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ONTOLOGY REPORT - ANNOTATIONS

Term:icosanoid biosynthetic process
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Accession:GO:0046456 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids.
Synonyms:exact_synonym: eicosanoid biosynthesis;   eicosanoid biosynthetic process;   eoxin biosynthesis;   eoxin synthesis;   icosanoid anabolism;   icosanoid biosynthesis;   icosanoid formation;   icosanoid synthesis
 xref: Wikipedia:Eicosanoid


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icosanoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase involved_in NAS PMID:15123652 UniProt PMID:15123652 RGD:5509794 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 involved_in IDA PMID:15766564 UniProt PMID:15766564 RGD:14402444 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 involved_in IDA PMID:15766564 UniProt PMID:15766564 RGD:14402444 NCBI chr 1:242,889,218...242,913,869
Ensembl chr 1:242,889,224...242,913,858 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 involved_in ISO (PMID:15766564) RGD PMID:15766564
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 involved_in IMP
IBA		 PMID:21873635 RGD
GO_Central		 PMID:12857783 PMID:21873635 RGD:1625451, RGD:13792537 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 involved_in IMP
IBA		 PMID:21873635 RGD
GO_Central		 PMID:12857783 PMID:21873635 RGD:1625451, RGD:13792537 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 involved_in IMP
IBA		 PMID:21873635 RGD
GO_Central		 PMID:12857783 PMID:21873635 RGD:1625451, RGD:13792537 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463 		JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476 		JBrowse link
G Pla2g4a phospholipase A2 group IVA acts_upstream_of_or_within ISO (MGI:3709446|PMID:17293613) RGD PMID:17293613 MGI:3709446 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
cyclooxygenase pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb1 bradykinin receptor B1 involved_in ISO (PMID:23846981) RGD PMID:23846981 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 involved_in IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
(PMID:1380156)		 Ensembl
RGD		 PMID:1380156 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in
acts_upstream_of_or_within		 ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(MGI:5315361|PMID:12925531)
(MGI:52337|PMID:1419907)
(PMID:1380156), (PMID:7592599), (PMID:7947975)		 UniProt
RGD		 PMID:1380156 PMID:1419907 PMID:7592599 PMID:7947975 PMID:12925531 More... GO_REF:0000024 MGI:52337 MGI:5315361, RGD:13792537 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO MGI:2182095|MGI:5758867 (MGI:6093414|PMID:28973536) RGD PMID:28973536 MGI:6093414 NCBI chr10:51,744,656...51,757,246
Ensembl chr10:51,744,656...51,757,237 		JBrowse link
G Sphk1 sphingosine kinase 1 IDA RGD PMID:18723875 RGD:2311353 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
leukotriene A4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24282679), (PMID:31664810)
(MGI:6392995|PMID:31642348)		 UniProt
Ensembl
RGD		 PMID:24282679 PMID:31642348 PMID:31664810 GO_REF:0000024 GO_REF:0000107 MGI:6392995 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
leukotriene biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase acts_upstream_of_or_within
involved_in		 TAS
ISO
ISS		 (MGI:3821938|PMID:19075240)
(MGI:1933116|PMID:7809134)
MGI:1933120 (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
GO_REF:0000024
(PMID:21233389), (PMID:24893149)		 RGD
UniProt		 PMID:7809134 PMID:9091580 PMID:19075240 PMID:21233389 PMID:24893149 More... GO_REF:0000024 MGI:1933116 MGI:3821938 MGI:86611, RGD:632194 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein involved_in
acts_upstream_of_or_within		 IDA
IBA
ISO		 PMID:21873635
MGI:2156546 (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
(PMID:2300173)		 RGD PMID:2300173 PMID:9091580 PMID:19075240 PMID:2300173 PMID:21873635 More... MGI:3821938 MGI:86611, RGD:69749, RGD:13792537, RGD:2313889 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Lta4h leukotriene A4 hydrolase involved_in ISO
IBA
ISS		 (PMID:11675384), (PMID:15078870), (PMID:9774412)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:9774412 PMID:11675384 PMID:15078870 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Ltc4s leukotriene C4 synthase involved_in TAS
IBA
IDA		 PMID:21873635 RGD
GO_Central		 PMID:12767051 PMID:21873635 PMID:14637132 RGD:724432, RGD:13792537, RGD:2302289 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO
IBA		 (PMID:23409838), (PMID:8703034), (PMID:9092565)
PMID:21873635		 RGD PMID:8703034 PMID:9092565 PMID:23409838 PMID:21873635 RGD:13792537 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 involved_in ISO (PMID:9278457) RGD PMID:9278457 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Pla2g1b phospholipase A2 group IB involved_in ISO (PMID:16005851) RGD PMID:16005851 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226 		JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in ISO (PMID:18451993)
(MGI:1100763|PMID:9403693)		 RGD PMID:9403693 PMID:18451993 MGI:1100763 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IDA
ISO		 (PMID:20432503) RGD PMID:20432503 PMID:11106649 RGD:2303037 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2384078 (MGI:85068|PMID:9000133)		 Ensembl
RGD		 PMID:9000133 GO_REF:0000107 MGI:85068 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
leukotriene D4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:14754911), (PMID:21447318) RGD PMID:14754911 PMID:21447318 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA
ISS		 (PMID:1676842), (PMID:21447318)
GO_REF:0000107
MGI:2182354 (MGI:1306746|PMID:9774450), (MGI:2384601|PMID:12163373)
PMID:21873635
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:1676842 PMID:9774450 PMID:12163373 PMID:21447318 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:1306746 MGI:2384601, RGD:13792537 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450 		JBrowse link
negative regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir204 microRNA 204 involved_in ISO (PMID:29441883) RGD PMID:29441883 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:3863495) RGD PMID:3863495 NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:5306564|PMID:20042607) RGD PMID:20042607 MGI:5306564 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
positive regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IMP
IBA		 PMID:21873635 RGD
GO_Central		 PMID:8260938 PMID:21873635 RGD:2306959, RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Avp arginine vasopressin IMP RGD PMID:17254553 RGD:2300349 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:17254553 RGD:2300349 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Cd74 CD74 molecule involved_in ISO (PMID:24569872) RGD PMID:24569872 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO RNAcentral:URS0000424278_9606 (PMID:29384235) RGD PMID:29384235 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:9786861 RGD:2304243 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:23624557)
(MGI:5492190|PMID:23624557)		 RGD PMID:23624557 MGI:5492190 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Pla2g4a phospholipase A2 group IVA IMP RGD PMID:16203828 RGD:1642461 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:24287039) RGD PMID:24287039 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISO (PMID:21716255)
(MGI:5474549|PMID:21716255)		 RGD PMID:21716255 MGI:5474549 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07054614.1 involved_in IEA
IBA		 GO_REF:0000043
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000043, RGD:13792537
G Cd74 CD74 molecule involved_in ISO
ISS		 (PMID:12782713)
GO_REF:0000024		 RGD
UniProt		 PMID:12782713 GO_REF:0000024 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Daglb diacylglycerol lipase, beta involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:6414691|PMID:23103940)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23103940 GO_REF:0000024 GO_REF:0000107 MGI:6414691 NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154 		JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:9492062) RGD PMID:9492062 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn2 endothelin 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3847878|PMID:9492062)
(PMID:9492062)		 Ensembl
RGD		 PMID:9492062 GO_REF:0000107 MGI:3847878 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814 		JBrowse link
G Hpgds hematopoietic prostaglandin D synthase TAS RGD PMID:9323136 RGD:68838 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:12782713) RGD PMID:12782713 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Pla2g10 phospholipase A2, group X involved_in IEA
ISO		 GO_REF:0000107
(MGI:5818640|PMID:27292189)		 Ensembl
RGD		 PMID:27292189 GO_REF:0000107 MGI:5818640 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000 		JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in ISO
ISS
IEA		 (PMID:18451993), (PMID:27642067)
(MGI:1100762|PMID:9403692), (MGI:1100763|PMID:9403693)
GO_REF:0000024
GO_REF:0000041		 RGD
UniProt		 PMID:9403692 PMID:9403693 PMID:18451993 PMID:27642067 GO_REF:0000024 GO_REF:0000041 MGI:1100762 MGI:1100763 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pla2g4f phospholipase A2, group IVF acts_upstream_of_or_within ISO (MGI:3709446|PMID:17293613) RGD PMID:17293613 MGI:3709446 NCBI chr 3:107,249,053...107,266,201
Ensembl chr 3:107,250,075...107,264,689 		JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 involved_in ISO (PMID:15695510) RGD PMID:15695510 NCBI chr 6:61,329,810...61,391,736
Ensembl chr 6:61,329,810...61,391,734 		JBrowse link
G Prxl2b peroxiredoxin like 2B involved_in ISS
ISO		 PMID:18006499
(MGI:3771130|PMID:18006499)
GO_REF:0000024
(PMID:18006499)		 RGD
UniProt		 PMID:18006499 PMID:18006499 GO_REF:0000024 MGI:3771130, RGD:8552775 NCBI chr 5:165,462,610...165,465,213 JBrowse link
G Ptgds prostaglandin D2 synthase involved_in IDA
ISO		 PMID:7836410
(MGI:3761957|PMID:17715133)
(PMID:20347284), (PMID:20667974)		 RGD PMID:17715133 PMID:20347284 PMID:20667974 PMID:7836410 MGI:3761957, RGD:8553429 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptges prostaglandin E synthase involved_in TAS
ISO
IBA
IEA
IDA		 (MGI:6393388|PMID:11795891)
PMID:21873635
(PMID:25726376)
(PMID:18682561)
GO_REF:0000041		 RGD
UniProt		 PMID:11795891 PMID:18682561 PMID:25726376 PMID:11067848 PMID:21873635 More... GO_REF:0000041 MGI:6393388, RGD:67929, RGD:13792537, RGD:67929 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptges2 prostaglandin E synthase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688 		JBrowse link
G Ptges3 prostaglandin E synthase 3 acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA
IEA
ISS
IDA		 MGI:3701300 (MGI:3714109|PMID:17438133)
PMID:21873635
GO_REF:0000041
GO_REF:0000024
(PMID:10922363)		 RGD
UniProt		 PMID:10922363 PMID:17438133 PMID:10922363 PMID:21873635 PMID:10922363 GO_REF:0000024 GO_REF:0000041 MGI:3714109, RGD:5688071, RGD:13792537, RGD:5688071 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptges3l1 prostaglandin E synthase 3-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:42,215,200...42,224,472
Ensembl chr  X:42,214,756...42,225,047 		JBrowse link
G Ptgis prostaglandin I2 synthase involved_in TAS
IEA
ISO
ISS
IBA
IDA		 GO_REF:0000043
(PMID:15115769), (PMID:20122998), (PMID:21296955)
GO_REF:0000024
PMID:21873635		 UniProt
RGD		 PMID:15115769 PMID:20122998 PMID:21296955 PMID:10359560 PMID:21873635 More... GO_REF:0000024 GO_REF:0000043, RGD:727270, RGD:13792537, RGD:8693629 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 acts_upstream_of_or_within
involved_in		 IMP
ISO
ISS		 MGI:1857238 (MGI:2181847|PMID:12093889)
GO_REF:0000024		 RGD
UniProt		 PMID:12093889 PMID:17673564 GO_REF:0000024 MGI:2181847, RGD:2300259 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in IMP
ISO		 (MGI:5315361|PMID:12925531)
(PMID:27642067)		 RGD PMID:12925531 PMID:27642067 PMID:17673564 MGI:5315361, RGD:2300259 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxas1 thromboxane A synthase 1 involved_in ISO
ISS		 (PMID:11097184)
GO_REF:0000024		 RGD
UniProt		 PMID:11097184 GO_REF:0000024 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp5 fatty acid binding protein 5 involved_in ISO (MGI:6157571|PMID:29440395) RGD PMID:29440395 MGI:6157571 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    metabolic process 11591
      small molecule metabolic process 1834
        organic acid metabolic process 1001
          organic acid biosynthetic process 307
            carboxylic acid biosynthetic process 305
              icosanoid biosynthetic process 56
                leukotriene biosynthetic process + 14
                prostanoid biosynthetic process + 35
Path 2
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  biological_process 18877
    metabolic process 11591
      cellular metabolic process 9831
        organic acid metabolic process 1001
          oxoacid metabolic process 987
            carboxylic acid metabolic process 972
              icosanoid metabolic process 138
                icosanoid biosynthetic process 56
                  leukotriene biosynthetic process + 14
                  prostanoid biosynthetic process + 35
paths to the root