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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of steroid metabolic process
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Accession:GO:0045939 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.
Synonyms:exact_synonym: down regulation of steroid metabolic process;   downregulation of steroid metabolic process;   negative regulation of steroid metabolism
 narrow_synonym: inhibition of steroid metabolic process


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negative regulation of steroid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO PMID:24201375 ARUK-UCL PMID:24201375 RGD:14697729 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776 		JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:6,765,161...6,777,728
Ensembl chr20:6,546,173...6,558,610 		JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:55,302,721...55,425,248
Ensembl chr 6:56,936,850...57,059,519 		JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:12,131,306...12,177,906
Ensembl chr11:11,824,955...11,871,139 		JBrowse link
G REST RE1 silencing transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:66,984,466...67,012,301
Ensembl chr 4:73,526,085...73,582,242 		JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801 		JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within 		IEA
ISO 		(PMID:23747249) Ensembl
MGI		 PMID:23747249 GO_REF:0000107 NCBI chr11:64,794,157...64,800,512
Ensembl chr11:68,085,306...68,090,028 		JBrowse link
G MALRD1 MAM and LDL receptor class A domain containing 1 acts_upstream_of_or_within ISO (PMID:23747249) MGI PMID:23747249 NCBI chr10:19,461,865...19,886,155 JBrowse link
G PROX1 prospero homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:189,556,124...189,609,297
Ensembl chr 1:194,412,980...194,460,763 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO
IEA 		RGD
Ensembl		 PMID:9225228 GO_REF:0000107 RGD:10059686 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G CHLSN cholesin involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chr 7:1,156,770...1,383,223
Ensembl chr 7:1,369,532...1,497,518 		JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:96,756,261...96,791,925
Ensembl chr10:100,238,320...100,273,942 		JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:37,034,391...37,057,164
Ensembl chr 8:34,212,704...34,233,583 		JBrowse link
G IDI2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within ISO (PMID:17202134) MGI PMID:17202134 NCBI chr10:1,056,280...1,062,070
Ensembl chr10:1,102,655...1,108,246 		JBrowse link
G INSIG1 insulin induced gene 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:146,893,730...146,906,329
Ensembl chr 7:158,619,531...158,632,012 		JBrowse link
negative regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CH25H cholesterol 25-hydroxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:85,930,638...85,932,065
Ensembl chr10:89,471,441...89,472,259 		JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:6,765,161...6,777,728
Ensembl chr20:6,546,173...6,558,610 		JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:55,302,721...55,425,248
Ensembl chr 6:56,936,850...57,059,519 		JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:12,131,306...12,177,906
Ensembl chr11:11,824,955...11,871,139 		JBrowse link
G REST RE1 silencing transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:66,984,466...67,012,301
Ensembl chr 4:73,526,085...73,582,242 		JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829 		JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:86,162,401...86,193,883
Ensembl chr 1:121,212,488...121,243,099 		JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829 		JBrowse link
negative regulation of steroid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:6,765,161...6,777,728
Ensembl chr20:6,546,173...6,558,610 		JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:55,302,721...55,425,248
Ensembl chr 6:56,936,850...57,059,519 		JBrowse link
G HRH1 histamine receptor H1 ISO RGD PMID:15917347 RGD:2316921 NCBI chr 3:11,074,451...11,199,871
Ensembl chr 3:11,541,294...11,542,757 		JBrowse link
G INSIG1 insulin induced gene 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:146,893,730...146,906,329
Ensembl chr 7:158,619,531...158,632,012 		JBrowse link
G INSIG2 insulin induced gene 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2B:5,046,971...5,068,757
Ensembl chr2B:118,632,402...118,652,647 		JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr  X:22,903,403...22,908,527
Ensembl chr  X:30,459,527...30,464,652 		JBrowse link
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801 		JBrowse link
negative regulation of steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE8B phosphodiesterase 8B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:37,874,089...38,121,322
Ensembl chr 5:38,402,790...38,617,743 		JBrowse link
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKKL1 dickkopf like acrosomal protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,375,301...46,389,822
Ensembl chr19:55,301,955...55,313,690 		JBrowse link
G GGCX gamma-glutamyl carboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:85,599,227...85,612,274
Ensembl chr2A:87,152,111...87,164,567 		JBrowse link
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801 		JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GFI1 growth factor independent 1 transcriptional repressor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 1:95,139,171...95,151,054
Ensembl chr 1:93,876,245...93,883,528 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:46,321,075...46,328,865
Ensembl chr20:47,384,818...47,390,733 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:45,341,857...45,345,544
Ensembl chr 8:42,723,971...42,730,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18867
      metabolic process 12794
        negative regulation of metabolic process 3241
          negative regulation of lipid metabolic process 108
            negative regulation of steroid metabolic process 28
              negative regulation of aldosterone metabolic process + 4
              negative regulation of bile acid metabolic process + 3
              negative regulation of cholesterol metabolic process + 7
              negative regulation of ecdysteroid metabolic process + 0
              negative regulation of glucocorticoid metabolic process + 5
              negative regulation of steroid biosynthetic process + 26
Path 2
Term Annotations click to browse term
  biological_process 19315
    biological regulation 11855
      regulation of biological process 11474
        regulation of cellular process 11118
          regulation of metabolic process 6552
            regulation of primary metabolic process 5127
              regulation of lipid metabolic process 361
                negative regulation of lipid metabolic process 108
                  negative regulation of steroid metabolic process 28
                    negative regulation of aldosterone metabolic process + 4
                    negative regulation of bile acid metabolic process + 3
                    negative regulation of cholesterol metabolic process + 7
                    negative regulation of ecdysteroid metabolic process + 0
                    negative regulation of glucocorticoid metabolic process + 5
                    negative regulation of steroid biosynthetic process + 26
paths to the root