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ONTOLOGY REPORT - ANNOTATIONS


Term:aflatoxin metabolic process
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Accession:GO:0046222 term browser browse the term
Definition:The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Synonyms:exact_synonym: aflatoxin metabolism
 narrow_synonym: aflatoxin B metabolic process
 related_synonym: aflatoxin B1 metabolic process;   aflatoxin B1 metabolism;   aflatoxin B2 metabolic process;   aflatoxin B2 metabolism
 alt_id: GO:0043389;   GO:0043390;   GO:0043391



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aflatoxin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 IDA RGD PMID:8234296 RGD:632009 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Cyp2w1 cytochrome P450, family 2, subfamily w, polypeptide 1 involved_in ISO (PMID:16551781) RGD PMID:16551781 NCBI chr12:15,291,552...15,296,421
Ensembl chr12:15,291,704...15,296,421
JBrowse link
aflatoxin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 IMP RGD PMID:12727802 RGD:1304380 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:4430389 (MGI:4429761|PMID:19850059)
GO_REF:0000107
RGD
Ensembl
PMID:19850059 GO_REF:0000107 MGI:4429761 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 IMP RGD PMID:27071940 RGD:12910550 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20091
    metabolic process 12359
      secondary metabolic process 65
        toxin metabolic process 19
          mycotoxin metabolic process 4
            aflatoxin metabolic process 4
              aflatoxin biosynthetic process + 0
              aflatoxin catabolic process 3
paths to the root