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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of alpha-beta T cell activation
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Accession:GO:0046636 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.
Synonyms:exact_synonym: down regulation of alpha-beta T cell activation;   downregulation of alpha-beta T cell activation;   negative regulation of alpha-beta T lymphocyte activation
 narrow_synonym: inhibition of alpha-beta T cell activation


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negative regulation of alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10069416) Ensembl
MGI		 PMID:10069416 GO_REF:0000107 NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,877...49,485,850 		JBrowse link
G VSIR V-set immunoregulatory receptor involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr14:74,667,081...74,693,347
Ensembl chr14:74,666,624...74,693,281 		JBrowse link
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI3 GLI family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:52,403,463...52,697,906
Ensembl chr18:52,404,072...52,697,900 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:121,083,750...121,090,548
Ensembl chr15:121,083,753...121,090,121 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10981962) Ensembl
MGI		 PMID:10981962 GO_REF:0000107 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,994...2,555,484 		JBrowse link
negative regulation of alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTLA B and T lymphocyte associated acts_upstream_of_or_within ISO (PMID:15568026) MGI PMID:15568026 NCBI chr13:147,348,641...147,376,741 JBrowse link
G CLEC4G C-type lectin domain family 4 member G involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23487419) Ensembl
MGI		 PMID:23487419 GO_REF:0000107 NCBI chr 2:71,433,406...71,436,570
Ensembl chr 2:71,433,421...71,436,567 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16945588) Ensembl
MGI		 PMID:16945588 GO_REF:0000107 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TARM1 T cell-interacting, activating receptor on myeloid cells 1 involved_in ISO (PMID:26311901) UniProt PMID:26311901 NCBI chr 6:56,038,524...56,051,487
Ensembl chr 6:56,038,524...56,049,764 		JBrowse link
G TWSG1 twisted gastrulation BMP signaling modulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:98,629,116...98,678,322
Ensembl chr 6:98,625,505...98,678,258 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:27,684,320...27,750,856
Ensembl chr 6:27,684,030...27,750,852 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:22473704) UniProt PMID:22473704 NCBI chr11:7,195,556...7,321,071 JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,837...198,638,189 		JBrowse link
G RUNX3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr 6:82,531,203...82,595,044
Ensembl chr 6:82,531,559...82,595,026 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARG2 arginase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:91,343,987...91,385,911
Ensembl chr 7:91,343,988...91,385,909 		JBrowse link
G CBLB Cbl proto-oncogene B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14973438) Ensembl
MGI		 PMID:14973438 GO_REF:0000107 NCBI chr13:153,480,525...153,700,115
Ensembl chr13:153,395,978...153,700,056 		JBrowse link
G CD274 CD274 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724 		JBrowse link
G CD44 CD44 molecule involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chr 2:25,788,699...25,884,209
Ensembl chr 2:25,788,703...25,884,153 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17028180) Ensembl
MGI		 PMID:17028180 GO_REF:0000107 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
G ITCH itchy E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14973438) Ensembl
MGI		 PMID:14973438 GO_REF:0000107 NCBI chr17:37,810,113...37,918,963
Ensembl chr17:37,810,235...37,918,209 		JBrowse link
G LGALS12 galectin 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:8,454,362...8,475,360
Ensembl chr 2:8,463,402...8,475,162 		JBrowse link
G LGALS9 galectin 9 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr12:44,155,079...44,173,634 JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17137798) Ensembl
MGI		 PMID:17137798 GO_REF:0000107 NCBI chr 2:143,688,946...143,734,523
Ensembl chr 2:143,629,783...143,734,520 		JBrowse link
G TARM1 T cell-interacting, activating receptor on myeloid cells 1 involved_in ISO (MGI:5908526|PMID:26311901) UniProt PMID:26311901 MGI:5908526 NCBI chr 6:56,038,524...56,051,487
Ensembl chr 6:56,038,524...56,049,764 		JBrowse link
G TWSG1 twisted gastrulation BMP signaling modulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:98,629,116...98,678,322
Ensembl chr 6:98,625,505...98,678,258 		JBrowse link
G VSIR V-set immunoregulatory receptor involved_in
acts_upstream_of_or_within		 ISO (PMID:24691993)
(PMID:21383057)		 UniProt
MGI		 PMID:21383057 PMID:24691993 NCBI chr14:74,667,081...74,693,347
Ensembl chr14:74,666,624...74,693,281 		JBrowse link
G XCL1 chemokine (C motif) ligand 1 involved_in ISO (PMID:10887101) BHF-UCL PMID:10887101 NCBI chr 4:82,432,845...82,436,150
Ensembl chr 4:82,432,204...82,436,180 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD274 CD274 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724 		JBrowse link
G DAPL1 death associated protein like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:65,796,462...65,820,450
Ensembl chr15:65,796,462...65,820,448 		JBrowse link
G HFE homeostatic iron regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,767,000 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A2 solute carrier family 4 member 2 involved_in ISO (MGI:6840447|PMID:24515893) UniProt PMID:24515893 MGI:6840447 NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,459...6,165,212 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,408...94,796,657 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A2 solute carrier family 4 member 2 involved_in ISO (MGI:6840447|PMID:24515893) UniProt PMID:24515893 MGI:6840447 NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,459...6,165,212 		JBrowse link
G VSIR V-set immunoregulatory receptor involved_in ISO (PMID:24691993) UniProt PMID:24691993 NCBI chr14:74,667,081...74,693,347
Ensembl chr14:74,666,624...74,693,281 		JBrowse link
negative regulation of NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in ISO (PMID:10540326) UniProt PMID:10540326 NCBI chr12:6,665,578...6,681,329 JBrowse link
negative regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,408...94,796,657 		JBrowse link
negative regulation of T-helper 1 cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G XCL1 chemokine (C motif) ligand 1 involved_in ISO (PMID:10887101) BHF-UCL PMID:10887101 NCBI chr 4:82,432,845...82,436,150
Ensembl chr 4:82,432,204...82,436,180 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:1,558,459...1,560,112
Ensembl chr 2:1,558,459...1,560,112 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chr 9:115,535,185...115,857,457
Ensembl chr 9:115,550,569...115,659,263 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:1,558,459...1,560,112
Ensembl chr 2:1,558,459...1,560,112 		JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18792410) TreeGrafter
MGI		 PMID:18792410 GO_REF:0000118 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:116,204,807...116,292,455
Ensembl chr 9:116,208,799...116,292,381 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:263,769,403...263,822,101
Ensembl chr 1:263,772,173...263,822,104 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,514,267...98,542,382 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23034280) Ensembl
MGI		 PMID:23034280 GO_REF:0000107 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,408...94,796,657 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:93,541,334...93,551,200
Ensembl chr 6:93,541,334...93,551,193 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:68,498,114...68,516,829
Ensembl chr 3:68,498,189...68,517,445 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chr 9:115,447,438...115,460,649
Ensembl chr 9:115,448,973...115,460,950 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in ISS
IEA		 UniProt
TreeGrafter
Ensembl		 GO_REF:0000024 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279 		JBrowse link
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:1,558,459...1,560,112
Ensembl chr 2:1,558,459...1,560,112 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12594267) Ensembl
MGI		 PMID:12594267 GO_REF:0000107 NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,250...125,393,330 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr10:10,263,441...10,269,882
Ensembl chr10:10,264,244...10,269,879 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:93,777,402...93,925,859
Ensembl chr 3:93,783,964...93,925,863 		JBrowse link
G ZNF397 zinc finger protein 397 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:119,076,683...119,144,643
Ensembl chr 6:119,076,714...119,086,759 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RC3H1 ring finger and CCCH-type domains 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15917799) Ensembl
MGI		 PMID:15917799 GO_REF:0000107 NCBI chr 9:116,204,807...116,292,455
Ensembl chr 9:116,208,799...116,292,381 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17799
    immune system process 2496
      leukocyte activation 1024
        lymphocyte activation 837
          T cell activation 597
            alpha-beta T cell activation 195
              negative regulation of alpha-beta T cell activation 47
                negative regulation of CD4-positive, alpha-beta T cell activation + 36
                negative regulation of CD8-positive, alpha-beta T cell activation + 7
                negative regulation of NK T cell activation + 2
                negative regulation of alpha-beta T cell differentiation + 29
                negative regulation of alpha-beta T cell proliferation + 17
Path 2
Term Annotations click to browse term
  biological_process 17799
    biological regulation 12896
      regulation of biological process 12533
        regulation of cellular process 12038
          regulation of cell activation 641
            regulation of leukocyte activation 587
              regulation of lymphocyte activation 512
                regulation of T cell activation 375
                  regulation of alpha-beta T cell activation 117
                    negative regulation of alpha-beta T cell activation 47
                      negative regulation of CD4-positive, alpha-beta T cell activation + 36
                      negative regulation of CD8-positive, alpha-beta T cell activation + 7
                      negative regulation of NK T cell activation + 2
                      negative regulation of alpha-beta T cell differentiation + 29
                      negative regulation of alpha-beta T cell proliferation + 17
paths to the root