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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of natural killer cell mediated cytotoxicity
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Accession:GO:0045953 term browser browse the term
Definition:Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.
Synonyms:exact_synonym: down regulation of natural killer cell mediated cytotoxicity;   downregulation of natural killer cell mediated cytotoxicity;   negative regulation of NK cell mediated cell death;   negative regulation of NK cell mediated cell killing;   negative regulation of NK cell mediated cytotoxicity;   negative regulation of natural killer cell mediated cell death;   negative regulation of natural killer cell mediated cell killing
 narrow_synonym: inhibition of natural killer cell mediated cytotoxicity
 related_synonym: negative regulation of NK cell mediated cytolysis;   negative regulation of natural killer cell mediated cytolysis



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negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO (PMID:18604210) RGD PMID:18604210 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Clec12b C-type lectin domain family 12, member B involved_in ISO (PMID:17562706) RGD PMID:17562706 NCBI chr 4:162,827,462...162,843,821
Ensembl chr 4:162,827,462...162,838,946
JBrowse link
G Crk CRK proto-oncogene, adaptor protein IMP RGD PMID:18835194 RGD:11568650 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Gfer growth factor, augmenter of liver regeneration IDA RGD PMID:9021955 RGD:9685777 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869
JBrowse link
G Igf2 insulin-like growth factor 2 IDA RGD PMID:9021955 RGD:9685777 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Klrc1 killer cell lectin like receptor C1 involved_in ISO (PMID:9485206), (PMID:9486650) RGD PMID:9485206 PMID:9486650 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
JBrowse link
G Klrd1 killer cell lectin like receptor D1 involved_in ISO
ISS
(PMID:9486650)
GO_REF:0000024
RGD
UniProt
PMID:9486650 GO_REF:0000024 NCBI chr 4:163,044,920...163,056,568
Ensembl chr 4:163,045,067...163,056,518
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) RGD PMID:23408620 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Mill1 MHC I like leukocyte 1 involved_in ISO (PMID:20068167) RGD PMID:20068167 NCBI chr 1:78,372,138...78,398,932
Ensembl chr 1:78,372,802...78,398,930
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 IMP RGD PMID:10837412 RGD:2313500 NCBI chr20:4,905,309...4,914,593 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:10799855), (PMID:17179229), (PMID:23335510), (PMID:9486650) RGD PMID:9486650 PMID:10799855 PMID:17179229 PMID:23335510 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,403,418...3,479,476 JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:10190900), (PMID:12874224) RGD PMID:10190900 PMID:12874224 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in ISO (PMID:10799855), (PMID:17179229), (PMID:23335510), (PMID:9486650) RGD PMID:9486650 PMID:10799855 PMID:17179229 PMID:23335510 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 acts_upstream_of_or_within ISO MGI:3641175 (MGI:3639618|PMID:16127454) RGD PMID:16127454 MGI:3639618 NCBI chr13:82,416,362...82,461,511
Ensembl chr13:82,437,428...82,461,509
JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,403,418...3,479,476 JBrowse link
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS
(PMID:23696226)
(MGI:5512785|PMID:23696226)
GO_REF:0000024
RGD
UniProt
PMID:23696226 GO_REF:0000024 MGI:5512785 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) RGD PMID:22842346 MGI:5437532 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
JBrowse link
G Klre1 killer cell lectin-like receptor, family E, member 1 IDA RGD PMID:12782717 RGD:1299590 NCBI chr 4:163,032,938...163,041,641
Ensembl chr 4:163,033,563...163,041,638
JBrowse link
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec2d C-type lectin domain family 2, member D acts_upstream_of_or_within ISO MGI:107539 (MGI:2682492|PMID:12858173), (MGI:3041277|PMID:14990792), (MGI:3849756|PMID:19535641) RGD PMID:12858173 PMID:14990792 PMID:19535641 MGI:2682492 MGI:3041277 MGI:3849756 NCBI chr 4:162,216,052...162,239,530
Ensembl chr 4:162,216,572...162,239,527
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 involved_in ISO (PMID:18502829), (PMID:2784569), (PMID:8046333) RGD PMID:2784569 PMID:8046333 PMID:18502829 NCBI chr20:4,905,309...4,914,593 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:25631937), (PMID:9754572) RGD PMID:9754572 PMID:25631937 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:11290782) RGD PMID:11290782 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in ISO (PMID:25631937), (PMID:9754572) RGD PMID:9754572 PMID:25631937 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Serpinb3a serpin family B member 3A involved_in ISO (PMID:21857942) RGD PMID:21857942 NCBI chr13:23,241,303...23,246,328
Ensembl chr13:23,236,972...23,246,985
JBrowse link
G Serpinb9 serpin family B member 9 involved_in ISO (PMID:21795594) RGD PMID:21795594 NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member IMP RGD PMID:8120379 RGD:2312378 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member IMP RGD PMID:8120379 RGD:2312378 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    cellular process 18695
      negative regulation of cellular process 5121
        negative regulation of cell killing 36
          negative regulation of leukocyte mediated cytotoxicity 29
            negative regulation of natural killer cell mediated cytotoxicity 23
              negative regulation of natural killer cell degranulation 2
              negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 3
              protection from natural killer cell mediated cytotoxicity 9
Path 2
Term Annotations click to browse term
  biological_process 20099
    response to stimulus 10542
      response to external stimulus 3276
        response to external biotic stimulus 1760
          response to other organism 1756
            defense response to other organism 1210
              innate immune response 897
                natural killer cell mediated immunity 86
                  regulation of natural killer cell mediated immunity 66
                    negative regulation of natural killer cell mediated immunity 24
                      negative regulation of natural killer cell mediated cytotoxicity 23
                        negative regulation of natural killer cell degranulation 2
                        negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 3
                        protection from natural killer cell mediated cytotoxicity 9
paths to the root