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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of steroid metabolic process
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Accession:GO:0045939 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.
Synonyms:exact_synonym: down regulation of steroid metabolic process;   downregulation of steroid metabolic process;   negative regulation of steroid metabolism
 narrow_synonym: inhibition of steroid metabolic process


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negative regulation of steroid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISS (PMID:24201375) ARUK-UCL PMID:24201375 NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 involved_in IC (PMID:19996319) BHF-UCL PMID:19996319 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 involved_in IC (PMID:19996319) BHF-UCL PMID:19996319 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246 		JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590 		JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr11:11,963,036...12,009,745
Ensembl chr11:11,956,207...12,009,769 		JBrowse link
G REST RE1 silencing transcription factor involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr 4:56,907,900...56,935,844
Ensembl chr 4:56,907,876...56,966,808 		JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in IDA (PMID:16959810) UniProt PMID:16959810 NCBI chr 1:22,117,313...22,143,097
Ensembl chr 1:22,117,313...22,143,969 		JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within 		IDA
IEA 		(PMID:12815072) UniProt
Ensembl		 PMID:12815072 GO_REF:0000107 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022 		JBrowse link
G MALRD1 MAM and LDL receptor class A domain containing 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:19,046,927...19,734,478
Ensembl chr10:19,048,801...19,790,401 		JBrowse link
G MIR33A microRNA 33a involved_in IDA (PMID:23536474) BHF-UCL PMID:23536474 NCBI chr22:41,900,944...41,901,012
Ensembl chr22:41,900,944...41,901,012 		JBrowse link
G PROX1 prospero homeobox 1 involved_in IMP (PMID:16488887) BHF-UCL PMID:16488887 NCBI chr 1:213,983,151...214,041,510
Ensembl chr 1:213,983,181...214,041,510 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO
IDA 		(PMID:1917954) RGD
BHF-UCL		 PMID:1917954 PMID:9225228 RGD:10059686 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G CHLSN cholesin involved_in IDA (PMID:38503280) UniProt PMID:38503280 NCBI chr 7:977,964...1,138,257
Ensembl chr 7:996,986...1,138,260 		JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in IMP (PMID:24217618) UniProt PMID:24217618 NCBI chr10:100,150,094...100,186,029
Ensembl chr10:100,150,094...100,186,033 		JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IMP (PMID:24217618) UniProt PMID:24217618 NCBI chr 8:37,736,634...37,758,422
Ensembl chr 8:37,736,601...37,758,422 		JBrowse link
G IDI2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within ISO (PMID:17202134) MGI PMID:17202134 NCBI chr10:1,018,910...1,025,859
Ensembl chr10:1,018,910...1,025,859 		JBrowse link
G INSIG1 insulin induced gene 1 involved_in IDA (PMID:26311497) UniProt PMID:26311497 NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235 		JBrowse link
G MIR185 microRNA 185 acts_upstream_of IGI
IDA 		(PMID:24296663)
(PMID:23951060) 		BHF-UCL PMID:23951060 PMID:24296663 NCBI chr22:20,033,139...20,033,220
Ensembl chr22:20,033,139...20,033,220 		JBrowse link
G MIR30C1 microRNA 30c-1 acts_upstream_of ISS (PMID:27365390) BHF-UCL PMID:27365390 NCBI chr 1:40,757,284...40,757,372
Ensembl chr 1:40,757,284...40,757,372 		JBrowse link
G MIR30C2 microRNA 30c-2 acts_upstream_of ISS (PMID:27365390) BHF-UCL PMID:27365390 NCBI chr 6:71,376,960...71,377,031
Ensembl chr 6:71,376,960...71,377,031 		JBrowse link
G MIR342 microRNA 342 acts_upstream_of IDA (PMID:23951060) BHF-UCL PMID:23951060 NCBI chr14:100,109,655...100,109,753
Ensembl chr14:100,109,655...100,109,753 		JBrowse link
G MIR548P microRNA 548p involved_in IDA (PMID:28336556) BHF-UCL PMID:28336556 NCBI chr 5:100,816,482...100,816,565
Ensembl chr 5:100,816,482...100,816,565 		JBrowse link
G MIR98 microRNA 98 involved_in IDA (PMID:30195495) BHF-UCL PMID:30195495 NCBI chr  X:53,556,223...53,556,341
Ensembl chr  X:53,556,223...53,556,341 		JBrowse link
G SCAP SREBF chaperone involved_in NAS (PMID:11969205) UniProt PMID:11969205 NCBI chr 3:47,413,681...47,477,127
Ensembl chr 3:47,413,681...47,477,126 		JBrowse link
negative regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CH25H cholesterol 25-hydroxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:89,205,629...89,207,317
Ensembl chr10:89,205,629...89,207,317 		JBrowse link
G MIR27A microRNA 27a involved_in IDA (PMID:24608080) ARUK-UCL PMID:24608080 NCBI chr19:13,836,440...13,836,517
Ensembl chr19:13,836,440...13,836,517 		JBrowse link
G MIR27B microRNA 27b involved_in IDA (PMID:24608080) ARUK-UCL PMID:24608080 NCBI chr 9:95,085,445...95,085,541
Ensembl chr 9:95,085,445...95,085,541 		JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246 		JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590 		JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr11:11,963,036...12,009,745
Ensembl chr11:11,956,207...12,009,769 		JBrowse link
G REST RE1 silencing transcription factor involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr 4:56,907,900...56,935,844
Ensembl chr 4:56,907,876...56,966,808 		JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261 		JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
negative regulation of steroid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246 		JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590 		JBrowse link
G HRH1 histamine receptor H1 ISO RGD PMID:15917347 RGD:2316921 NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557 		JBrowse link
G INSIG1 insulin induced gene 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235 		JBrowse link
G INSIG2 insulin induced gene 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:118,088,471...118,110,997
Ensembl chr 2:118,088,452...118,110,997 		JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 acts_upstream_of IDA (PMID:9384387) HGNC-UCL PMID:9384387 NCBI chr  X:30,304,206...30,309,390
Ensembl chr  X:30,304,206...30,309,390 		JBrowse link
G WNT4 Wnt family member 4 involved_in IDA (PMID:15317892), (PMID:18182450) UniProt PMID:15317892 PMID:18182450 NCBI chr 1:22,117,313...22,143,097
Ensembl chr 1:22,117,313...22,143,969 		JBrowse link
negative regulation of steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE8B phosphodiesterase 8B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:77,086,715...77,428,256
Ensembl chr 5:77,210,449...77,428,256
Ensembl chr 5:77,210,449...77,428,256 		JBrowse link
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKKL1 dickkopf like acrosomal protein 1 involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:49,360,515...49,375,116
Ensembl chr19:49,361,783...49,375,116 		JBrowse link
G GGCX gamma-glutamyl carboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,544,720...85,561,493
Ensembl chr 2:85,544,720...85,561,532 		JBrowse link
G WNT4 Wnt family member 4 involved_in IEA
IMP 		(PMID:12949260) Ensembl
UniProt		 PMID:12949260 GO_REF:0000107 NCBI chr 1:22,117,313...22,143,097
Ensembl chr 1:22,117,313...22,143,969 		JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GFI1 growth factor independent 1 transcriptional repressor acts_upstream_of IDA (PMID:15947108) BHF-UCL PMID:15947108 NCBI chr 1:92,473,043...92,486,925
Ensembl chr 1:92,473,043...92,486,925 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in IDA (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in IDA (PMID:19502595) BHF-UCL PMID:19502595 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in IDA (PMID:18485278), (PMID:19502595) BHF-UCL PMID:18485278 PMID:19502595 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27205
    cellular process 19782
      metabolic process 13524
        negative regulation of metabolic process 3765
          negative regulation of lipid metabolic process 142
            negative regulation of steroid metabolic process 40
              negative regulation of aldosterone metabolic process + 4
              negative regulation of bile acid metabolic process + 4
              negative regulation of cholesterol metabolic process + 16
              negative regulation of ecdysteroid metabolic process + 0
              negative regulation of glucocorticoid metabolic process + 5
              negative regulation of steroid biosynthetic process + 34
Path 2
Term Annotations click to browse term
  biological_process 27205
    biological regulation 13700
      regulation of biological process 13241
        regulation of cellular process 12825
          regulation of metabolic process 7574
            regulation of primary metabolic process 5939
              regulation of lipid metabolic process 423
                negative regulation of lipid metabolic process 142
                  negative regulation of steroid metabolic process 40
                    negative regulation of aldosterone metabolic process + 4
                    negative regulation of bile acid metabolic process + 4
                    negative regulation of cholesterol metabolic process + 16
                    negative regulation of ecdysteroid metabolic process + 0
                    negative regulation of glucocorticoid metabolic process + 5
                    negative regulation of steroid biosynthetic process + 34
paths to the root