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ONTOLOGY REPORT - ANNOTATIONS


Term:icosanoid biosynthetic process
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Accession:GO:0046456 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids.
Synonyms:exact_synonym: eicosanoid biosynthesis;   eicosanoid biosynthetic process;   icosanoid anabolism;   icosanoid biosynthesis;   icosanoid formation;   icosanoid synthesis
 xref: Wikipedia:Eicosanoid


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icosanoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase involved_in NAS PMID:15123652 UniProt PMID:15123652, PMID:15123652 RGD:5509794, RGD:5509794 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 involved_in IDA PMID:15766564 UniProt PMID:15766564, PMID:15766564 RGD:14402444, RGD:14402444 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 involved_in IDA PMID:15766564 UniProt PMID:15766564, PMID:15766564 RGD:14402444, RGD:14402444 NCBI chr 1:263,778,510...263,803,166
Ensembl chr 1:263,778,516...263,803,150
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 involved_in ISO (PMID:15766564) RGD PMID:15766564 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:12857783, PMID:21873635, PMID:21873635 RGD:1625451, RGD:13792537, RGD:13792537 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:12857783, PMID:21873635, PMID:21873635 RGD:1625451, RGD:13792537, RGD:13792537 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:12857783, PMID:21873635, PMID:21873635 RGD:1625451, RGD:13792537, RGD:13792537 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 5:133,978,953...134,008,255
Ensembl chr 5:133,978,954...134,008,255
JBrowse link
G Pla2g4a phospholipase A2 group IVA acts_upstream_of_or_within ISO (MGI:3709446|PMID:17293613) RGD PMID:17293613 MGI:3709446 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
cyclooxygenase pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb1 bradykinin receptor B1 involved_in ISO (PMID:23846981) RGD PMID:23846981 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 involved_in ISO
IEA
(PMID:1380156)
GO_REF:0000107
RGD
Ensembl
PMID:1380156 GO_REF:0000107 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:5315361|PMID:12925531)
(MGI:52337|PMID:1419907)
(PMID:1380156), (PMID:7592599), (PMID:7947975)
(MGI:52337|PMID:1419907), (MGI:5315361|PMID:12925531)
UniProt
RGD
PMID:1380156 PMID:1419907 PMID:7592599 PMID:7947975 PMID:12925531 GO_REF:0000024 MGI:52337 MGI:5315361 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO MGI:218209|MGI:5758867 (MGI:6093414|PMID:28973536) RGD PMID:28973536 MGI:6093414 NCBI chr10:53,595,854...53,608,437
Ensembl chr10:53,595,854...53,608,435
JBrowse link
G Sphk1 sphingosine kinase 1 IDA RGD PMID:18723875 RGD:2311353 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
leukotriene A4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISO
ISS
IEA
(PMID:24282679), (PMID:31664810)
GO_REF:0000024
GO_REF:0000107
(MGI:6392995|PMID:31642348)
RGD
UniProt
Ensembl
PMID:24282679 PMID:31642348 PMID:31664810 GO_REF:0000024 GO_REF:0000107 MGI:6392995 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
leukotriene biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in
acts_upstream_of_or_within
TAS
ISO
ISS
(MGI:1933116|PMID:7809134)
MGI:1933120 (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
GO_REF:0000024
(PMID:21233389), (PMID:24893149)
MGI:1933120 (MGI:1933116|PMID:7809134), (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
RGD
UniProt
PMID:7809134 PMID:9091580 PMID:19075240 PMID:21233389 PMID:24893149, PMID:3417684 GO_REF:0000024 MGI:1933116 MGI:3821938 MGI:86611, RGD:632194 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
MGI:2156546 (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
PMID:21873635
(PMID:2300173)
RGD PMID:2300173 PMID:9091580 PMID:19075240, PMID:2300173, PMID:21873635, PMID:21873635, PMID:19075240 MGI:3821938 MGI:86611, RGD:69749, RGD:13792537, RGD:13792537, RGD:2313889 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
JBrowse link
G Lta4h leukotriene A4 hydrolase involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:11675384), (PMID:15078870), (PMID:9774412)
UniProt
RGD
PMID:9774412 PMID:11675384 PMID:15078870, PMID:21873635, PMID:21873635 GO_REF:0000024, RGD:13792537, RGD:13792537 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Ltc4s leukotriene C4 synthase involved_in TAS
IBA
IDA
PMID:21873635 RGD
GO_Central
PMID:12767051, PMID:21873635, PMID:21873635, PMID:14637132 RGD:724432, RGD:13792537, RGD:13792537, RGD:2302289 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO
IBA
(PMID:23409838), (PMID:8703034), (PMID:9092565)
PMID:21873635
RGD PMID:8703034 PMID:9092565 PMID:23409838, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 involved_in ISO (PMID:9278457) RGD PMID:9278457 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
JBrowse link
G Pla2g1b phospholipase A2 group IB involved_in ISO (PMID:16005851) RGD PMID:16005851 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in ISO
IEA
(PMID:18451993)
(MGI:1100763|PMID:9403693)
GO_REF:0000107
RGD
Ensembl
PMID:9403693 PMID:18451993 GO_REF:0000107 MGI:1100763 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IDA
ISO
(PMID:20432503) RGD PMID:20432503, PMID:11106649 RGD:2303037 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:72,395,194...72,401,254
Ensembl chr 3:72,395,218...72,401,318
JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within
involved_in
IEA
ISO
GO_REF:0000107
MGI:2384078 (MGI:85068|PMID:9000133)
Ensembl
RGD
PMID:9000133 GO_REF:0000107 MGI:85068 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
leukotriene D4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07044631.2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 Ensembl chr20:13,988,442...14,001,269 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:14754911), (PMID:21447318) RGD PMID:14754911 PMID:21447318 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 acts_upstream_of_or_within
involved_in
ISO
IBA
ISS
(PMID:1676842), (PMID:21447318)
MGI:2182354 (MGI:1306746|PMID:9774450), (MGI:2384601|PMID:12163373)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:1676842 PMID:9774450 PMID:12163373 PMID:21447318, PMID:21873635, PMID:21873635 GO_REF:0000024 MGI:1306746 MGI:2384601, RGD:13792537, RGD:13792537 NCBI chr20:13,988,444...14,001,296 JBrowse link
negative regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:3863495) RGD PMID:3863495 NCBI chr15:83,494,110...83,663,202
Ensembl chr15:83,495,377...83,663,143
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:5306564|PMID:20042607) RGD PMID:20042607 MGI:5306564 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
positive regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:8260938, PMID:21873635, PMID:21873635 RGD:2306959, RGD:13792537, RGD:13792537 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Avp arginine vasopressin IMP RGD PMID:17254553 RGD:2300349 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:17254553 RGD:2300349 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Cd74 CD74 molecule involved_in ISO (PMID:24569872) RGD PMID:24569872 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO
GO_REF:0000107
RNAcentral:URS0000424278_9606 (PMID:29384235)
Ensembl
RGD
PMID:29384235 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:9786861 RGD:2304243 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:23624557)
(MGI:5492190|PMID:23624557)
RGD PMID:23624557 MGI:5492190 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Pla2g4a phospholipase A2 group IVA IMP RGD PMID:16203828 RGD:1642461 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISO (PMID:21716255)
(MGI:5474549|PMID:21716255)
RGD PMID:21716255 MGI:5474549 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07034131.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 Ensembl chr11:54,829,620...54,830,081 JBrowse link
G AABR07054614.1 involved_in IBA
IEA
PMID:21873635
GO_REF:0000043
UniProt PMID:21873635, PMID:21873635 GO_REF:0000043, RGD:13792537, RGD:13792537 Ensembl chr 3:163,950,777...163,986,059 JBrowse link
G Cd74 CD74 molecule involved_in ISO
ISS
(PMID:12782713)
GO_REF:0000024
RGD
UniProt
PMID:12782713 GO_REF:0000024 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Daglb diacylglycerol lipase, beta involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6414691|PMID:23103940)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:23103940 GO_REF:0000024 GO_REF:0000107 MGI:6414691 NCBI chr12:13,113,073...13,157,748
Ensembl chr12:13,113,237...13,157,666
JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:9492062) RGD PMID:9492062 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 involved_in ISO
IEA
(PMID:9492062)
(MGI:3847878|PMID:9492062)
GO_REF:0000107
RGD
Ensembl
PMID:9492062 GO_REF:0000107 MGI:3847878 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase TAS RGD PMID:9323136 RGD:68838 NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:12782713) RGD PMID:12782713 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Pla2g10 phospholipase A2, group X involved_in IEA
ISO
GO_REF:0000107
(MGI:5818640|PMID:27292189)
Ensembl
RGD
PMID:27292189 GO_REF:0000107 MGI:5818640 NCBI chr10:1,509,732...1,520,970
Ensembl chr10:1,509,732...1,520,970
JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in ISO
ISS
IEA
(PMID:18451993), (PMID:27642067)
(MGI:1100762|PMID:9403692), (MGI:1100763|PMID:9403693)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000041
RGD
UniProt
Ensembl
PMID:9403692 PMID:9403693 PMID:18451993 PMID:27642067 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 MGI:1100762 MGI:1100763 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Pla2g4f phospholipase A2, group IVF acts_upstream_of_or_within ISO (MGI:3709446|PMID:17293613) RGD PMID:17293613 MGI:3709446 NCBI chr 3:112,068,617...112,083,978
Ensembl chr 3:112,072,330...112,084,144
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 involved_in ISO (PMID:15695510) RGD PMID:15695510 NCBI chr 6:64,224,870...64,288,465
Ensembl chr 6:64,224,861...64,286,785
JBrowse link
G Prxl2b peroxiredoxin like 2B involved_in ISS
ISO
GO_REF:0000024
(MGI:3771130|PMID:18006499)
(PMID:18006499)
UniProt
RGD
PMID:18006499, PMID:18006499, PMID:18006499 GO_REF:0000024 MGI:3771130, RGD:8552775, RGD:8552775 NCBI chr 5:172,304,799...172,307,402
Ensembl chr 5:172,304,758...172,307,431
JBrowse link
G Ptgds prostaglandin D2 synthase involved_in IDA
ISO
PMID:7836410
(MGI:3761957|PMID:17715133)
(PMID:20347284), (PMID:20667974)
RGD PMID:17715133 PMID:20347284 PMID:20667974, PMID:7836410, PMID:7836410 MGI:3761957, RGD:8553429, RGD:8553429 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptges prostaglandin E synthase involved_in TAS
ISO
IBA
IEA
IDA
(MGI:6393388|PMID:11795891)
PMID:21873635
(PMID:25726376)
(PMID:18682561)
GO_REF:0000041
RGD
UniProt
PMID:11795891 PMID:18682561 PMID:25726376, PMID:11067848, PMID:21873635, PMID:21873635, PMID:11067848 GO_REF:0000041 MGI:6393388, RGD:67929, RGD:13792537, RGD:13792537, RGD:67929 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptges2 prostaglandin E synthase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:11,424,195...11,431,379
Ensembl chr 3:11,424,099...11,431,402
JBrowse link
G Ptges3 prostaglandin E synthase 3 acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
IEA
ISS
IDA
MGI:3701300 (MGI:3714109|PMID:17438133)
PMID:21873635
GO_REF:0000041
GO_REF:0000024
(PMID:10922363)
RGD
UniProt
PMID:10922363 PMID:17438133, PMID:10922363, PMID:21873635, PMID:21873635, PMID:10922363 GO_REF:0000024 GO_REF:0000041 MGI:3714109, RGD:5688071, RGD:13792537, RGD:13792537, RGD:5688071 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G Ptges3l1 prostaglandin E synthase 3-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr  X:45,410,545...45,419,817
Ensembl chr  X:45,410,546...45,419,817
JBrowse link
G Ptgis prostaglandin I2 synthase involved_in TAS
ISO
ISS
IBA
IDA
(PMID:15115769), (PMID:20122998), (PMID:21296955)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:15115769 PMID:20122998 PMID:21296955, PMID:10359560, PMID:21873635, PMID:21873635, PMID:16094316 GO_REF:0000024, RGD:727270, RGD:13792537, RGD:13792537, RGD:8693629 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 acts_upstream_of_or_within
involved_in
IMP
ISO
ISS
MGI:1857238 (MGI:2181847|PMID:12093889)
GO_REF:0000024
RGD
UniProt
PMID:12093889, PMID:17673564 GO_REF:0000024 MGI:2181847, RGD:2300259 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in IMP
ISO
(MGI:5315361|PMID:12925531)
(PMID:27642067)
RGD PMID:12925531 PMID:27642067, PMID:17673564 MGI:5315361, RGD:2300259 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tbxas1 thromboxane A synthase 1 involved_in ISO
ISS
(PMID:11097184)
GO_REF:0000024
RGD
UniProt
PMID:11097184 GO_REF:0000024 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp5 fatty acid binding protein 5 involved_in ISO (MGI:6157571|PMID:29440395) RGD PMID:29440395 MGI:6157571 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
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  biological_process 20082
    metabolic process 12142
      small molecule metabolic process 1824
        organic acid metabolic process 1018
          organic acid biosynthetic process 298
            carboxylic acid biosynthetic process 290
              icosanoid biosynthetic process 56
                leukotriene biosynthetic process + 15
                prostanoid biosynthetic process + 34
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  biological_process 20082
    metabolic process 12142
      cellular metabolic process 11078
        organic acid metabolic process 1018
          oxoacid metabolic process 980
            carboxylic acid metabolic process 961
              icosanoid metabolic process 139
                icosanoid biosynthetic process 56
                  leukotriene biosynthetic process + 15
                  prostanoid biosynthetic process + 34
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