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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of complement activation
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Accession:GO:0045916 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
Synonyms:exact_synonym: down regulation of complement activation;   downregulation of complement activation;   negative regulation of complement cascade
 narrow_synonym: inhibition of complement activation



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negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in IDA
ISO
(PMID:28657829), (PMID:6211481) RGD PMID:6211481 PMID:28657829 PMID:10929073 RGD:2326180 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cd59 CD59 molecule acts_upstream_of_or_within ISO (MGI:1888643|PMID:10946279) RGD PMID:10946279 MGI:1888643 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within IMP
ISO
MGI:2158683 (MGI:1351571|PMID:10642554) RGD PMID:10642554 PMID:11861390 MGI:1351571, RGD:625470 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) RGD PMID:11485744 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59 CD59 molecule acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:1888643|PMID:10946279), (MGI:2148385|PMID:11471050)
PMID:21873635
RGD PMID:10946279 PMID:11471050 PMID:15843577 PMID:21873635 MGI:1888643 MGI:2148385, RGD:1600482, RGD:13792537 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IBA
(PMID:23482636)
PMID:21873635
RGD PMID:23482636 PMID:21873635 RGD:13792537 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750
JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in IBA
ISO
PMID:21873635
UniProtKB:P01024 (PMID:17051150)
RGD PMID:17051150 PMID:21873635 RGD:13792537 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212
JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpa complement component 4 binding protein, alpha involved_in ISO
IBA
IEA
(PMID:22333221)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:22333221 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in ISO (PMID:22333221) RGD PMID:22333221 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G Cd46 CD46 molecule involved_in ISO
IBA
(PMID:9029106)
PMID:21873635
RGD PMID:9029106 PMID:21873635 RGD:13792537 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cr2 complement C3d receptor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
JBrowse link
G RGD1559810 similar to hypothetical protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:33,996,404...33,997,405
Ensembl chr20:33,996,224...33,997,432
JBrowse link
G Susd4 sushi domain containing 4 involved_in IBA
ISO
PMID:21873635
(PMID:23482636)
RGD PMID:23482636 PMID:21873635 RGD:13792537 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750
JBrowse link
G Zp3r zona pellucida 3 receptor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:42,019,998...42,064,836
Ensembl chr13:42,020,018...42,064,812
JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO (PMID:12538697) RGD PMID:12538697 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Serping1 serpin family G member 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:10946292)
UniProt
RGD
PMID:10946292 GO_REF:0000024 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19512
    immune system process 2869
      immune effector process 726
        negative regulation of immune effector process 129
          negative regulation of complement activation 14
            negative regulation of activation of membrane attack complex 1
            negative regulation of complement activation, alternative pathway + 3
            negative regulation of complement activation, classical pathway + 9
            negative regulation of complement activation, lectin pathway + 2
            suppression by virus of host complement activation 0
Path 2
Term Annotations click to browse term
  biological_process 19512
    biological regulation 13616
      regulation of biological process 12887
        positive regulation of biological process 6699
          positive regulation of immune system process 1014
            positive regulation of immune response 638
              activation of immune response 412
                complement activation 166
                  regulation of complement activation 25
                    negative regulation of complement activation 14
                      negative regulation of activation of membrane attack complex 1
                      negative regulation of complement activation, alternative pathway + 3
                      negative regulation of complement activation, classical pathway + 9
                      negative regulation of complement activation, lectin pathway + 2
                      suppression by virus of host complement activation 0
paths to the root