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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of insulin receptor signaling pathway
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Accession:GO:0046628 term browser browse the term
Definition:Any process that increases the frequency, rate or extent of insulin receptor signaling.
Synonyms:exact_synonym: positive regulation of insulin receptor signalling pathway;   up regulation of insulin receptor signaling pathway;   upregulation of insulin receptor signaling pathway
 narrow_synonym: activation of insulin receptor signaling pathway;   stimulation of insulin receptor signaling pathway

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positive regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 ISO RGD PMID:18394428 RGD:2317907 NCBI chrNW_004955406:38,939,167...38,955,647
Ensembl chrNW_004955406:38,936,588...38,955,352 		JBrowse link
G Agt angiotensinogen ISO RGD PMID:24184594 RGD:11039409 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G C1qtnf12 C1q and TNF related 12 acts_upstream_of_or_within ISO (PMID:22275362) MGI PMID:22275362 NCBI chrNW_004955486:9,541,466...9,545,231
Ensembl chrNW_004955486:9,541,367...9,547,097 		JBrowse link
G Gkap1 G kinase anchoring protein 1 involved_in ISO (MGI:6201784|PMID:25586176) UniProt PMID:25586176 MGI:6201784 NCBI chrNW_004955432:3,459,100...3,532,889
Ensembl chrNW_004955432:3,459,103...3,532,889 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:11500506 RGD:13508599 NCBI chrNW_004955532:2,059,038...2,079,120
Ensembl chrNW_004955532:2,059,038...2,079,957 		JBrowse link
G Igf2 insulin like growth factor 2 involved_in ISO (PMID:11500939) BHF-UCL PMID:11500939 NCBI chrNW_004955422:13,880,525...13,907,963
Ensembl chrNW_004955422:13,880,471...13,888,566 		JBrowse link
G Ins insulin involved_in ISO (PMID:7513704)
(PMID:7688386)		 BHF-UCL PMID:7513704 PMID:7688386 NCBI chrNW_004955422:13,909,408...13,910,419
Ensembl chrNW_004955422:13,909,407...13,910,419 		JBrowse link
G Irs1 insulin receptor substrate 1 involved_in ISO (PMID:7493946)
PMID:18285345		 BHF-UCL PMID:7493946 PMID:18285345 RGD:8553881 NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262 		JBrowse link
G Lep leptin ISO RGD PMID:20977462 RGD:5128575 NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472 		JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:25034891 RGD:13204821 NCBI chrNW_004955486:1,937,873...1,962,577
Ensembl chrNW_004955486:1,937,802...1,962,772 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 involved_in ISO (MGI:3640632|PMID:16446356) UniProt PMID:16446356 MGI:3640632 NCBI chrNW_004955405:36,160,360...36,236,258
Ensembl chrNW_004955405:36,160,049...36,237,751 		JBrowse link
G Nucks1 nuclear casein kinase and cyclin dependent kinase substrate 1 acts_upstream_of_or_within ISO (PMID:24931609) MGI PMID:24931609 NCBI chrNW_004955406:41,412,855...41,448,551
Ensembl chrNW_004955406:41,417,983...41,449,177 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase ISO RGD PMID:24085037 RGD:13208948 NCBI chrNW_004955420:14,927,490...15,007,082
Ensembl chrNW_004955420:14,923,575...15,007,081 		JBrowse link
G Osbpl8 oxysterol binding protein like 8 involved_in
acts_upstream_of_or_within		 ISO (MGI:5644010|PMID:23812417)
(PMID:21441927)		 BHF-UCL
MGI		 PMID:21441927 PMID:23812417 MGI:5644010 NCBI chrNW_004955405:15,577,003...15,728,983
Ensembl chrNW_004955405:15,577,003...15,728,983 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO RGD PMID:25199455 RGD:11533947 NCBI chrNW_004955414:14,365,325...14,447,470
Ensembl chrNW_004955414:14,365,157...14,450,611 		JBrowse link
G Prkcz protein kinase C zeta involved_in ISO PMID:9374484 UniProt PMID:9374484 RGD:8553908 NCBI chrNW_004955486:8,947,579...9,021,702
Ensembl chrNW_004955486:8,947,579...9,021,702 		JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 involved_in ISO (PMID:7493946) BHF-UCL PMID:7493946 NCBI chrNW_004955482:8,934,734...9,031,230
Ensembl chrNW_004955482:8,934,306...9,035,203 		JBrowse link
G Serpina12 serpin family A member 12 acts_upstream_of_or_within ISO (PMID:22837305) MGI PMID:22837305 NCBI chrNW_004955438:17,826,596...17,849,341
Ensembl chrNW_004955438:17,833,919...17,849,393 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:21241768) UniProt PMID:21241768 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663 		JBrowse link
G Snx5 sorting nexin 5 involved_in ISO (PMID:25825816) CACAO PMID:25825816 NCBI chrNW_004955415:26,786,836...26,805,762
Ensembl chrNW_004955415:26,785,326...26,796,566 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 involved_in ISO (MGI:3690172|PMID:11001060) UniProt PMID:11001060 MGI:3690172 NCBI chrNW_004955507:1,622,567...1,849,047
Ensembl chrNW_004955507:1,622,567...1,738,423 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:27322061)
(MGI:5811185|PMID:27322061)		 UniProt PMID:27322061 MGI:5811185 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:14985360 RGD:1581139 NCBI chrNW_004955445:19,213,210...19,227,670
Ensembl chrNW_004955445:19,215,161...19,228,695 		JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO (PMID:15249583) MGI PMID:15249583 NCBI chrNW_004955442:15,178,356...15,216,978
Ensembl chrNW_004955442:15,178,487...15,216,362 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6120228|PMID:29420538) UniProt PMID:29420538 MGI:6120228 NCBI chrNW_004955545:1,504,656...1,519,954
Ensembl chrNW_004955545:1,503,514...1,521,003 		JBrowse link
insulin receptor recycling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsd cathepsin D involved_in ISO (PMID:27703010) MGI PMID:27703010 NCBI chrNW_004955422:13,576,315...13,584,267
Ensembl chrNW_004955422:13,576,202...13,584,298 		JBrowse link
G Ide insulin degrading enzyme involved_in ISO (PMID:27703010) MGI PMID:27703010 NCBI chrNW_004955425:819,461...926,440
Ensembl chrNW_004955425:847,615...926,318 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 involved_in ISO (PMID:17068137) MGI PMID:17068137 NCBI chrNW_004955445:7,754,313...7,819,229
Ensembl chrNW_004955445:7,754,319...7,819,275 		JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (PMID:15632081) MGI PMID:15632081 NCBI chrNW_004955402:771,410...846,671 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:27322061) UniProt
MGI		 PMID:27322061 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    cellular process 11480
      signal transduction 3950
        positive regulation of signal transduction 1498
          positive regulation of insulin receptor signaling pathway 29
            insulin receptor recycling 5
            positive regulation of insulin receptor signaling pathway by insulin receptor internalization 0
Path 2
Term Annotations click to browse term
  biological_process 12346
    biological regulation 8880
      regulation of biological process 8618
        signaling 4445
          signal transduction 3950
            cell surface receptor signaling pathway 2177
              enzyme-linked receptor protein signaling pathway 837
                cell surface receptor protein tyrosine kinase signaling pathway 525
                  insulin receptor signaling pathway 127
                    regulation of insulin receptor signaling pathway 76
                      positive regulation of insulin receptor signaling pathway 29
                        insulin receptor recycling 5
                        positive regulation of insulin receptor signaling pathway by insulin receptor internalization 0
paths to the root