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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of steroid metabolic process
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Accession:GO:0045939 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.
Synonyms:exact_synonym: down regulation of steroid metabolic process;   downregulation of steroid metabolic process;   negative regulation of steroid metabolism
 narrow_synonym: inhibition of steroid metabolic process


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negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,765,161...6,777,728
Ensembl chr20:6,546,173...6,558,610
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,302,721...55,425,248
Ensembl chr 6:56,936,850...57,059,519
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr11:12,131,306...12,177,906
Ensembl chr11:11,824,955...11,871,139
JBrowse link
G REST RE1 silencing transcription factor involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chr 4:66,984,466...67,012,301
Ensembl chr 4:73,526,085...73,582,242
JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in ISO (PMID:16959810) UniProt PMID:16959810 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801
JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within
ISO (PMID:12815072)
(MGI:5501367|PMID:23747249)
UniProt
MGI
PMID:12815072 PMID:23747249 MGI:5501367 NCBI chr11:64,794,157...64,800,512
Ensembl chr11:68,085,306...68,090,028
JBrowse link
G MALRD1 MAM and LDL receptor class A domain containing 1 acts_upstream_of_or_within ISO (MGI:5501367|PMID:23747249) MGI PMID:23747249 MGI:5501367 NCBI chr10:19,461,865...19,886,155 JBrowse link
G PROX1 prospero homeobox 1 involved_in ISO (PMID:16488887) BHF-UCL PMID:16488887 NCBI chr 1:189,556,124...189,609,297
Ensembl chr 1:194,412,980...194,460,763
JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in ISO (PMID:16549446) BHF-UCL PMID:16549446 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822
JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in ISO (PMID:15947108) BHF-UCL PMID:15947108 NCBI chr 1:95,139,171...95,151,054
Ensembl chr 1:93,876,245...93,883,528
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098
JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO (PMID:1917954) RGD
BHF-UCL
PMID:1917954 PMID:9225228 RGD:10059686 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chr10:96,756,261...96,791,925
Ensembl chr10:100,238,320...100,273,942
JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chr 8:37,034,391...37,057,164
Ensembl chr 8:34,212,704...34,233,583
JBrowse link
G IDI2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within ISO (MGI:5490819|PMID:17202134) MGI PMID:17202134 MGI:5490819 NCBI chr10:1,056,280...1,062,070
Ensembl chr10:1,102,655...1,108,246
JBrowse link
G SOD1 superoxide dismutase 1 involved_in ISO (PMID:15473258) UniProt PMID:15473258 NCBI chr21:18,029,831...18,037,526 JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484)
PMID:24201375
ARUK-UCL PMID:21810484 PMID:24201375 RGD:14697729 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,765,161...6,777,728
Ensembl chr20:6,546,173...6,558,610
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,302,721...55,425,248
Ensembl chr 6:56,936,850...57,059,519
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr11:12,131,306...12,177,906
Ensembl chr11:11,824,955...11,871,139
JBrowse link
G REST RE1 silencing transcription factor involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chr 4:66,984,466...67,012,301
Ensembl chr 4:73,526,085...73,582,242
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within ISO (MGI:3696486|PMID:17234593) MGI PMID:17234593 MGI:3696486 NCBI chr 1:86,162,401...86,193,883
Ensembl chr 1:121,212,488...121,243,099
JBrowse link
negative regulation of steroid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,765,161...6,777,728
Ensembl chr20:6,546,173...6,558,610
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,302,721...55,425,248
Ensembl chr 6:56,936,850...57,059,519
JBrowse link
G HRH1 histamine receptor H1 ISO RGD PMID:15917347 RGD:2316921 NCBI chr 3:11,074,451...11,199,871
Ensembl chr 3:11,541,294...11,542,757
JBrowse link
G INSIG1 insulin induced gene 1 acts_upstream_of_or_within ISO (MGI:3603108|PMID:16100574) MGI PMID:16100574 MGI:3603108 NCBI chr 7:146,893,730...146,906,329
Ensembl chr 7:158,619,531...158,632,012
JBrowse link
G INSIG2 insulin induced gene 2 acts_upstream_of_or_within ISO (MGI:3603108|PMID:16100574) MGI PMID:16100574 MGI:3603108 NCBI chr2B:5,046,971...5,068,757
Ensembl chr2B:118,632,402...118,652,647
JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 acts_upstream_of ISO (PMID:9384387) HGNC-UCL PMID:9384387 NCBI chr  X:22,903,403...22,908,527
Ensembl chr  X:30,459,527...30,464,652
JBrowse link
G WNT4 Wnt family member 4 involved_in ISO (PMID:15317892), (PMID:18182450) UniProt PMID:15317892 PMID:18182450 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801
JBrowse link
negative regulation of steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE8B phosphodiesterase 8B acts_upstream_of_or_within ISO (MGI:5526088|PMID:21187369) MGI PMID:21187369 MGI:5526088 NCBI chr 5:37,874,089...38,121,322 JBrowse link
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKKL1 dickkopf like acrosomal protein 1 involved_in ISO (MGI:3839065|PMID:18818293) UniProt PMID:18818293 MGI:3839065 NCBI chr19:46,375,301...46,389,822
Ensembl chr19:55,301,955...55,313,690
JBrowse link
G WNT4 Wnt family member 4 involved_in ISO (PMID:12949260)
(MGI:2675528|PMID:12949260)
UniProt PMID:12949260 MGI:2675528 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801
JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAI1 snail family transcriptional repressor 1 involved_in ISO (PMID:19502595) BHF-UCL PMID:19502595 NCBI chr20:46,321,075...46,328,865
Ensembl chr20:47,384,818...47,390,733
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in ISO (PMID:18485278), (PMID:19502595) BHF-UCL PMID:18485278 PMID:19502595 NCBI chr 8:45,341,857...45,345,544
Ensembl chr 8:42,723,971...42,730,904
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12652
    metabolic process 7925
      negative regulation of metabolic process 2595
        negative regulation of lipid metabolic process 102
          negative regulation of steroid metabolic process 26
            negative regulation of aldosterone metabolic process + 4
            negative regulation of bile acid metabolic process + 3
            negative regulation of cholesterol esterification 1
            negative regulation of cholesterol metabolic process + 5
            negative regulation of ecdysteroid metabolic process + 0
            negative regulation of glucocorticoid metabolic process + 5
            negative regulation of steroid biosynthetic process + 25
Path 2
Term Annotations click to browse term
  biological_process 12652
    biological regulation 9217
      regulation of biological process 8711
        regulation of metabolic process 5177
          regulation of primary metabolic process 4386
            regulation of lipid metabolic process 352
              regulation of steroid metabolic process 103
                negative regulation of steroid metabolic process 26
                  negative regulation of aldosterone metabolic process + 4
                  negative regulation of bile acid metabolic process + 3
                  negative regulation of cholesterol esterification 1
                  negative regulation of cholesterol metabolic process + 5
                  negative regulation of ecdysteroid metabolic process + 0
                  negative regulation of glucocorticoid metabolic process + 5
                  negative regulation of steroid biosynthetic process + 25
paths to the root