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ONTOLOGY REPORT - ANNOTATIONS


Term:aflatoxin metabolic process
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Accession:GO:0046222 term browser browse the term
Definition:The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Synonyms:exact_synonym: aflatoxin metabolism
 narrow_synonym: aflatoxin B metabolic process
 related_synonym: aflatoxin B1 metabolic process;   aflatoxin B1 metabolism;   aflatoxin B2 metabolic process;   aflatoxin B2 metabolism
 alt_id: GO:0043389;   GO:0043390;   GO:0043391


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aflatoxin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 IDA RGD PMID:8234296 RGD:632009 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Cyp2w1 cytochrome P450, family 2, subfamily w, polypeptide 1 involved_in ISO (PMID:16551781) RGD PMID:16551781 NCBI chr12:17,382,749...17,387,909
Ensembl chr12:17,383,159...17,387,879
JBrowse link
aflatoxin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 IMP RGD PMID:12727802 RGD:1304380 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 acts_upstream_of_or_within ISO MGI:4430389 (MGI:4429761|PMID:19850059) RGD PMID:19850059 MGI:4429761 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 IMP RGD PMID:27071940 RGD:12910550 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      secondary metabolic process 63
        toxin metabolic process 19
          mycotoxin metabolic process 4
            aflatoxin metabolic process 4
              aflatoxin biosynthetic process + 0
              aflatoxin catabolic process 3
paths to the root