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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of alpha-beta T cell activation
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Accession:GO:0046636 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.
Synonyms:exact_synonym: down regulation of alpha-beta T cell activation;   downregulation of alpha-beta T cell activation;   negative regulation of alpha-beta T lymphocyte activation
 narrow_synonym: inhibition of alpha-beta T cell activation


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negative regulation of alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3822045|PMID:10069416) MGI
Ensembl
PMID:10069416 GO_REF:0000107 MGI:3822045 NCBI chrNW_004936619:597,970...618,564 JBrowse link
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli3 GLI family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:17,129,922...17,403,630 JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:1,474,693...1,480,562 JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1888832|PMID:10981962) MGI
Ensembl
PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chrNW_004936527:10,033,095...10,042,713 JBrowse link
negative regulation of alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btla B and T lymphocyte associated acts_upstream_of_or_within ISO (MGI:3521631|PMID:15568026) MGI PMID:15568026 MGI:3521631 NCBI chrNW_004936536:155,401...183,039 JBrowse link
G Clec4g C-type lectin domain family 4 member G acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5475030|PMID:23487419) MGI
Ensembl
PMID:23487419 GO_REF:0000107 MGI:5475030 NCBI chrNW_004936588:4,737,278...4,740,750 JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3692513|PMID:16945588) MGI
Ensembl
PMID:16945588 GO_REF:0000107 MGI:3692513 NCBI chrNW_004936721:1,118,376...1,125,282 JBrowse link
negative regulation of CD4-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twsg1 twisted gastrulation BMP signaling modulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936626:1,901,686...1,946,554 JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:17,537,273...17,589,383 JBrowse link
G Hmgb1 high mobility group box 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:25,236,728...25,246,585 JBrowse link
G Runx3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chrNW_004936474:9,751,946...9,802,910 JBrowse link
negative regulation of CD4-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:11,004,296...11,045,467 JBrowse link
G Cblb Cbl proto-oncogene B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3038342|PMID:14973438) MGI
Ensembl
PMID:14973438 GO_REF:0000107 MGI:3038342 NCBI chrNW_004936701:1,157,790...1,353,375 JBrowse link
G Cd274 CD274 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936539:132,870...145,288 JBrowse link
G Cd44 CD44 molecule (Indian blood group) involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3697020|PMID:17028180) MGI
Ensembl
PMID:17028180 GO_REF:0000107 MGI:3697020 NCBI chrNW_004936721:1,118,376...1,125,282 JBrowse link
G Itch itchy E3 ubiquitin protein ligase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3038342|PMID:14973438) MGI
Ensembl
PMID:14973438 GO_REF:0000107 MGI:3038342 NCBI chrNW_004936561:6,140,236...6,265,734 JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097)
(MGI:5688819|PMID:25065622)
UniProt PMID:20209097 PMID:25065622 MGI:5688819 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G LOC101970885 lymphotactin involved_in ISO (PMID:10887101) BHF-UCL PMID:10887101 NCBI chrNW_004936481:17,825,714...17,828,955 JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO (MGI:3694584|PMID:17137798) MGI PMID:17137798 MGI:3694584 NCBI chrNW_004936504:12,053,470...12,103,346 JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 acts_upstream_of_or_within ISO (MGI:3521631|PMID:15568026) MGI PMID:15568026 MGI:3521631 NCBI chrNW_004936737:1,008,228...1,013,575 JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936626:1,901,686...1,946,554 JBrowse link
negative regulation of CD8-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936539:132,870...145,288 JBrowse link
G Hfe homeostatic iron regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936671:1,940,079...1,947,574 JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Socs1 suppressor of cytokine signaling 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936530:9,312,965...9,315,593 JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,546,139...4,560,157 JBrowse link
negative regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,546,139...4,560,157 JBrowse link
negative regulation of T-helper 1 cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101970885 lymphotactin involved_in ISO (PMID:10887101) BHF-UCL PMID:10887101 NCBI chrNW_004936481:17,825,714...17,828,955 JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (MGI:3761239|PMID:16424184) MGI PMID:16424184 MGI:3761239 NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chrNW_004936596:3,212,593...3,224,426 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936721:1,118,376...1,125,282 JBrowse link
G Il2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:13,919,006...13,973,868 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:11,341,663...11,393,275 JBrowse link
G Smad7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:13,894,586...13,921,978 JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635 JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5450776|PMID:23034280) MGI
Ensembl
PMID:23034280 GO_REF:0000107 MGI:5450776 NCBI chrNW_004936580:4,546,139...4,560,157 JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:19,714,145...19,722,512 JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936556:745,798...765,926 JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635 JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:14,499,495...14,508,074 JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:9,124,314...9,142,372 JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2450484|PMID:12594267) MGI
Ensembl
PMID:12594267 GO_REF:0000107 MGI:2450484 NCBI chrNW_004936578:2,371,976...2,395,034 JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3761239|PMID:16424184) MGI
Ensembl
PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chrNW_004936650:1,416,825...1,422,595 JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:5,531,002...5,588,022 JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3580753|PMID:15917799) MGI
Ensembl
PMID:15917799 GO_REF:0000107 MGI:3580753 NCBI chrNW_004936481:13,919,006...13,973,868 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15039
    immune system process 2001
      leukocyte activation 879
        lymphocyte activation 715
          T cell activation 498
            alpha-beta T cell activation 169
              negative regulation of alpha-beta T cell activation 38
                negative regulation of CD4-positive, alpha-beta T cell activation + 30
                negative regulation of CD8-positive, alpha-beta T cell activation + 4
                negative regulation of NK T cell activation + 1
                negative regulation of alpha-beta T cell differentiation + 24
                negative regulation of alpha-beta T cell proliferation + 14
Path 2
Term Annotations click to browse term
  biological_process 15039
    biological regulation 10785
      regulation of biological process 10216
        regulation of cellular process 9651
          regulation of cell adhesion 747
            regulation of cell-cell adhesion 439
              regulation of leukocyte cell-cell adhesion 316
                negative regulation of leukocyte cell-cell adhesion 128
                  negative regulation of T cell activation 118
                    negative regulation of alpha-beta T cell activation 38
                      negative regulation of CD4-positive, alpha-beta T cell activation + 30
                      negative regulation of CD8-positive, alpha-beta T cell activation + 4
                      negative regulation of NK T cell activation + 1
                      negative regulation of alpha-beta T cell differentiation + 24
                      negative regulation of alpha-beta T cell proliferation + 14
paths to the root