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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrahydrobiopterin metabolic process
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Accession:GO:0046146 term browser browse the term
Definition:The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
Synonyms:exact_synonym: 5,6,7,8-tetrahydrobiopterin metabolic process;   tetrahydrobiopterin metabolism


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tetrahydrobiopterin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPR sepiapterin reductase acts_upstream_of_or_within ISO (MGI:3722569|PMID:16532389) MGI PMID:16532389 MGI:3722569 NCBI chr17:49,950,192...49,957,455
Ensembl chr17:49,950,800...49,957,417
JBrowse link
tetrahydrobiopterin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCH1 GTP cyclohydrolase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:30,733,422...30,784,067
Ensembl chr 8:30,732,608...30,784,156
JBrowse link
G PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:21,719,863...21,723,493
Ensembl chr 4:21,719,863...21,721,574
JBrowse link
G PTS 6-pyruvoyltetrahydropterin synthase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1328867|PMID:9894812) UniProt
MGI
PMID:9894812 GO_REF:0000041 MGI:1328867 NCBI chr 5:20,883,128...20,912,318
Ensembl chr 5:20,896,236...20,912,297
JBrowse link
G QDPR quinoid dihydropteridine reductase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:660556 PMID:9235988 PMID:21873635 RGD:4139903 RGD:5128582 NCBI chr 3:62,970,850...62,987,512
Ensembl chr 3:62,970,121...63,028,395
JBrowse link
G SPR sepiapterin reductase ISO RGD PMID:2179471 RGD:1600056 NCBI chr17:49,950,192...49,957,455
Ensembl chr17:49,950,800...49,957,417
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13864
    metabolic process 8968
      cellular metabolic process 8160
        heterocycle metabolic process 4310
          pteridine-containing compound metabolic process 28
            tetrahydrobiopterin metabolic process 5
              tetrahydrobiopterin biosynthetic process 5
              tetrahydrobiopterin catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 13864
    metabolic process 8968
      organic substance metabolic process 8616
        organic hydroxy compound metabolic process 457
          alcohol metabolic process 285
            polyol metabolic process 103
              diol metabolic process 25
                tetrahydrobiopterin metabolic process 5
                  tetrahydrobiopterin biosynthetic process 5
                  tetrahydrobiopterin catabolic process 0
paths to the root