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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrobiopterin metabolic process
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Accession:GO:0046146 term browser browse the term
Definition:The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
Synonyms:exact_synonym: 5,6,7,8-tetrahydrobiopterin metabolic process;   tetrahydrobiopterin metabolism


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tetrahydrobiopterin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spr sepiapterin reductase acts_upstream_of_or_within ISO (MGI:3722569|PMID:16532389) MGI PMID:16532389 MGI:3722569 NCBI chrNW_004936491:16,693,940...16,699,040 JBrowse link
tetrahydrobiopterin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO (PMID:23707606)
(MGI:5645206|PMID:19666465)
BHF-UCL PMID:19666465 PMID:23707606 MGI:5645206 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:17101830), (PMID:19666465)
(PMID:7678411), (PMID:9445252)
BHF-UCL
UniProt
PMID:7678411 PMID:9445252 PMID:17101830 PMID:19666465 NCBI chrNW_004936697:232,048...275,420 JBrowse link
G Pts 6-pyruvoyltetrahydropterin synthase acts_upstream_of_or_within ISO (MGI:1328867|PMID:9894812) MGI PMID:9894812 MGI:1328867 NCBI chrNW_004936612:2,247,825...2,255,277 JBrowse link
G Qdpr quinoid dihydropteridine reductase involved_in ISO PMID:1898002 RGD
UniProt
PMID:660556 PMID:1898002 PMID:9235988 RGD:4139903 RGD:5128582 RGD:8553309 NCBI chrNW_004936477:10,687,328...10,708,015 JBrowse link
G Spr sepiapterin reductase ISO RGD PMID:2179471 RGD:1600056 NCBI chrNW_004936491:16,693,940...16,699,040 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12170
    metabolic process 7647
      cellular metabolic process 7012
        heterocycle metabolic process 3724
          pteridine-containing compound metabolic process 22
            tetrahydrobiopterin metabolic process 5
              tetrahydrobiopterin biosynthetic process 5
              tetrahydrobiopterin catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 12170
    metabolic process 7647
      organic substance metabolic process 7372
        organic hydroxy compound metabolic process 404
          alcohol metabolic process 249
            polyol metabolic process 89
              diol metabolic process 24
                tetrahydrobiopterin metabolic process 5
                  tetrahydrobiopterin biosynthetic process 5
                  tetrahydrobiopterin catabolic process 0
paths to the root