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ONTOLOGY REPORT - ANNOTATIONS


Term:aflatoxin catabolic process
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Accession:GO:0046223 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Synonyms:exact_synonym: aflatoxin breakdown;   aflatoxin catabolism;   aflatoxin degradation



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aflatoxin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta3 glutathione S-transferase, alpha 3 acts_upstream_of_or_within IMP (MGI:4429761|PMID:19850059) MGI PMID:19850059 MGI:4429761 NCBI chr 1:21,310,789...21,335,799
Ensembl chr 1:21,310,813...21,335,885
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G Nfe2l2 nuclear factor, erythroid derived 2, like 2 involved_in ISO RGD
MGI
PMID:27071940 GO_REF:0000096 MGI:4417868 RGD:12910550 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28742
    detoxification 96
      toxin catabolic process 2
        mycotoxin catabolic process 2
          aflatoxin catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 28742
    response to stimulus 10791
      response to chemical 5537
        response to toxic substance 268
          detoxification 96
            toxin catabolic process 2
              mycotoxin catabolic process 2
                aflatoxin catabolic process 2
paths to the root