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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of steroid metabolic process
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Accession:GO:0045939 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.
Synonyms:exact_synonym: down regulation of steroid metabolic process;   downregulation of steroid metabolic process;   negative regulation of steroid metabolism
 narrow_synonym: inhibition of steroid metabolic process


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negative regulation of steroid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 involved_in IC (PMID:19996319) BHF-UCL PMID:19996319 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 involved_in IC (PMID:19996319) BHF-UCL PMID:19996319 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr11:11,963,036...12,009,827
Ensembl chr11:11,956,207...12,009,769
JBrowse link
G REST RE1 silencing transcription factor involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr 4:56,907,900...56,935,847
Ensembl chr 4:56,907,876...56,966,808
JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in IDA (PMID:16959810) UniProt PMID:16959810 NCBI chr 1:22,117,308...22,143,981
Ensembl chr 1:22,117,313...22,143,969
JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within
IDA
ISO
(PMID:12815072)
(MGI:5501367|PMID:23747249)
UniProt
MGI
PMID:12815072 PMID:23747249 MGI:5501367 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022
JBrowse link
G MALRD1 MAM and LDL receptor class A domain containing 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5501367|PMID:23747249) Ensembl
MGI
PMID:23747249 GO_REF:0000107 MGI:5501367 NCBI chr10:19,046,931...19,734,478
Ensembl chr10:19,048,801...19,790,401
JBrowse link
G PROX1 prospero homeobox 1 involved_in IMP (PMID:16488887) BHF-UCL PMID:16488887 NCBI chr 1:213,983,239...214,041,510
Ensembl chr 1:213,983,181...214,041,510
JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IDA (PMID:16549446) BHF-UCL PMID:16549446 NCBI chr12:57,762,334...57,767,078
Ensembl chr12:57,762,334...57,768,986
JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in IDA (PMID:15947108) BHF-UCL PMID:15947108 NCBI chr 1:92,473,043...92,486,925
Ensembl chr 1:92,473,043...92,486,925
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in IDA (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IDA
ISO
(PMID:1917954) BHF-UCL
RGD
PMID:1917954 PMID:9225228 RGD:10059686 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in IMP (PMID:24217618) UniProt PMID:24217618 NCBI chr10:100,150,094...100,186,029
Ensembl chr10:100,150,094...100,186,033
JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IMP (PMID:24217618) UniProt PMID:24217618 NCBI chr 8:37,736,627...37,758,422
Ensembl chr 8:37,736,601...37,758,422
JBrowse link
G IDI2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within ISO (MGI:5490819|PMID:17202134) MGI PMID:17202134 MGI:5490819 NCBI chr10:1,018,910...1,025,859
Ensembl chr10:1,018,910...1,025,859
JBrowse link
G SCAP SREBF chaperone involved_in NAS (PMID:11969205) UniProt PMID:11969205 NCBI chr 3:47,413,681...47,477,126
Ensembl chr 3:47,413,681...47,477,126
JBrowse link
G SOD1 superoxide dismutase 1 involved_in IDA (PMID:15473258) UniProt PMID:15473258 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISS
IDA
(PMID:24201375)
(PMID:21810484)
ARUK-UCL PMID:21810484 PMID:24201375 NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,922
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr11:11,963,036...12,009,827
Ensembl chr11:11,956,207...12,009,769
JBrowse link
G REST RE1 silencing transcription factor involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr 4:56,907,900...56,935,847
Ensembl chr 4:56,907,876...56,966,808
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3696486|PMID:17234593) Ensembl
MGI
PMID:17234593 GO_REF:0000107 MGI:3696486 NCBI chr 1:116,372,986...116,410,259
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
negative regulation of steroid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590
JBrowse link
G HRH1 histamine receptor H1 ISO RGD PMID:15917347 RGD:2316921 NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557
JBrowse link
G INSIG1 insulin induced gene 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3603108|PMID:16100574) Ensembl
MGI
PMID:16100574 GO_REF:0000107 MGI:3603108 NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235
JBrowse link
G INSIG2 insulin induced gene 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3603108|PMID:16100574) Ensembl
MGI
PMID:16100574 GO_REF:0000107 MGI:3603108 NCBI chr 2:118,088,471...118,110,997
Ensembl chr 2:118,088,452...118,110,997
JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 acts_upstream_of IDA (PMID:9384387) HGNC-UCL PMID:9384387 NCBI chr  X:30,304,206...30,309,390
Ensembl chr  X:30,304,206...30,309,390
JBrowse link
G WNT4 Wnt family member 4 involved_in IDA (PMID:15317892), (PMID:18182450) UniProt PMID:15317892 PMID:18182450 NCBI chr 1:22,117,308...22,143,981
Ensembl chr 1:22,117,313...22,143,969
JBrowse link
negative regulation of steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE8B phosphodiesterase 8B acts_upstream_of_or_within ISO (MGI:5526088|PMID:21187369) MGI PMID:21187369 MGI:5526088 NCBI chr 5:77,180,304...77,428,256
Ensembl chr 5:77,210,449...77,428,256
JBrowse link
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKKL1 dickkopf like acrosomal protein 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:49,360,520...49,375,132
Ensembl chr19:49,361,783...49,375,116
JBrowse link
G WNT4 Wnt family member 4 involved_in IMP (PMID:12949260) UniProt PMID:12949260 NCBI chr 1:22,117,308...22,143,981
Ensembl chr 1:22,117,313...22,143,969
JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GFI1 growth factor independent 1 transcriptional repressor involved_in IC (PMID:15947108) BHF-UCL PMID:15947108 NCBI chr 1:92,473,043...92,486,925
Ensembl chr 1:92,473,043...92,486,925
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in IC (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in IDA (PMID:19502595) BHF-UCL PMID:19502595 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in IDA (PMID:18485278), (PMID:19502595) BHF-UCL PMID:18485278 PMID:19502595 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18536
    metabolic process 11863
      negative regulation of metabolic process 3373
        negative regulation of lipid metabolic process 119
          negative regulation of steroid metabolic process 29
            negative regulation of aldosterone metabolic process + 4
            negative regulation of bile acid metabolic process + 3
            negative regulation of cholesterol esterification 1
            negative regulation of cholesterol metabolic process + 6
            negative regulation of ecdysteroid metabolic process + 0
            negative regulation of glucocorticoid metabolic process + 5
            negative regulation of steroid biosynthetic process + 26
Path 2
Term Annotations click to browse term
  biological_process 18536
    biological regulation 13081
      regulation of biological process 12367
        regulation of metabolic process 7181
          regulation of primary metabolic process 6111
            regulation of lipid metabolic process 392
              regulation of steroid metabolic process 118
                negative regulation of steroid metabolic process 29
                  negative regulation of aldosterone metabolic process + 4
                  negative regulation of bile acid metabolic process + 3
                  negative regulation of cholesterol esterification 1
                  negative regulation of cholesterol metabolic process + 6
                  negative regulation of ecdysteroid metabolic process + 0
                  negative regulation of glucocorticoid metabolic process + 5
                  negative regulation of steroid biosynthetic process + 26
paths to the root