chr 6:150,865,702...151,101,887
Ensembl chr 6:150,865,679...151,101,887 		JBrowse link
10-formyltetrahydrofolate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase acts_upstream_of_positive_effect IMP (PMID:19933275), (PMID:21238436) UniProt PMID:19933275 PMID:21238436 NCBI chr11:106,077,662...106,098,695
Ensembl chr11:106,075,501...106,098,699 		JBrowse link
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 involved_in IDA
IEA
ISS		 (PMID:19933275) UniProt
Ensembl
InterPro		 PMID:19933275 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:126,103,570...126,197,945
Ensembl chr 3:126,103,562...126,197,994 		JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 involved_in IDA
IEA		 (PMID:21238436) UniProt
Ensembl
InterPro		 PMID:21238436 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 NCBI chr12:105,019,790...105,084,458
Ensembl chr12:105,019,784...105,107,643 		JBrowse link
10-formyltetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like ISO RGD PMID:21163947 RGD:7244288 NCBI chr 4:74,114,560...74,303,099
Ensembl chr 4:74,114,174...74,303,099 		JBrowse link
tetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase involved_in ISO
IEA		 RGD
Ensembl		 PMID:7057182 GO_REF:0000107 RGD:2301991 NCBI chr 2:215,312,059...215,368,592
Ensembl chr 2:215,311,956...215,349,773 		JBrowse link
G DHFR dihydrofolate reductase involved_in ISO
IEA
IBA
IDA		 (PMID:2303423) RGD
TreeGrafter
GO_Central
BHF-UCL
InterPro
UniProt		 PMID:2303423 PMID:11502523 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118 RGD:1298877 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983 		JBrowse link
G DHFR2 dihydrofolate reductase 2 involved_in IEA
IBA		 InterPro
UniProt
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118 NCBI chr 3:94,057,922...94,063,320
Ensembl chr 3:94,047,836...94,063,389 		JBrowse link
G DHFRP1 dihydrofolate reductase pseudogene 1 involved_in IEA
IBA
IDA		 (PMID:2303423) UniProt
GO_Central
InterPro
BHF-UCL		 PMID:2303423 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 NCBI chr18:26,167,862...26,171,357
Ensembl chr18:26,170,726...26,171,284 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase involved_in ISO
IEA		 RGD
Ensembl		 PMID:4078017 GO_REF:0000107 RGD:2301990 NCBI chr21:33,503,931...33,542,893
Ensembl chr21:33,503,931...33,543,491 		JBrowse link
G GCH1 GTP cyclohydrolase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826 		JBrowse link
tetrahydrofolate interconversion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHFR dihydrofolate reductase involved_in ISO (PMID:360074) MGI PMID:360074 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983 		JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:6163778 RGD:7245485 NCBI chr 5:78,997,564...79,069,674
Ensembl chr 5:78,997,564...79,236,038 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA
IBA
IDA
ISS		 (PMID:10828945), (PMID:1881876) UniProt
GO_Central
TreeGrafter
Ensembl
BHF-UCL		 PMID:1881876 PMID:10828945 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 NCBI chr 6:150,865,702...151,101,887
Ensembl chr 6:150,865,679...151,101,887 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:74,198,615...74,217,565
Ensembl chr 2:74,186,172...74,217,565 		JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like involved_in ISO
IBA
ISS
IEA		 RGD
GO_Central
UniProt		 PMID:21163947 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 RGD:7244288 NCBI chr 4:74,114,560...74,303,099
Ensembl chr 4:74,114,174...74,303,099 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in IMP
IBA
IEA
IGI
IDA		 (PMID:12673793), (PMID:25736335)
(PMID:10551815)
(PMID:12673793), (PMID:29891918)		 UniProt
GO_Central
TreeGrafter
BHF-UCL		 PMID:10551815 PMID:12673793 PMID:25736335 PMID:29891918 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G MTHFS methenyltetrahydrofolate synthetase involved_in IMP
IBA
IEA		 (PMID:12764149) BHF-UCL
GO_Central
TreeGrafter		 PMID:12764149 GO_REF:0000033 GO_REF:0000118 NCBI chr15:79,843,547...79,897,285
Ensembl chr15:79,833,585...79,897,379 		JBrowse link
G SARDH sarcosine dehydrogenase ISO RGD PMID:6163778 RGD:7245485 NCBI chr 9:133,659,418...133,739,955
Ensembl chr 9:133,663,560...133,739,955 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 involved_in IEA
IDA		 (PMID:24698160) UniProt
TreeGrafter
InterPro
Ensembl
BHF-UCL		 PMID:24698160 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chr17:18,327,873...18,363,550
Ensembl chr17:18,327,873...18,363,550 		JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 involved_in IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chr12:57,229,711...57,234,935
Ensembl chr12:57,229,573...57,234,935 		JBrowse link
G ST20-MTHFS ST20-MTHFS readthrough involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:79,843,547...79,923,092
Ensembl chr15:79,845,150...79,923,754 		JBrowse link
G TYMS thymidylate synthetase involved_in IDA
IEA		 (PMID:15093541) BHF-UCL
Ensembl		 PMID:15093541 GO_REF:0000107 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    cellular process 18300
      cellular metabolic process 10651
        cellular modified amino acid metabolic process 210
          folic acid-containing compound metabolic process 32
            tetrahydrofolate metabolic process 22
              10-formyltetrahydrofolate metabolic process + 6
              tetrahydrofolate biosynthetic process + 8
              tetrahydrofolate interconversion 13
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      organic substance metabolic process 11967
        organonitrogen compound metabolic process 5570
          cellular modified amino acid metabolic process 210
            folic acid-containing compound metabolic process 32
              tetrahydrofolate metabolic process 22
                10-formyltetrahydrofolate metabolic process + 6
                tetrahydrofolate biosynthetic process + 8
                tetrahydrofolate interconversion 13
paths to the root