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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of steroid metabolic process
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Accession:GO:0045939 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.
Synonyms:exact_synonym: down regulation of steroid metabolic process;   downregulation of steroid metabolic process;   negative regulation of steroid metabolism
 narrow_synonym: inhibition of steroid metabolic process


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negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 ISO
IEA
(PMID:19584291)
GO_REF:0000107
RGD
Ensembl
PMID:19584291 GO_REF:0000107 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp5 bone morphogenetic protein 5 ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
JBrowse link
G Rest RE1-silencing transcription factor IMP
ISO
PMID:19342457
(PMID:19342457)
RGD PMID:19342457, PMID:19342457 RGD:4891166 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 IEA
ISO
GO_REF:0000107
(PMID:16959810)
Ensembl
RGD
PMID:16959810 GO_REF:0000107 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf19 fibroblast growth factor 19 ISO MGI:MGI:1928271 (MGI:MGI:5501367|PMID:23747249)
(PMID:12815072)
RGD PMID:12815072, PMID:23747249 MGI:MGI:5501367 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Malrd1 MAM and LDL receptor class A domain containing 1 ISO MGI:MGI:1096383|MGI:MGI:2154956 (MGI:MGI:5501367|PMID:23747249) RGD PMID:23747249 MGI:MGI:5501367 NCBI chr17:82,430,836...83,156,696
Ensembl chr17:82,430,836...82,953,864
JBrowse link
G Prox1 prospero homeobox 1 ISO (PMID:16488887) RGD PMID:16488887 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 ISO (PMID:16549446) RGD PMID:16549446 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor ISO (PMID:15947108) RGD PMID:15947108 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO
IEA
(PMID:15243130)
GO_REF:0000107
RGD
Ensembl
PMID:15243130 GO_REF:0000107 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO
IEA
IDA
(PMID:1917954)
GO_REF:0000107
RGD
Ensembl
PMID:1917954, PMID:9225228 GO_REF:0000107, RGD:10059686 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Erlin1 ER lipid raft associated 1 ISO (PMID:24217618) RGD PMID:24217618 NCBI chr 1:263,810,439...263,845,762
Ensembl chr 1:263,810,439...263,845,762
JBrowse link
G Erlin2 ER lipid raft associated 2 ISO (PMID:24217618) RGD PMID:24217618 NCBI chr16:69,179,005...69,195,452
Ensembl chr16:69,179,588...69,195,097
JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 ISO (MGI:MGI:5490819|PMID:17202134) RGD PMID:17202134 MGI:MGI:5490819 NCBI chr17:63,107,152...63,107,469 JBrowse link
G Sod1 superoxide dismutase 1 ISO
ISS
(PMID:15473258)
GO_REF:0000024
RGD
UniProt
PMID:15473258 GO_REF:0000024 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO
IEA
IMP
(PMID:21810484)
GO_REF:0000107
PMID:24201375
RGD
Ensembl
PMID:21810484, PMID:24201375 GO_REF:0000107, RGD:14697729 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 ISO
IEA
(PMID:19584291)
GO_REF:0000107
RGD
Ensembl
PMID:19584291 GO_REF:0000107 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp5 bone morphogenetic protein 5 ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
JBrowse link
G Rest RE1-silencing transcription factor IMP
ISO
PMID:19342457
(PMID:19342457)
RGD PMID:19342457, PMID:19342457 RGD:4891166 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO MGI:MGI:2451290 (MGI:MGI:3696486|PMID:17234593) RGD PMID:17234593 MGI:MGI:3696486 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
negative regulation of steroid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp5 bone morphogenetic protein 5 ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Hrh1 histamine receptor H 1 IMP RGD PMID:15917347 RGD:2316921 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Insig1 insulin induced gene 1 ISO MGI:MGI:1920249 (MGI:MGI:3603108|PMID:16100574) RGD PMID:16100574 MGI:MGI:3603108 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insig2 insulin induced gene 2 ISO MGI:MGI:1916289 (MGI:MGI:3603108|PMID:16100574) RGD PMID:16100574 MGI:MGI:3603108 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 ISO
IEA
ISS
(PMID:9384387)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
HGNC-UCL
PMID:9384387 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:54,734,385...54,738,513
Ensembl chr  X:54,734,385...54,738,513
JBrowse link
G Wnt4 Wnt family member 4 ISO (PMID:15317892), (PMID:18182450) RGD PMID:15317892, PMID:18182450 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
negative regulation of steroid hormone biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde8b phosphodiesterase 8B ISO MGI:MGI:5526098 (MGI:MGI:5526088|PMID:21187369) RGD PMID:21187369 MGI:MGI:5526088 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkkl1 dickkopf like acrosomal protein 1 ISO (MGI:MGI:3839065|PMID:18818293) RGD PMID:18818293 MGI:MGI:3839065 NCBI chr 1:101,205,426...101,210,675
Ensembl chr 1:101,205,426...101,210,675
JBrowse link
G Wnt4 Wnt family member 4 IEA
ISO
GO_REF:0000107
(MGI:MGI:2675528|PMID:12949260)
(PMID:12949260)
Ensembl
RGD
PMID:12949260 GO_REF:0000107, MGI:MGI:2675528 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snai1 snail family transcriptional repressor 1 ISO (PMID:19502595) RGD PMID:19502595 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 ISO (PMID:18485278), (PMID:19502595) RGD PMID:18485278, PMID:19502595 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      negative regulation of metabolic process 3315
        negative regulation of lipid metabolic process 107
          negative regulation of steroid metabolic process 26
            negative regulation of aldosterone metabolic process + 4
            negative regulation of bile acid metabolic process + 3
            negative regulation of cholesterol esterification 1
            negative regulation of cholesterol metabolic process + 5
            negative regulation of ecdysteroid metabolic process + 0
            negative regulation of glucocorticoid metabolic process + 5
            negative regulation of steroid biosynthetic process + 25
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of metabolic process 7007
          regulation of primary metabolic process 6028
            regulation of lipid metabolic process 397
              regulation of steroid metabolic process 117
                negative regulation of steroid metabolic process 26
                  negative regulation of aldosterone metabolic process + 4
                  negative regulation of bile acid metabolic process + 3
                  negative regulation of cholesterol esterification 1
                  negative regulation of cholesterol metabolic process + 5
                  negative regulation of ecdysteroid metabolic process + 0
                  negative regulation of glucocorticoid metabolic process + 5
                  negative regulation of steroid biosynthetic process + 25
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.