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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of alpha-beta T cell proliferation
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Accession:GO:0046640 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation.
Synonyms:exact_synonym: regulation of alpha-beta T lymphocyte proliferation



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negative regulation of alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btla B and T lymphocyte associated acts_upstream_of_or_within ISO MGI:3027713 (MGI:3521631|PMID:15568026) RGD PMID:15568026 MGI:3521631 NCBI chr11:55,563,683...55,588,187
Ensembl chr11:55,564,899...55,587,181
JBrowse link
G Cblb Cbl proto-oncogene B acts_upstream_of_or_within ISO MGI:2180572 (MGI:3038342|PMID:14973438) RGD PMID:14973438 MGI:3038342 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
JBrowse link
G Clec4g C-type lectin domain family 4, member G acts_upstream_of_or_within ISO MGI:5510586 (MGI:5475030|PMID:23487419) RGD PMID:23487419 MGI:5475030 NCBI chr12:1,780,370...1,785,027
Ensembl chr12:1,780,371...1,784,985
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034 (MGI:3692513|PMID:16945588) RGD PMID:16945588 MGI:3692513 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Itch itchy E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:1856404 (MGI:3038342|PMID:14973438) RGD PMID:14973438 MGI:3038342 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3521631|PMID:15568026)
PMID:21873635
RGD PMID:15568026 PMID:21873635 MGI:3521631, RGD:13792537 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
JBrowse link
negative regulation of CD4-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5908533|PMID:25009204)
Ensembl
RGD
PMID:25009204 GO_REF:0000107 MGI:5908533 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Cblb Cbl proto-oncogene B acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:2180572 (MGI:3038342|PMID:14973438)
GO_REF:0000107
RGD
Ensembl
PMID:14973438 GO_REF:0000107 MGI:3038342 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
JBrowse link
G Cd274 CD274 molecule involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd44 CD44 molecule (Indian blood group) involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (MGI:3697020|PMID:17028180) RGD PMID:17028180 MGI:3697020 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Itch itchy E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:1856404 (MGI:3038342|PMID:14973438) RGD PMID:14973438 MGI:3038342 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
JBrowse link
G Lgals5 galectin 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153
JBrowse link
G Lgals7 galectin 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015
JBrowse link
G Lgals9 galectin 9 involved_in ISO
IBA
(PMID:20209097)
(MGI:5688819|PMID:25065622)
PMID:21873635
RGD PMID:20209097 PMID:25065622 PMID:21873635 MGI:5688819, RGD:13792537 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO MGI:3695433 (MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:3694584 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311
JBrowse link
G Tarm1 T cell-interacting, activating receptor on myeloid cells 1 involved_in ISO (MGI:5908526|PMID:26311901) RGD PMID:26311901 MGI:5908526 NCBI chr 1:65,666,742...65,682,402
Ensembl chr 1:65,671,902...65,679,626
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 acts_upstream_of_or_within ISO (MGI:3521631|PMID:15568026) RGD PMID:15568026 MGI:3521631 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 involved_in ISO (PMID:17164348) RGD PMID:17164348 NCBI chr 9:105,533,116...105,567,525
Ensembl chr 9:105,533,136...105,567,479
JBrowse link
G Vsir V-set immunoregulatory receptor involved_in
acts_upstream_of_or_within
ISO (PMID:24691993)
(MGI:5292805|PMID:21383057)
RGD PMID:21383057 PMID:24691993 MGI:5292805 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:10887101) RGD PMID:10887101 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
JBrowse link
negative regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:5449456|PMID:23105140) RGD PMID:23105140 MGI:5449456 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
positive regulation of alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase acts_upstream_of_or_within ISO MGI:3053044|MGI:3663359 (MGI:3700903|PMID:17210642) RGD PMID:17210642 MGI:3700903 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3699670|PMID:14662900)
BHF-UCL
RGD
PMID:14662900 GO_REF:0000024 MGI:3699670 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (MGI:3510282|PMID:15314074), (MGI:3757614|PMID:9368605), (MGI:3757622|PMID:7908303), (MGI:3757624|PMID:1385153), (MGI:3757626|PMID:1346270), (MGI:65397|PMID:8125140)
MGI:2179996 (MGI:3757614|PMID:9368605), (MGI:3757622|PMID:7908303), (MGI:3757624|PMID:1385153), (MGI:3757626|PMID:1346270)
RGD PMID:1346270 PMID:1385153 PMID:7908303 PMID:8125140 PMID:9368605 More... MGI:3510282 MGI:3757614 MGI:3757622 MGI:3757624 MGI:3757626 MGI:65397 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (MGI:3038342|PMID:14973438), (MGI:3757614|PMID:9368605), (MGI:65397|PMID:8125140) RGD PMID:8125140 PMID:9368605 PMID:14973438 MGI:3038342 MGI:3757614 MGI:65397 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of_or_within ISO (MGI:2176424|PMID:11894097), (MGI:3038342|PMID:14973438), (MGI:65397|PMID:8125140) RGD PMID:8125140 PMID:11894097 PMID:14973438 MGI:2176424 MGI:3038342 MGI:65397 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Cd80 Cd80 molecule acts_upstream_of_or_within ISO (MGI:3757624|PMID:1385153) RGD PMID:1385153 MGI:3757624 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (MGI:73253|PMID:7751624) RGD PMID:7751624 MGI:73253 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070|MGI:2660793 (MGI:2176422|PMID:11894098), (MGI:2176424|PMID:11894097) RGD PMID:11894097 PMID:11894098 MGI:2176422 MGI:2176424 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
MGI:99613 (MGI:1096306|PMID:9275205)
GO_REF:0000107
RGD
Ensembl
PMID:9275205 PMID:21873635 GO_REF:0000107 MGI:1096306, RGD:13792537 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3772919|PMID:16670306) RGD PMID:16670306 MGI:3772919 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO MGI:99515 (MGI:1096306|PMID:9275205) RGD PMID:9275205 MGI:1096306 NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700
JBrowse link
positive regulation of CD4-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 acts_upstream_of_or_within ISO MGI:3039682 (MGI:3039643|PMID:12867038) RGD PMID:12867038 MGI:3039643 NCBI chr12:13,620,979...13,758,115
Ensembl chr12:13,621,087...13,758,112
JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (MGI:3510282|PMID:15314074), (MGI:65397|PMID:8125140) RGD PMID:8125140 PMID:15314074 MGI:3510282 MGI:65397 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (MGI:3038342|PMID:14973438), (MGI:3757614|PMID:9368605), (MGI:65397|PMID:8125140) RGD PMID:8125140 PMID:9368605 PMID:14973438 MGI:3038342 MGI:3757614 MGI:65397 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of_or_within ISO (MGI:2176424|PMID:11894097), (MGI:3038342|PMID:14973438), (MGI:65397|PMID:8125140) RGD PMID:8125140 PMID:11894097 PMID:14973438 MGI:2176424 MGI:3038342 MGI:65397 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) involved_in ISO (PMID:16818763) RGD PMID:16818763 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cd81 Cd81 molecule involved_in ISO
ISS
(PMID:22307619)
GO_REF:0000024
RGD
UniProt
PMID:22307619 GO_REF:0000024 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO MGI:3053071|MGI:5609428 (MGI:5451119|PMID:23123061) RGD PMID:23123061 MGI:5451119 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Prkcq protein kinase C, theta acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:2664379 (MGI:3039643|PMID:12867038)
GO_REF:0000107
RGD
Ensembl
PMID:12867038 GO_REF:0000107 MGI:3039643 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070|MGI:2660793 (MGI:2176422|PMID:11894098), (MGI:2176424|PMID:11894097) RGD PMID:11894097 PMID:11894098 MGI:2176422 MGI:2176424 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO (PMID:17164348) RGD PMID:17164348 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5009207|PMID:9973465)
Ensembl
RGD
PMID:9973465 GO_REF:0000107 MGI:5009207 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
positive regulation of CD8-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd244 CD244 molecule involved_in ISO (MGI:5700312|PMID:11739483) RGD PMID:11739483 MGI:5700312 NCBI chr13:84,018,887...84,036,612
Ensembl chr13:84,020,095...84,036,100
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in IBA
ISO
PMID:21873635
(MGI:5562517|PMID:23871208)
RGD PMID:23871208 PMID:21873635 MGI:5562517, RGD:13792537 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:25631937) RGD PMID:25631937 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in ISO (PMID:25631937) RGD PMID:25631937 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:10887101) RGD PMID:10887101 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
positive regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12a interleukin 12A involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769
JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 4:96,424,615...96,515,327
Ensembl chr 4:96,426,842...96,515,289
JBrowse link
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(PMID:19088061)
Ensembl
RGD
PMID:19088061 GO_REF:0000107 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Jak2 Janus kinase 2 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Rasal3 RAS protein activator like 3 involved_in ISO (PMID:25652366) RGD PMID:25652366 NCBI chr 7:11,396,090...11,411,349
Ensembl chr 7:11,396,090...11,411,465
JBrowse link
G Tyk2 tyrosine kinase 2 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044
JBrowse link
regulation of CD4-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2 interleukin 2 acts_upstream_of_or_within ISO MGI:1857191 (MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:3662823 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1857192 (MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:3662823 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
regulation of CD8-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf1 interferon regulatory factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5317515|PMID:21909274)
UniProt
RGD
PMID:21909274 GO_REF:0000024 MGI:5317515 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5546548|PMID:23963642)
UniProt
RGD
PMID:23963642 GO_REF:0000024 MGI:5546548 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5546548|PMID:23963642)
UniProt
RGD
PMID:23963642 GO_REF:0000024 MGI:5546548 NCBI chr16:28,735,522...28,901,690
Ensembl chr16:28,735,440...28,901,644
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    immune system process 2569
      leukocyte activation 1038
        lymphocyte activation 849
          T cell activation 567
            regulation of T cell activation 377
              regulation of alpha-beta T cell activation 122
                regulation of alpha-beta T cell proliferation 53
                  negative regulation of alpha-beta T cell proliferation + 18
                  positive regulation of alpha-beta T cell proliferation + 32
                  regulation of CD4-positive, alpha-beta T cell proliferation + 27
                  regulation of CD8-positive, alpha-beta T cell proliferation + 9
                  regulation of NK T cell proliferation + 10
Path 2
Term Annotations click to browse term
  biological_process 20091
    biological regulation 13996
      regulation of biological process 13218
        regulation of cellular process 12482
          regulation of cell activation 721
            regulation of leukocyte activation 665
              regulation of lymphocyte activation 551
                regulation of lymphocyte proliferation 267
                  regulation of T cell proliferation 204
                    regulation of alpha-beta T cell proliferation 53
                      negative regulation of alpha-beta T cell proliferation + 18
                      positive regulation of alpha-beta T cell proliferation + 32
                      regulation of CD4-positive, alpha-beta T cell proliferation + 27
                      regulation of CD8-positive, alpha-beta T cell proliferation + 9
                      regulation of NK T cell proliferation + 10
paths to the root