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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidic acid metabolic process
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Accession:GO:0046473 term browser browse the term
Definition:The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
Synonyms:exact_synonym: phosphatidic acid metabolism


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phosphatidic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkb diacylglycerol kinase, beta involved_in IDA PMID:23949095 UniProt PMID:23949095 RGD:30309912 NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043 		JBrowse link
G Dgkh diacylglycerol kinase, eta involved_in ISO (PMID:23949095) RGD PMID:23949095 NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706 		JBrowse link
G Lipc lipase C, hepatic type IDA RGD PMID:2223857 RGD:1600650 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lpin1 lipin 1 involved_in ISO (PMID:20231281) RGD PMID:20231281 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Pla2g10 phospholipase A2, group X involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:12359733)		 Ensembl
UniProt
RGD		 PMID:12359733 GO_REF:0000024 GO_REF:0000107 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000 		JBrowse link
G Pla2g2a phospholipase A2 group IIA involved_in ISO (PMID:9032461) RGD PMID:9032461 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:28947740) RGD PMID:28947740 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Pla2g6 phospholipase A2 group VI involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
negative regulation of phosphatidic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpin1 lipin 1 IMP RGD PMID:21715287 RGD:38599010 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
phosphatidic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966 		JBrowse link
G Abhd5 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase involved_in ISO
IBA
IEA
ISS		 (PMID:18606822)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:18606822 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:122,000,241...122,026,447
Ensembl chr 8:122,000,389...122,026,447 		JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:9212163)
(PMID:9299423)
GO_REF:0000033		 RGD
GO_Central		 PMID:9212163 PMID:9299423 GO_REF:0000033 NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278 		JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 involved_in ISO
IBA		 (PMID:9212163)
GO_REF:0000033		 RGD
GO_Central		 PMID:9212163 GO_REF:0000033 NCBI chr 3:9,416,837...9,428,567
Ensembl chr 3:9,416,843...9,428,371 		JBrowse link
G Dgka diacylglycerol kinase, alpha involved_in ISO
IBA
IEA
ISS		 (PMID:15544348), (PMID:2175712), (PMID:22627129)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024
(PMID:23949095)		 RGD
GO_Central
Ensembl
UniProt		 PMID:2175712 PMID:15544348 PMID:22627129 PMID:23949095 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110 		JBrowse link
G Dgkb diacylglycerol kinase, beta involved_in IDA
IBA		 PMID:23949095
GO_REF:0000033		 GO_Central PMID:23949095 GO_REF:0000033, RGD:30309912 NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043 		JBrowse link
G Dgkd diacylglycerol kinase, delta involved_in ISO
IBA		 (PMID:17880279), (PMID:23949095)
GO_REF:0000033		 RGD
GO_Central		 PMID:17880279 PMID:23949095 GO_REF:0000033 NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345 		JBrowse link
G Dgke diacylglycerol kinase epsilon involved_in ISO (PMID:15544348), (PMID:19744926), (PMID:22108654) RGD PMID:15544348 PMID:19744926 PMID:22108654 NCBI chr10:73,853,030...73,877,334
Ensembl chr10:73,855,583...73,877,100 		JBrowse link
G Dgkg diacylglycerol kinase, gamma involved_in ISO
IBA
ISS		 (PMID:8034597)
(PMID:32033984)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:8034597 PMID:32033984 GO_REF:0000024 GO_REF:0000033 NCBI chr11:78,384,212...78,579,158
Ensembl chr11:78,384,458...78,577,212 		JBrowse link
G Dgkh diacylglycerol kinase, eta involved_in IBA
ISO		 GO_REF:0000033
(PMID:27643686)		 GO_Central
RGD		 PMID:27643686 GO_REF:0000033 NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706 		JBrowse link
G Dgki diacylglycerol kinase, iota involved_in IDA
IBA		 PMID:15024004
GO_REF:0000033		 GO_Central PMID:15024004 GO_REF:0000033, RGD:1302915 NCBI chr 4:65,410,878...65,872,733
Ensembl chr 4:65,420,108...65,872,733 		JBrowse link
G Dgkk diacylglycerol kinase kappa involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:15,581,991...15,713,814
Ensembl chr  X:15,583,572...15,712,987 		JBrowse link
G Dgkq diacylglycerol kinase, theta involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:22732145), (PMID:23610160), (PMID:23767959), (PMID:23949095), (PMID:9099683)		 UniProt
GO_Central
RGD		 PMID:9099683 PMID:22732145 PMID:23610160 PMID:23767959 PMID:23949095 GO_REF:0000024 GO_REF:0000033 NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131 		JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:12883552), (PMID:27739494)
GO_REF:0000033
GO_REF:0000107
(PMID:15544348), (PMID:19744926)		 UniProt
RGD
GO_Central
Ensembl		 PMID:12883552 PMID:15544348 PMID:19744926 PMID:27739494 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial involved_in IMP PMID:22905194 UniProt PMID:22905194 RGD:30309909 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gpat2 glycerol-3-phosphate acyltransferase 2, mitochondrial involved_in ISS
ISO		 GO_REF:0000024
(PMID:22905194)		 UniProt
RGD		 PMID:22905194 GO_REF:0000024 NCBI chr 3:114,646,446...114,657,051
Ensembl chr 3:114,648,498...114,657,051 		JBrowse link
G Pld1 phospholipase D1 involved_in
acts_upstream_of_or_within		 IEA
IMP		 GO_REF:0000002
PMID:18519738		 InterPro PMID:18519738 GO_REF:0000002, RGD:8554572 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 involved_in ISO (PMID:22560221) RGD PMID:22560221 NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 acts_upstream_of_or_within ISO (PMID:12456676) RGD PMID:12456676 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 involved_in ISO
IEA		 (PMID:19523918)
GO_REF:0000107		 RGD
Ensembl		 PMID:19523918 GO_REF:0000107 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
positive regulation of phosphatidic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO
IEA		 (PMID:23767959)
GO_REF:0000107		 RGD
Ensembl		 PMID:23767959 GO_REF:0000107 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
regulation of phosphatidic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin involved_in ISO MGI:5014325 (PMID:27806294) RGD PMID:27806294 NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        primary metabolic process 10582
          lipid metabolic process 1452
            phospholipid metabolic process 372
              glycerophospholipid metabolic process 276
                phosphatidic acid metabolic process 29
                  phosphatidic acid biosynthetic process + 24
paths to the root