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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of steroid metabolic process
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Accession:GO:0045939 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.
Synonyms:exact_synonym: down regulation of steroid metabolic process;   downregulation of steroid metabolic process;   negative regulation of steroid metabolism
 narrow_synonym: inhibition of steroid metabolic process


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negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,089,429...23,202,176
Ensembl chr12:23,089,459...23,202,348
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr21:35,032,501...35,074,664
Ensembl chr21:35,033,552...35,074,664
JBrowse link
G REST RE1 silencing transcription factor involved_in ISS UniProt GO_REF:0000024 NCBI chr13:49,041,082...49,062,596
Ensembl chr13:49,041,047...49,059,388
JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in ISO (PMID:16959810) UniProt PMID:16959810 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111
JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF19 fibroblast growth factor 19 acts_upstream_of_or_within
involved_in
ISO (MGI:5501367|PMID:23747249)
(PMID:12815072)
MGI
UniProt
PMID:12815072 PMID:23747249 MGI:5501367 NCBI chr18:48,464,931...48,469,967
Ensembl chr18:48,464,928...48,469,782
JBrowse link
G LOC608668 MAM and LDL-receptor class A domain-containing protein 1 acts_upstream_of_or_within ISO (MGI:5501367|PMID:23747249) MGI PMID:23747249 MGI:5501367 NCBI chr 2:13,151,316...13,904,122 JBrowse link
G PROX1 prospero homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:11,996,282...12,047,693
Ensembl chr 7:11,996,703...12,044,036
JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in ISO (PMID:16549446) BHF-UCL PMID:16549446 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911
JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:56,473,032...56,484,422
Ensembl chr 6:56,256,305...56,484,422
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703
JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO (PMID:1917954) RGD
BHF-UCL
PMID:1917954 PMID:9225228 RGD:10059686 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440
JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chr28:12,924,942...12,962,016
Ensembl chr28:12,927,018...12,961,983
JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:27,622,549...27,639,807
Ensembl chr16:27,625,417...27,639,202
JBrowse link
G SOD1 superoxide dismutase 1 involved_in ISO (PMID:15473258) UniProt PMID:15473258 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484)
PMID:24201375
ARUK-UCL PMID:21810484 PMID:24201375 RGD:14697729 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,089,429...23,202,176
Ensembl chr12:23,089,459...23,202,348
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr21:35,032,501...35,074,664
Ensembl chr21:35,033,552...35,074,664
JBrowse link
G REST RE1 silencing transcription factor involved_in ISS UniProt GO_REF:0000024 NCBI chr13:49,041,082...49,062,596
Ensembl chr13:49,041,047...49,059,388
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within ISO (MGI:3696486|PMID:17234593) MGI PMID:17234593 MGI:3696486 NCBI chr17:53,828,482...53,847,043
Ensembl chr17:53,813,976...53,847,167
JBrowse link
negative regulation of steroid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr12:23,089,429...23,202,176
Ensembl chr12:23,089,459...23,202,348
JBrowse link
G HRH1 histamine receptor H1 ISO RGD PMID:15917347 RGD:2316921 NCBI chr20:7,160,903...7,236,147
Ensembl chr20:7,162,393...7,235,869
JBrowse link
G INSIG1 insulin induced gene 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3603108|PMID:16100574) Ensembl
MGI
PMID:16100574 GO_REF:0000107 MGI:3603108 NCBI chr16:18,260,456...18,271,855
Ensembl chr16:18,259,935...18,271,378
JBrowse link
G INSIG2 insulin induced gene 2 acts_upstream_of_or_within ISO (MGI:3603108|PMID:16100574) MGI PMID:16100574 MGI:3603108 NCBI chr19:31,796,984...31,811,556
Ensembl chr19:31,791,710...31,811,386
JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 acts_upstream_of ISO (PMID:9384387) HGNC-UCL PMID:9384387 NCBI chr  X:25,396,527...25,401,587
Ensembl chr  X:25,396,527...25,401,715
JBrowse link
G WNT4 Wnt family member 4 involved_in ISO (PMID:15317892), (PMID:18182450) UniProt PMID:15317892 PMID:18182450 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111
JBrowse link
negative regulation of steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE8B phosphodiesterase 8B acts_upstream_of_or_within ISO (MGI:5526088|PMID:21187369) MGI PMID:21187369 MGI:5526088 NCBI chr 3:29,289,867...29,432,557
Ensembl chr 3:29,291,549...29,432,542
JBrowse link
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKKL1 dickkopf like acrosomal protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,109,787...107,113,932
Ensembl chr 1:107,109,791...107,113,811
JBrowse link
G WNT4 Wnt family member 4 involved_in ISO (PMID:12949260)
(MGI:2675528|PMID:12949260)
UniProt PMID:12949260 MGI:2675528 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111
JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAI1 snail family transcriptional repressor 1 involved_in ISO (PMID:19502595) BHF-UCL PMID:19502595 NCBI chr24:36,498,343...36,503,623
Ensembl chr24:36,498,062...36,503,628
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in ISO (PMID:18485278), (PMID:19502595) BHF-UCL PMID:18485278 PMID:19502595 NCBI chr29:1,154,132...1,156,653
Ensembl chr29:1,154,036...1,156,653
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13872
    metabolic process 8970
      negative regulation of metabolic process 2795
        negative regulation of lipid metabolic process 105
          negative regulation of steroid metabolic process 25
            negative regulation of aldosterone metabolic process + 4
            negative regulation of bile acid metabolic process + 3
            negative regulation of cholesterol esterification 1
            negative regulation of cholesterol metabolic process + 4
            negative regulation of ecdysteroid metabolic process + 0
            negative regulation of glucocorticoid metabolic process + 5
            negative regulation of steroid biosynthetic process + 24
Path 2
Term Annotations click to browse term
  biological_process 13872
    biological regulation 10017
      regulation of biological process 9456
        regulation of metabolic process 5652
          regulation of primary metabolic process 4755
            regulation of lipid metabolic process 358
              regulation of steroid metabolic process 104
                negative regulation of steroid metabolic process 25
                  negative regulation of aldosterone metabolic process + 4
                  negative regulation of bile acid metabolic process + 3
                  negative regulation of cholesterol esterification 1
                  negative regulation of cholesterol metabolic process + 4
                  negative regulation of ecdysteroid metabolic process + 0
                  negative regulation of glucocorticoid metabolic process + 5
                  negative regulation of steroid biosynthetic process + 24
paths to the root