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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of JNK cascade
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Accession:GO:0046329 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
Synonyms:exact_synonym: down regulation of JNK cascade;   downregulation of JNK cascade
 narrow_synonym: inhibition of JNK cascade


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negative regulation of JNK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated involved_in
acts_upstream_of_or_within		 IMP
IPI
ISO		 (MGI:3799599|PMID:17681137)
(PMID:17681137)		 UniProt
MGI		 PMID:17681137 MGI:3799599 NCBI chr 1:183,078,604...183,105,356
Ensembl chr 1:183,078,134...183,106,331 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 involved_in ISO RGD
MGI		 PMID:17064355 GO_REF:0000096 MGI:4417868 RGD:2298577 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Cdc42se1 CDC42 small effector 1 acts_upstream_of_or_within ISS (PMID:10910960) MGI PMID:10910960 NCBI chr 3:95,135,735...95,143,735
Ensembl chr 3:95,136,043...95,143,720 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in IDA
ISO		 (MGI:6162308|PMID:29291351) UniProt
MGI		 PMID:29291351 GO_REF:0000119 MGI:4834177 MGI:6162308 NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573 		JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 involved_in IDA
ISO
IBA		 (MGI:5437437|PMID:17197390) UniProt
MGI
GO_Central		 PMID:17197390 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5437437 NCBI chr12:71,356,658...71,366,881
Ensembl chr12:71,356,658...71,366,881 		JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in
acts_upstream_of_or_within		 ISO
IMP		 (PMID:15306813) MGI PMID:15306813 GO_REF:0000119 MGI:4834177 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833 		JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in IDA (MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:2182169 NCBI chr 2:80,447,558...80,462,005
Ensembl chr 2:80,447,389...80,462,705 		JBrowse link
G Dusp3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:101,861,967...101,877,839
Ensembl chr11:101,861,969...101,877,839 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735 		JBrowse link
G Fktn fukutin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:53,713,745...53,765,785
Ensembl chr 4:53,713,998...53,777,890 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in IMP
ISO		 (MGI:6148454|PMID:22424771) UniProt
MGI		 PMID:22424771 GO_REF:0000119 MGI:4834177 MGI:6148454 NCBI chr11:69,804,805...69,807,882
Ensembl chr11:69,804,714...69,807,417 		JBrowse link
G Hdac3 histone deacetylase 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069 		JBrowse link
G Itch itchy, E3 ubiquitin protein ligase involved_in IMP (MGI:3774677|PMID:18246070) BHF-UCL PMID:18246070 MGI:3774677 NCBI chr 2:154,975,401...155,068,775
Ensembl chr 2:154,975,429...155,068,775 		JBrowse link
G Klhl31 kelch-like 31 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:77,544,014...77,567,407
Ensembl chr 9:77,543,782...77,567,409 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in ISO RGD
MGI		 PMID:12064607 GO_REF:0000096 MGI:4417868 RGD:1299562 NCBI chr 2:92,214,021...92,231,608
Ensembl chr 2:92,214,021...92,231,608 		JBrowse link
G Marveld3 MARVEL (membrane-associating) domain containing 3 acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr 8:110,674,541...110,688,837
Ensembl chr 8:110,674,546...110,688,835 		JBrowse link
G Mecom MDS1 and EVI1 complex locus involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:30,005,445...30,563,937
Ensembl chr 3:30,005,445...30,602,157 		JBrowse link
G Men1 multiple endocrine neoplasia 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 acts_upstream_of_or_within IGI (PMID:22073305) MGI PMID:22073305 NCBI chr11:74,564,775...74,615,210
Ensembl chr11:74,564,775...74,615,496 		JBrowse link
G Per1 period circadian clock 1 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786 		JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992 		JBrowse link
G Sfrp4 secreted frizzled-related protein 4 involved_in ISO RGD
MGI		 PMID:18567805 GO_REF:0000096 MGI:4417868 RGD:4107045 NCBI chr13:19,807,345...19,816,995
Ensembl chr13:19,807,274...19,817,164 		JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr18:42,185,531...42,291,760
Ensembl chr18:42,186,732...42,292,025 		JBrowse link
G Sirpa signal-regulatory protein alpha involved_in IMP (MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:3760575 NCBI chr 2:129,432,962...129,474,148
Ensembl chr 2:129,434,755...129,474,148 		JBrowse link
G Taok3 TAO kinase 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:117,258,180...117,413,283
Ensembl chr 5:117,258,194...117,413,284 		JBrowse link
G Zmynd11 zinc finger, MYND domain containing 11 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:9,734,872...9,816,050
Ensembl chr13:9,734,869...9,815,366 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr 2:92,214,021...92,231,608
Ensembl chr 2:92,214,021...92,231,608 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    negative regulation of biological process 5923
      negative regulation of signaling 1628
        negative regulation of signal transduction 1481
          negative regulation of intracellular signal transduction 632
            negative regulation of MAPK cascade 170
              negative regulation of JNK cascade 27
                negative regulation of JUN kinase activity 1
Path 2
Term Annotations click to browse term
  biological_process 28573
    biological regulation 13112
      regulation of biological process 12722
        regulation of cellular process 12175
          signal transduction 6659
            intracellular signal transduction 2790
              intracellular signaling cassette 1936
                MAPK cascade 811
                  regulation of MAPK cascade 722
                    negative regulation of MAPK cascade 170
                      negative regulation of JNK cascade 27
                        negative regulation of JUN kinase activity 1
paths to the root