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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of alpha-beta T cell activation
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Accession:GO:0046636 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.
Synonyms:exact_synonym: down regulation of alpha-beta T cell activation;   downregulation of alpha-beta T cell activation;   negative regulation of alpha-beta T lymphocyte activation
 narrow_synonym: inhibition of alpha-beta T cell activation



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negative regulation of alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3822045|PMID:10069416) MGI
Ensembl
Ensembl
PMID:10069416 GO_REF:0000107 MGI:3822045 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G LILRB1 leukocyte immunoglobulin like receptor B1 involved_in IDA (PMID:21213105) UniProt
UniProt
PMID:21213105 NCBI chr19:54,616,322...54,638,022
Ensembl chr19:54,617,158...54,638,022
JBrowse link
G VSIR V-set immunoregulatory receptor involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:71,747,556...71,773,520
Ensembl chr10:71,747,556...71,773,520
JBrowse link
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI3 GLI family zinc finger 3 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 7:41,960,949...42,264,268
Ensembl chr 7:41,960,949...42,264,100
JBrowse link
G IHH Indian hedgehog signaling molecule involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:219,054,424...219,060,921
Ensembl chr 2:219,054,424...219,060,921
JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1888832|PMID:10981962) Ensembl
Ensembl
MGI
PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463
JBrowse link
negative regulation of alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTLA B and T lymphocyte associated acts_upstream_of_or_within ISO (MGI:3521631|PMID:15568026) MGI PMID:15568026 MGI:3521631 NCBI chr 3:112,463,966...112,499,624
Ensembl chr 3:112,463,966...112,499,472
JBrowse link
G CBLB Cbl proto-oncogene B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:105,655,461...105,869,449
Ensembl chr 3:105,655,461...105,869,552
JBrowse link
G CLEC4G C-type lectin domain family 4 member G acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5475030|PMID:23487419) MGI
Ensembl
PMID:23487419 GO_REF:0000107 MGI:5475030 NCBI chr19:7,728,957...7,732,110
Ensembl chr19:7,728,957...7,733,906
JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3692513|PMID:16945588) MGI
Ensembl
PMID:16945588 GO_REF:0000107 MGI:3692513 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,270,477
JBrowse link
G ITCH itchy E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:34,363,273...34,511,773
Ensembl chr20:34,363,235...34,511,773
JBrowse link
G TNFRSF14 TNF receptor superfamily member 14 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 1:2,554,234...2,563,829
Ensembl chr 1:2,555,639...2,565,382
JBrowse link
negative regulation of CD4-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TARM1 T cell-interacting, activating receptor on myeloid cells 1 involved_in IDA (PMID:26311901) UniProt
UniProt
PMID:26311901 NCBI chr19:54,069,895...54,081,365
Ensembl chr19:54,069,895...54,081,365
JBrowse link
G TWSG1 twisted gastrulation BMP signaling modulator 1 involved_in IDA (PMID:17164348) BHF-UCL
BHF-UCL
PMID:17164348 NCBI chr18:9,334,773...9,402,420
Ensembl chr18:9,334,767...9,402,420
JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr16:67,029,149...67,101,058
Ensembl chr16:67,028,984...67,101,058
JBrowse link
G HMGB1 high mobility group box 1 involved_in IDA (PMID:22473704) UniProt
UniProt
PMID:22473704 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISS UniProt
UniProt
GO_REF:0000024 NCBI chr21:34,787,801...35,049,302
Ensembl chr21:34,787,801...36,004,667
JBrowse link
G RUNX3 RUNX family transcription factor 3 involved_in ISS UniProt
UniProt
GO_REF:0000024 NCBI chr 1:24,899,511...24,965,138
Ensembl chr 1:24,899,511...24,965,121
JBrowse link
negative regulation of CD4-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARG2 arginase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708
JBrowse link
G CBLB Cbl proto-oncogene B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3038342|PMID:14973438) MGI
Ensembl
PMID:14973438 GO_REF:0000107 MGI:3038342 NCBI chr 3:105,655,461...105,869,449
Ensembl chr 3:105,655,461...105,869,552
JBrowse link
G CD274 CD274 molecule involved_in IDA (PMID:24691993) UniProt
UniProt
PMID:24691993 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G CD44 CD44 molecule (Indian blood group) involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3697020|PMID:17028180) MGI
Ensembl
PMID:17028180 GO_REF:0000107 MGI:3697020 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,270,477
JBrowse link
G ITCH itchy E3 ubiquitin protein ligase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3038342|PMID:14973438) MGI
Ensembl
PMID:14973438 GO_REF:0000107 MGI:3038342 NCBI chr20:34,363,273...34,511,773
Ensembl chr20:34,363,235...34,511,773
JBrowse link
G LGALS7 galectin 7 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr19:38,770,968...38,773,517
Ensembl chr19:38,789,200...38,791,754
Ensembl chr19:38,789,200...38,791,754
JBrowse link
G LGALS7B galectin 7B involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr19:38,789,200...38,791,754
Ensembl chr19:38,789,200...38,791,754
Ensembl chr19:38,789,200...38,791,754
JBrowse link
G LGALS9 galectin 9 involved_in IDA
IBA
(PMID:20209097)
(PMID:21873635)
UniProt
GO_Central
GO_Central
UniProt
PMID:20209097 PMID:21873635 NCBI chr17:27,631,188...27,649,560
Ensembl chr17:27,629,798...27,649,560
JBrowse link
G LGALS9B galectin 9B involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr17:20,449,395...20,467,539
Ensembl chr17:20,449,395...20,467,539
JBrowse link
G LGALS9C galectin 9C involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr17:18,476,789...18,494,945
Ensembl chr17:18,476,737...18,494,945
JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3694584|PMID:17137798) MGI
Ensembl
PMID:17137798 GO_REF:0000107 MGI:3694584 NCBI chr 5:142,108,779...142,154,440
Ensembl chr 5:142,108,779...142,154,440
JBrowse link
G TARM1 T cell-interacting, activating receptor on myeloid cells 1 involved_in ISO (MGI:5908526|PMID:26311901) UniProt PMID:26311901 MGI:5908526 NCBI chr19:54,069,895...54,081,365
Ensembl chr19:54,069,895...54,081,365
JBrowse link
G TNFRSF14 TNF receptor superfamily member 14 acts_upstream_of_or_within ISO (MGI:3521631|PMID:15568026) MGI PMID:15568026 MGI:3521631 NCBI chr 1:2,554,234...2,563,829
Ensembl chr 1:2,555,639...2,565,382
JBrowse link
G TWSG1 twisted gastrulation BMP signaling modulator 1 involved_in IDA (PMID:17164348) BHF-UCL
BHF-UCL
PMID:17164348 NCBI chr18:9,334,773...9,402,420
Ensembl chr18:9,334,767...9,402,420
JBrowse link
G VSIR V-set immunoregulatory receptor involved_in
acts_upstream_of_or_within
IMP
ISO
(PMID:24691993)
(MGI:5292805|PMID:21383057)
UniProt
UniProt
MGI
PMID:21383057 PMID:24691993 MGI:5292805 NCBI chr10:71,747,556...71,773,520
Ensembl chr10:71,747,556...71,773,520
JBrowse link
G XCL1 X-C motif chemokine ligand 1 involved_in IDA (PMID:10887101) BHF-UCL
BHF-UCL
PMID:10887101 NCBI chr 1:168,576,605...168,582,069
Ensembl chr 1:168,576,605...168,582,069
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD274 CD274 molecule involved_in IMP (PMID:28813410), (PMID:28813417) UniProt
UniProt
PMID:28813410 PMID:28813417 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G HFE homeostatic iron regulator involved_in IGI (PMID:24643698) BHF-UCL
BHF-UCL
PMID:24643698 NCBI chr 6:26,087,429...26,098,343
Ensembl chr 6:26,087,281...26,098,343
JBrowse link
G LILRB1 leukocyte immunoglobulin like receptor B1 involved_in IDA (PMID:21213105) UniProt
UniProt
PMID:21213105 NCBI chr19:54,616,322...54,638,022
Ensembl chr19:54,617,158...54,638,022
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOCS1 suppressor of cytokine signaling 1 involved_in ISS
IEA
UniProt
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204
JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 1:155,001,750...155,018,523
Ensembl chr 1:155,002,630...155,018,523
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VSIR V-set immunoregulatory receptor involved_in IMP (PMID:24691993) UniProt
UniProt
PMID:24691993 NCBI chr10:71,747,556...71,773,520
Ensembl chr10:71,747,556...71,773,520
JBrowse link
negative regulation of NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in IDA (PMID:10540326) UniProt
UniProt
PMID:10540326 NCBI chr17:74,466,373...74,484,798
Ensembl chr17:74,466,399...74,484,794
JBrowse link
negative regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZBTB7B zinc finger and BTB domain containing 7B involved_in ISS
IEA
UniProt
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 1:155,001,750...155,018,523
Ensembl chr 1:155,002,630...155,018,523
JBrowse link
negative regulation of T-helper 1 cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G XCL1 X-C motif chemokine ligand 1 involved_in IDA (PMID:10887101) BHF-UCL
BHF-UCL
PMID:10887101 NCBI chr 1:168,576,605...168,582,069
Ensembl chr 1:168,576,605...168,582,069
JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4R interleukin 4 receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3761239|PMID:16424184) Ensembl
Ensembl
MGI
PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778
JBrowse link
G JAK3 Janus kinase 3 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr19:17,824,782...17,847,982
Ensembl chr19:17,824,780...17,848,071
JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,183,731...173,207,331
JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in IMP (PMID:23169781) UniProt
UniProt
PMID:23169781 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,270,477
JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3817792|PMID:18792410)
GO_Central
GO_Central
MGI
PMID:18792410 PMID:21873635 MGI:3817792 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 1:173,931,084...174,022,357
Ensembl chr 1:173,931,084...174,022,357
JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:122,844,556...122,905,359
Ensembl chr 9:122,844,556...122,905,359
JBrowse link
G SMAD7 SMAD family member 7 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965
JBrowse link
G TBX21 T-box transcription factor 21 involved_in ISS
IEA
UniProt
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5450776|PMID:23034280) Ensembl
Ensembl
MGI
PMID:23034280 GO_REF:0000107 MGI:5450776 NCBI chr 1:155,001,750...155,018,523
Ensembl chr 1:155,002,630...155,018,523
JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 1:37,474,580...37,484,377
Ensembl chr 1:37,474,580...37,484,377
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOXL3 lysyl oxidase like 3 involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:74,532,258...74,555,702
Ensembl chr 2:74,532,258...74,555,690
JBrowse link
G TBX21 T-box transcription factor 21 involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:173,039,202...173,050,941
Ensembl chr 1:173,039,202...173,050,941
JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IBA
IDA
(PMID:21873635)
(PMID:17008549)
GO_Central
UniProt
GO_Central
UniProt
PMID:17008549 PMID:21873635 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2450484|PMID:12594267) Ensembl
Ensembl
MGI
PMID:12594267 GO_REF:0000107 MGI:2450484 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725
JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3761239|PMID:16424184) Ensembl
Ensembl
MGI
PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chr 1:220,879,443...220,885,059
Ensembl chr 1:220,879,431...220,885,059
JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:46,698,937...46,763,129
Ensembl chr 2:46,698,952...46,780,245
JBrowse link
G ZNF271P zinc finger protein 271, pseudogene acts_upstream_of_or_within ISO (MGI:4366385|PMID:19783676) MGI PMID:19783676 MGI:4366385 NCBI chr18:35,290,272...35,310,766
Ensembl chr18:35,290,276...35,328,390
JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RC3H1 ring finger and CCCH-type domains 1 involved_in
acts_upstream_of_or_within
ISS
IEA
ISO
(MGI:3580753|PMID:15917799) BHF-UCL
Ensembl
BHF-UCL
MGI
PMID:15917799 GO_REF:0000024 GO_REF:0000107 MGI:3580753 NCBI chr 1:173,931,084...174,022,357
Ensembl chr 1:173,931,084...174,022,357
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19733
    immune system process 3058
      leukocyte activation 1179
        lymphocyte activation 977
          T cell activation 635
            alpha-beta T cell activation 206
              negative regulation of alpha-beta T cell activation 49
                negative regulation of CD4-positive, alpha-beta T cell activation + 39
                negative regulation of CD8-positive, alpha-beta T cell activation + 6
                negative regulation of NK T cell activation + 2
                negative regulation of alpha-beta T cell differentiation + 27
                negative regulation of alpha-beta T cell proliferation + 20
Path 2
Term Annotations click to browse term
  biological_process 19733
    biological regulation 13881
      regulation of biological process 13143
        regulation of cellular process 12165
          regulation of cell adhesion 908
            regulation of cell-cell adhesion 550
              regulation of leukocyte cell-cell adhesion 417
                negative regulation of leukocyte cell-cell adhesion 171
                  negative regulation of T cell activation 152
                    negative regulation of alpha-beta T cell activation 49
                      negative regulation of CD4-positive, alpha-beta T cell activation + 39
                      negative regulation of CD8-positive, alpha-beta T cell activation + 6
                      negative regulation of NK T cell activation + 2
                      negative regulation of alpha-beta T cell differentiation + 27
                      negative regulation of alpha-beta T cell proliferation + 20
paths to the root