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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of smooth muscle contraction
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Accession:GO:0045986 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.
Synonyms:exact_synonym: down regulation of smooth muscle contraction;   downregulation of smooth muscle contraction
 narrow_synonym: inhibition of smooth muscle contraction
 related_synonym: smooth muscle relaxation


show annotations for term's descendants           Sort by:
negative regulation of smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:18306009 RGD:5129131 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:88398|MGI:98496 (PMID:12925702)		 Ensembl
RGD		 PMID:12925702 GO_REF:0000107 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within IMP
ISO		 (PMID:9322931) RGD PMID:9322931 PMID:11230364 RGD:68890 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Calcrl calcitonin receptor like receptor IMP RGD PMID:17363466 RGD:1625357 NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910 		JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 acts_upstream_of_or_within ISO MGI:3525059 (PMID:15483626) RGD PMID:15483626 NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO MGI:1934143 (PMID:17993584) RGD PMID:17993584 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 acts_upstream_of_or_within ISO MGI:2181586 (PMID:15483626) RGD PMID:15483626 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:21051526 RGD:5135055 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
negative regulation of small intestine smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 IMP RGD PMID:23647678 RGD:10412032 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11991626 RGD:10003093 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
negative regulation of uterine smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A IMP RGD PMID:17664026 RGD:6893570 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2c adrenoceptor alpha 2C IMP RGD PMID:17664026 RGD:6893570 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
negative regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap42 Rho GTPase activating protein 42 acts_upstream_of_or_within ISO MGI:3871380 (PMID:24335996) RGD PMID:24335996 NCBI chr 8:6,154,759...6,384,497
Ensembl chr 8:6,156,865...6,384,870 		JBrowse link
G Dock4 dedicator of cytokinesis 4 involved_in ISO (PMID:22158624) RGD PMID:22158624 NCBI chr 6:57,512,929...57,902,597
Ensembl chr 6:57,512,908...57,901,855 		JBrowse link
G Dock5 dedicator of cytokinesis 5 involved_in ISO (PMID:22158624) RGD PMID:22158624 NCBI chr15:41,979,728...42,158,733
Ensembl chr15:41,979,729...42,158,649 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IMP PMID:19237536 UniProt PMID:19237536 RGD:401901238 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
relaxation of vascular associated smooth muscle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor acts_upstream_of_or_within ISO MGI:3773754 (PMID:18340377) RGD PMID:18340377 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 acts_upstream_of_or_within ISO MGI:3640802 (PMID:16614755) RGD PMID:16614755 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671 		JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 acts_upstream_of_or_within ISO MGI:3525059 (PMID:15483626) RGD PMID:15483626 NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:25139746)
MGI:3050114 (PMID:15867178)		 RGD PMID:15867178 PMID:25139746 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 acts_upstream_of_or_within ISO MGI:2181586 (PMID:15483626) RGD PMID:15483626 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 involved_in ISO (MGI:2682081|PMID:14608379) RGD PMID:14608379 MGI:2682081 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Sod1 superoxide dismutase 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:1857873 (PMID:12433839), (PMID:14679182)		 UniProt
RGD		 PMID:12433839 PMID:14679182 GO_REF:0000024 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 involved_in ISO (PMID:25139746) RGD PMID:25139746 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 involved_in ISO (PMID:25139746) RGD PMID:25139746 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
smooth muscle relaxation of the bladder outlet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb1 bradykinin receptor B1 involved_in ISO (PMID:23846981) RGD PMID:23846981 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Pgr progesterone receptor involved_in ISO (PMID:24296318) RGD PMID:24296318 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    negative regulation of biological process 5810
      negative regulation of multicellular organismal process 1363
        negative regulation of muscle contraction 35
          negative regulation of smooth muscle contraction 24
            negative regulation of gastro-intestinal system smooth muscle contraction + 2
            negative regulation of hindgut contraction 0
            negative regulation of smooth muscle contraction involved in micturition 0
            negative regulation of uterine smooth muscle contraction 2
            negative regulation of vascular associated smooth muscle contraction + 4
            relaxation of vascular associated smooth muscle 9
            smooth muscle relaxation of the bladder outlet 2
Path 2
Term Annotations click to browse term
  biological_process 20115
    biological regulation 13553
      regulation of biological process 13127
        regulation of multicellular organismal process 3372
          regulation of system process 679
            regulation of muscle system process 283
              regulation of muscle contraction 176
                regulation of smooth muscle contraction 74
                  negative regulation of smooth muscle contraction 24
                    negative regulation of gastro-intestinal system smooth muscle contraction + 2
                    negative regulation of hindgut contraction 0
                    negative regulation of smooth muscle contraction involved in micturition 0
                    negative regulation of uterine smooth muscle contraction 2
                    negative regulation of vascular associated smooth muscle contraction + 4
                    relaxation of vascular associated smooth muscle 9
                    smooth muscle relaxation of the bladder outlet 2
paths to the root