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ONTOLOGY REPORT - ANNOTATIONS

Term:S-adenosylmethionine metabolic process
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Accession:GO:0046500 term browser browse the term
Definition:The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.
Synonyms:exact_synonym: S-adenosyl methionine metabolic process;   S-adenosyl methionine metabolism;   S-adenosylmethionine metabolism;   SAM metabolic process


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S-adenosylmethionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 involved_in IEA
ISO		 Ensembl
RGD
Ensembl		 PMID:1415709 PMID:21048303 GO_REF:0000107 RGD:7242909 RGD:7242912 NCBI chr 6:110,814,617...110,895,713
Ensembl chr 6:110,874,770...110,898,879 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase NOT|involved_in IDA (PMID:18230605) BHF-UCL
BHF-UCL		 PMID:18230605 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IDA (PMID:18230605) BHF-UCL
BHF-UCL		 PMID:18230605 NCBI chr 5:79,069,767...79,090,069
Ensembl chr 5:79,069,767...79,090,069 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO RGD PMID:3856245 RGD:2301219 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G GAMT guanidinoacetate N-methyltransferase ISO RGD PMID:15533043 RGD:1359081 NCBI chr19:1,397,026...1,401,542
Ensembl chr19:1,397,026...1,401,570 		JBrowse link
G GNMT glycine N-methyltransferase involved_in IBA
IDA
ISO
IEA		 (PMID:21873635)
(PMID:15340920)		 GO_Central
UniProt
RGD
Ensembl
UniProt
GO_Central		 PMID:12054489 PMID:15340920 PMID:18501206 PMID:21873635 GO_REF:0000107 RGD:7242952 RGD:728472 NCBI chr 6:42,960,754...42,963,880
Ensembl chr 6:42,960,754...42,963,880 		JBrowse link
G HNMT histamine N-methyltransferase ISO RGD PMID:15739896 RGD:152985534 NCBI chr 2:137,964,473...138,016,364
Ensembl chr 2:137,964,020...138,016,364 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in ISO
IEA		 RGD
Ensembl
Ensembl		 PMID:1201245 GO_REF:0000107 RGD:6893692 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase ISO RGD PMID:8263531 RGD:729481 NCBI chr 6:149,749,695...149,811,421
Ensembl chr 6:149,749,443...149,811,420 		JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO RGD PMID:8344945 RGD:729486 NCBI chr17:17,505,563...17,592,142
Ensembl chr17:17,505,563...17,591,708 		JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APIP APAF1 interacting protein involved_in IEA UniProt
UniProt		 GO_REF:0000104 NCBI chr11:34,882,295...34,916,379
Ensembl chr11:34,853,094...34,916,379 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt
UniProt		 GO_REF:0000104 NCBI chr 4:82,430,590...82,461,177
Ensembl chr 4:82,430,590...82,461,177 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt
UniProt		 GO_REF:0000104 NCBI chr19:13,764,522...13,774,282
Ensembl chr19:13,764,522...13,774,282 		JBrowse link
S-adenosylmethionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAT1A methionine adenosyltransferase 1A involved_in IEA
ISS
IBA
IDA
IMP
ISO		 (PMID:21873635)
(PMID:25075345)
(PMID:10677294)		 UniProt
ComplexPortal
GO_Central
UniProt
InterPro
ComplexPortal
RGD
GO_Central		 PMID:9202427 PMID:10677294 PMID:10898761 PMID:19497982 PMID:21873635 More... GO_REF:0000002 GO_REF:0000041 GO_REF:0000114 GO_REF:0000117 RGD:1359039 RGD:7242770 RGD:7242777 NCBI chr10:80,271,820...80,289,658
Ensembl chr10:80,271,820...80,289,658 		JBrowse link
G MAT2A methionine adenosyltransferase 2A involved_in
acts_upstream_of_or_within		 IBA
IEA
IDA
ISO		 (PMID:21873635)
(PMID:10644686), (PMID:25075345)
(MGI:2183618|PMID:12023972)		 GO_Central
GO_Central
UniProt
Ensembl
InterPro
MGI
RGD
UniProt		 PMID:10644686 PMID:10898761 PMID:12023972 PMID:12029623 PMID:21873635 More... GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 GO_REF:0000117 MGI:2183618 RGD:7242777 RGD:727376 NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281 		JBrowse link
G MAT2B methionine adenosyltransferase 2B involved_in IDA
IEA
IBA		 (PMID:10644686), (PMID:25075345)
(PMID:21873635)		 UniProt
UniProt
GO_Central
GO_Central		 PMID:10644686 PMID:21873635 PMID:25075345 GO_REF:0000041 NCBI chr 5:163,503,064...163,519,354
Ensembl chr 5:163,503,114...163,519,558 		JBrowse link
G METTL16 methyltransferase 16, N6-methyladenosine acts_upstream_of IMP
IDA		 (PMID:30197299)
(PMID:28525753), (PMID:30197297)		 UniProt
UniProt		 PMID:28525753 PMID:30197297 PMID:30197299 NCBI chr17:2,415,715...2,511,888
Ensembl chr17:2,405,562...2,511,891 		JBrowse link
S-adenosylmethionine cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr20:34,231,981...34,311,836
Ensembl chr20:34,280,268...34,311,802 		JBrowse link
G AHCYL1 adenosylhomocysteinase like 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 1:109,984,765...110,023,742
Ensembl chr 1:109,984,765...110,023,742 		JBrowse link
G AHCYL2 adenosylhomocysteinase like 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 7:129,225,030...129,430,211
Ensembl chr 7:129,225,030...129,430,211 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISS (PMID:17369066) BHF-UCL
BHF-UCL		 PMID:17369066 NCBI chr 5:7,850,859...7,901,113
Ensembl chr 5:7,851,186...7,906,025 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19769
    metabolic process 13199
      organic substance metabolic process 12735
        S-adenosylmethionine metabolic process 21
          S-adenosylmethionine biosynthetic process 4
          S-adenosylmethionine catabolic process + 0
          S-adenosylmethionine cycle + 7
Path 2
Term Annotations click to browse term
  biological_process 19769
    metabolic process 13199
      cellular metabolic process 10353
        sulfur compound metabolic process 357
          S-adenosylmethionine metabolic process 21
            S-adenosylmethionine biosynthetic process 4
            S-adenosylmethionine catabolic process + 0
            S-adenosylmethionine cycle + 7
paths to the root