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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of receptor signaling pathway via JAK-STAT
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Accession:GO:0046427 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
Synonyms:exact_synonym: up regulation of JAK-STAT cascade;   upregulation of JAK-STAT cascade
 narrow_synonym: activation of JAK-STAT cascade;   positive regulation of STAT protein import into nucleus;   positive regulation of STAT protein nuclear translocation;   stimulation of JAK-STAT cascade
 alt_id: GO:2000366

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positive regulation of receptor signaling pathway via JAK-STAT term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 ISO RGD PMID:18394428 RGD:2317907 NCBI chrNW_004936567:1,658,405...1,674,794
Ensembl chrNW_004936567:1,658,383...1,676,199 		JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20075866) Ensembl
MGI		 PMID:20075866 GO_REF:0000107 NCBI chrNW_004936646:1,865,154...1,881,614
Ensembl chrNW_004936646:1,865,395...1,876,453 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B ISO RGD PMID:15746188 RGD:1626095 NCBI chrNW_004936579:1,312,175...1,328,397 JBrowse link
G Calm1 calmodulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:17,580,425...17,588,480
Ensembl chrNW_004936488:17,580,454...17,588,507 		JBrowse link
G Calm2 calmodulin 2 involved_in ISO (PMID:11972023), (PMID:35568036) UniProt PMID:11972023 PMID:35568036 NCBI chrNW_004936508:5,207,909...5,223,780
Ensembl chrNW_004936508:5,207,904...5,223,780 		JBrowse link
G Calm3 calmodulin 3 involved_in ISO (PMID:11972023), (PMID:35568036) UniProt PMID:11972023 PMID:35568036 NCBI chrNW_004936664:471,446...480,858
Ensembl chrNW_004936664:471,440...480,441 		JBrowse link
G Camk2a calcium/calmodulin dependent protein kinase II alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936504:4,636,863...4,700,887
Ensembl chrNW_004936504:4,638,176...4,700,984 		JBrowse link
G Cenpj centromere protein J acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12198240) MGI
Ensembl		 PMID:12198240 GO_REF:0000107 NCBI chrNW_004936720:2,149,296...2,201,599
Ensembl chrNW_004936720:2,149,302...2,204,139 		JBrowse link
G Cntf ciliary neurotrophic factor ISO RGD PMID:15574731 RGD:1626128 NCBI chrNW_004936581:3,710,171...3,715,753
Ensembl chrNW_004936581:3,710,160...3,715,638 		JBrowse link
G Crlf3 cytokine receptor like factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:2,877,564...2,916,952
Ensembl chrNW_004936538:2,877,564...2,916,925 		JBrowse link
G Ep300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:696,982...778,132
Ensembl chrNW_004936492:696,960...778,138 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936586:4,065,767...5,100,690
Ensembl chrNW_004936586:4,066,498...5,100,035 		JBrowse link
G Ghr growth hormone receptor involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:10976913 PMID:11064147 GO_REF:0000118 RGD:1624963 RGD:1624964 NCBI chrNW_004936518:235,996...380,225
Ensembl chrNW_004936518:235,990...380,272 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936711:640,002...642,580
Ensembl chrNW_004936711:639,905...642,622 		JBrowse link
G Hes5 hes family bHLH transcription factor 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936737:1,045,496...1,047,865
Ensembl chrNW_004936737:1,046,613...1,047,950 		JBrowse link
G Ifne interferon epsilon involved_in ISO (PMID:23964570) CACAO PMID:23964570 NCBI chrNW_004936652:3,140,568...3,141,122
Ensembl chrNW_004936652:3,140,568...3,141,122 		JBrowse link
G Il10 interleukin 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:3,099,484...3,113,159
Ensembl chrNW_004936542:3,099,430...3,113,210 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:9,033,077...9,057,465
Ensembl chrNW_004936500:9,030,809...9,057,519 		JBrowse link
G Il26 interleukin 26 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:6,143,665...6,207,430
Ensembl chrNW_004936545:6,191,368...6,207,597 		JBrowse link
G Il5 interleukin 5 ISO RGD PMID:10867506 RGD:2303751 NCBI chrNW_004936647:2,647,982...2,651,477
Ensembl chrNW_004936647:2,648,241...2,651,430 		JBrowse link
G Il6 interleukin 6 involved_in ISO
IEA		 STAT3 phosphorylation RGD
TreeGrafter		 PMID:15659221 PMID:16413512 GO_REF:0000118 RGD:1580483 RGD:1641883 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Jak2 Janus kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867 		JBrowse link
G Kit KIT proto-oncogene, receptor tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936482:17,162,854...17,238,319
Ensembl chrNW_004936482:17,162,950...17,238,274 		JBrowse link
G Lep leptin involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:21250909 GO_REF:0000107 GO_REF:0000118 RGD:5128518 NCBI chrNW_004936479:15,394,966...15,411,334
Ensembl chrNW_004936479:15,394,966...15,411,334 		JBrowse link
G LOC101969021 somatotropin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936541:4,524,397...4,528,234 JBrowse link
G LOC101970101 cytochrome P450 1B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936663:345,021...355,188
Ensembl chrNW_004936663:348,368...355,191 		JBrowse link
G Notch1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:1,292,016...1,334,061
Ensembl chrNW_004936669:1,292,088...1,332,428 		JBrowse link
G Prl prolactin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12388746) TreeGrafter
MGI		 PMID:12388746 GO_REF:0000118 NCBI chrNW_004936552:7,204,298...7,212,632 JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 acts_upstream_of_or_within ISO (PMID:23839944) MGI PMID:23839944 NCBI chrNW_004936471:33,224,174...33,245,076
Ensembl chrNW_004936471:33,224,859...33,245,030 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO PMID:29702085 ARUK-UCL PMID:29702085 RGD:13800534 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Tyk2 tyrosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:681,463...704,484
Ensembl chrNW_004936659:681,310...702,962 		JBrowse link
G Usp1 ubiquitin specific peptidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936692:147,699...159,921
Ensembl chrNW_004936692:148,116...159,170 		JBrowse link
G Wdr48 WD repeat domain 48 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:28,307,913...28,351,727
Ensembl chrNW_004936473:28,307,875...28,354,279 		JBrowse link
activation of Janus kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:9314843 RGD:6478796 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G Ghr growth hormone receptor ISO RGD PMID:11244571 RGD:1624962 NCBI chrNW_004936518:235,996...380,225
Ensembl chrNW_004936518:235,990...380,272 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO RGD PMID:11818507 RGD:633057 NCBI chrNW_004936675:216,970...325,670
Ensembl chrNW_004936675:275,288...324,810 		JBrowse link
negative regulation of activation of Janus kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnf4a hepatocyte nuclear factor 4 alpha ISO RGD PMID:16584384 RGD:1625011 NCBI chrNW_004936530:2,401,053...2,425,989
Ensembl chrNW_004936530:2,401,043...2,454,466 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15871
    response to stimulus 8520
      positive regulation of response to stimulus 2234
        positive regulation of signal transduction 1573
          positive regulation of receptor signaling pathway via STAT 44
            positive regulation of receptor signaling pathway via JAK-STAT 37
              activation of Janus kinase activity + 4
Path 2
Term Annotations click to browse term
  biological_process 15871
    biological regulation 11036
      regulation of biological process 10703
        signaling 6159
          signal transduction 5667
            cell surface receptor signaling pathway 2506
              cell surface receptor signaling pathway via STAT 152
                regulation of receptor signaling pathway via STAT 88
                  regulation of receptor signaling pathway via JAK-STAT 78
                    positive regulation of receptor signaling pathway via JAK-STAT 37
                      activation of Janus kinase activity + 4
paths to the root