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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrofolate metabolic process
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Accession:GO:0046653 term browser browse the term
Definition:The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
Synonyms:exact_synonym: tetrahydrofolate metabolism



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tetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO
ISS
(PMID:12096917), (PMID:21876184)
GO_REF:0000024
RGD
UniProt
PMID:12096917 PMID:21876184 GO_REF:0000024 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 TAS RGD PMID:2186031 RGD:1299513 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in ISO (PMID:8218174) RGD PMID:8218174 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Mthfr methylenetetrahydrofolate reductase IDA RGD PMID:11730351 RGD:1601423 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO (PMID:19738041), (PMID:7766710) RGD PMID:7766710 PMID:19738041 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
IMP
RGD PMID:11730351 PMID:21121936 RGD:1601423, RGD:7207080 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Pipox pipecolic acid and sarcosine oxidase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:62,769,874...62,783,484
Ensembl chr10:62,769,900...62,782,370
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IBA
ISO
PMID:21873635
(PMID:24698160)
RGD PMID:24698160 PMID:21873635 PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr10:45,468,698...45,497,820
Ensembl chr10:45,468,700...45,497,820
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in IBA
ISO
PMID:21873635
(PMID:24075985), (PMID:25619277)
RGD PMID:24075985 PMID:25619277 PMID:21873635 PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236
JBrowse link
G Tyms thymidylate synthetase IEP 5-formyltetrahydrofolate RGD PMID:7503782 RGD:5133451 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (PMID:1881876)
(MGI:5503248|PMID:23704330)
RGD PMID:1881876 PMID:23704330 MGI:5503248 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in ISO (PMID:12937168) RGD PMID:12937168 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link
10-formyltetrahydrofolate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase acts_upstream_of_positive_effect ISO (PMID:19933275), (PMID:21238436) RGD PMID:19933275 PMID:21238436 NCBI chr 8:1,453,226...1,463,990
Ensembl chr 8:1,452,282...1,463,966
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 involved_in IEA
IMP
ISO
IDA
GO_REF:0000002
PMID:10585460
(MGI:6369507|PMID:31624291)
PMID:1848231
(PMID:19933275)
GO_REF:0000104
InterPro
RGD
UniProt
PMID:19933275 PMID:31624291 PMID:10585460 PMID:1848231 GO_REF:0000002 GO_REF:0000104 MGI:6369507, RGD:150521656, RGD:632027 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 involved_in IEA
ISO
GO_REF:0000104
(MGI:6489626|PMID:33168096)
(PMID:21238436)
UniProt
RGD
PMID:21238436 PMID:33168096 GO_REF:0000104 MGI:6489626 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776
JBrowse link
10-formyltetrahydrofolate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IDA RGD PMID:21163947 RGD:7244288 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112
JBrowse link
tetrahydrofolate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 TAS RGD PMID:14729668 RGD:1547843 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IDA RGD PMID:7057182 RGD:2301991 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889
JBrowse link
G Dhfr dihydrofolate reductase involved_in IDA
IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:2303423)
UniProt
RGD
PMID:2303423 PMID:11502523 PMID:21873635 GO_REF:0000041, RGD:1298877, RGD:13792537 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IDA RGD PMID:4078017 RGD:2301990 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125
JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
tetrahydrofolate interconversion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO (MGI:67444|PMID:360074) RGD PMID:360074 MGI:67444 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Dmgdh dimethylglycine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
JBrowse link
G LOC680432 similar to methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase involved_in IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:116,195,791...116,198,973 JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA
ISS
ISO
IBA
GO_REF:0000041
GO_REF:0000024
(PMID:10828945), (PMID:1881876)
(MGI:5503248|PMID:23704330)
PMID:21873635
UniProt
RGD
PMID:1881876 PMID:10828945 PMID:23704330 PMID:21873635 GO_REF:0000024 GO_REF:0000041 MGI:5503248, RGD:13792537 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like involved_in IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like involved_in IDA
IEA
IBA
PMID:24733394
GO_REF:0000041
PMID:21873635
UniProt
RGD
PMID:21163947 PMID:24733394 PMID:21873635 GO_REF:0000041, RGD:7244288, RGD:150521648, RGD:13792537 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112
JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in IEA
ISO
IBA
GO_REF:0000041
UniProtKB:P53128 (PMID:10551815), (PMID:12673793), (PMID:25736335), (PMID:29891918)
PMID:21873635
UniProt
RGD
PMID:10551815 PMID:12673793 PMID:25736335 PMID:29891918 PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Mthfs methenyltetrahydrofolate synthetase involved_in ISO
IBA
(PMID:12764149)
PMID:21873635
RGD PMID:12764149 PMID:21873635 RGD:13792537 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089
JBrowse link
G Sardh sarcosine dehydrogenase IDA RGD PMID:6163778 RGD:7245485 NCBI chr 3:10,510,553...10,575,342
Ensembl chr 3:10,510,553...10,573,874
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in IBA
ISO
IEA
PMID:21873635
MGI:1277989 (MGI:3849912|PMID:19513116)
(PMID:24698160)
GO_REF:0000041
RGD
UniProt
PMID:19513116 PMID:24698160 PMID:21873635 PMID:21873635 GO_REF:0000041 MGI:3849912, RGD:13792537, RGD:13792537 NCBI chr10:45,468,698...45,497,820
Ensembl chr10:45,468,700...45,497,820
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 involved_in IBA
ISO
IEA
PMID:21873635
MGI:98299 (MGI:3849912|PMID:19513116)
GO_REF:0000041
RGD
UniProt
PMID:19513116 PMID:21873635 PMID:21873635 GO_REF:0000041 MGI:3849912, RGD:13792537, RGD:13792537 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236
JBrowse link
G Tyms thymidylate synthetase involved_in ISO (PMID:15093541)
(MGI:5300404|PMID:22057276)
RGD PMID:15093541 PMID:22057276 MGI:5300404 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19812
    cellular process 18617
      cellular metabolic process 10904
        cellular modified amino acid metabolic process 203
          folic acid-containing compound metabolic process 29
            tetrahydrofolate metabolic process 22
              10-formyltetrahydrofolate metabolic process + 6
              tetrahydrofolate biosynthetic process + 7
              tetrahydrofolate interconversion 14
Path 2
Term Annotations click to browse term
  biological_process 19812
    cellular process 18617
      cellular metabolic process 10904
        cellular aromatic compound metabolic process 5730
          pteridine-containing compound metabolic process 35
            folic acid-containing compound metabolic process 29
              tetrahydrofolate metabolic process 22
                10-formyltetrahydrofolate metabolic process + 6
                tetrahydrofolate biosynthetic process + 7
                tetrahydrofolate interconversion 14
paths to the root